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Preprint ARTICLE | doi:10.20944/preprints202404.1235.v1

Association between Opioid-Benzodiazepine Trajectories and Injurious Fall Risk among US Medicare Beneficiaries

Grace Hsin-Min Wang, Juan M. Hincapie-Castillo, Walid F. Gellad, Bobby L. Jones, Ronald I. Shorr, Seonkyeong Yang, Debbie L. Wilson, Jeannie K. Lee, Gary M. Reisfield, Chian K. Kwoh, Chris Delcher, Khoa A. Nguyen, Christopher A. Harle, Zachary A. Marcum, Wei-Hsuan Lo-Ciganic

Subject: Public Health And Healthcare, Primary Health Care Keywords: trajectory; opioid; benzodiazepine; falls; fractures

Online: 18 April 2024 (10:14:30 CEST)

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Background/Objectives: Concurrent opioid (OPI) and benzodiazepine (BZD) use may exacerbate falls/fractures risk compared to no use or use alone. Yet, patients may need concurrent OPI-BZD use for co-occurring conditions (e.g., pain and anxiety). Therefore, we examined the association between longitudinal OPI-BZD dosing patterns and subsequent injurious falls risk. Methods: We conducted a retrospective cohort study including non-cancer fee-for-service Medicare beneficiaries initiating OPI and/or BZD in 2016-2018. We identified OPI-BZD use patterns during the 3 months following OPI and/or BZD initiation (i.e., trajectory period) using group-based multi-trajectory models. We estimated time to first injurious fall within 3 months post-trajectory period using inverse-probability-of-treatment-weighted Cox proportional hazards models. Results: Among 622,588 beneficiaries (age≥65=84.6%, female=58.1%, White=82.7%; having injurious falls=0.45%), we identified 13 distinct OPI-BZD trajectories: Group(A):Very-low OPI-only (early discontinuation)(44.9% of the cohort); (B):Low OPI-only (rapid decline)(15.1%); (C):Very-low OPI-only (late discontinuation)(7.7%); (D):Low OPI-only (gradual decline)(4.0%); (E):Moderate OPI-only (rapid decline)(2.3%); (F):Very-low BZD-only (late discontinuation)(11.5%); (G):Low BZD-only (rapid decline)(4.5%); (H):Low BZD-only (stable) (3.1%); (I):Moderate BZD-only (gradual decline)(2.1%); (J):Very-low OPI (rapid decline)/Very-low BZD (late discontinuation)(2.9%); (K):Very-low OPI (rapid decline)/Very-low BZD (increasing)(0.9%); (L):Very-low OPI (stable)/Low BZD (stable)(0.6%); and (M):Low OPI (gradual decline)/Low BZD (gradual decline)(0.6%). Compared with Group(A), 6 trajectories had increased 3-month injurious fall risks: (C): HR, 95%CI=1.78, 1.58-2.01; (D): 2.24, 1.93-2.59; (E): 2.60, 2.18-3.09; (H): 2.02, 1.70-2.40; (L): 2.73, 1.98-3.76; and (M): 1.96, 1.32-2.91. Conclusions: Our findings suggest that 3-month injurious fall risk varied across OPI-BZD trajectories, highlighting the importance of considering both dose and duration when assessing fall risks of OPI-BZD use among older adults.

Preprint ARTICLE | doi:10.20944/preprints202404.1119.v1

Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine Against XBB.1.5, BA.2.86, and JN.1 Sublineages: A Phase 2/3 Trial

Juleen Gayed, Vishva Bangad, Xia Xu, Federico Mensa, Mark Cutler, Özlem Türeci, Uǧur Şahin, Kayvon Modjarrad, Kena A. Swanson, Annaliesa S. Anderson, Alejandra Gurtman, Nicholas Kitchin

Subject: Public Health And Healthcare, Primary Health Care Keywords: BA.2.86; BNT162b2; booster; COVID-19; JN.1; Omicron; SARS-CoV-2; vaccine; variant-adapted; XBB.1.5

Online: 17 April 2024 (08:24:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0610.v1

Comparative Analysis of Individual Level and Community Level Approach for Achieving Sustainable Development Goals for Under-Five Mortality Rate

Jaimini Sarkar, Chiradeep Sarkar

Subject: Public Health And Healthcare, Primary Health Care Keywords: Under-five mortality, India, internet use, population

Online: 9 April 2024 (09:24:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1577.v2

Role of Community Infrastructure in Improving Nutrition in Under-Five Children for Better Implementation of Integrated Child Development Services

Jaimini Sarkar, Chiradeep Sarkar

Subject: Public Health And Healthcare, Primary Health Care Keywords: Internet Access; India; Malnutrition; under-five children; population

Online: 8 April 2024 (11:19:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0172.v1

Estimated Cardiorespiratory Fitness and Metabolic Risks

Robert A. Sloan

Subject: Public Health And Healthcare, Primary Health Care Keywords: cardiorespiratory fitness; estimated CRF; metabolic risk factors; noncommunicable diseases; public health; eCRF prediction models; hypertension; hyperglycemia; dyslipidemia; obesity

Online: 2 April 2024 (10:32:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1796.v1

Working as a Healthcare Professional at Island Primary Care: An Exploratory Qualitative Study in Cyclades Islands, Greece

Anna Maria Kefala, Areti Triantafyllou, Emmanouil K. Symvoulakis, Eleni-Margarita Tzouganatou, Nikolaos Kapellas, Emmanouil Smyrnakis

Subject: Public Health And Healthcare, Primary Health Care Keywords: Island Primary Care; Rural areas; Greek Islands; Primary Health Care; Healthcare Professionals; Motivations

Online: 29 March 2024 (17:06:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1850.v1

Using Communicative Analysis to Evaluate Engagement in a Community-Based, Expert-Led Public-Health Intervention

Thomas Barker, Heather Allen, Karen Fulton, Nienke Klaver, Lori Motluk, Tanya Osborne, Edward Staples

Subject: Public Health And Healthcare, Primary Health Care Keywords: communicative analysis, communicative intervention, public health, alcohol use disorder, formative evaluation, summative evaluation, text data analytics

Online: 29 March 2024 (13:18:04 CET)

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The focus of this article is the evaluation of the quality and the degree of community engagement in an expert-based, public-health communicative intervention for Alcohol Use Disorder (AUD). In 2023 the Canadian Alcohol Use Disorder Society collaborated with a grass-roots community health group, a regional health authority, and an academic participatory researcher to organize a working group to mount a social-marketing campaign to increase community support for AUD medical treatment in family-practice settings in a rural community in British Columbia. The partnership working group conducted a series of activities in the school system, the town council, and the community. This article covers the formative evaluation and the summative evaluation of the working group's effectiveness. The formative evaluation ("lessons learned" and "recommendations") consists of consensus evaluations of the quality of each activity using a variety of data sources. The formative evaluation followed improvement science methods and used consensus meetings to provide and reflect on formal and informal feedback. Formative results reflect the consensus of the participants in the working group and they record the reactions in the community. The summative evaluation measures evidence of community engagement found in transcribed text from meeting minutes. The summative evaluation used theory-based frameworks and text data visualization to assess the engagement dynamics of the working group. The summative evaluation helps to put the formative evaluation into perspective as communicative action. The summative evaluation validates the formative evaluation by revealing the communicative dynamics of engagement which resulted in the community’s increased capacity to understand and support Alcohol Use Disorder Treatment options. The working group and the entire intervention was seen by the participants and the public as a success and capable of replication. In a small community, it instilled new understandings and attitudes, bringing an emerging awareness of medication as an optional health mitigation strategy for Alcohol Use Disorder. Our study furthers this overall assessment by using theoretical constructs and analysis of communicative records to trace engagement characteristics of interest to researchers, societies, and community groups contemplating similar interventions in the future. The study also validates the effectiveness of communicative analysis as a measure of social-marketing for expert-based public health interventions.

Preprint ARTICLE | doi:10.20944/preprints202403.1827.v1

Harnessing Metabolites as Serum Biomarkers for Liver Graft Pathology Prediction Using Machine Learning

Cristina Baciu, Soumita Ghosh, Sara Naimimohasses, Arya Rahmani, Elisa Pasini, Maryam Naghibzadeh, Azhie Amirhossein, Mamatha Bhat

Subject: Public Health And Healthcare, Primary Health Care Keywords: metabolomics; liver transplant; T-cell mediated rejection; metabolic dysfunction-associated steatohepatitis (MASH); biliary complications.

Online: 29 March 2024 (11:48:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1768.v1

Pilot Testing of Useful Tools Validity for Frailty Assessment in Greece: Translated PRISMA-7 Tool, Modified Fried Criteria and Clinical Frailty Scale

George Soulis, Efstathia Kyriakopoulou, Aristea Leventouri, Eleni Zigkiri, Vasiliki Efthymiou, Zikos Kentros, Anastasia Koutsouri

Subject: Public Health And Healthcare, Primary Health Care Keywords: Frailty; Greek Translation of PRISMA-7; Modified Fried criteria; Greek version of Clinical Frailty Scale

Online: 28 March 2024 (12:12:26 CET)

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The importance of frailty in older people is getting constant recognition as an important aspect both in terms of public health, as well in personal level for the appropriate management of an older person health condition. This is reflected by the continuously increasing number of research studies carried out in several settings across different countries. Sometimes this is very solid, but in other cases there is a considerable gap in terms of accurate and well grounded documentation of frailty status. This is the case in Greece, where we are missing clinically validated tools to approach frailty. We are missing frailty screening tools, such as for instance PRISMA 7, the gold standard tool of Fried criteria is somehow problematic since the question referring to physical activity originates from a questionnaire that has not been translated and validated, while Clinical Frailty Scale has been validated for the translation but not for the capacity to detect frailty. Aim of this study is to validate these tools for their accuracy to detect frailty by using a measurable index of frailty, previously proposed for use in clinical studies: the Short Physical Performance Battery (SPPB). 74 male and female participants have been evaluated for their frailty status using different tools. We observed that PRISMA 7 translation detects frailty only when one question is removed at a cut-off of ≥ 2 and indicated a sensitivity of 88.1%, and specificity of 99.9% with a good correlation with SPPB measurements (r = 0.858; p < 0.001). When CFS was validated using SPPB it demonstrated a very good correlation (r = -0.838; p < 0.001 respectively) as it was the case for the modified Fried Criteria (r = -0.725; p < 0.001). All items demonstrated a good correlation between them. We can here propose that we can accurately assess frailty status in the community setting by using a modified version of Fried criteria, Clinical Frailty Scale translation in Greek and we can screen for frailty by using the Greek translation of PRISMA 7 only after removing the item 6 of the questionnaire.

Preprint CASE REPORT | doi:10.20944/preprints202403.1712.v1

Postural Orthostatic Tachycardia Syndrome (POTS) as an Adverse Event to the Human Papilloma Virus (HPV) Vaccine and its Relationship to Ehlers Danlos Syndrome (EDS)

Nicole Schipperijn, Megan Wijensinghe, Aisa Romo, Benjamin Brooks

Subject: Public Health And Healthcare, Primary Health Care Keywords: Ehlers Danlos Syndrome; Vaccine Adverse Events; Postural Orthostatic Tachycardia Syndrome

Online: 28 March 2024 (09:30:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1577.v1

Role of Community Infrastructure in Improving Nutrition in Under-Five Children for Better Implementation of Integrated Child Development Services

Jaimini Sarkar, Chiradeep Sarkar

Subject: Public Health And Healthcare, Primary Health Care Keywords: Internet Access; India; Malnutrition; under-five children; population

Online: 26 March 2024 (14:15:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1376.v1

Prognostic significance of Lung ultrasound for Heart Failure Patient Management in Primary Care. A Systematic Review

Anna Panisello-Tafalla, Marcos Haro Montoya, Rosa Caballol-Angelats, Maylin Montelongo-Sol, Yoenia Rodriguez-Carralero, Jorgina Lucas-Noll, Josep Lluis Clua-Espuny

Subject: Public Health And Healthcare, Primary Health Care Keywords: Lung ultrasound; Heart Failure; B-lines; prognosis; mortality; hospital admissions; Primary care.

Online: 22 March 2024 (11:38:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1249.v1

Long-Term Follow Up of Fecundability after Ectopic Pregnancy in Taiwan: A Nationwide Population-Based Study

Chih-Hsiang Yin, Yi-Liang Lee, Chia-Ching Chang, Wu-Chien Chien, Gwo-Jang Wu

Subject: Public Health And Healthcare, Primary Health Care Keywords: Ectopic pregnancy; pregnancy; pregnancy rate; fecundability

Online: 21 March 2024 (12:45:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1270.v1

A Triangulation of Information from Healthcare Workers and Patients about the Concurrent Use of Traditional Medicine and Conventional Prescribed Medicines for Schistosomiasis in iLembe District, KwaZulu-Natal, South Africa

Aganze Gloire-Aime Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha, Manimani Ghislain Riziki, Tambwe Willy Muzumbukilwa, Mukanda Gedeon Kadima, Ntabaza Ndage, Bakari Salvius Amuri, Kahumba Byanga, Hezekiel M. Kumalo, Manimbulu Nlooto

Subject: Public Health And Healthcare, Primary Health Care Keywords: Schistosomiasis; Praziquantel; Conventional Medicine; Traditional Medicine; Healthcare workers; Patients

Online: 21 March 2024 (11:21:55 CET)

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Background Praziquantel is the commonly used conventional treatment recommended for schistosomiasis in the mainstream healthcare system. Although Praziquantel may be free in healthcare facilities, many individuals may resort to the use of traditional medicine. This study aimed to assess perceptions of participants on the availability of Praziquantel and to ascertain whether individuals infected with schistosomiasis used concurrently African traditional medicines with this treatment. Methods A cross–sectional descriptive study, using face-to-face interviews, was conducted from January to April 2023 among healthcare workers (HCWs) and patients. A review of medical chart records of patients was further carried out to triangulate the information from interviews. Ddescriptive statistics including frequency and percentage were used; categorical data were represented as tables. Chi-squared tests were performed for the association between continuous variables. A p value ≤ 0.05 was estimated as statistically significant. Results Most of HCWs (114/124; 91.9%) reported that Praziquantel was available in healthcare facilities. Majority of HCWs (76/124; 61.3%) did not know whether patients seen by them used concurrently traditional medicine and Praziquantel for schistosomiasis. There was no significant relationship between the availability of Praziquantel and the concurrent use of TM by patients for schistosomiasis (X2 = 3.042, p = 0.551). Patients seen by THPs (8/20, 40%) did not use Praziquantel for schistosomiasis. Those patients (8/15, 53.3%) who crossed from TM to the mainstream healthcare system did not disclose their use of TM to HCWs. Their main reason was that concurrent use of TM and Praziquantel could destroy organs or make Praziquantel not to work properly. None of the medical chart records analysed documented the concurrent use of TM and Praziquantel. Conclusion Most of HCWs were not aware of the concurrent use of TM and Praziquantel by patients for the treatment of schistosomiasis. Patients seen by THPs relied solely on TM for schistosomiasis. Although patients indicated crossing from TM to the mainstream healthcare system, there was no evidence of documented use of TM in medical chart records of patients. Further studies are needed to contribute to the knowledge of medicinal plants used by THPs for schistosomiasis.

Preprint ARTICLE | doi:10.20944/preprints202403.1190.v1

Patient Knowledge, Medication Adherence, and Influencing Factors: A Cross-Sectional Study among Hypertensive Patients in Greece

Konstantinos Giakoumidakis, Evridiki Patelarou, Hero Brokalaki, Maria Bastaki, Nikolaos V. Fotos, Parthena Ifantopoulou, Antonios Christodoulakis, Anastasia A. Chatziefstratiou, Athina Patelarou

Subject: Public Health And Healthcare, Primary Health Care Keywords: Patient Knowledge; Medication Adherence; Hypertensive Patients

Online: 20 March 2024 (12:19:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1193.v1

Knowledge, Perceptions, and Experiences of Traditional Health Practitioners about Managing Female Urogenital Schistosomiasis: The Case of ILembe District, KwaZulu-Natal Province, South Africa

Aganze Gloire-Aime Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha, Manimani Ghislain Riziki, Tambwe Willy Muzumbukilwa, Mukanda Gedeon Kadima, Ntabaza Ndage, Bakari Salvius Amuri, Kahumba Byanga, Hezekiel M. Kumalo, Manimbulu Nlooto

Subject: Public Health And Healthcare, Primary Health Care Keywords: Female urogenital schistosomiasis; Traditional health practitioners; Traditional medicine; Management; South Africa; qualitative study

Online: 20 March 2024 (08:24:28 CET)

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Background: Schistosomiasis is the third most important Neglected Tropical Disease, with more than 4 million South Africans being infected. Cases of re-infection with schistosomiasis after being treated using modern medication has opened ways to seeking alternative treatment modalities using medicinal plants. This study aims to explore and understand the way traditional healers diagnose schistosomiasis, the types of traditional medicines they use to treat it in communities with a high prevalence of infection, and to establish whether the unavailability of prescribed anti-schistosomal medicines leads to the use of traditional medicine. Methods: A qualitative exploratory study was conducted using a questionnaire from December 2022 to March 2023 in the iLembe District, KwaZulu-Natal Province, South Africa. In-depth individual interviews were carried out among traditional health practitioners (THPs) involved in managing female urogenital schistosomiasis (FUS). Recorded narrative data was transcribed verbatim, read through thoroughly and coded, and analysed using thematic or content analysis Results: Traditional Health Practitioners provide services to many women who did not want to be treated in the mainstream health care system for their FUS. The disease was perceived and understood the same way by most of the respondents, that being caused by use of fresh water. Various plants species, either alone or in combination, were used to manage bilharzia in women. Senecio serratuloides (Asteraceae) and Hypoxis hemerocallidea (Hypoxidaceae) were prominently used by THPs in FUS management. Conclusion: Traditional Health Practitioners are playing a key role in managing bilharzia in women in rural areas of the iLembe District, this study reported that THPs can diagnose schistosomiasis symptoms based on their knowledge and experience. Respondents indicated that modern conventional treatment was readily available and free in public sector healthcare facilities; however, they consulted patients suffering from FUS. Various traditional herbal medicines are reportedly used by THPs to manage bilharzia in women. Further studies are needed to investigate the views and experiences of clients regarding the success of the treatments used and why they seek care from THPs.

Preprint REVIEW | doi:10.20944/preprints202403.1025.v1

The Role of Technology in Burn Disaster Response

Herbert L. Haller, Frank Sander, Colleen M. Ryan, Stian Kreken Almeland, Lars Peter Kamolz

Subject: Public Health And Healthcare, Primary Health Care Keywords: Mass casualties; Search and Rescue; Internet of Things; Artificial Intelligence; drones; remote Sensors; telemedicine

Online: 18 March 2024 (10:42:45 CET)

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Technological advancements in the Internet of Things (IoT), unmanned aerial vehicles (UAVs), and novel technological tools have transformed disaster management practices from localized approaches to a global framework. These innovations necessitate a unified understanding and application of diverse methodologies at an international level, ensuring they are accessible and operational across different sectors. This integration is crucial not only for technical personnel but also for medical teams, who play a pivotal role in disaster response and management. By fostering a comprehensive grasp of these methods, we can enhance coordination, efficiency, and effectiveness in addressing disasters on a global scale. The authors aimed to provide a comprehensive overview of emerging techniques that are driving shifts in strategic approaches and treatment technologies. Recognized as a domain of continuous research and development, this overview, by necessity, remains an incomplete snapshot of an evolving field. It highlights the dynamic nature of technological and strategic advancements, underscoring the importance of ongoing investigation and innovation to stay abreast of current trends and future directions. The article also highlights the importance of international collaboration beyond societal and national boundaries A single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions.

Preprint REVIEW | doi:10.20944/preprints202403.0694.v1

Precision Medicine – Are We There Yet? A Narrative Review of Precision Medicine’s Applicability in Primary Care

William Evans, Eric M Meslin, Joe Kai, Nadeem Qureshi

Subject: Public Health And Healthcare, Primary Health Care Keywords: Precision medicine; personalised medicine; primary care; genomics; pharmacogenoics; prediction modelling; artificial intelligence

Online: 12 March 2024 (08:22:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0501.v1

The Effect of Hot Application Applied to the Breast with the Help of Thera Pearl in the Postpartum Period on Mothers' Milk Perception and Postpartum Breastfeeding Self-Efficacy: Randomized Controlled Study

Hava Ozkan, Betül Uzun Ozer, Özlem ARI

Subject: Public Health And Healthcare, Primary Health Care Keywords: breast milk; breastfeeding; thera pearl; self-efficacy; perception of insufficient milk

Online: 8 March 2024 (10:50:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0302.v1

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults' Clinical Characteristics

Renata de Souza Freitas, Calliandra Maria De Souza Silva, Caroline Caroline Ferreira Fratelli, Luciano Ramos de Lima, Marina Morato Stival, Silvana Schwerz Funghetto, Izabel Cristina Rodrigues da Silva, Rosângela Vieira de Andrade

Subject: Public Health And Healthcare, Primary Health Care Keywords: Metabolic Syndrome; Interlekine-10; Interlekine-1β ; older population; IL10 rs1800890; IL1B rs1143627

Online: 6 March 2024 (11:09:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0024.v1

Occupational Exposure to Antineoplastic Drugs among Healthcare Workers: A Literature Review

Myanna Charles

Subject: Public Health And Healthcare, Primary Health Care Keywords: hedging; transaction costs; dynamic programming; risk management; post-decision state variable

Online: 1 March 2024 (07:58:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1504.v1

The Development and Testing of the Hippocratic Heart Failure Self-care Scale

Hero Brokalaki, ANASTASIA A CHATZIEFSTRATIOU, Nikolaos V. Fotos, Athina Patelarou, Konstantinos Giakoumidakis

Subject: Public Health And Healthcare, Primary Health Care Keywords: self-care; self-management; heart failure; validation; scale development

Online: 27 February 2024 (12:39:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0998.v1

Development and Implementation of Virtual Reality Application: Age-Friendly Health System Scenario

Sweta Tewary, Oksana Shnayder, Marie Dezine, Naushira Pandya

Subject: Public Health And Healthcare, Primary Health Care Keywords: virtual reality; age friendly health systems; medical education; older adults

Online: 19 February 2024 (15:45:44 CET)

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INTRODUCTION: With an increase in the aging population, the application of evidence-based practice in geriatric education can strengthen knowledge, skills, and clinical experience for healthcare students caring for older adults. Age Friendly Health Systems (AFHS) is one of the frameworks founded on providing evidence-based and low-risk care centered on what matters most to older adults, their families, and caregivers. Virtual Reality (VR) platforms are gaining popularity due to their ability to provide an immersive, hands-on learning experience resembling an actual medical practice or care setting. Immersive learning enhances students’ sensory perceptions, promoting an innovative and engaging way of acquiring concepts that are difficult to teach in real life. This study aimed to design, develop, implement, and evaluate a case-based training module highlighting AFHS and educating medical students on the 4Ms approach in geriatric care (What Matters, Medication, Mentation, and Mobility). METHODOLOGY: The project was a feasibility study completed in two phases. Phase one included planning and development of a case-based scenario incorporating 4Ms of AFHS. Phase two included implementing and evaluating the VR training module into the geriatric curriculum for medical students. RESULTS: The final VR case displays a hospital and post-acute setting where an elderly patient is admitted for a hip fracture. Students learn how to triage and treat patients from admission to discharge while demonstrating their knowledge of AFHS. Approximately 10% of students completed the evaluation survey, and preliminary results indicate significant knowledge change in pre-post scenario-based training on AFHS. CONCLUSION: The VR education platform and embedded scenario promise an innovative adaptation of technology in learning the concepts of the 4Ms of AFHS. However, future studies should explore VR education with clinical assessment evaluation to ensure competence in providing Age-Friendly care.

Preprint ARTICLE | doi:10.20944/preprints202402.0886.v1

Tandem Mass Spectrometry Screening for Inborn Errors of Metabolism: Comprehensive Bibliometric Analysis

Victoria Kononets, Gulmira Zharmakhanova, Saule Balmagambetova, Lyazzat Syrlybayeva, Gulshara Berdesheva, Zhanna Zhussupova, Aidana Tautanova, Yergen Kurmambayev

Subject: Public Health And Healthcare, Primary Health Care Keywords: tandem mass spectrometry; inborn errors of metabolism; newborn screening; selective screening; scientometrics; bibliometric analysis; visualization; VOSviewer

Online: 16 February 2024 (05:37:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0542.v1

Plant-Based Diets in Children: Secular Trends, Associations with Health Outcomes, and a Roadmap for Urgent Practice Recommendations and Research

Małgorzata Agnieszka Desmond, Mary Fewtrell, Jonathan CK Wells

Subject: Public Health And Healthcare, Primary Health Care Keywords: Keywords: vegetarian; vegan; children; secular trend; bone health; growth; nutrient deficiencies; clinical practice

Online: 9 February 2024 (10:53:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0272.v1

A Quick Look at the Present and Immediate Future of Type 1 DM

IGNACIO Diez Lopez, Sandra Maeso Mendez

Subject: Public Health And Healthcare, Primary Health Care Keywords: diabetes mellitus; future; childhood

Online: 5 February 2024 (15:27:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2175.v1

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Gladys Maribel Hidalgo-Lozada, Angelica Villarruel-López, Karla Nuño, Abel García-García, Yaír Adonaí Sánchez-Nuño, César Octavio Ramos-García

Subject: Public Health And Healthcare, Primary Health Care Keywords: natural compounds; functional foods; carotenoids; resveratrol; ellagic acid; berberine; probiotics; obesity; treatment; cardiovascular risk factors

Online: 31 January 2024 (07:28:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2014.v1

Optimizing Invasive Neonatal Respiratory Care: A Review of Invasive Neurally Adjusted Ventilatory Assist

Palanikumar Balasundaram, Mohamed Sakr

Subject: Public Health And Healthcare, Primary Health Care Keywords: neurally adjusted ventilatory assist; bronchopulmonary dysplasia; preterm; patient-ventilator synchrony

Online: 29 January 2024 (13:06:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1804.v1

Interprofessional Collaboration in Primary Care Practices during the COVID-19 Pandemic In Switzerland

Fatima El hakmaoui, Muriel Schuetz, Renzo Scuderi, Nicolas Senn, Christine Cohidon

Subject: Public Health And Healthcare, Primary Health Care Keywords: primary care; nurses; public health; interprofessionnal collaboration; covid-19

Online: 25 January 2024 (07:12:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1493.v1

Current Management and Treatment Paradigms of Gastroesophageal Reflux Disease Following Sleeve Gastrectomy

Muaaz Masood, Donald E Low, Shanley B. Deal, Richard A. Kozarek

Subject: Public Health And Healthcare, Primary Health Care Keywords: Gastroesophageal, reflux; GERD, esophagitis, morbid, obesity, bariatric, gastric, sleeve, gastrectomy

Online: 19 January 2024 (10:49:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1085.v2

Endogenous Neuromodulation at Infra-Low Frequency: Method and Theory

Siegfried Othmer, Susan FitzGerald Othmer

Subject: Public Health And Healthcare, Primary Health Care Keywords: Neuromodulation; Neurofeedback; Infra-Low Frequency; Slow Cortical Potential; Infra-Slow Fluctuations; EEG Biofeedback; Developmental Trauma

Online: 12 January 2024 (02:39:15 CET)

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Clinical work conducted over the last seventeen years at the EEG Institute in Los Angeles and by other neurofeedback providers around the world has demonstrated the utility of extending frequency-based neurofeedback deep into the infra-low frequency (ILF) region, using the method of endogenous neuromodulation described herein. The method is characterized by the absence of any overt reinforcements, which makes it possible to extend the clinical reach to extremely low frequencies. As the training frequency is lowered, the signal becomes more difficult to discriminate, and ultimately it can only be discerned by the brain itself, in the process of endogenous neuromodulation. The method emulates how the brain does skill learning in general: It must observe itself performing the skill, with feedback on its performance. While the immediate target of ILF neurofeedback is enhanced self-regulatory competence--with symptomatic relief and functional recovery the secondary consequences, progressive lowering of the target frequencies has led to improved outcomes in application to challenging dysfunctions such as episodic suicidality, migraine, seizures, and bipolar mood swings. The work has also yielded insights into how the frequency domain is organized. The training proceeds best at frequencies that are specific to each individual, and these are referred to as optimal response frequencies (ORFs). These frequencies differ for various placements but stand in two fixed relationships to one another, one that holds over the EEG spectral range, and another that holds over the entire ILF range. Training in the ILF region engages the dynamics of the glial-neuronal networks, which govern tonic, resting state regulation. The collective clinical experience with ILF neuromodulation within a large practitioner network supports the case for making protocol-based, individualized ‘homeodynamic’ regulation a therapeutic priority, particularly for our most impacted clinical populations: addiction, trauma formations, traumatic brain injury, and the dementias. The case is made for further outcome studies and foundational research.

Preprint REVIEW | doi:10.20944/preprints202401.0893.v1

Post-traumatic Stress Disorder in Children and Adolescents. A Comprehensive Review of Clinical Interventions

Evgenia Gkintoni, Elias Kourkoutas, Dimitra Prinianaki, Vasiliki Yotsidi, Pilios Dimitris Stavrou

Subject: Public Health And Healthcare, Primary Health Care Keywords: PTSD; Trauma; Psychotherapy; Intervention; Children; Adolescents

Online: 11 January 2024 (08:02:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0871.v1

Measles Trends in The Kingdom of Saudi Arabia, 2002-2012.

Fayez Saud Alreshidi, Fawaz Alrasheedi

Subject: Public Health And Healthcare, Primary Health Care Keywords: Measles; Elimination; KSA; Vaccination; Immunizable disease

Online: 11 January 2024 (07:55:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0670.v1

Safety and Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine in Individuals ≥12 Years Old: A Phase 2/3 Trial

Juleen Gayed, Oyeniyi Diya, Francine S. Lowry, Xia Xu, Vishva Bangad, Federico Mensa, Jing Zou, Xuping Xie, Yanping Hu, Claire Lu, Mark Cutler, Todd Belanger, David Cooper, Kenneth Koury, Annaliesa S. Anderson, Özlem Türeci, Uǧur Şahin, Kena A. Swanson, Kayvon Modjarrad, Alejandra Gurtman, Nicholas Kitchin

Subject: Public Health And Healthcare, Primary Health Care Keywords: BNT162b2; COVID-19; SARS-CoV-2; vaccine; variant-adapted; booster; Omicron; XBB.1.5

Online: 9 January 2024 (04:43:05 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.0553.v1

Effectiveness and Safety of the Intermittently Scanned Continuous Glucose Monitoring System FreeStyle Libre 2 in Patients with Type 2 Diabetes Treated with Basal Insulin or Oral Antidiabetic Drugs: An Observational, Retrospective Real-World Study

Matteo Conti, Giulia Massari, Elena Meneghini, Bernadetta Pasquino, Barbara Agosti, Federica Chinotti, Basilio Pintaudi, Angela Girelli, Federico Bertuzzi

Subject: Public Health And Healthcare, Primary Health Care Keywords: Flash Glucose monitoring; Basal insulin; Type 2 diabetes mellitus

Online: 8 January 2024 (11:27:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0564.v1

Artificial Intelligence and Pediatrics: Synthetic Knowledge Synthesis

Jernej Završnik, Peter Kokol, Bojan Žlahtič, Helena Blažun Vošner

Subject: Public Health And Healthcare, Primary Health Care Keywords: pediatrics; artificial intelligence; synthetic knowledge synthesis; bibliometrics; machine learning

Online: 8 January 2024 (06:55:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0420.v1

Effectiveness of Diabetes Self-Management Education among Diabetes Mellitus Patients. Systematic Review

Emirjona Kiçaj, Aurela Saliaj, Liliana Marcela Rogozea

Subject: Public Health And Healthcare, Primary Health Care Keywords: newly diabetic patients with T2DM; diabetes self-management,; health education

Online: 4 January 2024 (14:20:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0300.v1

Atypical and Unpredictable Superficial Mycosis Presentations: A Narrative Review

Zoubir Belmokhtar, Samira Djaroud, Derouicha Matmour, Yassine Merad

Subject: Public Health And Healthcare, Primary Health Care Keywords: Atypical mycosis; tinea incognito; Tinea corporis; Onychomycosis; Dermatophytes; mycosis fungoides; Majocchi's disease

Online: 4 January 2024 (07:09:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0258.v1

Does Adaptive Radiotherapy for Head and Neck Cancer Have a Favorable Impact on Dosimetric, Clinical, and Toxicity Outcomes? A Review.

Foteini Simopoulou, George Kyrgias, Ioannis Georgakopoulos, Raphaela Avgousti, Christina Armpilia, Pantelis Skarlos, Vassiliki Softa, Kiki Theodorou, Anna Zygogianni

Subject: Public Health And Healthcare, Primary Health Care Keywords: head and neck cancer; adaptive radiotherapy; intensity-modulated radiation therapy; anatomic changes; dosimetric changes; time of adaptation; clinical outcomes

Online: 4 January 2024 (05:41:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2258.v1

Examining the Role of Social Determinants of Health and Healthcare System Measures on COVID-19 Outcomes in 28 African Countries

Imelda K Moise, Lola R Ortiz-Whittingham, Kazeem Owolabi, Hikabasa Halwindi, Benard A Miti

Subject: Public Health And Healthcare, Primary Health Care Keywords: Social determiants of health; Africa; vaccines; prevention

Online: 29 December 2023 (09:14:44 CET)

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Background Although COVID-19 outcomes vary between and within countries, there is little published data on how aspects of social determinants of health (SDoH) affect COVID-19 outcomes in the African context. Objective The current study set to examine COVID-19 case and death rates and their correlates among African countries using data from different sources. Methods An ecological cross-sectional study comprising 28 African countries with a recent Demographic and Health Survey, DHS (2010-2018). Response variables were COVID-19 case and death rates (as of August 15, 2020). Covariates comprised three healthcare systems measures; rates of hospital beds (2005-2017), ventilators (2020) and doctors (2010-2018) per 10,000 population, and 9 broad topics common to multiple SDoH frameworks aggregated to the country level; geography (urban residence), wealth index, education, employment, crowding, and access to information. Rates per 10,000 population were calculated for healthcare measures and mapped for visualization. A Negative Binomial regression was used to assess whether aspects of SDoH are correlated with COVID-19. Results Our analysis indicated that 1 in 4 (25.1%) households in study countries are without clean water and handwashing access. Country-level health system capacity (hospital beds, ventilators, and medical doctors) varied considerably between the countries. Negative Binomial regression showed that the odds of COVID-19 morbidity and death was higher in countries with a high proportion of households without access to quality water and doctors per 10,000 people. Having a high proportional of educated women (1.003: 95% CI, 1.001 – 1.005), hospital beds per population and less people per room (0.959: 95% CI, 0.920 – 1.000) was negatively correlated with COVID-19 deaths while being insured and owning a mobile phone was correlated with illness. Conclusion Both aspects of SDoH and healthcare system contribute either negatively or positively to COVID-19 outcomes. Addressing healthcare system capacity and economic and environmental SDoH will be critical for mitigating the spread of COVID-19 and re-emerging diseases on the African continent.

Preprint REVIEW | doi:10.20944/preprints202312.1789.v1

Unveiling the Enigma: Exploring the Influences of Sexual Hormones in Adpkd Women and the Urgency for Novel Insight

Micaela Petrone, Martina Catania, Liliana Italia De Rosa, Rebecca S. Degliuomini, Kristiana Kola, Chiara Lupi, Matteo Brambilla Pisoni, Stefano Salvatore, Massimo Candiani, Giuseppe Vezzoli, Maria Teresa Sciarrone Alibrandi

Subject: Public Health And Healthcare, Primary Health Care Keywords: ADPKD; CKD; RAAS; female sexual hormones; hepatomegaly; childbearing age; postmenopausal; contraception; HRT

Online: 26 December 2023 (01:32:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1277.v2

Surface Modification and Functionalization of Sorafenib-Loaded PLGA Nanoparticles for Targeting Hepatocellular and Renal Cell Carcinoma

Ismail Khan, Zafar Iqbal, Abad Khan, Lateef Ahmad, Amjad Khan, Saeed Ahmad Khan, Muhammad Delwar Hussain, Mohsin Kazi

Subject: Public Health And Healthcare, Primary Health Care Keywords: Sorafenib; PLGA; Pluronic F-127; Nanosuspensions; In-vitro release; In-vivo pharmacokinetics

Online: 19 December 2023 (02:20:56 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202312.1191.v1

Retinoic Acid Action in Cumulus Cells: Implications to Oocyte Development and In Vitro Fertilization

Neil Sidell, Augustine Rajakumar

Subject: Public Health And Healthcare, Primary Health Care Keywords: retinoic acid; oocyte; granulosa cells; in vitro fertilization; connexin 43

Online: 18 December 2023 (02:10:51 CET)

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In the field of human in vitro fertilization (IVF), selecting the best oocyte for freezing or embryo for transfer remains an important focus of clinical practice. Although several techniques are and have been used for this goal, results have generally not been favorable and/or are invasive such that damage to some embryos occurs, resulting in a reduced number of healthy births. Therefore, the search continues for non-invasive oocyte and embryo quality markers that signal the development of high-quality embryos. Multiple studies indicate the important positive effects of retinoic acid (RA) on oocyte maturation and function. Here, we present evidence that part of these effects are via the ability of RA to regulate the activity of connexin 43 (Cx43), the main subunit of gap junction channels in human cumulus granulosa cells (CGC). These channels play an important role in regulating the micronutrient environment of the oocyte by allowing the transfer of ions, metabolites, and small molecules. Multiple studies have demonstrated the requirement for Cx43 in CGC for the normal progression of folliculogenesis, and that increased expression of this connexin is linked to improved developmental competence of the oocyte. The data has shown that RA can up-regulate gap junction intercellular communication (GJIC) in the cumulus-oocyte complex by a non-genomic mechanism that results in the dephosphorylation of Cx43 and enhanced GJIC. Recognizing the positive role played by gap junctions in CGC on oocyte development and the regulation of Cx43 by RA, the findings have highlighted the possibility that CGC RA levels may serve as a non-invasive indicator for selecting high-quality oocytes for IVF procedures. In addition, the data suggests that manipulation of Cx43 with retinoid compounds could provide new pharmacological approaches to improve IVF outcomes in cases of failed implantation, recurrent miscarriage, or in certain diseases that are characterized by reduced fecundity, such as endometriosis.

Preprint ARTICLE | doi:10.20944/preprints202312.1109.v2

Quality of Life and Incidence of Clinical Signs and Symptoms among Caregivers of Person with Mental Disorder

Vasiliki Oikonomou, Evgenia Gkintoni, Constantinos Halkiopoulos, Evangelos C Karademas

Subject: Public Health And Healthcare, Primary Health Care Keywords: clinical symptoms; caregivers; mental disorders; quality of life; stress; anxiety; depression; social support

Online: 15 December 2023 (12:16:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1109.v1

Quality of Life and Incidence of Clinical Signs and Symptoms among Caregivers of Person with Mental Disorder

Vasiliki Oikonomou, Evgenia Gkintoni, Constantinos Halkiopoulos, Evangelos Karademas

Subject: Public Health And Healthcare, Primary Health Care Keywords: clinical symptoms; caregivers; mental disorders; quality of life; stress; anxiety; depression; social support

Online: 14 December 2023 (15:32:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0779.v1

Intestinal Intussusception in Adult Patients. A Single Center Experience and Review of the Literature

Stefanos Atmatzidis, Dimitrios N. Raptis, Vasiliki Elisavet Stratinaki, Nikolaos Voloudakis, Eirini Martzivanou, Athanasios Papatzelos, Eftychia Kyriakidou, Ioannis Koutelidakis, Grigoris Chatzimavroudis, Basilios Papaziogas

Subject: Public Health And Healthcare, Primary Health Care Keywords: adult intussusception; intestinal obstruction; diagnosis; treatment; neoplasm

Online: 12 December 2023 (05:07:11 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202312.0374.v1

Multiple Sclerosis Treatment Strategy Optimization by PREdicting DIsease Progression through Linear and Non-linear Dynamics of Eeg Time-Series: The “MuST Predict” Conceptual Framework

Vasilis-Spyridon Tseriotis

Subject: Public Health And Healthcare, Primary Health Care Keywords: Multiple sclerosis; progression; treatment optimization; EEG; non-linear dynamics; criticality

Online: 6 December 2023 (10:33:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0235.v1

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation

Mauro Di Ianni, Carmine Liberatore, Nicole Santoro, Paola Ranalli, Francesco Guardalupi, Giulia Corradi, Ida Villanova, Barbara Di Francesco, Stefano Lattanzio, Cecilia Passeri, Paola Lanuti, Patrizia Accorsi

Subject: Public Health And Healthcare, Primary Health Care Keywords: GvHD; GvL; TCR alpha-beta; CD45RA; Tregs; NK; Suicide gene; immunotherapies

Online: 5 December 2023 (09:18:26 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.0211.v1

Strategic Investigation of Ligands for Melanoma Therapy: Docking Analysis and Predictive Toxicity Assessment

Ivan Vito Ferrari

Subject: Public Health And Healthcare, Primary Health Care Keywords: ; Melanoma; pKCSM; Docking approach; Diosmin; MAGEB1

Online: 5 December 2023 (04:39:27 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202311.1033.v1

SARS-CoV-2 and Influenza Virus Coinfections in the Tuscan Population during the 2021/2022 Influenza Season

Giovanna Milano, Serena Marchi, Ilaria Vicenti, Camilla Biba, Lia Fiaschi, Claudia Maria Trombetta, Giacomo Lazzeri, Emanuele Montomoli, Ilaria Manini

Subject: Public Health And Healthcare, Primary Health Care Keywords: coinfection; population; respiratory viruses.

Online: 15 November 2023 (15:49:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0529.v1

Mechanistic Insights into Targeting SARS-CoV-2 Papain-Like Protease in the Evolution and Management of COVID-19: A Comprehensive Review

NONJABULO N. MAGWAZA, AGANZE MUSHEBENGE, SAMUEL CHIMA UGBAJA, NONKULULEKO AVRIL MBATHA, RENE B. KHAN, HEZEKIEL M. KUMALO

Subject: Public Health And Healthcare, Primary Health Care Keywords: SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs

Online: 8 November 2023 (16:11:55 CET)

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The new coronavirus SARS-CoV-2 is the cause of the COVID-19 pandemic, which has created an incomparable global health problem. PLpro is a key protein involved in viral polyprotein processing and immune system evasion, making it a prime target for the development of antiviral drugs to combat COVID-19. The review begins by elucidating the functional and structural properties of SARS-CoV-2 PLpro, underscoring its significance in viral pathogenicity and replication. Employing homology modeling, a tertiary structure model of PLpro is constructed, laying the groundwork for subsequent investigations. To expedite the search for potential therapeutic candidates, the study harnesses computational methodologies. Molecular docking techniques are employed to explore binding sites for antiviral drugs within the catalytic region of PLpro. This computational approach not only aids in drug development but also provides crucial preliminary data before experimental research commences. The stability of drug-PLpro complexes is assessed through comprehensive all-atom molecular dynamics (MD) simulations, affording dynamic insights into drug-PLpro interactions. By evaluating binding energy estimates from MD simulations, stable drug-PLpro complexes with potential antiviral properties are identified. However, it is emphasized that experimental validation is imperative to confirm these computational findings, necessitating in vitro and in vivo tests to assess safety and efficacy. This pivotal stage bridges the computational realm with real-world clinical applications. The review emphasizes the imperative need for enhancements in the existing PLpro-targeting drugs currently on the market. Their actions are insufficient for clinical use and necessitate thorough characterization and improvement. The Supervised Molecular Dynamics (SuMD) simulation technique reveals critical information about drug unbinding pathways, shedding light on opportunities for refinement. In addition to optimizing existing drugs, the investigation of sub-structurally similar molecules emerges as a promising avenue for drug development. In conclusion, the review underscores the pivotal role of targeting SARS-CoV-2 PLpro in the ongoing battle against COVID-19. By integrating molecular dynamics simulations, structural modeling, and computational insights, a robust foundation is established for identifying promising antiviral drug candidates. The continual need for improvement in existing drugs and the exploration of novel compounds remain paramount in the global effort to combat COVID-19. The evolution and management of COVID-19 hinge on the symbiotic relationship between computational insights and experimental validation, illustrating the interdisciplinary synergy crucial to this endeavor.

Preprint ARTICLE | doi:10.20944/preprints202311.0330.v1

Association between lifestyle factors and COVID-19: findings from Qatar Biobank

Zoha Akbar, Hasna H. Kunhipurayil, Jessica Saliba, Jamil Ahmad, Layla Al-Mansoori, Hebah A Al-Khatib, Asmaa A. Al Thani, Zumin Shi, Abdullah A. Shaito

Subject: Public Health And Healthcare, Primary Health Care Keywords: COVID-19; Smoking; Vitamin D; Obesity; Bariatric Surgery; Dietary Patterns

Online: 7 November 2023 (02:18:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0294.v1

A Study on Fertility Desire of Chinese Players in Education Simulation: Investigating the Mesomeric Effects of Parasocial Relationship, Game Concentration, and Individual Role Identity

Qi Yuan, Shaojun Liu, Jun Yin

Subject: Public Health And Healthcare, Primary Health Care Keywords: Fertility Desire; Parasocial Relationship; Education Simulation Game

Online: 6 November 2023 (07:31:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0017.v1

Current Status of Nanomedicine in CNS Cancer Therapeutics in the Post-COVID-19 Era

Is aventurato

Subject: Public Health And Healthcare, Primary Health Care Keywords: nanomedicine; CNS cancer; therapeutics; blood-brain barrier; personalized medicine; nanoparticles; COVID-19; drug delivery; regulatory landscape; precision oncology

Online: 1 November 2023 (08:31:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1600.v1

Recent Progresses in Signal Processing for Alzheimer's Disease Detection

Mengyao Zhao

Subject: Public Health And Healthcare, Primary Health Care Keywords: Alzheimer's disease; signal processing methods; Fourier transform; time-frequency analysis; statistical signal processing; EEG; signal characteristics; signal noise

Online: 25 October 2023 (08:00:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1411.v1

Study to Determine the Prevalence of Premenstrual Migraine among Women with Premenstrual Syndrome in Saudi Arabia

Zainah Al-Qahtani, Bayapa Reddy Narapureddy, Lingala Kalyan Viswanath Reddy, Hassan Yahya Asiri, Abdulkhaliq Hadi H Asiri, Hassan A Alarafy Asiri, Rammas A. Shawkhan, Nouf Abdulraheem Hamood, Ahmad Abdullah H Alsalamy, Nawaf Khalid Ahmed Hassan, Hussein Ahmed M Almahdi, Yousef Yahya Al Qasim, Yahya Ayed Mohammed Al Majbar, Abdullah Ali A Swadi

Subject: Public Health And Healthcare, Primary Health Care Keywords: Menstrual Migraine; Migraine; Non-Menstrual Migraine; Premenstrual Dysphoric Disorder; Premenstrual Syndrome; Prevalence; Saudi Arabia

Online: 23 October 2023 (12:32:01 CEST)

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Background: Migraine is one of the most common health conditions in the reproductive male and female population. Premenstrual syndrome (PMS) is a common condition that affects many women during their menstrual cycle. around 50 to 60% have menstrual headaches among the migraineur women. The symptoms in the majority were mild, but 5–8% may suffer moderate to severe symptoms, accompanied by considerable distress or functional dysfunction. Premenstrual migraine (PMM) refers to migraines that occur with the menstrual cycle. It affects approximately 50% of women with migraine and can be debilitating in terms of both frequency and severity of symptoms. This information is important for medical professionals in Saudi Arabia to be aware of so, as to provide better medical care and support which can significantly improve the person's quality of life of women who suffer from PMS and menstrual migraines. Objectives: To estimate the prevalence of menstrual migraines in women, to evaluate the severity and frequency of menstrual migraines in women with PMS, and to identify potential risk factors aggravating menstrual migraines in women with PMS. Methodology: A cross-sectional community-based study was conducted on reproductive age (18-50Years) women who have regular menstrual cycles with experience migraine headaches and are diagnosed with PMS and menstrual migraine, using a self-administered questionnaire between December 2022 to May 2023 in Saudi Arabia. Results: Out of 2130 women participants 397 were suffering from migraine which is 18.6%. Of the total 397(18.6%) Migraineurs individuals 230 (57.9%) were suffering from menstrual migraine and 167 (42.1%) were non-menstrual migraineurs, in general, reproductive women menstrual migraine is 10.7% and non-menstrual migraine is 7.8%. The BMI is increasing the incidence of menstrual migraines is increasing. Migraine Disability Around one-third of the participants were suffering from III–moderate disability 134 (33.8) Most of the menstrual migraine victims at least 3 days in the last three months were absent from their duties due to their menstrual migraines. Conclusions: Migraine attacks during the menstrual cycle cause the impairment of their social and physical ability to perform their routine household, and academic activities and unable to fulfill their professional commitments. To better understand the Menstrual Migraine and Non-menstrual migraine large prospective studies are required to plan the best management methods.

Preprint ARTICLE | doi:10.20944/preprints202310.1360.v1

Enhanced Monitoring and Decision Support in Pancreatic Cancer through Holistic Health Records and Advanced Data Processing: the iHELP Platform

George Manias, Ainhoa Azqueta-Alzúaz, Juan Ramon Berenguer Mari, Athanasios Dalianis, Jake Griffiths, Maritini Kalogerini, Konstantina Kostopoulou, Eleftheria Kouremenou, Pavlos Kranas, Sofoklis Kyriazakos, Danae Lekka, Fabio Melillo, Marta Patiño-Martínez, Óscar García-Perales, Aristodemos Pnevmatikakis, Spyros Spanos, Salvador Garcia Torrens, Usman Wajid, Dimosthenis Kyriazis

Subject: Public Health And Healthcare, Primary Health Care Keywords: artificial intelligence; holistic health records; pancreatic cancer; real-time monitoring; primary and secondary data

Online: 20 October 2023 (16:12:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1315.v1

“You’re Just Fat”: A 36 cm Cyst Causing an Ovarian Torsion in a Twenty-Year-Old Woman After Presenting Symptoms of Concern to her Doctor for Years—A Case Report

Anita Udabor, Chase Beverley Becker, Jan Becker

Subject: Public Health And Healthcare, Primary Health Care Keywords: ovarian torsion; large cyst; acute abdomen; case report; fertility; third presentation rule; ovarian serous cystadenoma; diagnostic process in primary care, case report

Online: 20 October 2023 (10:30:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0889.v1

Postural Orthostatic Tachycardia Syndrome Following SARS-CoV-2 Infection and COVID-19 Vaccination: A Comparative Review

Zeinab Mohseni Afshar, Homa Mazaherinia, Hosein Nazari rostami, Arefeh Babazadeh, Mohammad Barary, Erfan Hashemi, Soheil Ebrahimpour

Subject: Public Health And Healthcare, Primary Health Care Keywords: Postural Orthostatic Tachycardia Syndrome (POTS); COVID-19; SARS-CoV-2; Vaccination

Online: 13 October 2023 (10:58:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0786.v1

Factors Affecting Exclusive Breastfeeding Practices among Working Class Women Attending Antenatal Clinic in Egbedore Local Government Area, Osun State, Nigeria

Ruth T. Abioye, Adeyemi O. Omoge, Olawumi J. Ajao, Blessing O Olatunji, Elizabeth O. Olatunji, Oluwatoromoleyin M. Olamide, Adedapo O. Dada

Subject: Public Health And Healthcare, Primary Health Care Keywords: Exclusive breastfeeding, Working class, Women, Knowledge.

Online: 13 October 2023 (08:27:52 CEST)

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Background: Exclusive breastfeeding (EBF) for the first 6 months of life improves the growth, health and survival status of newborns. Breastfeeding has been accepted as the most vital intervention for reducing infant mortality and ensuring optimal growth and development of children. Objectives: The general objective was to identify the factors affecting exclusive breastfeeding among working class women in selected wards in Egbedore Local Government in Osun state, Nigeria. Methodology: This was descriptive cross-sectional study. Leslie Kish formula was used for sample size calculation and multistage sampling was used in selecting 316 working class women for the study. A structured, self-administered questionnaire was used for data collection. Data was analyzed using SPSS version 21.0 and level of significance was set at 5%. Results: 58% of the respondents were between the ages of 25-30. 72% demonstrated good understanding of exclusive breastfeeding based on the 6 months WHO recommendation for exclusive breast feeding, 25.9% had a fair knowledge and awareness of exclusive breastfeeding. 63.3% of the working class mother has a good practice of exclusive breast feeding, 19.6% of the women moderately practices exclusive breastfeeding while 17.1% poorly practices exclusive breastfeeding. Less than 3-months maternity leave for mothers, lack of crèche closer to place of work and lack of breastfeeding break were identified as barriers to exclusive breastfeeding practices among the working class women. The findings demonstrated a significant relationship between knowledge and practices of exclusively breastfeeding among working class women (P-value .009). Conclusion: This study demonstrated that working class women had good knowledge of exclusive breastfeeding and this influenced their breastfeeding practices. A good knowledge was associated with favorable attitudes to the practice of exclusive breast feeding. To derive long-term benefits from early childhood nutrition, interventions should focus on health education and community-based sensitization programs on the needs for mothers to engage in exclusive breast needing for global development.

Preprint ARTICLE | doi:10.20944/preprints202310.0753.v1

Association of Vitamin B12 levels with Sleep Quality, Insomnia and Sleepiness in Adult Primary Health Care Users in Greece

Izolde Bouloukaki, Maria Lampou, Konstantina Maria Raouzaiou, Eirini Lambraki, Sophia Schiza, Ioanna Tsiligianni

Subject: Public Health And Healthcare, Primary Health Care Keywords: sleep disorders; primary care; vitamin B12; insomnia symptoms; excessive daytime sleepiness; sleep quality

Online: 12 October 2023 (05:00:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0575.v1

Family Planning Services Utilization among Women Visiting Better Life Primary Healthcare Centre for Family Planning Services in Ondo City, Ondo State, Nigeria

Adeyemi O. Omoge, Modupe O. Oyedele, Oluwabunmi B. Erinsakin, Oladunni D. Oluwafemi

Subject: Public Health And Healthcare, Primary Health Care Keywords: Family, Planning, Utilization, Women

Online: 11 October 2023 (07:47:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0616.v1

Assessment of Body Mass Index (BMI) of Women Visiting Better Life Primary Health Care Centre, Ondo City, Ondo State Nigeria for Healthcare Services

Adeyemi O. Omoge, Modupe O. Oyedele, Oluwabunmi B. Erinsakin, Oladunni D. Oluwafemi

Subject: Public Health And Healthcare, Primary Health Care Keywords: assessment; body; mass; index; women; healthcare services

Online: 10 October 2023 (10:42:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0315.v1

Association between Dietary Protein Energy Supply Ratio and Obesity in United States Children and Adolescents

Feng Zhao, Zhaoyi Liu, Jiao Wang, Yinyin Xia, Xuejun Jiang, Lixiao Zhou, Ahmad Khan, Shuqun Cheng, Zhen Zou, Chengzhi Chen, Jingfu Qiu

Subject: Public Health And Healthcare, Primary Health Care Keywords: Protein energy supply ratio; Overweight/obesity; Children; Adolescents; NHANES

Online: 6 October 2023 (05:47:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2042.v1

An Analysis of the Impact of Religious Affiliation and Strength of Religiosity on Sexual Health Practices of Sexually Active Female College Students

Emily Glazer, Emma Valdez, Justin A. DeBlauw, Stephen Ives

Subject: Public Health And Healthcare, Primary Health Care Keywords: Sexual health; contraceptives; religion; social determinants

Online: 29 September 2023 (08:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1854.v1

Primary Care Patient Interest in Multi-Cancer Early Detection for Cancer Screening

Ronald Myers, Mie Hallman, Ayako Shimada, Melissa DiCarlo, Kaitlyn Davis, William T Leach, Hattie Jackson, BSc, Amanda Indictor, Christopher Chambers

Subject: Public Health And Healthcare, Primary Health Care Keywords: multi-cancer early detection test; primary care; cancer screening

Online: 27 September 2023 (08:38:12 CEST)

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Preprint ESSAY | doi:10.20944/preprints202309.1795.v1

Strengthening Primary Healthcare in Jordan for Achieving Universal Health Coverage: A Need for Family Health Team Approach

Yousef Khader, Mohannad Al Nsour, Sara Abu Khudair, Randa Saad, Mohammad Rassoul Tarawneh, Faris Lami

Subject: Public Health And Healthcare, Primary Health Care Keywords: primary healthcare; reform; family health team

Online: 27 September 2023 (05:42:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1761.v1

Design, Implementation and Evaluation of an Innovative Pilot Intervention to Improve the Quality of Life of the Family of Students with Specific Learning Disabilities. A Quantitative Analysis

Nektaria Pedioti, Stavroula Lioliou, Katerina Koutra, Stavros Parlalis, Maria Papadakaki

Subject: Public Health And Healthcare, Primary Health Care Keywords: specific learning disabilities; children; parenting; authoritarian; intervention; quality of life; experimental design

Online: 26 September 2023 (11:55:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1474.v1

Modification of Lipid Profile, LDL Subfractions and other Cardiovascular Risk Markers in Hypercholesterolemic Women through the Sea Buckthorn Juice Consumption

Jana Kopčeková, Jana Mrázová, Katarína Fatrcová-Šramková, Peter Chlebo, Maroš Bihari, Martina Gažarová, Petra Lenártová, Marta Habánová, Alica Navrátilová

Subject: Public Health And Healthcare, Primary Health Care Keywords: berries; sea buckthorn juice; lipid profile; cholesterol; inflammation markers; intervention; anthropometric characteristics.

Online: 21 September 2023 (11:31:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1311.v1

Stepping up for Climate Change and Health: The Three Pillars of Green Podiatry

Angela Margaret Evans

Subject: Public Health And Healthcare, Primary Health Care Keywords: green podiatry; health; climate emergency; climate change; healthcare; greenhouse gases; sustainability; environment

Online: 20 September 2023 (04:48:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1110.v1

Empirical Investigation of the Impact of Traditional Medicine on Life Expectancy in Nasarawa State, Nigeria

Patience TANKO KURE, Victoria Nwachukwu, DANJUMA Nanbol, Beatrice Inchikida, Sharinya Jacob Tyolumun

Subject: Public Health And Healthcare, Primary Health Care Keywords: traditional medicine; life expectancy; health care

Online: 18 September 2023 (07:17:14 CEST)

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The study investigated the impact of traditional medicine on life expectancy in Nasarawa State, Nigeria. The study adopted a quantitative research approach. Purposive or judgmental sampling was used to elucidate the data set used for the study. Cross-sectional data were gathered with the help of a well-designed questionnaire from a total of three hundred and fifty-seven (357) respondents who were available for the survey. The data set collected was analysed using descriptive and linear regression using Ordinary Least Squares (OLS). From the results, 53%, 87%, and 56% were male, below 50 years old, and in the low-income class, respectively, suggesting that the bulk of the respondents under investigation were male, young, and had rather modest incomes. Also, 53% were married, and all had one form of formal education. 67% of respondents acknowledge using traditional medicine; however, the majority of respondents preferred Orthodox medical care over alternative kinds of care. Traditional medicine (TM) and factors that contribute to the advancement of traditional medicine (FITM) have a negative impact on life expectancy, according to the regression analysis. On the other hand, TM has no statistically significant impact on life expectancy, despite FITM having a statistically significant effect at the 5% level. All available data, however, indicates that TM and FITM have an impact on life expectancy, either directly or indirectly. Based on the results, this study concluded that traditional medicine has the potential to significantly increase life expectancy in Nasarawa State and throughout Nigeria. The study recommends that traditional health professionals, stakeholders, and concerned government agencies should put efforts in place to improve and promote modern traditional medicine among the people, especially its effectiveness and medicinal quality, increase its accessibility to people, and efficiently regulate its prices to increase its affordability for low-income earners

Preprint REVIEW | doi:10.20944/preprints202309.0596.v1

The Importance of Toothbrushing and Oral Hygiene in Maintaining Oral Health

Tanny Pérez-Portilla, Domingo Lubín Ortíz-Benitez, Salvador Eduardo Lucas-Rincón, Gabriel Canseco-Prado, Víctor Jesús Delgado-Pérez, Rogelio José Scougall-Vilchis, Norma Leticia Robles-Bermeo, Carmen Celina Alonso-Sánchez, Miriam Alejandra Veras-Hernández, Carlo Eduardo Medina-Solís

Subject: Public Health And Healthcare, Primary Health Care Keywords: oral health; toothbrushing; caries; periodontal diseases; halitosis

Online: 11 September 2023 (07:14:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0503.v1

Knowledge and Awareness of Iron Deficiency Anemia among Female Students in Dubai

Maryam Alhatemi, Dalia Haroun

Subject: Public Health And Healthcare, Primary Health Care Keywords: iron deficiency anemia; IDA; anemia; knowledge; awareness

Online: 7 September 2023 (11:13:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0186.v1

The New Era of Therapeutic Strategies for the Treatment of Retinitis Pigmentosa: From Pathomolecular Mechanisms to the Development of Cell-Based Therapies

Valentina Becherucci, Giacomo Maria Bacci, Elisa Marziali, Andrea Sodi, Franco Bambi, Roberto Caputo

Subject: Public Health And Healthcare, Primary Health Care Keywords: Inherited Retinal Dystrophies; Retinitis Pigmentosa; therapeutic strategies; cell therapies

Online: 4 September 2023 (11:29:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.2166.v1

Artificial Intelligence in the Interpretation of Videofluoroscopic Swallowing Studies: Implications and Advances for Speech Pathologists

Anna M Girardi, Elizabeth A Cardell, Stephen P Bird

Subject: Public Health And Healthcare, Primary Health Care Keywords: dysphagia; artificial intelligence; videofluoroscopic swallowing study; deep learning; machine learning; imaging; speech pathology

Online: 31 August 2023 (10:42:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1895.v1

Multi Drug Resistant and Heteroresistant Mycobacterium tuberculosis Isolates Variants from Patients in Rural Areas in Eastern Cape

Lindiwe M. Faye, Mojisola C. Hosu, Yanga Mbiza, Nomzi Lubuzo, Ncomeka Sineke, Thulani Knowledge Gumede, Carine Bokop, Bonnie Ifaedi, Ntandazo Dlatu, Sandeep Vasaikar, Teke Apalata

Subject: Public Health And Healthcare, Primary Health Care Keywords: keyword multidrug-resistant tuberculosis; gene mutations; heteroresistance; Beijing variants

Online: 29 August 2023 (03:33:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1443.v1

Sociodemographic and Health Indicators of Diet Quality in Pre-Frail Older Adults in New Zealand

Esther Tay, Daniel Barnett, Maisie Rowland, Ngaire Kerse, Richard Edlin, Debra L Waters, Martin Connolly, Avinesh Pillai, Evelingi Tupou, Ruth Teh

Subject: Public Health And Healthcare, Primary Health Care Keywords: frailty; older adults; diet quality; sociodemographic; BMI

Online: 22 August 2023 (03:25:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1370.v1

Unraveling the Intricate Mechanisms: Regulation and Secretion of Glucagon in Response to Nutrient Composition

Jiudan Zhang, Yang Zheng, Lisa Martens, Andreas F.H Pfeiffer

Subject: Public Health And Healthcare, Primary Health Care Keywords: gucagon; glucose; lipid; amino acid; hyperglucagonemia

Online: 21 August 2023 (03:07:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0815.v1

Biological Activities and Catechins Content of Qi Cha Tea®, a Patented Preparation of White Tea (Camellia sinensis) with Botanicals and Dry Botanical Extracts as a Functional Beverage According European Health Claims

Jean Michel Maixent, Meriam Belaiba, Olivier Pons, Enora tessa Rouleau, Jalloul Bouajila, Jean-Marc Zeil

Subject: Public Health And Healthcare, Primary Health Care Keywords: camellia sinensis; acacia gum; medicinal plants; tea; food; infusion beverages; health claims

Online: 10 August 2023 (05:44:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0711.v1

Young Women’s Attitudes and Concerns on Pornography and Their Sexual Experiences: A Qualitative Approach

Mónica Fernández-Ruiz, Olga María López-Entrambasaguas, Jose Manuel Martínez-Linares, José Granero-Molina

Subject: Public Health And Healthcare, Primary Health Care Keywords: pornography; qualitative research; sexual behavior; sex education; sexual health; young women

Online: 9 August 2023 (09:05:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0594.v1

Areas of Concern and Support among the Austrian General Population. A Qualitative Content Analytic Mapping of the Shift between Winter 2020/21 and Spring 2022

Afsaneh Gächter, Barbara Zauner, Katja Haider, Yvonne Schaffler, Thomas Probst, Christoph Pieh, Elke Humer

Subject: Public Health And Healthcare, Primary Health Care Keywords: concerns; resources; pandemic; inflation; war in Ukraine; content analysis; Austria

Online: 8 August 2023 (07:20:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0599.v1

VaccineHero: An XR System That Reduces Toddler’s Discomfort during Vaccination

Stavros Antonopoulos, Vasiliki Rentoula, Manolis Wallace, Vassilis Poulopoulos, Georgios Lepouras

Subject: Public Health And Healthcare, Primary Health Care Keywords: Vaccination; discomfort; extended reality; toddlers

Online: 8 August 2023 (04:03:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0464.v1

Evidence Based Pharmaceutical Care in Community Pharmacies: A Survey of 595 French Pharmacists

Louis Bosson, Francesca Veyer, Jean-Didier Bardet, Céline Vermorel, Alison Foote, Benoit Allenet, Jean-Luc Bosson

Subject: Public Health And Healthcare, Primary Health Care Keywords: Evidence based practice; Pharmaceutical care; Community pharmacy; France; Over-the-counter medication; sources of information

Online: 7 August 2023 (10:45:26 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202308.0440.v1

Health Access, Health Promotion and Health Self-Management: Barriers When Building Comprehensive Ageing Communities

Leticia Pérez-Saiz, Mireia Ferri, Maite Ferrando, Mirian Fernández Salido, Tamara Alhambra-Borrás, Jorge Garcés Ferrer, Rachael Dix

Subject: Public Health And Healthcare, Primary Health Care Keywords: value-based care; healthy ageing; frailty; social care; barriers; health promotion; community; digital solution

Online: 4 August 2023 (14:45:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0218.v1

Association Between Glomerular Filtration Rate and Thalassemia: A Systematic Review and Meta-Analysis

Shahad Saif Khandker, Nurani Jannat, Deepannita Sarkar, Alif Hasan Pranto, Ismoth Ara Hoque, Jemema Zaman, Md. Nizam Uddin, Ehsan Suez

Subject: Public Health And Healthcare, Primary Health Care Keywords: glomerular; GFR; kidney; thalassemia; anemia; hemoglobin; hereditary diseases

Online: 3 August 2023 (08:05:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1972.v1

Participants’ Bias in Disability Research on Family Quality of Life During the 0-6 Years Stage

Carmen Tania Francisco Mora, Alba Ibáñez-García, Anna Balcells-Balcells

Subject: Public Health And Healthcare, Primary Health Care Keywords: Family Quality of Life; Conceptualization; Participants; Research Ethics; Disability; Family

Online: 28 July 2023 (13:14:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1627.v1

Health Providers’ Response to Female Adolescents’ Survivors of Sexual Violence, and Demand Side Barriers in the Utilization of Support Services in Urban Slums of Nigeria

Olutoyin Opeyemi Ikuteyijo, Andrea Kaiser-Grolimund, Michael D. Fetters, Akanni Ibukun Akinyemi, Sonja Merten

Subject: Public Health And Healthcare, Primary Health Care Keywords: Health providers; female adolescents; slums; sexual and gender-based violence; barriers

Online: 25 July 2023 (08:56:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1383.v1

Investigating the Effectiveness of Mindfulness-Based Stress Reduction on Mental Health, Mindfulness, and Sleep Quality in Post COVID Period

Mansooreh Azizzadeh Forouzi, Fahimeh Baghbani, Azam Zare Arashlouei, Abolfazl Hossein Nataj, Malihe Pooredalati, Fatemeh Khajooi, Elham Pourafrouz, Atefeh Ahmadi, Vahideh Arabfaridy

Subject: Public Health And Healthcare, Primary Health Care Keywords: Mindfulness based stress reduction; mental health; mindfulness; sleep quality; post COVID period

Online: 20 July 2023 (05:16:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1235.v1

Misconceptions and Knowledge Gaps on Antibiotic Use in Primary Care – a Delphi Study in Four Sectors and Five European Countries

Athina Chalkidou, Maarten Lambert, Gloria Cordoba, Katja Taxis, Malene Plejdrup Hansen, Lars Bjerrum

Subject: Public Health And Healthcare, Primary Health Care Keywords: antimicrobial resistance; antibiotics; antibiotic use; misconceptions and knowledge gaps; general practice; out-of-hours services; nursing homes; community pharmacies

Online: 18 July 2023 (12:23:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1083.v1

Neuropsychology of Generalized Anxiety Disorder in Clinical Setting. A Systematic Evaluation

Evgenia Gkintoni, Paula Suárez Ortiz

Subject: Public Health And Healthcare, Primary Health Care Keywords: Neuropsychology; Anxiety Disorders; Clinical Setting; Generalized Disorder; Prisma; Systematic Review

Online: 17 July 2023 (11:11:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0896.v1

Association of Possible Sarcopenia or Sarcopenia with Body Composition, Nutritional Intakes, Serum Vitamin D3 Levels, and Physical Activity among Patients with Type 2 Diabetes Mellitus in Taiwan

Yu-Ting Hsu, Jian-Yu Lin, Chien-Ju Lin, Yau-Jiunn Lee, Wen-Hsin Chang

Subject: Public Health And Healthcare, Primary Health Care Keywords: type 2 diabetes mellitus; sarcopenia; serum vitamin D3 levels; nutritional intake; physical performance

Online: 13 July 2023 (08:08:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0700.v1

Reaching the Frail Elderly for the Diagnosis and Management of Atrial Fibrillation - REAFEL

Carsten Bamberg, Caroline Thorup Ladegaard, Mathias Aalling, Dorthea Marie Jensen, Christoffer Læssøe Madsen, Sadaf Kamil, Henrik Guldbergsen, Thomas Saxild, Michaela Louise Schiøtz, Julie Grew, Luana Sandoval Castillo, Iben Tousgaard, Rie Laurine Rosenthal Johansen, Jakob Eyvind Bardram, Anne Frølich, Helena Domínguez

Subject: Public Health And Healthcare, Primary Health Care Keywords: sensor; Holter; monitoring; atrial fibrillation; health professionals; frail elderly; cross-sector collaboration; CardioShare model; C3+

Online: 11 July 2023 (11:49:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0296.v1

Knowledge of pregnant women regarding maternity facility-based delivery at primary health care facilities in the province of KwaZulu-Natal in South Africa

Puseletso Ruth Mlotshwa, Maureen Nokuthula Sibiya

Subject: Public Health And Healthcare, Primary Health Care Keywords: Acceptance; antenatal care; facility-based delivery; South Africa

Online: 6 July 2023 (13:21:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0435.v1

Risk Factors of Health-Related Quality of Life Among Gastrointestinal Cancer Survivors in the U.S: With a Focus on Social and Behavioral Determinants of Health (SBDH)

Claire J Han, Fode Tounkara, Mathew Kalady, Ann M Noonan, Natasha R Burse, Electra D Paskett, Diane Von Ah

Subject: Public Health And Healthcare, Primary Health Care Keywords: Gastrointestinal; Cancer survivor; Social and behavioral determinants of health; Health-related quality of life

Online: 6 July 2023 (12:31:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0106.v1

Exploring the Theory of Leaky Intestine: Gender Differences in Intestinal Parasitic Infections and Associated Cytoskeletal Wall Dysfunctions and Hypertension

Philip C Njemanze, Anthonia Amadi, Joy E Onuchukwu, Chinwendu C Darlington, Nneoma E Ukeje, Clinton O Mezu, Clara C Ofoegbu, Chidera Okuh, Chidimma Ukaegbu, Linda O Uzoma, Marvis Amuchie, Faustina N Ojilere, Lilian C Mbara

Subject: Public Health And Healthcare, Primary Health Care Keywords: Intestinal Microbiome; Gut Microbiota; Parasites; Ultrasound; Parasites

Online: 3 July 2023 (14:03:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1701.v1

Evaluating Sarcopenia Using Bioelectrical Impedance Vector Analysis and Phase Angle

Saizhao Tang, Fang Lin Jiang, Seon-Ho Eom, Jae-Young Lee, Ji Heon Chae, Chul-Hyun Kim

Subject: Public Health And Healthcare, Primary Health Care Keywords: bioelectrical impedance vector analysis; phase angle; aging; diagnosis; noninvasive

Online: 25 June 2023 (03:09:52 CEST)

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Sarcopenia becomes more common with age, being most prevalent among elderly individuals. According to the EWGSOP, muscle mass is one of the criteria for the evaluation of sarcopenia. The main methods for evaluating muscle mass are CT, MRI, and DXA, but these methods are difficult to apply in the field due to equipment costs, radioactivity, and lack of portability. BIVA and PhA are alternative approaches for assessing somatic cell mass and volume and do not require predictive equations. These variables are clinically relevant parameters that indicate cell health, especially cell membrane integrity and cell function. This study in sarcopenic and nonsarcopenic elderly volunteers aimed to determine the BIVA distribution pattern among individual sarcopenia patients; to evaluate the relationship between PhA and muscle strength, muscle quality, and physical function; and to find any correlates of PhA. The sample comprised 134 free-living elderly individuals of both sexes aged 69–91 years. Anthropometric parameters, grip strength, DXA findings, BIA results, and physical performance (the 6-meter walk test) were measured. Impedance vector distributions were evaluated in sarcopenia patients and healthy elderly individuals using BIVA. According to the AWGS criteria, sarcopenia was diagnosed according to DXA findings, grip strength and physical performance test results. Group differences were evaluated using the t test, Mann‒Whitney U test, and Hotelling's T2 test. Correlation analysis was performed to identify variables significantly associated with PhA. Linear regression analysis was performed to determine whether PhA was associated with muscle strength, muscle quality and physical function. BIVA detected a significant difference between the sarcopenia and non-sarcopenia groups (both sexes) due to higher R/H values and lower phase angles in a few individuals, whereas Xc/Ht values did not differ between the two groups. The sarcopenia group had a significantly lower PhA than the non-sarcopenia group among both males (p<0.01) and females (p<0.05). PhA was significantly correlated with age, ASM, HGS, and muscle quality in both sexes and significantly correlated with ASM/Ht2 and physical performance in males. PhA was a significant indicator of muscle strength in both males (β = 2.6; p<0.01) and females (β = 3.4; p<0.01), a significant indicator of muscle quality in both males (β = 0.07; p<0.05) and females (β = 0.17; p<0.01), and a significant indicator of physical performance in males (β = 0.3; p<0.01). BIVA can detect changes in muscle mass in individuals with sarcopenia and is a practical method for the assessment of sarcopenia in the field. PhA is a good indicator of muscle strength, muscle quality and physical performance (in males). These methods can help diagnose sarcopenia in elderly individuals with reduced mobility.

Preprint ARTICLE | doi:10.20944/preprints202306.1542.v1

Sleep Quality and Fatigue During Exam Periods in University Students: Prevalence and Associated Factors

Izolde Bouloukaki, Ioanna Tsiligianni, Georgios Stathakis, Michail Fanaridis, Athina Koloi, Ekaterini Bakiri, Maria Moudatsaki, Eleni Pouladaki, Sophia Schiza

Subject: Public Health And Healthcare, Primary Health Care Keywords: sleep quality; fatigue; university students; exam period

Online: 21 June 2023 (11:40:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0776.v1

Microbiological analysis of surgeons' hands in a public hospital in São Luis, Maranhão State, Brazil

Artur Serra Neto, Sirlei Garcia Marques, Maria Rosa Quaresma Bomfim, Silvio Gomes Monteiro, Rosangela Cipriano Souza, Rodolfo Acatauassu Nunes

Subject: Public Health And Healthcare, Primary Health Care Keywords: hands; antisepsis; surgeons; surgical sites; microbiology.

Online: 12 June 2023 (07:44:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0633.v1

Roux-En-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women With and Without Metabolic Syndrome: A Randomized Controlled Trial

Sandra M.B.P. Moreira, Andre L. L. Bachi, Elias I. Jirjos, Carlos A. Malheiros, Sergio Vencio, Vera Lúcia dos Santos Alves, Alan R. T. Sousa, Lucenda A. Felipe, Eduardo A. Perez, Maria E. M. Lino, Shayra K. A. Souza, Juliana M. B. Santos, Miriã C. Oliveira, Adriano Luís Fonseca, Carlos H. M. Silva, Rodolfo P Vieira, Giuseppe Insalaco, Wilson R. Freitas Júnior, Luis V. F. Oliveira

Subject: Public Health And Healthcare, Primary Health Care Keywords: Roux-en-Y Gastric Bypass; Adiponectin to leptin ratio; Inflammatory profile; Severely obese; Metabolic syndrome

Online: 8 June 2023 (10:47:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0319.v1

Study on the Prevalence of Pneumocystis jirovecii as a Causative Agent of Lung Pathology in People with Different Immune Status

Rumen Harizanov, Nina Tsvetkova, Aleksandra Ivanova, Raina Enikova, Mihaela Videnova, Iskra Rainova, Eleonora Kaneva, Iskren Kaftandjiev, Dimitar Strashimirov, Nina Yancheva-Petrova, Ivan Simeonovski, Viktoria Levterova, Nikolai Yanev

Subject: Public Health And Healthcare, Primary Health Care Keywords: Pneumocystis pneumonia; immune status; real-time PCR; staining methods

Online: 5 June 2023 (12:55:05 CEST)

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Public Health and Healthcare