Sort by

Article
Business, Economics and Management
Econometrics and Statistics

Alireza Yazdani

Abstract: This paper revisits and extends the machine learning framework for U.S. recession prediction introduced by Yazdani2020 by incorporating post-pandemic macroeconomic dynamics, an expanded predictor set and machine learning models. Using monthly data from January 1959 through December 2024, recession forecasting is formulated as an imbalanced binary classification problem. We use downsampling for static models and class-weighted loss functions for neural networks and evaluate model performance using classification metrics robust to rare events. We further examine structural stability across four economic regimes and assess economic value through a dynamic stock–bond allocation strategy. We observe that ensemble tree methods, particularly gradient boosting (XGBoost, LightGBM) and random forests, consistently deliver the strongest discrimination, with out-of-sample AUC above 0.99 and PR-AUC above 0.96. The Transformer achieves probability calibration, and Deep sequence models exhibit high discrimination, while performance deteriorates across model classes in the 2020–2024 regime, especially for linear specifications. We also examine risk-adjusted returns of models. Overall, ensemble trees and Transformers show high predictive power and emerge as complementary tools in macroeconomic recession forecasting.

Review
Public Health and Healthcare
Other

Jean Baptiste Lamango

,

Elizabeth Mazzio

,

Renee Reams

,

Diana J. Wilkie

,

Ramesh Badisa

,

Ebenezer Oriaku

,

Karam F. A. Soliman

Abstract: Oral squamous cell carcinoma (OSCC) remains a major contributor to global head and neck cancer morbidity and mortality. This review examines the epidemiological aspects of OSCC and the biological mechanisms through which established exposures (e.g., tobacco, alcohol, betel/areca nut, socioeconomic and selected viral infections etc.) and emerging determinants (oral microbiome dysbiosis, host genetics/epigenetics, and immune dysfunction) converge to initiate and promote malignant transformation. We emphasize that OSCC risk is probabilistic and multifactorial: incidence rises markedly with age and cumulative exposures, yet the majority of individuals risk exposed to these risk factors will not develop disease. Mechanistically, carcinogen-driven DNA damages intersects with dysbiosis characterized by enrichment of periodontal pathobionts (notably Porphyromonas gingivalis and Fusobacterium nucleatum), which can sustain chronic inflammation, increase local generation of acetaldehyde and nitrosamines, and promote immune evasion via expansion of immunosuppressive cell populations and checkpoint signaling. We summarize recurrent molecular and genetic alterations in OSCC and highlight progress in early detection, including adjunctive visualization, optical and vibrational spectroscopy, and liquid-biopsy approaches using salivary and blood-based biomarkers. Finally, we discuss prevention opportunities spanning risk-factor modification, historical cultural practices, oral hygiene to mitigate dysbiosis (pH modulation and probiotics), and dietary/nutritional strategies. Integrating exposure history with microbial and molecular profiling may enable risk-stratified screening and prevention paradigms for OSCC.

Article
Medicine and Pharmacology
Dentistry and Oral Surgery

Cristinel Adrian Nechita

,

Corina Marilena Cristache

,

Oana Elena Burlacu Vatamanu

,

Cristian Corneliu Butnarasu

,

Victor Nimigean

Abstract: Background/Objectives: Immediate provisionalization in the esthetic zone is a well-documented but technique-sensitive procedure, and the choice of provisional connection geometry (indexed vs. non-indexed) remains debated. The aim of this ret-rospective single-arm cohort clinical study was to evaluate the clinical performance of a digitally planned, guide-delivered provisionalization protocol using prefabricated provisional crowns connected to 5-degree Morse taper implants without an antirota-tional index, with emphasis on emergence profile shaping and peri-implant tissue sta-bility at one year; Methods: Twenty consecutive single-implant cases (19 female, 1 male; mean age 38.1 ± 12.7 years; 18 anterior and 2 premolar sites) were treated between January 2024 and February 2026. All implants were placed with primary inser-tion torque ≥ 30 N·cm (mean 34.75 ± 2.55 N·cm) and immediately restored with a digitally designed, non-antirotational provisional crown. Primary outcome was provision-al retention without major intervention; secondary outcomes included biologic com-plications, papilla score, marginal bone change at T0–T3 and T3–T4, and buccal con-tour change (T0 vs T2 intraoral scan superimposition). Wilson 95% confidence inter-vals, Fisher’s exact test, and Mann–Whitney U test were used (α = 0.05); Results: Pro-visional retention without major intervention was 75.0% (15/20; 95% CI 53.1–88.8). Biologic complications were uncommon (bleeding on probing, suppuration, midfacial recession, and chairside adjustment, each 5.0%). Mean total marginal bone loss at one year was 0.37 ± 0.20 mm; mean buccal contour gain was 1.41 ± 0.48 mm. A complete papilla was preserved in 70.0% of cases; Conclusions: Digitally planned, guide-delivered provisionalization on a non-antirotational 5-degree Morse taper interface appears clinically feasible for emergence profile shaping in the esthetic zone, with stable peri-implant tissues at one year.

Article
Computer Science and Mathematics
Information Systems

Rahid Zahid Alekberli

,

Hikmat Karimov

Abstract: Maritime ports—now deeply digitalized andinterdependent—face escalating cyber risk amid hybridgeopolitical pressures, complex vendor ecosystems, andwidening social dependence on uninterrupted trade flows.Situated at the intersection of the Belt and Road Initiative andthe Trans-Caspian International Transport Route, the CaspianBasin exemplifies both the promise of data-driven logistics andthe vulnerability of fragmented cybersecurity governance. Thisstudy extends the Strategic Data Alignment Framework(SDAF), originally designed to align corporate strategy withdata governance, into a cybersecurity governance model forcritical maritime infrastructure under hybrid threat conditions.Using comparative policy analysis and benchmarking againstcontemporary global standards (e.g., NIS2-style obligations,maritime cyber guidelines, and digital trade principles), thestudy identifies systemic weaknesses in harmonization,institutional capacity, supply-chain assurance, and resilienceplanning. It reconceptualizes cyber-resilience as a strategicresource and proposes a five-step roadmap combining regionalthreat-intelligence sharing, vendor risk controls, standardsalignment, AI-enabled detection, and stress-tested recovery.The findings underscore urgent needs for coordinated action tosafeguard digital corridors and the societies they serve.

Article
Public Health and Healthcare
Primary Health Care

Scarlet Hauri-Opazo

,

Bárbara Burgos-Mansilla

,

Cinthya Espejo-Alvarado

,

Angela Navarrete González

Abstract: Breast cancer constitutes one of the oncological diagnoses with the greatest impact on women’s lives, with consequences that extend beyond active treatment into a survi-vorship period marked by profound transformations in identity, relationships, and well-being. This study aimed to explore the impacts that breast cancer produces on the everyday lives of survivor women in the municipality of Villarrica, La Araucanía Region. A qualitative methodology with a phenomenological orientation was employed, based on discourse analysis of three focus groups with breast cancer survivor women. The analysis identified five categories: impact on everyday life and work, management of uncertainty and fear, transformation of self-care and life priorities, support networks and community, and barriers to accessing the healthcare system. The findings demon-strate the coexistence of posttraumatic growth and persistent psychological distress, together with structural inequities that limit access to comprehensive care during the survivorship period. It is concluded that cancer survivorship demands public policy responses that are continuous, multilevel, and integrative of a gender perspective, ar-ticulating individual, family, and community interventions from primary healthcare.

Review
Computer Science and Mathematics
Other

Md Khurram Monir Rabby

,

David Ason

Abstract: This paper presents a comprehensive cross-era analysis of the algorithmic evolution of Large Language Models (LLMs) through four developmental epochs: Before Transformer (pre-2017), Transformer (post-2017), Instruction-tuned \& Open-source LLMs, and Multimodal Agents (2024-2025). A novel innovation pathway framework is introduced that traces causal relationships between architectural breakthroughs and emergent capabilities, addressing critical research gaps in three dimensions: (1) Cross-paradigm synthesis connecting statistical foundations to modern multimodal systems, (2) Causal innovation mapping demonstrating how architectural choices propagate through model generations, and (3) Cross-domain capability analysis quantifying transfer between representation learning, knowledge acquisition, behavioral alignment, and multimodal integration. This analysis reveals that LLM progression represents fundamental paradigm shifts rather than incremental improvements, with transformer architectures, human feedback mechanisms, and open-source ecosystems collectively enabling the transition from specialized NLP tools to general reasoning systems. We provide empirical evidence through case studies of capability emergence, quantify innovation impacts using performance metrics, and examine safety implications through recent jailbreak analysis and refusal mechanism studies. The contributions include: (a) a unified lifecycle synthesis with original analytical framework, (b) innovation trajectory mapping with causal pathway analysis, and (c) validated evolutionary principles for forecasting next-generation AI capabilities.

Article
Chemistry and Materials Science
Nanotechnology

Wan Mand Dizayee

,

Zhala Dara Omer Meran

,

Layla A. Abu-Naba'a

Abstract: Background/Objectives: One of the ongoing clinical constraints is limiting microbial growth on facial and dental prostheses, justifying the need for material surface enhancements for reducing the associated microbial complications. This study aimed to investigate a clinically applicable and reproducible coating technique to overcome microbial clinical challenges. Methods: Ag nanoparticles (NPs) were applied to three types of facial materials through spray, spin, and dip coating techniques. Surface characterization, elemental composition, and chemical bond formation were assessed by Scanning Electron Microscopy (SEM), Energy-dispersive X-ray Spectroscopy (EDS), and Fourier Transform Infrared (FTIR) spectroscopy, respectively. Subsequent optimization of spray numbers was performed. Antimicrobial performance was examined by agar diffusion, direct contact, and adhesion (time-dependent) assays, with different layers, against Pseudomonas aeruginosa. Results: Spray coating exhibited superior coating uniformity compared with others. 15 sprays was determined as optimal number for a single layer coating. EDS confirmed Ag NP presence, FTIR revealed no chemical alteration of specimens. Disk diffusion tests showed no inhibition zones. Adhesion and direct contact tests displayed antibacterial activity, the effect of which was stronger for the latter. Time-dependent adhesion test of 1-layer coating of acrylic and silicone had a consistent decrease in bacterial amount, whilst zirconia had only a strong initial activity. In general, the 3-layer coating did not showcase an increased antimicrobial activity, suggesting that the increase in layering negatively impacts surface effectiveness. Conclusions: spray coating of Ag NPs can provide a promising, clinically-applicable, large-scale manufacturing strategy for improving dental and facial material antibacterial qualities without altering the inherent prosthetic properties.

Article
Public Health and Healthcare
Public Health and Health Services

Joycelyn Williams Green

,

Joseph D. Adekunle

,

Caroline Olamojiba Afolabi

Abstract: Introduction: Online forums use as a source for mental health support has surged among individuals worldwide. Social media has become popular for sharing personal experiences and seeking information and support. Studies have analyzed posts on social media forums, focusing on frequency of engagement by users, why individuals engage, and how they engage on these web-based platforms. However, key questions about how mental illness is experienced, discussed and emotionally expressed from the user's perspective is needed to add important insight. Objective: This study aims to investigate how mental health related disorders and conditions are discussed, experienced, and emotionally framed in online discourse, specifically focusing on how mental health symptoms and distress language across mental health dialogues are expressed and examining the text-based communication beyond prevalence-based analyses and simplified sentiment analysis through symptom and experience-centered approach to uncover patterns in how symptoms are articulated and emotions expressed, and how distress is framed across multiple mental health conditions, by systematically analyzing digital textual data associated with various mental illnesses. Methodology: A retrospective observational design was conducted. The dataset used in this study was scrapped from YouTube between 11/2/2025 to 11/30/2025 by using a predefined keyword resulting in a total sample of 646 279 comments. The data was prepared and preprocessed using standard NLP procedures. Descriptive analysis of Disorder Representation, Symptom Expression Analysis, Emotional Tone and Distress Analysis, Cross-Disorder Statistical Comparisons and Crisis-Oriented Language Analysis was conducted. Kruskal–Wallis test a non-parametric analysis revealed no statistically significant differences in emotional proportion scores across mental health condition categories. Pearson’s chi-squared test indicted a robust and statistically significant association between mental health disorder type and symptom category. Result: Among the mental health conditions discussed online, content related to anxiety made up the largest count of the dataset (n = 125,001; 19.3%), followed by depression (n = 100,281; 15.5%) mental breakdown (n = 93,836; 14.5%), and PTSD (n = 110,935; 14.2%). However, Obsessive-Compulsive Disorder exhibited a robust engagement (Eng = 158.5); and panic attack–related posts showed higher levels of engagement (Eng = 189). Mental health conditions such as panic attacks (0.1050), anxiety (0.0532), depression (0.0490), and mental illness (0.0497) demonstrated intense emotions. For the category Anxiety Terms, the most negative terminology was recorded with the most negative sentiment score (−62,667). Stigmatizing revealed a net negative sentiment (−7,787) while Self-Disclosure also revealed a net negative sentiment (−2,344). Empathy showed the highest positive sentiment score (50,432), followed by Supportive (24,867) and Advocacy (4,897) categories.No statistically significant differences in emotional proportion scores across mental health disorder categories were revealed (X2 (6) = 0.118, p=1.000). However, a robust and statistically significant association between mental health disorder type and symptom category was identified (X2(18) =11, 623, p<0.001), suggesting that each mental health condition presents different symptom profiles across cognitive, emotional, and somatic dimensions. Conclusion: In conclusion, this study makes several important contributions to mental health research and practice in understanding mental illness as a lived experience rather than solely a diagnostic category. This finding also provides empirical support for conceptualizing OCD as a cognitive-based disorder, where distress is often expressed through intrusive thought patterns and not solely emotional states.

Article
Biology and Life Sciences
Food Science and Technology

Haifen Wang

,

Weiwei Liu

,

Fei Peng

,

Ziye Zhang

,

Jiawei Cao

,

Jiayu Shi

,

Liang He

,

Yunbin Jiang

,

Mengshi Wang

,

Junwei Yuan

Abstract: To investigated the effect of exogenous selenium on selenium enrichment and antioxidant activity of germinated chestnut. We treated ‘Zaofeng’ chestnuts with 0, 20, 40, 60 and 80 mg/L concentration of Na2SeO3, and the analyses focused on total Se, SeCys2, MeSecys, SeIV, SeMet, SeVI, γ -aminobutyric acid (GABA), antioxidant enzyme (PAL, SOD, GPX, CAT) activity, non-enzymatic antioxidant substances (total polyphenols and flavonoids) content and antioxidant capacity (DPPH, ABTS) during germination. The results indicated that low concentration of selenium (20-40 mg/L) significantly promoted the organic transformation of selenium, increased antioxidant enzyme activity and phenol accumulation, and enhanced antioxidant capacity of chestnut. High concentration of selenium (80 mg/L) induced oxidative stress, inhibited enzyme activity and reduces antioxidant capacity of chestnut. During the germination of chestnut, selenite was absorbed by embryo and subsequently transformed into organic Se in vivo, ultimately being stored in the form of SeCys2. The selenium enrichment rate decreased significantly with the increase of Na2SeO3 treatment concentration. Furthermore, the treatment with 40 mg/L Na2SeO3 led to a significant increase in GABA content of germinated chestnut. Overall, 20-40 mg/L Na2SeO3 were identified as the suitable concentration for germinated chestnut. This study provides a theoretical basis for developing functional food of selenium-enriched germinated chestnut.

Article
Computer Science and Mathematics
Computer Networks and Communications

Clarissa Astuto

,

Daniele Francesco Santamaria

Abstract: Self-regulated transportation networks belong to the class of continuous network models and are widely used not only in biological applications, such as vascular systems, neural networks or tissues regeneration but also in urban infrastructure and in communication technologies. Their well-established tree structure prevents the formation of loops, which limits their ability to capture an important feature observed in real systems: when a disruption or damage occurs, the network should be able to reorganize to restore transport pathways. In this work, we propose alternative modeling strategies to incorporate this capability. These approaches allow the network to adapt to perturbations by modifying its structure and, in some cases, by creating alternative routes that compensate for damaged regions. Numerical results illustrate how the modified models can reproduce self-repair mechanisms that are not captured by standard formulations.

Article
Environmental and Earth Sciences
Soil Science

Zhengrong Bao

,

Changbo Ji

,

Wanning Dai

,

Xiao Liang

,

Chunlian Wang

,

Zunqi Liu

,

Jun Meng

Abstract:

To investigate the effects of long-term biochar application on different forms of potassium (K) content in maize rhizosphere soil and maize growth, two biochar application rates (B0: 0 t ha⁻¹ yr⁻¹, B1: 2.625 t ha⁻¹ yr⁻¹) and two K fertilizer application rates (K0: 0 kg ha⁻¹ yr⁻¹, K1: 60 kg ha⁻¹ yr⁻¹) to create four treatments (B0K0, B0K1, B1K0, B1K1). In this long-term field trial, we investigated various forms of K in the maize rhizosphere soil, together with soil physicochemical properties and maize growth indicators. Results indicate that biochar significantly increased microbial biomass carbon (MBC), cation exchange capacity (CEC), and electrical conductivity (EC) in the rhizosphere soil, while also improving rhizosphere soil pH. Compared with the treatment without biochar, biochar application significantly increased the content of water-soluble potassium (WSK), exchangeable potassium (EK), and non-exchangeable potassium (NEK) in the rhizosphere soil by 18.57% (2021) and 11.18% (2022), 13.49% (2021), and 11.43% (2022), 14.65% (2021), and 17.06% (2022), respectively. Maize roots were more developed, and plant height, stem diameter, and leaf area index were significantly increased. With above-ground dry weight and K uptake significantly increasing by 13.87% (2021) and 12.04% (2022), and 41.84% (2021) and 43.87% (2022), respectively. Compared with B0K0, the B1K1 treatment—which combined biochar with K fertilizer—exhibited the highest K content in all forms within the rhizosphere soil, along with the greatest maize aboveground dry weight and K uptake. This study demonstrates biochar’s potential in meeting crop root K demands, laying the foundation for its application in enhancing soil K fertility.

Article
Engineering
Electrical and Electronic Engineering

Antonio Carlos Bento

,

Carlos Vazquez-Hurtado

Abstract: The high cost and complexity of Industry 4.0 laboratory infrastructure limit the adoption of Digital Twin concepts in engineering education. This paper proposes a low-cost Digital Twin framework for sustainable manufacturing education integrating SAP NetWeaver, Node-RED, and AI-based decision support. The framework adopts a layered architecture that connects PLC-based simulation, IoT middleware, enterprise resource planning systems, and intelligent decision-making components. Node-RED enables real-time data exchange, while SAP NetWeaver provides enterprise-level integration through OData services. An AI module supports decision-making for production and inventory management. The proposed framework is implemented as a functional prototype, demonstrating end-to-end integration without requiring physical manufacturing equipment. Competency-based mapping aligns the framework with Industry 4.0 engineering skills, supporting its use in academic environments. A sustainability assessment highlights reductions in infrastructure cost, energy consumption, and resource usage compared to traditional laboratory approaches. The results indicate that the framework provides a scalable and accessible solution for teaching Digital Twin concepts, contributing to sustainable engineering education in resource-constrained contexts.

Article
Physical Sciences
Other

Ramón Serrano Montesinos

,

Joan Josep Ferrando

,

Juan Antonio Morales-Lladosa

Abstract: A covariant formulation of the Geometric Dilution of Precision (GDOP) matrix is presented in the framework of a Relativistic Positioning System (RPS). By including the receiver-emitter frequency ratios, the Frequency Geometric Dilution of Precision (FGDOP) scalar is computed in terms of observable quantities, the received frequencies and the angular separation between pairs of emitters in view. Some required concepts are first introduced: the FGDOP matrix and the Gram matrix associated to k light-like vectors. From the tensor form of the FGDOP matrix and its trace, a closed form of the FGDOP scalar is obtained, extending previous matrix calculations. Clarifying computations for symmetric emitter configurations are presented. The geometric interpretation of the GDOP scalar in terms of volumes and areas defined by the relative position of the emitters on the unit celestial sphere of the user is also recovered.

Article
Computer Science and Mathematics
Algebra and Number Theory

Ebrahim E. Elsayed

Abstract: ZPIF (Zero Pair Interaction Functional) is introduced as a quadratic spectral operator framework extending the classical explicit formula of the Riemann zeta function. Unlike the standard linear spectral decomposition, ZPIF incorporates second-order interactions between spectral modes within a Hilbert space formulation. The framework includes a rigorous operator definition, spectral expansion, trace-class regularization, and conditional convergence under truncation. A computational scheme based on numerical zeta zeros is also proposed. The novelty of ZPIF lies in introducing a quadratic spectral energy functional consistent with classical spectral heuristics without assuming unresolved conjectures. Numerical experiments demonstrate nonlinear growth behavior and quadratic interaction effects that are absent in classical linear formulations.

Article
Biology and Life Sciences
Agricultural Science and Agronomy

Santo Orlando

,

Fabrizio Colverde

,

Carlo Greco

,

Pietro Catania

,

Mariangela Vallone

,

Michele Massimo Mammano

Abstract: This study evaluates the performance of LiDAR sensing and UAV photogrammetry for three-dimensional canopy reconstruction and structural parameter estimation in precision agriculture. Experiments were conducted in Sicily (Italy) on Moringa oleifera Lam. and Ficus macrophylla subsp. columnaris, representing contrasting canopy architectures. LiDAR and UAV data were used to generate canopy models and estimate canopy height, volume, and vegetation density. A voxel-based approach was applied to LiDAR point clouds to analyze internal canopy structure. LiDAR significantly outperformed UAV photogrammetry, achieving lower errors in canopy height estimation (RMSE = 0.19–0.21 m vs. 0.52–0.60 m) and canopy volume (3.5–4.2% vs. 13.7–16.1%). UAV photogrammetry provided reliable estimates of canopy surface but underestimated structural parameters in dense vegetation due to occlusion effects. Differences were more pronounced in Ficus macrophylla than in Moringa oleifera, highlighting the influence of canopy complexity. These findings demonstrate that LiDAR-derived structural metrics can improve canopy characterization and support precision agriculture applications such as biomass estimation, irrigation planning, and canopy management in Mediterranean cropping systems.

Article
Physical Sciences
Optics and Photonics

P.B. Parchinsky

,

A.A. Nasirov

,

Sh. U. Yuldashev

,

A. Arslanov

,

R.A. Nusretov

,

N.A. Kulagina

,

S. Kh. Suleymanov

,

Peng Li

,

Sergei A. Khakhomov

,

Alina V. Semchenko

+3 authors

Abstract: This study investigates the effect of co-doping with nanographene on the properties of FTO layers produced by spray pyrolysis. The results show that co-doping with nanographene enhances phase separation processes within the bulk of the FTO layer. The inhomogeneities formed during phase separation are depleted of fluorine compared to the film bulk. Co-doping with nanographene also significantly modifies the optical properties of the FTO layers. Specifically, it alters the position and intensity of the peaks in the reflection spectra, indicating a change in the nature of the absorbing centers. Furthermore, the optical bandgap of the FTO layers decreases with an increasing degree of nanographene doping. Finally, co-doping with nanographene reduces the resistance of the FTO layers, which can be attributed to an increase in charge carrier mobility.

Review
Medicine and Pharmacology
Urology and Nephrology

Giuseppe Seminara

,

Leonardo Meduri

,

Marco Leuzzi

,

Gabriele Antonini

,

Antonio Aversa

Abstract: Background/Objectives: Penile rehabilitation (PR) techniques are claimed to counteract chronic degenerative processes of cavernous tissue such as penile hypoxia, neurovascular damage, and cavernous fibrosis. The objective of this umbrella review is to synthesize findings from existing meta-analyses to evaluate the efficacy of traditional and emerging PR strategies, providing an evidence-based roadmap for clinical management after surgery for prostate cancer. Methods: Conducted in accordance with PRIOR guidelines, a comprehensive literature search of PubMed, The Cochrane Library, and Scopus was performed through April 2026. The review included primarily systematic reviews and meta-analyses investigating pharmacological, physical, surgical, and regenerative interventions for post-prostatectomy erectile dysfunction (ED). Methodological quality was independently assessed using standardized tools. Results: PDE5 inhibitors (PDE5-is) significantly improve erectile function during active treatment, yet evidence supporting their role in promoting spontaneous, "unassisted" recovery remains limited. Vacuum erectile devices demonstrate high efficacy for assisted intercourse but show minimal impact on returning to baseline function compared to placebo. Penile prosthesis (PP) implantation maintains robust efficacy with exceptionally high satisfaction rates (83–85%), proving independent of prior pelvic surgery. Although early-phase trials suggest clinical potential for regenerative therapies like low-intensity extracorporeal shockwave therapy, platelet-rich plasma, and stem cell interventions, the evidence is currently undermined by substantial heterogeneity in study protocols and concerns regarding methodological quality. Conclusions: PR following radical prostatectomy remains a complex challenge characterized by poor evidence. While PDE5-Is are established first-line therapy for assisted function, PP remains the most reliable definitive treatment for refractory ED cases. Regenerative approaches show promise but remain investigational until standardized protocols and large-scale trials are established.

Essay
Public Health and Healthcare
Health Policy and Services

Ziad D. Bsghdadi

Abstract: Purpose: To provide an evidence calibrated, time bound clinical framework for the use of 38% silver diamine fluoride (SDF) as interim stabilization for severe early childhood caries (SECC) in young children, addressing gaps in existing guidelines regarding treatment duration, exit criteria, equity, and system accountability. Methods: This framework was developed from the American Academy of Pediatric Dentistry (AAPD) guidance (2017–2025), the 2024 Cochrane review, real world utilization studies, and a narrative review proposing a preservation to precision heuristic. Recommendations are expressed using GRADE terminology. Results: The framework includes ten recommendations, a systems drift principle, explicit time thresholds (< 6 months, 6–12 months, >12 months), a 12 month reassessment mandate, equity guardrails, a bridge vs destination consent model, and a future research agenda. A clinical vignette contrasts appropriate short term bridging with prolonged temporization due to access barriers. Conclusion: SDF is conditionally recommended for caries arrest in primary teeth. In children with SECC, SDF should be used within a documented, time bound preservation to precision pathway. SDF should not become an open ended substitute for definitive restorative care. Equity explicit implementation prevents the framework from penalizing underserved children.

Review
Biology and Life Sciences
Agricultural Science and Agronomy

Sonia Ojeda

,

Catarina Leal

,

Emilia Diaz-Losada

,

David Gramaje

Abstract: Grapevine trunk diseases (GTDs), caused mainly by fungal ascomycetes and some basidiomycetes, threaten vineyard sustainability through yield losses, higher management costs and reduced vineyard lifespan. Because pruning wounds are the main infection courts, pruning decisions strongly shape GTD risk. This review critically analyses advances over the last decade, with a particular focus on studies published since 2018, on how pruning practices influence infection dynamics and management outcomes across GTD complexes. We synthesize evidence on spore dispersal and weather drivers, temporal patterns of wound susceptibility, and the performance of mitigation strategies, including pruning timing (early/late and double pruning), training systems and sap-flow-oriented pruning concepts, optimization of wound number and size, and inoculum reduction through sanitation and remedial surgery. We also review recent field evaluations of pruning-wound protectants under artificial inoculation and natural infection, covering fungicides, biological control agents and physical barriers. Reported outcomes are highly variable among regions, climates and pathogen groups, indicating that universal recommendations are unreliable without local epidemiological context. Priority research gaps include: (i) field validation of traditional pruning concepts (protective wood/desiccation cones and diaphragm preservation) under natural infection; (ii) the epidemiological contribution of growing-season wounds; (iii) mechanistic drivers of the wide range of reported wound-susceptibility duration; (iv) development of cold-tolerant biological control agents effective across pathogen-host combinations; and (v) validation and transferability of spore-dispersal and risk-forecast models across viticultural regions. Overall, GTD management is best approached as a region-adapted, integrated strategy combining pruning decisions, inoculum management and timely wound protection.

Article
Engineering
Telecommunications

Massimo Celidonio

,

Fernando Consalvi

Abstract: The integration of satellite and terrestrial networks within the same spectrum is a key enabler for extending mobile connectivity in future communication systems. In this context, the Direct Connectivity between Mobile Satellite Service and International Mobile Telecommunications user equipment (DC-MSS-IMT) paradigm, currently under study within the International Telecommunication Union [1], foresees the use of terrestrial IMT frequency bands by satellite systems to directly serve conventional mobile devices. This paper presents an experimental study to assess the coexistence between a terrestrial 5G-NR receiver and a co-channel interfering signal representative of a Low Earth Orbit (LEO) satellite downlink. A controlled laboratory setup in conducted configuration was implemented to ensure repeatability and accurate control of interference conditions. Measurements were performed over four carrier frequencies representative of IMT bands (763 MHz, 1482 MHz, 2150 MHz, and 2635 MHz) [2], considering different traffic load conditions (100% and 50%) and Doppler shifts associated with satellite motion. The interference impact was evaluated in terms of receiver desensitization, defined as the increase in the total received power relative to the baseline noise level [3]. The results show that a 1 dB desensitization threshold is consistently reached when the interfering signal power is approximately 5–6 dB below the receiver noise floor, corresponding to an interference-to-noise ratio (I/N) of about −6 dB. This behavior is observed across all tested frequency bands, traffic conditions, and Doppler scenarios, indicating limited sensitivity to frequency offsets within the considered range. The findings confirm the validity of commonly adopted coexistence criteria and provide experimentally derived reference values to support ongoing regulatory and technical studies on spectrum sharing between satellite and terrestrial IMT systems.

of 5,870

Prerpints.org logo

Preprints.org is a free preprint server supported by MDPI in Basel, Switzerland.

Subscribe

Disclaimer

Terms of Use

Privacy Policy

Privacy Settings

© 2026 MDPI (Basel, Switzerland) unless otherwise stated