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Article
Medicine and Pharmacology
Oncology and Oncogenics

Mario Uccello

,

Stergios Boussios

,

Christine Maï

,

Hilary Worton

,

Arthur Bazire

,

Bertrand de Buhren

Abstract: Background/Objectives: First-line maintenance is established in advanced epithelial ovarian cancer (AEOC), but management remains uncertain for patients without BRCA mutation or homologous recombination deficiency (HRD)-positive disease. We assessed real-world use of bevacizumab, poly(ADP-ribose) polymerase (PARP) inhibitors and active surveillance in France (FR), Germany (DE), Italy (IT), Spain (ES) and the United Kingdom (UK). Methods: Anonymised physician-reported charts were analysed from a retrospective, non-interventional online survey conducted by AplusA Healthcare Marketing Research. Eligible patients had stage III–IV AEOC, no known BRCA-mutated or HRD-positive disease, no progression after first-line platinum chemotherapy, and started maintenance therapy or active surveillance between November 2024 and March 2026. Treatment allocation was compared by chi-square testing. Multinomial logistic regression assessed whether country remained associated with strategy after adjustment for clinical and disease characteristics. Results: Among 3293 patients, 1295 (39.3%) received bevacizumab, 1087 (33.0%) niraparib, 158 (4.8%) rucaparib, 477 (14.5%) active surveillance and 276 (8.4%) other therapy. Treatment allocation differed by country (χ²=725.4, df=16, P< 0.001). Bevacizumab was most frequent in FR and least frequent in the UK; niraparib was most frequent in ES and the UK; active surveillance was most common in the UK and IT. In the adjusted model, country was the strongest factor associated with strategy (likelihood-ratio χ²=550.1, df=8, P< 0.001). Conclusions: First-line maintenance practice in AEOC without an actionable BRCA/HRD biomarker varies substantially across European countries, suggesting influence from national access, reimbursement and clinical practice factors. Outcome-based real-world studies are needed to clarify the best strategy.

Article
Engineering
Other

Arpan Guha

Abstract: ANSI/IES TM-30-24 designates CES #15 and CES #18 as skin-representative color-evaluation samples, summarized by their mean individual fidelity (Rf,CES15,18). This analysis tested how well that two-sample mean represents average fidelity and category-level variation across a 100-spectrum skin-reflectance library stratified into five lightness-defined categories, evaluated across 1,432 architectural LED sources from the DTU PhotoLED database. Rf,CES15,18 closely tracked mean fidelity across the full reference library (r = 0.9976; RMSE = 0.84 Rf points). Benchmarked against all 4,950 possible two-spectrum means from the same library, it exceeded 85.7% of pairs in correlation and 82.7% in RMSE, favorable performance that was not unique. Raw category means within individual sources differed by 4.74 Rf points on average and by as much as 10.66 points. This ordering tracked chroma and was largely captured by the lightness-chroma geometry of the sampled spectra; little category-specific structure remained once that geometry was modeled, and the ordering was not fixed across the two reflectance libraries. Compact subsets were tested under source-only holdout and under simultaneous source-and-skin-spectrum holdout. Greedy selection held a modest source-held-out error advantage over an optimized category-matched random search at 9 to 10 samples. Under simultaneous holdout, subsets of that size preserved source-rank recovery, while reconstruction of unseen category means carried median errors near 1 Rf point. CES #15/#18 therefore serves as a favorable aggregate indicator within this library. Characterizing variation across the sampled skin-reflectance locus requires broader reflectance sets.

Article
Engineering
Industrial and Manufacturing Engineering

Christian Spreafico

,

Daniele Landi

,

Davide Russo

Abstract: The transition from rigid-body to compliant mechanisms offers well-recognized advantages in mechanical design, including reduced part count, improved energy efficiency, and expanded functional integration. However, existing catalogue-based and artificial intelligence–assisted design approaches often rely on abstract functional archetypes, limiting practical applicability and hindering identification of integrated, application-specific compliant solutions. This study presents a methodological framework for extracting compliant mechanism solutions from patent literature based on a structured, multi-agent pipeline employing Large Language Models (LLMs) within a Retrieval-Augmented Generation (RAG) architecture. The proposed approach integrates product decomposition, lexical and technological expansion, patent retrieval, compatibility assessment, and taxonomy-grounded classification using compliant mechanism archetypes. The framework is demonstrated through a case study involving 40 patents related to pedal-actuated waste bin mechanisms, enabling qualitative evaluation against expert judgment. The results indicate consistent identification of compliant alternatives to conventional rigid mechanisms, ranging from localized compliant substitutions (e.g., living hinges and leaf springs) to more integrated compliant transmission architectures. The patent-derived solutions provide application-specific structural embodiments, including geometric details and implementation information suitable for design reuse. Rather than proposing a finalized design tool, the study clarifies the architectural and methodological requirements for leveraging patent data in compliant mechanism design. By grounding design exploration in validated prior art and taxonomy-based reasoning, the proposed framework supports systematic discovery of contextually relevant compliant mechanisms while reducing abstraction and cognitive load in early-stage design.

Article
Social Sciences
Psychiatry and Mental Health

Konstantinos Chelios

,

Ilias Vlachos

Abstract: Transformative experiences are often described as pivotal mo-ments of change in psychotherapy, yet relatively little is known about how such experiences are perceived within group settings. This study explored how group members and therapists describe transformative in-session moments in group psychotherapy and examined the therapeutic factors and relational processes associated with these ex-periences. Eight semi-structured interviews were conducted with four former group members and four licensed group therapists. Data were analyzed using reflexive thematic analysis, while descriptive counts were used to illustrate the prominence of Yalom’s therapeutic factors in participants’ accounts. All eleven of Yalom’s therapeutic factors were identified in participant narratives, with universality and cohesion emerging most frequently. Moments of change were described as emotionally significant relational experiences characterized by shared humanity, recognition, and meaning-making. Five relational pro-cesses were identified: emotional holding, risk-taking and courage, internalization of the group, therapist emotional presence, and liber-ation from shame. Findings suggest that moments of change emerge through the interplay of relational safety, attuned therapist presence, and courageous interpersonal engagement. The study highlights re-lational processes through which established therapeutic factors be-come experientially meaningful and contribute to psychological change within group psychotherapy and may be associated to psy-chological insight.

Review
Environmental and Earth Sciences
Geophysics and Geology

Michael Earle

Abstract: Timor is situated in the Lesser Sunda chain of islands in the non-volcanic outer Banda Arc of the Australia–Southeast Asia orogen. Diachronous collision of the irregular passive margin of Australia with the detached margin of SE Asia in the Miocene produced an assemblage of nappes, mélanges and metamorphic terranes that characterise the complex geology of Timor. This article has been developed from a keynote presentation delivered at the 6th International Geoscience Conference of the Institute of Geosciences of Timor-Leste (IGTL), held in Dili in February 2026. In keeping with that format, the paper is a synthesis and interpretive review of Timor’s metamorphic terranes, and a fuller ex-planation of the concept of ‘splinter tectonics’ that was introduced. Field, petrographic and geochemical evidence show that the unique features of the Boi metamorphic massif on West Timor can be explained by a process whereby blocks and slices of deeply-buried upper-plate crust became entrained in the subduction channel and juxtaposed against hot forearc mantle before being extruded by buoyancy forces. The Boi Massif is therefore interpreted as a case study that provides new insights into the tectonic evolution of the Banda Arc and possible processes operating within convergent margin systems elsewhere.

Article
Social Sciences
Sociology

Jiaxi Wang

,

Luca Caneparo

Abstract: Brussels Sprout Island is a research-creation and design-research prototype that examines how climate-friendly diet can be reframed as a sensory, relational, and non-shaming public communication practice. Rather than presenting lower-emission eating through carbon-footprint instruction, moral correction, or individual restraint, the prototype stages planting, cooking, sharing, slow environmental feedback, and repair as interaction mechanisms. Using interaction logs, pre/post micro-surveys, and short exhibition interviews with a small convenience sample (N = 16), the study asks whether participants can temporarily reframe climate-friendly eating through rhythm, care, shared meals, and repair rather than guilt or dietary purity. The findings are formative and exhibition-bound. They indicate short-term reductions in perceived judgment and guilt/shame, increased relational and self-efficacy language, and preliminary behavioral traces of kitchen/table repair routes after the monster trigger. The contribution is therefore a design-research prototype and provisional interaction grammar for future comparative and longitudinal testing of non-shaming climate-food communication.

Review
Medicine and Pharmacology
Pediatrics, Perinatology and Child Health

Marco Masetti

,

Giulia Zambelli

,

Sonia Rasmi

,

Elena Rossini

,

Salvatore Davide Tramonti

,

Mandy Ferrocino

,

Susanna Esposito

Abstract: Background: Community-acquired pneumonia (CAP) remains a leading cause of pediatric morbid-ity and mortality worldwide, particularly in low-resource settings. Although antimicrobial therapy is the cornerstone of treatment, disease severity is often influenced not only by pathogen burden but also by dysregulated host inflammation. Systemic corticosteroids have therefore been investigated as adjunctive agents to reduce inflammation-mediated lung injury, but their role in children remains controversial. Methods: This narrative review summarizes current evidence on systemic cortico-steroid use in pediatric pneumonia. The review focuses on biological mechanisms, clinical indica-tions, patient selection, therapeutic regimens, timing and duration of therapy, clinical outcomes, and safety. Particular attention is given to severe CAP, Mycoplasma pneumoniae pneumonia, complicated pneumonia with parapneumonic effusion or empyema, viral pneumonia, wheezing-associated phenotypes, and immunocompromised children. Results: Available evidence suggests that cortico-steroids may provide benefit in selected pediatric phenotypes characterized by severe inflammation, respiratory compromise, refractory disease, or airway hyperreactivity. Reported benefits include faster fever resolution, reduction in inflammatory markers, shorter hospital stay, more rapid clinical stabilization, and improved radiographic recovery, particularly in severe or refractory Mycoplasma pneumoniae pneumonia and selected complicated cases. However, findings are inconsistent, and treatment effects appear strongly dependent on etiology, disease severity, timing of administration, corticosteroid regimen, and patient phenotype. Routine use in uncomplicated CAP or unselected pediatric populations is not supported. Potential adverse effects include hyperglycemia, gastroin-testinal symptoms, behavioral changes, sleep disturbance, immunosuppression, and delayed viral clearance in selected viral infections. Conclusion: Current evidence supports a cautious, individu-alized, phenotype-driven approach to corticosteroid therapy in pediatric CAP. Well-designed pe-diatric randomized controlled trials are needed to define precise indications, optimal regimens, timing, and long-term safety.

Article
Environmental and Earth Sciences
Paleontology

Xiaoping Mao

,

Basel Alrawi

,

Yongwei Yang

,

Huiyun Mao

,

Xiurong Chen

,

Yan Li

,

Xiangwu Zeng

,

Congxian Lu

Abstract: The prevailing paradigm attributing biotic mass extinctions to Large Igneous Province (LIP)-driven global hyperthermia and oceanic anoxia faces a fundamental sedimentological paradox: coal seams and carbonaceous shales — indicative of cool-temperate climates — are systematically developed in the strata of all five major Phanerozoic extinction events, while typical hot-climate indicators such as red beds and evaporites are conspicuously absent from those same intervals. This contradiction strongly suggests that the climatic backdrop of extinction intervals may be cold rather than hot. To test this possibility, we apply an a priori, falsifiable lithological criterion — the Cold Rule — that is independent of geochemical proxies. Taking coal and carbonaceous shales as cool-temperate indicators and red beds and evaporites as tropical indicators, we systematically compile published stratigraphic successions from key sections of all five mass extinctions, assign lithology to climate zones bed by bed, and examine three independent lines of evidence: climate reverse cycles, the timing of coal measures relative to extinction pulses, and the latitudinal differentiation of extinction. Each mass extinction event records a complete climate reverse cycle from red beds (warm stage) through evaporites (arid-hot stage) and coal and carbonaceous shales (cool-temperate stage) to cold-zone or glacial conditions at the extinction horizon, across all five events. The horizons of coal and carbonaceous shale development consistently predate the main extinction pulse, indicating that they represent the climatic prelude to extinction rather than synchronous products of a hyperthermal–anoxic crisis. Extinction intensity is highest at mid-latitudes, while low-latitude equatorial regions serve as relative biological refugia; extinction timing displays a systematic progression from high latitudes through mid-latitudes to low latitudes. On the basis of this primary sedimentological evidence, we propose the "Cooling-Driven Mass Extinction" hypothesis. Its causal chain operates through two timescales: in the short term, volcanic eruptions and/or bolide impacts trigger abrupt cooling through stratospheric aerosol forcing; in the long term, low temperatures suppress organic matter decomposition and enhance carbon burial efficiency, initiating a positive feedback in which cooling lowers atmospheric CO₂ and drives further cooling, ultimately contracting climate zones until the cold zone invades mid-to-low latitudes and triggers ecosystem collapse. This hypothesis accommodates all five mass extinctions within a single climate-driven framework. Its core predictions — that cool-temperate lithologies must predate the extinction horizon, that extinction timing must display a latitudinal progression from high to low latitudes, and that tropical lithological indicators must be systematically absent at extinction boundaries — have received preliminary empirical support in the data analysis presented here and are directly testable by future high-resolution stratigraphic work.

Article
Physical Sciences
Theoretical Physics

Chein-Chih Chen

Abstract:

First-order Einstein–Cartan / Palatini geometry treats the coframe and spin connection as independent variables and therefore permits torsion as a geometric sector. This paper studies a scalar-gradient trace-torsion sector and defines a conditional parity-time (PT)-even projected branch sourced by an internal scalar phase $\phi(x)$, equivalently $\epsilon_{\rm ph}(x)$. Physical content is retained only after the stated PT-even observable projection and the parity-even branch restriction. Result C1 is branch-reduced and conditional: after imposing the branch projector, a metric-only linear map from $v_A=\partial_A\phi$ to $T^A{}_{BC}$ selects the pure-trace form $T^{A}{}_{BC}=2\,\eta\,\delta^{A}_{[B}\partial_{C]}\phi$, while axial pseudo-tensor and traceless tensor sectors are outside the retained assumptions. Result C2 is an operator-basis reduction within the C1 truncation: the retained PT-even, two-derivative, quadratic torsion basis is one-dimensional, represented by $I_T$ up to normalization and boundary terms. Dirac–Born–Infeld-like, determinant-like, and topological channels are treated only as bookkeeping routes for possible Wilson-coefficient contributions. Weak-field formulas are included only as a possible diagnostic interface for future work. No empirical galactic fit, complete dark-sector replacement, full scalar dynamics, scalar perturbation stability analysis, or cosmological completion is claimed.

Article
Business, Economics and Management
Economics

Ru Wang

,

Dong Han

Abstract: Ecological efficiency of grain production has attracted growing scholarly interest in recent decades. Agricultural insurance alleviates operational risks embedded in grain cultivation, which further promotes improvements in ecological efficiency. Using provincial panel data covering 31 provincial-level administrative regions of China over the period 2001–2021, this study adopts the super-efficiency SBM model to quantify and analyze agricultural insurance development as well as the ecological efficiency of grain production nationwide. The empirical results yield three core conclusions: (1) the advancement of agricultural insurance significantly raises grain production ecological efficiency. (2) Carbon emissions exert a significantly negative impact on ecological efficiency, demonstrating that carbon abatement policies are effective in boosting the green performance of grain production. (3) carbon emissions serve as a significant moderator in both Eastern and Western China. Specifically, the enforcement of carbon reduction policies amplifies the positive marginal effect of agricultural insurance on grain ecological efficiency. Drawing on the above empirical evidence, we propose three policy implications to improve grain production ecological efficiency: sustain the high-quality development of agricultural insurance, formulate differentiated eco-environmental regulations that accommodate regional heterogeneity, and expand fiscal subsidy programs for grain producers.

Article
Computer Science and Mathematics
Data Structures, Algorithms and Complexity

Giulio Ruffini

,

Francesca Castaldo

Abstract: The word agent now names systems as different as a tool-using language model and a chemotactic cell, with no shared definition across the fields that use it. We argue that these uses converge on one substrate-independent structure—the algorithmic agent: model-mediated regulation built from an implicit or explicit Modeling Engine, a scalar Objective Function, and a Planning Engine. Its root is algorithmic persistence: a pattern whose compressed identity survives the filter of time. Holding a pattern bounded under perturbation takes a load-bearing regulator somewhere in the pattern–world system—a structure that absorbs, cancels, or exports what interaction would otherwise let accumulate. By the Algorithmic Regulator Theorem, this regulator shares mutual algorithmic information with the world: it carries a model of what it regulates and can be read as-if acting through an objective and a planner. The pattern is an agent only when this regulator is localized within it (self-regulation), and telehomeostatic only when the regulator’s objective is the pattern’s own persistence. Regulation in macroscopic systems acts on coarse-grained, many-to-one variables. It is therefore irreversible andexacts a Landauer cost — a price that scales with the coarse-graining and vanishes for reversible, equilibrium persistence (e.g., an isolated atom). Hence the thesis: a macroscopic agent is a persistent pattern that conserves its own bounded code through a thin, thermodynamically costly boundary, in a world that, when closed and reversible, conserves algorithmic information up to the fixed description of its law and time index. Its conserved quantity is therefore algorithmic—program information, not probability mass—so Shannon entropy, free energy, and heat enter as its coarse-grained faces. We use it to reframe the free-energy principle and evolution: in a collective the parts need not share an objective, so alignment is an objective-distribution problem—the design of local objectives and of the constraints that bound them so that the whole persists, not the search for one correct reward. Whether a persistent collective is itself one agent or many is then read from a landscape of its regulation—distributed agency, not mere integration.

Article
Engineering
Textile Engineering

Md. Imtiyaz Hasnat

,

Md. Rezaul Karim

Abstract: Silk degumming is an essential pretreatment process that removes sericin from raw silk to improve softness, luster, and dyeability. Conventional alkaline degumming methods are effective but require harsh chemicals that may damage silk fibroin and generate environmentally harmful effluents. This study investigated a sustainable enzymatic degumming approach using papaya (Carica papaya) latex, a natural source of papain enzyme, followed by natural dyeing with henna (Lawsonia inermis) extract. Raw silk fabrics were treated with papaya enzyme concentrations of 5%, 10%, 15%, and 20% at 40 °C and 45 °C for 60 min. Degumming performance was evaluated through weight loss and CIE whiteness index measurements. The degummed fabrics were mordanted with potash alum or copper sulfate before dyeing with henna extract, and color characteristics together with rubbing and washing fastness were assessed. Degumming efficiency increased from 11.24% to 17.60% with increasing enzyme concentration, while the highest CIE whiteness index (59.52) was obtained at 20% enzyme concentration and 45 °C. Potash alum produced brighter yellow shades, whereas copper sulfate generated darker shades with comparable hue. All dyed samples exhibited excellent dry rubbing fastness (Grade 5), good wet rubbing fastness (Grade 4), and good washing fastness. The results demonstrate that papaya latex-assisted enzymatic degumming combined with natural henna dyeing provides an environmentally friendly alternative to conventional silk wet processing.

Article
Business, Economics and Management
Economics

Jisheng Chen

,

Guifu Chen

,

Junye Sun

Abstract: This study examines manufacturing firms listed on China’s A-share market from 2014 to 2024 using a triple-difference model to investigate the effect of green investment on the strategic resilience of semiconductor firms under Sino-US trade shocks. The results show that green investment considerably enhances strategic resilience, and this effect remains robust across parallel-trend and other robustness tests. Mechanism analysis indicates that green investment improves resilience by reducing operational performance volatility and increasing equity concentration. Heterogeneity analysis shows that the positive effect on human capital resilience is stronger among non-heavily polluting firms and firms in highly marketized and non-Eastern regions. Meanwhile, the effect on innovation resilience is more pronounced among non-heavily polluting firms and firms in highly marketized and Eastern regions. These findings provide practical and policy insights for strengthening human capital and innovation resilience in semiconductor firms, enhancing their capacity to withstand external shocks, and optimizing green investment strategies.

Review
Computer Science and Mathematics
Analysis

Alexia Gazeta

,

Constantinos Halkiopoulos

Abstract: Background: Consumer decision-making in digital advertising is a multifactorial process involving attention, emotional engagement, cognitive evaluation, and contextual influences. Traditional self-report methodologies fail to capture the automatic, unconscious, and real-time nature of these processes. Neuromarketing research, utilizing eye-tracking and physiological signals such as electroencephalography (EEG), electrodermal activity (EDA/GSR), heart rate, and event-related potentials (ERPs), offers objective, millisecond-resolution measurement of consumer responses during advertising exposure. Methods: Following systematic classification principles, we identified 19 empirical studies from a corpus of 69 papers as quantitatively eligible for meta-analytic synthesis. Studies were required to employ at least one eye-tracking or physiological measurement tool, examine consumer behavior or decision-making in digital or visual commercial contexts, and report sufficient quantitative data for synthesis (means, standard deviations, sample sizes, effect estimates, and/or p-values). A random-effects synthesis framework was adopted given the methodological heterogeneity across studies. Subgroup analyses were conducted by tool type (eye-tracking only, EEG-based, EDA/GSR, multimodal, machine learning pipeline, ERP), stimulus type (video, static/print, food-related, warning labels), and outcome type (attention, emotional arousal, neural decoding, preference/choice, effectiveness). Results: The 19 eligible studies (total N across studies &gt; 1,700) encompass diverse designs including between-subjects experiments, within-subjects repeated-measures paradigms, mega-analyses of multiple datasets, and machine learning prediction pipelines. Key findings include: (1) gaze fixation duration strongly predicts final consumer choice (r ≈ 0.62–0.80, e.g., wine label design studies); (2) frontal EEG gamma activity predicts commercial media success beyond self-reported liking; (3) the Late Positive Potential (LPP) reliably indexes emotional processing intensity in response to warning labels and food stimuli; (4) Random Forest machine learning classifiers achieve 81% accuracy in predicting advertising preferences from EDA and facial expression data; (5) multimodal integration of eye-tracking, EEG, and GSR provides richer consumer behavior profiling than any single method alone. Heterogeneity (I² estimated moderate-to-high across subgroups) reflects genuine variation in stimuli, populations, and measurement tools. Conclusions: Eye-tracking and physiological signal methodologies offer convergent and complementary evidence for how consumers process, respond to, and decide about digital advertising stimuli. The synthesis indicates that attention, emotional arousal, and cognitive effort are meaningfully associated with advertising effectiveness and consumer choice. Future research should prioritize methodological standardization, increased reporting transparency, and cross-cultural validation to strengthen the evidence base for biometric-informed advertising research.

Article
Environmental and Earth Sciences
Ecology

Jiaxi Wang

Abstract: This article presents a design-led environmental media prototype for translating saproxylic beetle evidence into a web-based narrative about slow forest degradation in Crete. The prototype uses five interface scenes to convert ecological constructs, including deadwood continuity, decay-stage diversity, microclimate refuge, drought-stress coupling, pathogen/vector risk, and fragmentation, into comparison, gradient, threshold, and reachability tasks. The contribution is methodological rather than ecological: it proposes an evidence-to-interface translation matrix and an anti-cutesification/anti-spectacle grammar for making proxy variables, uncertainty cues, and versioned sources inspectable in public-facing environmental media. A small mixed-background reader-response session (N = 18) is used as a boundary test of readability. The session suggests that many readers could retell the deadwood-removal inference and distinguish structural loss from simple character appeal, while also revealing recurring misreadings around proxy status, scenario precision, and particle-haze risk cues. The article therefore positions the prototype as a proof-of-concept for auditable environmental-media translation, with broader claims about public use, institutional uptake, and long-term durability reserved for future comparative and longitudinal testing.

Article
Biology and Life Sciences
Cell and Developmental Biology

Fred Y. Ye

Abstract: Background: The mammalian gene encoding OCT4, POU5F1, lies in or immediately adjacent to the major histocompatibility complex (MHC) region. In humans, POU5F1 is located at 6p21.33 within the extended HLA/MHC genomic neighborhood; in mice, Pou5f1 is on chromosome 17 within the homologous MHC-linked region. Marsupial data further suggest that this association belongs to an ancient mammalian immune supercomplex rather than to a lineage-specific accident. Yet birds and teleost fish show divergent arrangements, indicating that OCT4-MHC linkage is not required for all vertebrate zygotic genome activation. Objective: This paper expands a working outline on OCT4-MHC linkage into a formal theoretical article. It asks whether the tight mammalian linkage between a core pluripotency regulator and the principal immune-recognition complex could represent an evo-devo adaptation that coordinates developmental ignition, stress survival, maternal-fetal immune tolerance, chromosome-scale timing, and long-range chromatin topology. Methods: We synthesize comparative genomics, mammalian zygotic genome activation (ZGA), MHC evolution, preimplantation immunology, Hsp70 stress biology, ASAR6 replication-timing literature, 3D genome topology, and fractal genome concepts. We formulate quantitative descriptors for synteny strength, chromatin topological coupling, developmental timing, immune silencing, and evolutionary retention. Representative mammalian and non-mammalian model organisms are summarized, and a falsifiable validation pipeline is proposed. Results/Framework: The OCT4-MHC region is interpreted as a mammalian “start-and-shield” hub. OCT4/POU5F1 provides a developmental ignition module; MHC class III stress-response genes, including Hsp70 family genes, provide early cytoprotection; classical and non-classical MHC genes provide a tunable immune-recognition module; chromosome-scale elements such as ASAR6 suggest autonomous timing control; and 3D genome architecture provides a topological medium through which these modules may be co-regulated. Mathematical formulas define normalized synteny distance, linkage conservation, topological contact kernels, activation-repression coupling, fractal contact scaling, fitness effects, and Bayesian model validation. Conclusions: The OCT4-MHC linkage is best treated neither as a proven universal “origin of life” mechanism nor as a meaningless chromosomal accident. A more defensible hypothesis is that mammals conserved a genomic architecture in which the laws of development and the laws of immune recognition are compressed into a shared chromosomal neighborhood. At the most abstract level, the arrangement may reflect an isomorphic mapping between physical constraints of a genome universe and evolutionary constraints of mammalian life: stable development requires a coordinated geometry of ignition, protection, recognition, timing, and restraint.

Article
Computer Science and Mathematics
Robotics

Alireza Shojaei

Abstract: Every system that reached zero-shot cross-embodiment manipulation in the first half of 2026 made the same move, deleting body information from the interface between task reasoning and motor control, whether through body-agnostic handheld data, masked end-effectors, language-coded actions, or contact-intent latents. None of these systems tests that the deletion is what causes transfer, characterizes what the interface still retains, or asks whether the interface must be symbolic. This paper supplies all three on a scene-controlled manipulation substrate where appearance confounds cannot operate. A causal interface ladder over five source and five held-out arms shows that a body-blind end-effector interface transfers zero-shot while leaking body channels back into it collapses transfer once the leak passes a threshold, a gap of $0.157$ that every held-out arm reproduces, and that injecting body identity is actively harmful. At matched body-blindness and identical upstream information, a structured symbolic coding of the interface beats a language-token coding by $0.109$ with the margin compounding over task depth, while a low-capacity continuous latent falls below the task's precision floor. On a released vision-language-action model with scene controlled by robot-swap rendering, most apparent body recoverability is scene appearance, yet a modest scene-invariant residue exceeds a raw-pixel control in all three folds, and an in-model test finds the decoded action body-light. Recoverability is not reliance, at the interface and inside the released model alike, which is the mechanism the zero-shot wave depends on and the boundary it must respect.

Article
Computer Science and Mathematics
Geometry and Topology

Abdul Rahman

Abstract: We develop HodgeCY, a computational framework for studying Hodge atom profiles of singular and nodal Calabi–Yau threefolds. The first testbed is the Cynk–Meyer dataset of double octic Calabi–Yau threefolds arising from eight-plane arrangements. These examples exhibit useful collisions among standard invariants: arrangements 83 and 84 have the same singularity-count profile but different Hodge numbers, while 84 and 84a have the same singularity-count profile and Hodge numbers but different modular forms. We construct a smoothing bridge from arrangement geometry to finite-node conifold geometry: for A = P1 · · · P8, we study branch octics Fε = A + εQ2. For the explicit quartic Q0 = x4 + 2y4 + 3z4 + 5t4 + xyzt and ε = 1, the HodgeCY repository verifies the local genericity conditions over Q and records a characteristic-zero degree-112 certificate for the saturated Jacobian scheme associated with arrangements 84 and 84a. The current smoothing status is therefore degree112_certified, while reducedness, Hessian-rank, and defect verification remain unpromoted validation gates. We prove that first-order plane-node incidence is universal in this setting, hence too coarse to distinguish 84 from 84a. The main completed computation is instead a concurrency separation: the intersection-lattice concurrency profiles of 84 and 84a are non-isomorphic, detected by double-line point-type multiplicities and p4-collinearity graphs. This is an arrangement-level separation, not yet a proof of distinct smoothed Hodge atom spectra. The remaining ordinary-node, defect, and operator computations are recorded as explicit validation gates in the public HodgeCY repository.

Article
Engineering
Safety, Risk, Reliability and Quality

Cunfeng Zhang

,

Hongyong Yuan

,

Jinbin Yuan

,

Longxian Guo

,

Guoguan Lan

,

Wanki Chow

Abstract: Lithium-ion batteries (LIBs) electric bicycles are widely used in China, with many accidental fires occurring in parking facilities in high-rise building. Electric bicycle parking areas in high-rise buildings have become fire-prone zones. There are urgent needs to establish fire codes for the parking facilities in high-rise buildings. But only limited research has been conducted on protecting against such fires. There are also uncertainties in the appropriate methods for implementing fire barriers and fire suppression facilities. To better understand the parking facility fires in this area, four fire scenarios were studied in this paper, aiming to seek principles on how to prevent serious fire accidents by isolating E-bicycles parked in parking facilities. These principles include fire barrier design, fire separation distance between the islands and the selection of fire suppression devices. A total of six experiments on LIBs bicycle fires were conducted. Fire spread between the LIBs bicycles and the propagation patterns of smoke generated by electric bicycle fires within parking facilities were studied. The effectiveness of different fire extinguishing methods in suppressing LIBs bicycle fires was discussed. The reasonable fire separation distance for electric bicycles was determined. It was found that LIBs with ternary lithium-ion batteries (such as NCM) are more prone to initiate thermal runaway. A sprinkler system with lower hazard class is proposed to operate under lower water pressure and flow rates. Fire control methods were proposed, such as including fire-resistive eave and fire barrier. The results can be used in setting up fire code and are useful for AI training cases in developing fire models.

Article
Medicine and Pharmacology
Dentistry and Oral Surgery

Lucian Stefan Burlea

,

Laura Elisabeta Checherita

,

Ovidiu Stamatin

,

Loredana Golovcenco

,

Vlad Stefan Proca

,

Maria Antonela Beldiman

,

Gabriel Goian

,

Tudor Hamburda

,

Violina Budu

,

Bogdan Petru Bulancea

+3 authors

Abstract: Background/Objectives: Malocclusion and delayed expressive language are managed as separate clinical problems, yet both may be two faces of a single stomatognathic dysfunctional syndrome. This cross-sectional study investigated whether neonatal feeding modality — breastfeeding, enteral feeding with non-nutritive oral stimulation, or total parenteral nutrition — predicts occlusal morphology and language acquisition in preterm children.Methods: We enrolled 40 preterm children (gestational age below 37 weeks; corrected age 36–42 months) from two follow-up programmes in Iași, Romania; 7 of 47 were excluded. Children were stratified: breastfed (Group A, n = 14), tube-fed with non-nutritive oral stimulation (Group B, n = 13), or parenterally fed (Group C, n = 13). Occlusal morphology was scored blind (κ = 0.91); language was assessed with the Communicative Development Inventories and a phonological checklist. Kruskal-Wallis tests with Dunn-Bonferroni post hoc comparisons, Spearman rank correlation, and multivariable regression adjusting for sex, residence, and socioeconomic status were used.Results: All three outcomes differed significantly by feeding group. Kruskal-Wallis tests: occlusion H(2) = 33.1, p &lt; 0.001; language H(2) = 34.7, p &lt; 0.001; age at first words H(2) = 35.3, p &lt; 0.001. Median occlusion scores: 4.50 (A), 4.20 (B), 2.30 (C); median language scores: 8.40, 7.20, 3.50; median age at first words: 11, 15 and 24 months — a 13-month gap. All Dunn-Bonferroni pairwise contrasts were significant (p &lt; 0.05). Occlusion and language scores were near-perfectly correlated (Spearman ρ = 0.986, p &lt; 0.001). Malocclusion subtype distribution also differed significantly (χ²(6) = 19.1, p = 0.004).Conclusions: Breastfeeding was associated with the most favourable outcomes; parenteral nutrition without oral stimulation with the greatest delays. The near-perfect occlusion–language correlation supports combined stomatognathic screening as an early diagnostic tool and non-nutritive oral stimulation during tube feeding as a prophylactic priority.

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