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Preprint REVIEW | doi:10.20944/preprints201712.0023.v1

Does Irisin Link Physical Exercise with Alzheimer’s Disease?

Dewan Md. Sumsuzzman, Yunho Jin, Yonggeun Hong

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: physical exercise; irisin; neurodegeneration; aging; Alzheimer’s disease

Online: 4 December 2017 (08:46:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0033.v1

Cordycepin Modulate Body Weight by Reducing Prolactin via an Adenosine A₁ Receptor

Yuan Li , Yan Li, Xueyan Wang, Hongyue Xu, Chao Wang, Yanan An, Wenjing Luan, Xuefei Wang, Shulin Li, Mingyuan Liu, Xudong Tang, Lu Yu

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: cordycepin; adenosine A1 receptor; prolactin; anti-obesity

Online: 3 April 2018 (07:53:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0088.v2

NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells (ASCs)

Maria Pitrone, Giuseppe Pizzolanti, Laura Tomasello, Antonina Coppola, Lorenzo Morini, Gianni Pantuso, Romina Ficarella, Valentina Guarnotta, Sebastio Perrini, Francesco Giorgino, Carla Giordano

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Adipose derived stem cell (ASC); Regenerative medicine; embryonic stem cell marker network

Online: 20 January 2017 (04:56:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0466.v1

Angiotensin Converting Enzyme 2 in Coronavirus Disease (COVID-19): Evidence from Bioinformatics Analysis

Xiaomei Yang, Hongjin Zhao, Yan Li, Peng Zhang

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: COVID-19; coronavirus; ACE2; bioinformatics analysis; drug prediction

Online: 26 April 2020 (03:14:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0019.v1

“NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic Profiling

Marietta Kokla, Anton Klåvus, Stefania Noerman, Ville M. Koistinen, Marjo Tuomainen, Iman Zarei, Topi Meuronen, Merja R. Häkkinen, Soile Rummukainen, Ambrin Farizah Babu, Taisa Sallinen, Olli Kärkkäinen, Jussi Paananen, David Broadhurst, Carl Brunius, Kati Hanhineva

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; LC-MS; mass spectrometry; metabolic profiling; computational; statistical; unsupervised learning; supervised learning; pathway analysis

Online: 3 February 2020 (05:54:14 CET)

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Preprint REVIEW | doi:10.20944/preprints201704.0059.v1

Vitamin D Deficiency Increases the Risk of Diabetic Retinopathy: A Meta-Analysis of Observational Studies

Xiang Zhang, Guo-Tao Pan, Zeng-Li Zhang, Shasha Tao

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Keywords: vitamin D deficiency; diabetic retinopathy; meta-analysis.

Online: 11 April 2017 (06:16:22 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201901.0246.v1

A Method to Encourage Minimum Reporting Guideline Uptake for Data Analysis in Metabolomics

Elizabeth C. Considine, Reza M. Salek

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: reproducibility; minimum guidelines; reporting; data analysis; reporting

Online: 24 January 2019 (08:37:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0174.v1

Inhibitory Effects of Diclofenac on Steroid Glucuronidation in Vivo Do not Affect Hair-Based Doping Tests for Stanozolol

Gergely Zachár, Nawed I. K. Deshmukh, Andrea Petróczi, Andrea D. Székely, Iltaf Shah, James Barker, Declan P. Naughton

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: steroid; metabolism; anti-inflammatory drug; inhibition

Online: 24 May 2017 (08:25:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0088.v1

NANOG Plays a Hierarchical Role in the Transcription Network Regulating the Pluripotency and Plasticity of Adipose Tissue-Derived Stem Cells (ASCs)

Maria Pitrone, Giuseppe Pizzolanti, Laura Tomasello, Antonina Coppola, Lorenzo Morini, Gianni Pantuso, Romina Ficarella, Valentina Guarnotta, Sebastio Perrini, Francesco Giorgino, Carla Giordano

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: adipose derived stem cell (ASC); regenerative medicine; embryonic stem cell marker network

Online: 19 January 2017 (10:59:11 CET)

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Preprint REVIEW | doi:10.20944/preprints201712.0023.v2

Does Irisin Link Physical Exercise with Alzheimer’s Disease?

Dewan Md. Sumsuzzman, Yunho Jin, Jeonghyun Choi, Sang-Rae Lee, Yonggeun Hong

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: physical exercise; irisin; neurodegeneration; aging; Alzheimer’s disease

Online: 11 February 2018 (04:28:07 CET)

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Preprint REVIEW | doi:10.20944/preprints201704.0171.v1

Peroxiredoxin 4 (PRDX4): Its Critical In Vivo Roles in Animal Models of Metabolic Syndrome Using Our Unique PRDX4 Transgenic Mice

Sohsuke Yamada, Xin Guo, Akihide Tanimoto

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Peroxiredoxin (PRDX) 4, chronic inflammatory disease, metabolic syndrome, human PRDX4 transgenic mice (Tg), animal model.

Online: 26 April 2017 (17:57:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0040.v2

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

Junli Ma, Qihang Zhou, Houkai Li

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Gut microbiota; obesity; insulin resistance, NAFLD; probiotic; prebiotic; symbiotic

Online: 6 October 2017 (16:15:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0245.v1

Improvement in Diabetic Retinopathy through Protection against Retinal Apoptosis in Spontaneously Diabetic Torii Rats Mediated by Ethanol Extract of Osteomeles schwerinae C.K. Schneid.

Chan-Sik Kim, Junghyun Kim, Young Sook Kim, Kyuhyung Jo, Yun Mi Lee, Dong Ho Jung, Ik Soo Lee, Joo Hwan kim, Jin Sook Kim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Osteomeles Schwerinae; diabetic retinopathy (DR); spontaneously diabetic Torii (SDT) rat; human retinal microvascular endothelial cells (HRMECs); advanced glycation end products (AGEs); retinal apoptosis; oxidative stress; mitochondrial function; adjunctive effect; combination therapy

Online: 24 January 2019 (08:37:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0089.v1

Low Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation and Protocols

Benita Percival, Yasan Osman, Martin Grootveld, Miles Gibson, Marco Molinari, Fereshteh Jafari, Mark Martin, Federico Casanova, Melissa Mather, Mark Edgar, Philippe Wilson

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Metabolomics; Benchtop NMR; Biomarkers; Biomolecules; Validation; Protocol

Online: 4 October 2018 (16:23:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0049.v1

Mangosteen Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study

Mikiko Watanabe, Elena Gangitano, Davide Francomano, Eliana Addessi, Raffaella Toscano, Daniela Costantini, Dario Tuccinardi, Stefania Mariani, Sabrina Basciani, Giovanni Spera, Lucio Gnessi, Carla Lubrano

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: garcinia mangostana; inflammation; insulin resistance; metabolic syndrome; diabetes; xanthones; mangostin; phytotherapy; dietary supplements

Online: 4 April 2018 (06:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0210.v1

Intestinal Microbial and Metabolite Profiling of Mice Fed with Dietary Glucose and Fructose

João C. P. Silva, Marta Mota, Fátima O. Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S. Barros, John G. Jones, Ana M. Gil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: fructose; intestinal microbiota; short-chain fatty acids; metabolic profiling

Online: 23 January 2018 (05:31:27 CET)

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Preprint REVIEW | doi:10.20944/preprints201802.0120.v1

Alcoholism: A Multi-Systemic Molecular Insult to Organ Damage

Ucee Dguzeh, Natasha Haddad, Kathia Smith, John Johnson, Angelia Doye, Judith Gwathmey, Georges Haddad

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Alcohol abuse, Alcohol beneficial effects, multi-organ effects of alcohol

Online: 19 February 2018 (14:30:39 CET)

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Preprint REVIEW | doi:10.20944/preprints201709.0040.v1

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

Junli Ma, Qihang Zhou, Houkai Li

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: gut microbiota; obesity; insulin resistance; NAFLD; probiotic; prebiotic; symbiotic

Online: 11 September 2017 (08:22:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0245.v1

COVID-19 Comorbidity and Metabolic Syndrome: Is There a Molecular Basis?

Madhurima Basu, Chinmay Saha, Kamalika Roy Choudhury, Susmita Dutta, Sujoy Ghosh, Subhankar Chowdhury, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: COVID-19; Metabolic syndrome; Comorbidity; Enrichment analysis; biological processes and pathways

Online: 21 June 2020 (09:52:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0089.v1

Association of KCNJ11 Genetic Variations with Risk of Type 2 Diabetes Mellitus (T2DM) in North Indian Population

Vasiuddin Khan, Deepti Bhatt, Shahbaz Khan, AMIT KUMAR VERMA, Rameez Hasan, Sahar Rafat, Yamini Goyal, Prahlad Singh Bharti, Mohammad Yaqub Shareef, Mohammed A. Alsahli, Arshad Husain Rahmani, Kapil Dev

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: type 2 diabetes; KCNJ11; RFLP; SNP

Online: 5 July 2019 (04:53:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0193.v1

Combination of Aronia, Red Ginseng and Shiitake Mushroom Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

Hye Jeong Yang, Min Jung Kim, Dae Young Kwon, Da Sol Kim, Ting Zhang, Chulgyu Ha, Sunmin Park

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: aronia; ginseng; mushroom; pancreatectomy; type 2 diabetes; gut microbiome; insulin secretion

Online: 12 June 2018 (13:01:30 CEST)

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The combination of freeze-dried aronia, red ginseng, ultraviolet-irradiated shiitake mushroom and natokinase (AGM; 3.4: 4.1: 2.4: 0.1) was examined to evaluate its effects on insulin resistance, insulin secretion and gut microbiome in a non-obese type 2 diabetic animal model. Pancreatectomized (Px) rats were provided high fat diets supplemented with either of 1) 0.5 g AGM (AGM-L), 2) 1 g AGM (AGM-H), 3) 1 g dextrin (control), or 4) 1g dextrin with 120 mg metformin (positive-control) per kg body weight for 12 weeks. AGM (1 g) contained 6.22 mg cyanidin-3-galactose, 2.5 mg ginsenoside Rg3 and 0.6 mg β-glucan. Px rats had decreased bone mineral density in the lumbar spine and femur and lean body mass in the hip and leg compared to the normal-control and AGM-L and AGM-H prevented the decrease. Visceral fat mass was lower in the control group than the normal-control group and its decrease was smaller by AGM-L and AGM-H. HOMA-IR was lower in descending order of the control, positive-control, AGM-L, AGM-H and normal-control groups. Glucose tolerance was deteriorated in the control group and it was improved by AGM-L and AGM-H more than in the positive-control group. Glucose tolerance is associated with insulin resistance and insulin secretion. Insulin tolerance indicated insulin resistance was highly impaired in diabetic rats, but it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Insulin secretion capacity, measured by hyperglycemic clamp, was much lower in the control group than the normal-control group and it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Diabetes modulated the composition of gut microbiome and AMG prevented the modulation of gut microbiome. In conclusion, AGM improved glucose metabolism by potentiating insulin secretion and reducing insulin resistance in insulin deficient type 2 diabetic rats. The improvement of diabetic status alleviated body composition changes and prevented changes of gut microbiome composition.

Preprint ARTICLE | doi:10.20944/preprints201901.0297.v1

Overcoming Deterrent Metabolites by Gaining Essential Nutrients: A Lichen/Snail Case Study

Alice Gadea, Maryvonne Charrier, Mathieu Fanuel, Philippe Clerc, Corentin Daugan, Aurélie Sauvager, Hélène Rogniaux, Joël Boustie, Anne-Cécile Le Lamer, Françoise Le devehat

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: mass spectrometry imaging; feeding choice; lichen; snail; usnic acid; D-arabitol

Online: 30 January 2019 (04:29:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0182.v1

Rediscovering the Ethical Priority of the Most Actionable System of Biomolecules—The Metabolome

Cecil M. Lewis, Laura-Isobel McCall, Richard Sharp, Paul G. Spicer

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; genomics; ethics

Online: 15 May 2019 (10:09:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0103.v1

Molecular Basis of Aromatase Deficiency in a 46, XX Patient with Mutation of Arginine 550 to Tryptophan in POR: Expanding the Endocrine Phenotype in PORD

Shaheena Parween, Mónica Fernández Cancio, Sara Benito-Sanz, Núria Camats, Maria Natalia Rojas Velazquez, Juan-Pedro López-Siguero, Sameer S Udhane, Norio Kagawa, Christa Flück, Laura Audì, Amit Pandey

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: PORD; congenital adrenal hyperplasia; POR; CY19A1; CYP21A2, CYP17A1

Online: 9 September 2019 (14:48:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0256.v1

Effects of Bisphenol A and 4-Tert-octylphenol on Embryo Implantation Failure in Mouse

Dinh Nam Tran, Eui-Man Jung, Changhwan Ahn, Jae-Hwan Lee, Yeong-Min Yoo, Eui-Bae Jeung

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Implantation failure; Bisphenol A; 4-tert-octylphenol; calcium channel

Online: 18 May 2018 (07:38:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0240.v1

Inhibition of Late and Early Phases of Cancer Metastasis by NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review

Yinzhi Lin, Tamami Ukaji, Naoki Koide, Kazuo Umezawa

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: epoxyqinomicin; DHMEQ; metastasis; invasion; adhesion; 3D cell culture

Online: 25 January 2018 (10:27:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0026.v1

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation in Vivo

Marc Foretz, Patrick Even, Benoit Viollet

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: AMPK; liver; lipid metabolism; fatty acid oxidation; indirect calorimetry

Online: 1 August 2018 (16:06:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0237.v1

Boldine Improves Kidney Damage in the Goldblatt 2K1C Model Avoiding the Increase in TGF-β

Gonzalo I. Gómez, Victoria Velarde

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: renovascular hypertension; chronic kidney disease; oxidative stress; fibrosis; (S)-2,9-dihydroxy-1,10-dimethoxy-aporphine

Online: 17 May 2018 (07:50:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0065.v1

“Insulin-Like” Effects of Palmitate Might Contribute to the Development of Insulin Resistance in Hypothalamic Neurons

Martin Benzler, Jonas Benzler, Sigrid Stoehr, Cindy Hempp, Mohammed Z. Rizwan, Phil Heyward, Alexander Tups

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: hypothalamus; insulin resistance; inflammation; docosahexaenoic acid; PI3K inhibitor; AKT

Online: 4 July 2018 (09:58:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0180.v1

Lupine (Lupinus angustifolius L.) Peptide Prevents Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice

Ana Lemus-Conejo, Elena Grao-Cruces, Rocio Toscano, Lourdes M Varela, Carmen Claro, Justo Pedroche, Francisco Millan, Maria C Millan-Linares, Sergio Montserrat-de la Paz

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: GPETAFLR peptide; protein hydrolysate; liver; hepatic steatosis; high-fat diet

Online: 15 July 2019 (06:09:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0042.v1

In Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism

Nesli-Ece Sen, Aleksandar Arsovic, David Meierhofer, Susanne Brodesser, Carola Oberschmidt, Júlia Canet-Pons, Zeynep-Ece Kaya, Melanie V. Halbach, Suzana Gispert, Konrad Sandhoff, Georg Auburger

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: olivo-ponto-cerebellar atrophy (OPCA); amyotrophic lateral sclerosis (ALS); tauopathy; leukodystrophy; mass spectrometry; RT-qPCR; Ceramide Synthase (CERS2/CERS1); Serine Palmitoyltransferase 2 (Sptlc2); neutral Sphingomyelinase (Smpd3); neutral Ceramidase (Asah2); Fatty Acid Elongase (Elovl1/4/5); SCA34; SCA38; acid Sphingomyelinase (ASMase, Smpd1)

Online: 5 November 2019 (03:04:02 CET)

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Ataxin-2 (ATXN2) acts during stress-responses, modulating mRNA translation and nutrient metabolism. Atxn2 knockout mice exhibit progressive obesity, dyslipidemia and insulin resistance. Conversely, the progressive ATXN2 gain-of-function due to polyGlutamine (polyQ) expansions leads to a dominantly inherited neurodegenerative process named spinocerebellar ataxia type 2 (SCA2), with early adipose tissue loss and late muscle atrophy. We tried to understand lipid dysregulation in a SCA2 patient brain and in an authentic mouse model. Thin layer chromatography of a patient cerebellum was compared to the lipid metabolome of Atxn2-CAG100-KnockIn (KIN) mouse spinocerebellar tissue. The human pathology caused deficits of sulfatide, galactosylceramide, cholesterol, C22/24-sphingomyelin and gangliosides GM1a/GD1b, despite quite normal levels of C18-sphingomyelin. Cerebellum and spinal cord from the KIN mouse showed a consistent decrease of various ceramides, with a significant elevation of sphingosine in the more severely affected spinal cord. Deficiency of C24/26-sphingomyelins contrasted with excess C18/20-sphingomyelin. Spinocerebellar expression profiling revealed consistent reductions of CERS protein isoforms, of Sptlc2 and Smpd3, but upregulation of Cers2 mRNA, as prominent anomalies in the ceramide-sphingosine metabolism. Reduction of Asah2 mRNA correlated to deficient S1P levels. In addition, downregulations for the elongase Elovl1, Elovl4, Elovl5 mRNAs and ELOVL4 protein explain the deficit of very-long-chain sphingomyelin. Reduced ASMase protein levels correlated to the accumulation of long-chain sphingomyelin. Overall, a deficit of myelin lipids was prominent in SCA2 nervous tissue at prefinal stage, not compensated by transcriptional adaptation of several metabolic enzymes. Myelination is controlled by mTORC1 signals, so our human and murine observations are in agreement with the known role of ATXN2 yeast, nematode and mouse orthologs as mTORC1 inhibitors and autophagy promoters.

Preprint ARTICLE | doi:10.20944/preprints202202.0097.v1

Predictors of Adrenal and Gonadal Hormones in Relation to Biological and Management Factors Among Captive Red Pandas in Indian Zoos

Aamer Sohel Khan, Janine Brown, Vinod Kumar, Govindswamy Umapathy, Nagarajan Baskaran

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Captive breeding; endangered; red panda; reproductive hormone; stress hormone; welfare

Online: 7 February 2022 (16:07:29 CET)

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Animals in human care are affected by stressors that can ultimately reduce fitness. When reproduction is affected, endangered species’ conservation programmes can be severely compromised. Thus, understanding factors related to stress and reproduction, and measures of related hormones, are important to ensure captive breeding success. Red pandas are endangered and populations in the wild are threatened with extinction. A global captive breeding programme has been launched to conserve the species with the goal of reintroduction. However there is little informaiton on how stressors impact reproductive aspects of the species. This study measured fecal glucocorticoid (fGCM), fecal progestagen (fPM) and fecal androgen (fAM) metabolite concentrations in 12 female and 8 male red pandas (Ailurus fulgens fulgens) at three zoos in northeastern India to determine predictors of adrenal and gonadal steroid activity and the influence of fGCM on reproduction. Results indicated that fGCM concentrations were higher in males than females, and positively correlated with number of visitors, while negatively related to frequency of feedings and enclosure area. Sex, visitor number, frequency of feeding, and enclosure area explained 67% of the variations in fGCM concentrations in the study population. Concentrations of fPM were positively associated with tree density in the enclosure, explaining 47% of the variation among females. For fAM, positive associations were found with frequency of feeding, but concentrations were negatively related to age and number of visitors; these three covariates explained 45% of the variation in fAM concentration among males. Comparison of fGCM with fPM showed a negative trend, indicating increasing adrenal hormones may decrease reproductive function among female red pandas. The study thus suggests that zoo management should consider increasing feeding frequency, providing larger enclosures with more trees, and regulating visitor numbers to reduce stress and increase reproductive fitness among red pandas.

Preprint ARTICLE | doi:10.20944/preprints201810.0089.v2

Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models

Benita Percival, Martin Grootveld, Miles Gibson, Yasan Osman, Marco Molinari, Fereshteh Jafari, Tarsem Sahota, Mark Martin, Federico Casanova, Melissa Mather, Mark Edgar, Jinit Masania, Philippe Wilson

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Metabolomics; Benchtop NMR; Biomarkers; Biomolecules; Validation; Protocol

Online: 5 December 2018 (16:14:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0601.v1

Soy-enriched bread, a pilot study to determine its beneficial effects in menopause

Daniela Giustarini, Comasia Ricci, Ilaria Ceccarelli, Stefano Pieretti, Paolo Andre, Silvia Migliorini, Lauretta Massai, Paola Minosi, Ilenia Casini, Anna Maria Aloisi

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: menopause, women, phytoestrogens, bread, soy

Online: 29 January 2021 (06:05:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0086.v1

Hyperglycemia: The Metabolic Syndrome Component That Aggravates Erectile Dysfunction in Mexican Patients

Alan Espinosa-Marrón, Christian A. Quiñones-Capistrán, Aquiles Rubio-Blancas, María del Pilar Milke-García, Ricardo A. Castillejos-Molina

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: erectile dysfunction; metabolic syndrome; risk factors; hyperglycaemia

Online: 11 June 2019 (08:04:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0353.v1

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease: A Narrative Review

Fatkhu Rahman, Syahrul Tuba

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Diabetic; Chronic Kidney Disease; Metformin; Acidosis Lactate

Online: 28 February 2022 (09:28:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0655.v1

Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity

Preethi Cherian, Irina Al-Khairi, Mohammad Jamal, Suleiman Al-Sabah, Hamad Ali, Carol Dsouza, Eman Al Shawaf, Waleed Al-Ali, Ghanim Al-khaledi, Fahd Al-Mulla, Mohamed Abu-Farha, Jehad Abubaker

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Meteorin-like hormone, irisin, adipomyokines, bone markers, Osteoactivin , Syndecan, OPG, Osteonectin, type 2 diabetes, obesity.

Online: 26 April 2021 (10:57:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0125.v1

Dietary Patterns Independent of Fast Food Are Associated with Obesity among Korean Adults: Korea National Health and Nutrition Examination Survey 2010–2014

Do-Yeon Kim, Ahleum Ahn, Hansongyi Lee, Jaekyung Choi, Hyunjung Lim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: adults; dietary pattern; fast food; KNHANES; obesity

Online: 11 September 2019 (14:59:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0073.v1

Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown Adipose Tissue Activation

Byong-Keol Min, Hyeon-Ji Kang, Byung-Jun Choi, Yong Hyun Jeon, Je-Yoel Cho, In-Kyu Lee, Dong Wook Kim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Phenylbutyrate, PFKL, Obesity, UCP1, Brown adipose tissue

Online: 8 January 2019 (15:22:39 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201901.0246.v2

A Tool to Encourage Minimum Reporting GuidelineUptake for Data Analysis in Metabolomics

Elizabeth C. Considine, Reza M. Salek

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: reproducibility; minimum guidelines; reporting; data analysis; reporting

Online: 8 March 2019 (09:06:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0069.v1

Metabolic Reprogramming of Fibroblasts as Therapeutic Target in Rheumatoid Arthritis and Cancer: Deciphering Key Mechanisms using Computational Systems Biology Approaches

Sahar Aghakhani, Naouel Zerrouk, Anna Niarakis

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Fibroblasts; Rheumatoid Arthritis; Cancer; Metabolic Reprogramming; Glycolytic Switch; Systems Biology; Computational Modelling

Online: 2 November 2020 (19:28:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0219.v1

A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice

Domenico Nuzzo, Antonella Amato, Pasquale Picone, Simona Terzo, Giacoma Galizzi, Francesco Paolo Bonina, Flavia Mulè, Marta Di Carlo

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: High-Fat Diet, Dietary Supplement, Oxidative stress, Inflammation, Neurodegeneration.

Online: 12 July 2018 (15:45:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0143.v1

Linking Aromatic Hydroxy Metabolic Functionalization of Drug Molecules to Structure and Pharmacologic Activity

Babiker M. El-Haj, Samrein B.M. Ahmed, Mousa A. Qarawi, Heyam S. Ali

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Aromatic hydroxy metabolites; arenolic drug metabolites; metabolic O-dealkylation; metabolic aromatic ring hydroxylation; primary and auxiliary pharmacophores; auxophores; metabolic modification of drug activity

Online: 9 July 2018 (13:28:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0343.v1

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed High-fat Diet or a High-fat Diet Combined with STZ Treatment

Zhen-hong Xia, Wen-bo Chen, Li Shi, Xue Jiang, Ke Li, Yu-xiang Wang, Yan-qiang Liu

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: anti-apoptosis; anti-oxidant; curcumin; hyperglycemia; hyperlipidemia

Online: 27 November 2019 (09:57:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0069.v1

Gene Expression Profiling Reveals That PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice

Sharon Ann Barretto, Frederic Lasserre, Anne Fougerat, Lorraine Smith, Tiffany Fougeray, Celine Lukowicz, Arnaud Polizzi, Sarra Smati, Marion Régnier, Claire Naylies, Colette Betoulieres, Yannick Lippi, hervé guillou, Nicolas Loiseau, Laurence Payrastre, Laila Lakhal, Sandrine Ellero-Simatos

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: nuclear receptors; hepatokines; transcriptomics

Online: 3 July 2019 (15:08:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0200.v1

Ancient Origin Properties of Natural Exosomes Contribute to Their Therapeutic Superiority Compared to Artificial Nanoparticles

Philip Askenase

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: exosomes; micro vesicles; extracellular vesicles; mesenchymal stromal cells (MSC); miRNA; cell therapy; artificial nano particles

Online: 16 June 2020 (07:57:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0123.v1

Effects of Caffeinated and Decaffeinated Coffee Consumption on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis of Data from Randomised Controlled Trials

Nur Nadiah Syuhada Ramli, Areej A Alkhaldy, Abbe Maleyki Mhd Jalil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolic syndrome; caffeinated coffee; decaffeinated coffee; green coffee extract; chlorogenic acid

Online: 4 August 2021 (22:04:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0417.v1

FIB-4 First in Diagnostic Algorithm of MAFLD at the Era of “Global Metabodemic “

Yoshio Sumida, Masashi Yoneda, Katsutoshi Tokushige, Miwa Kawanaka, Hideki Fujii, Masato Yoneda, Kento Imajo, Hirokazu Takahashi, Yuichiro Eguchi, Masafumi Ono, Yuichi Nozaki, Hideyuki Hyogo, Masahiro Koseki, Yuichi Yoshida, Takumi Kawaguchi, Yoshihiro Kamada, Takeshi Okanoue, Atsushi Nakajima

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: hepatic fibrosis; hepatocullar carcinoma; vibration controlled transient elastography

Online: 19 August 2020 (13:00:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0357.v1

Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid

Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus Zabetian, Elaine R. Peskind, Ge Li, Daniel Promislow, Marie Y. Davis, Alexander Franks

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: predictive modeling; biomarker; cerebrospinal fluid; cross-sectional study; neurodegenerative disease

Online: 24 January 2022 (12:59:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0001.v1

System-level Insights into the Adaptation of Domestic Dairy Buffalo to Chronic Heat Stress

Zhaobing Gu, Shoukun Tang, Xianhai Fu, Chuanbin Liu, Huaming Mao

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: chronic heat stress; dairy buffaloes; proteomics; adaptation mechanisms

Online: 3 January 2019 (08:32:13 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0166.v1

Fat Mass and Obesity Associated (FTO) Gene and Hepatic Glucose and Lipid Metabolism

Tooru M. Mizuno

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: FTO; liver; gluconeogenesis; lipogenesis; glucose; insulin; type 2 diabetes; non-alcoholic fatty liver disease

Online: 9 October 2018 (03:52:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0235.v1

Metabolic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry

Nnenna Elebo, Jones Omoshoro-Jones, Pascaline Fonteh-Fru, John Devar, Christiaan De Wet van Zyl, Barend Christiaan Vorster, Martin Smith, Stefano Cacciatore, Luiz F. Zerbini, Geoffrey Candy, Ekene Emmanuel Nweke

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Pancreatic Ductal Adenocarcinoma; metabolites; cholestatic (obstructive) jaundice; lipoprotein; inflammation; tumour stages

Online: 10 August 2021 (14:08:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0096.v1

Interplay among calcium diet content, PTH(1-34) treatment and balance of bone homeostases in rat model: the trabecular bone as keystone

Marzia Ferretti, Francesco Cavani, Laura Roli, Marta Checchi, Maria Sara Magarò, Jessika Bertacchini, Carla Palumbo

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: calcium diet content; mineral homeostasis; skeletal homeostasis; trabecular bone; PTH(1-34); rat

Online: 10 January 2019 (11:38:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0448.v2

Diet Control to Achieve Euglycemia Induces Tau Hyperphosphorylation Via AMPK Activation in the Hippocampus of Diabetic Rats

Sang-Don Han, Jun-Ho Lee, Yun-Hee Noh, Mingli Jin, Jin-Seong Kim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Alzheimer’s disease; Diabetes; Diet control diet; AMPK; Tau hyperphosphorylation

Online: 8 October 2018 (15:32:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0273.v1

Overexpression of p75NTR in Testicular Germ Cell Tumors: a New Biomarker of Cancer Differentiation?

Anna Perri, Vittoria Rago, Rocco Malivindi, Lorenza Maltese, Danilo Lofaro, Emanuela Alessandra Greco, Luigi Tucci, Renzo Bonofiglio, Margherita Vergine, Sandro La Vignera, Eusebio Chiefari, Antonio Brunetti, Antonio Aversa

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: testicular germ cell tumors (TGCTs); human seminoma; p75 neurotrophin receptor (p75NTR); p75NTR -signaling.

Online: 9 March 2021 (14:52:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0474.v1

Identifying personalized metabolic signatures in breast cancer

Priyanka Baloni, Wikum Dinalankara, John C. Earls, Theo A. Knijnenburg, Donald Geman, Luigi Marchionni, Nathan D. Price

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Breast cancer, genome-scale metabolic models, constraint-based analysis, divergence analysis, gene expression, metabolism, drug targets, personalized metabolic networks.

Online: 18 November 2020 (12:29:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0536.v1

Alphavirus-driven Interferon Gamma (IFNg) Expression Inhibits Tumour Growth in Orthotopic 4T1 Breast Cancer Model

Olga Trofimova, Ksenija Korotkaja, Dace Skrastina, Juris Jansons, Karina Spunde, Maria Isaguliants, Anna Zajakina

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: interferon gamma; cancer immunotherapy; viral vectors; alphavirus; bone marrow-derived macrophages; spheroids; CD38; Pam3CSK4

Online: 30 August 2021 (10:18:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0464.v1

High Fructose Consumption: More Pain Than Gain to Human Health

Simon Isaiah, Oluwaseyi Olanrewaju, Abisola Sholeye, Modupe Ayilara

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Antioxidants; Free radicals; Fructose; Oxidative stress

Online: 17 June 2021 (14:40:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0008.v1

Adipophilin and Perilipin 3 Correlate with Total Lipid Content in Human Breast Milk

Tereza Pavlova, Zdenek Spacil, Veronika Vidova, Filip Zlamal, Eliska Cechova, Zuzana Hodicka, Julie Bienertova-Vasku

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: perilipins, milk lipid globules, human breast milk, lipid content, tandem mass spectrometry, ultra-high performance liquid chromatography

Online: 1 October 2018 (12:18:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0148.v1

Vitamin D Regulation of a SOD1-to-SOD2 Antioxidative Switch to Prevent Osteosarcoma Transformation

Thomas S. Lisse

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: osteosarcoma; cancer; tumor; vitamin D; vitamin D deficiency; vitamin D receptor; vdr; mitochondria; ROS; SOD; SOD1; SOD2; superoxide; superoxide dismutase

Online: 9 March 2020 (02:40:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0004.v1

Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections

Joann Diray-Arce, Maria-Giulia Conti, Boryana Petrova, Naama Kanarek, Asimenia Angelidou, Ofer Levy

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; vaccines; infections; integrative metabolomics; systems biology; diagnosis; response detection

Online: 1 September 2020 (10:25:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0685.v1

Skeletal Muscle and the Maintenance of Vitamin D Status

Mark S. Rybchyn, Myriam Abboud, David A. Puglisi, Clare Gordon-Thomson, Tara C. Brennan-Speranza, Rebecca S. Mason, David R. Fraser

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: vitamin D; muscle; parathyroid hormone; vitamin D-binding protein

Online: 30 August 2020 (18:31:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0268.v1

Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues Through Sympathetic Nerve Activation

Yuko Ishii, Orie Muta, Tomohiro Teshima, Nayuta Hirasima, Minayu Odaka, Taiki Fushimi, Yasuyuki Fujii, Naomi Osakabe

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: flavan-3-ols; adipose; browning; catecholamine; sympathetic nerve

Online: 15 September 2021 (15:16:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0363.v1

The Dual Role of Oat Bran Water Extract in Bone Homeostasis Through the Regulation of Osteoclastogenesis and Osteoblast Differentiation

Shin-Hye Kim, Kwang-Jin Kim, Hyeon Jung Kang, Young-Jin Son, Sik-Won Choi, Mi-Ja Lee

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Bone; Osteoclasts; Osteoblasts; Oat Bran; Osteoporosis

Online: 15 November 2018 (11:38:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0133.v1

Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster

Karis A. Ederer, Kelly Jin, Sarah Bouslog, Lu Wang, Gregory S. Gorman, Glenn C. Rowe, Peter Abadir, Daniel Raftery, Douglas Moellering, Daniel Promislow, Patricia Jumbo-Lucioni, Maria De Luca

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: aging; angiotensin-converting enzyme inhibitors; nutrient metabolism; genetic background; nutritional stress

Online: 8 October 2018 (08:04:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0580.v1

The Housekeeping Transporter SLC25A44 Bridges between the Secondary Metabolism and Mitochondrial Electron Transfer Chains

Behrooz Darbani

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Aminobenzoic acid; cinnamic acid; gene clusters; hydroxybenzoic acid; resveratrol; SLC25 subfamily 44; para-coumaric acid; ubiquinone

Online: 26 August 2020 (10:43:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0117.v1

Mutations in Conserved Regions of Eel Luteinizing Hormone Receptor Result in Constitutive Activation or Inactivation

Munkhzaya Byambaragchaa, Dong-An Kim, Dae-Jung Kim, Sun-Mee Hong, Myung-Hwa Kang, Kwan-Sik Min

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: eel luteinizing hormone receptor, constitutively activating mutation, inactivating mutation, cAMP responses.

Online: 8 July 2019 (12:38:11 CEST)

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Luteinizing hormone receptor (LHR) is a member of the seven-transmembrane (TM) receptor family. Several mutations in LHR have been identified in many mammalian species, leading to either constitutive activation or inactivation of the receptor. Mutations in highly conserved regions of the TM domain have been reported. In this study, we analyzed signal transduction by three constitutively active mutants (designated M410T, L469R, and D590Y) and two inactivating mutants (D383N and Y546F) of eelLHR known as naturally occurring in human LHR . To directly assess the functional effects of these mutations, site-directed mutant receptors were transiently expressed in CHO-K1 cells and cAMP accumulation stimulated by recombinant eelLH (rec-eelLH) was measured by homogeneous time-resolved fluorescence (HTRF) assays. The cAMP response in cells expressing eelLHR wild-type (eLHR-WT) increased in a dose-dependent manner with rec-eelLH ligand stimulation. Cells expressing the activating eelLHR mutants, M410T, L469R, and D590Y, exhibited a 4.0-, 19.1-, and 7.8-fold increase in basal cAMP response, respectively. However, their maximal responses were approximately 73, 53, and 92%, respectively, of the maximal response of LHR-WT. The L469R mutant exhibited a particularly marked increase in cAMP production in the absence of agonist. The maximal responses of the inactivating mutants, D383N and Y546F, were 32 and 24% of LHR-WT, respectively. However, the inactivating mutations did not completely impair signal transduction. Thus, we report here the first characterization of activating and inactivating mutations in eelLHR and we show that these mutations have similar effects as those reported for mammalian LHRs. Moreover, eelLHR with activating mutations showed constitutive cAMP responses. These results provide important data on the signal transduction of constitutively active and inactive LHR mutants. Further studies should aim to identify the mechanism responsible for the significant increase in basal cAMP response in the constitutively activated eelLHR mutants.

Preprint ARTICLE | doi:10.20944/preprints201909.0103.v2

Molecular Basis of CYP19A1 Deficiency in a 46, XX Patient with R550W Mutation in POR: Expanding the PORD Phenotype

Shaheena Parween, Mónica Fernández-Cancio, Sara Benito-Sanz, Núria Camats, Maria Natalia Rojas Velazquez, Juan-Pedro López-Siguero, Sameer S. Udhane, Norio Kagawa, Christa E. Flück, Laura Audì, Amit V. Pandey

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: PORD; congenital adrenal hyperplasia; POR; CY19A1; CYP21A2, CYP17A1

Online: 12 February 2020 (02:57:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0341.v1

Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus

Pilar Sanchis, Rosmeri Rivera, Regina Fortuny, Carlos Rio, Miguel Mas-Gelabert, Marta Gonzalez-Freire, Felix Grases, Luis Masmiquel

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: AGEs; aortic calcification; type 2 diabetes mellitus; diabetes-related complications

Online: 21 May 2020 (09:46:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0311.v1

Stressing Glucose: At the Crossroads of Early Life Adversity, HPA Axis Reactivity and Carbohydrate Metabolism

Snehaa Vivienne Seal, Myriam Merz, Sara Beatriz Fernandes, Sophie B. Meriaux, Pauline Guebels, Jamileh Movassat, Muriel Darnaudery, Martha M. C. Elwenspoek, Fleur A. D. Leenen, Claude P. Muller, Hartmut Schächinger, Jonathan D. Turner

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: glucose; cortisol; corticosterone; stress; early life adversity

Online: 21 July 2022 (07:53:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0052.v1

The Association between Self-Reported Daily Energy Intake from Carbohydrates with Insulin Resistance in Healthy Weight Nor-Mal-Weight Individuals

Fatema Al-Rashed, Sardar Sindhu, Ashraf Al Madhoun, Fatemah Alzaqqah, Nadeem Akter, Fahd Al-Mulla, Rasheed Ahmad

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Carbohydrates; keto diet; IRS; C-peptide

Online: 7 April 2022 (04:03:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0211.v1

Phosphocholine Steroid Conjugates: Are these Compounds the Mammalian Cardiotonic Steroids?

Fred Chasalow

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Ionotropin; Steroid phosphocholine esters; pre-eclampsia; endogenous ouabain; DLM; PTSD

Online: 10 July 2020 (09:55:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0448.v1

Diet Control Diet to Achieve Euglycemia Induces Tau Hyperphosphorylation Via AMPK Activation in the Hippocampus of Diabetic Rats

Sang-Don Han, Jun-Ho Lee, Yun-Hee Noh, Mingli Jin, Jin-Seong Kim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Alzheimer’s disease; Diabetes; Diet control diet; AMPK; Tau hyperphosphorylation

Online: 27 August 2018 (10:21:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0005.v1

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Rajan Singh, Albert Barrios, Golnaz Dirakvand, Shehla Pervin

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Brown adipose tissue; beige adipose tissue; obesity; cold exposure; uncoupling protein-1, beta-adrenergic receptor; energy expenditure; adipose browning; micro-RNA

Online: 1 October 2021 (11:30:39 CEST)

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Obesity-associated metabolic abnormalities comprise of a cluster of conditions including dyslipidemia, insulin resistance, diabetes, and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from accumulation of white adipose tissues mainly due to the chronic imbalance of energy intake and energy expenditure. Variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity. Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1). Since the confirmation of functional BAT in adult humans by several groups, approximately a decade ago and its association with a favorable metabolic phenotype, intense interest on the significance of BAT in adult human physiology and metabolic health has emerged within the scientific community to explore its therapeutic potential for the treatment of obesity and metabolic diseases. Substantially decreased BAT activity in individuals with obesity indicates a role for BAT in setting of human obesity. On the other hand, BAT mass and its prevalence has been reported to correlate with lower body mass index (BMI), decreased age and glucose levels, leading to lower incidence of cardio metabolic diseases. Increased cold exposure in adult humans with undetectable BAT was associated with decreased body fat mass and increased insulin sensitivity. Deeper understanding of the role of BAT in human metabolic health and its inter-relationship with body fat distribution and deciphering proper strategies to increase energy expenditure by either increasing functional BAT mass, or inducing white adipose browning holds the promise for possible therapeutic avenues for the treatment of obesity and associated metabolic disorders.

Preprint ARTICLE | doi:10.20944/preprints202110.0291.v1

SUCNR1 is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes

Reham Atallah, Jürgen Gindlhuber, Wolfgang Platzer, Thomas Bärnthaler, Eva Tatzl, Wolfgang Toller, Jasmin Strutz, Sonja Rittchen, Petra Luschnig, Ruth Birner-Gruenberger, Christian Wadsack, Akos Heinemann

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Succinate; SUCNR1; GDM; Placenta; Endothelial cells, Angiogenesis

Online: 20 October 2021 (12:35:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0314.v1

Surveillance of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Yoshio Sumida, Masashi Yoneda, Yuya Seko, Hiroshi Ishiba, Tasuku Hara, Hidenori Toyoda, Satoshi Yasuda, Takashi Kumada, Hideki Hayashi, Takashi Kobayashi, Kento Imajo, Masato Yoneda, Toshifumi Tada, Takumi Kawaguchi, Yuichiro Eguchi, Oeda Satoshi, Hirokazu Takahashi, Eiichi Tomita, Takeshi Okanoue, Atsushi Nakajima, Japan Study Group of NAFLD (JSG-NAFLD)

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: hepatic fibrosis; Mac-2 binding protein glycated isomer; apoptosis inhibitor of macrophage; patatin-like phospholipase domain-containing protein 3; α-fetoprotein; PIVKA-II

Online: 14 July 2020 (13:55:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0045.v1

A High-throughput Search for SFXN1 Physical Partners Led to the Identification of ATAD3, HSD10, TIM50 and Subunits of Respiratory Complexes

Nesrine Tifoun, Mourad Bekhouche, José M. De Las Heras, Arnaud Guillaume, Sylvina Bouleau, Isabelle Guénal, Bernard Mignotte, Nathalie Le Floch

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: sideroflexin; SFXN1; mitochondria; ATAD3A; 17beta-HSD10; TIM50

Online: 2 August 2022 (07:46:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0275.v1

Relationship between Cardiometabolic Factors and the Response of Blood Pressure to A One-year Primary Care Lifestyle Intervention in Metabolic Syndrome Patients

Elisa Marin-Couture, Marie-Josée Filion, Ryma Boukari, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Paula M. Brauer, Dawna Royall, David Mutch, Douglas Klein, Angelo Tremblay, Caroline Rhéaume

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: blood pressure; cardiorespiratory fitness; waist circumference; lifestyle intervention; primary care; adverse responders; metabolic syndrome

Online: 20 July 2022 (05:59:58 CEST)

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Systemic hypertension has been recognized as a modifiable traditional cardiovascular risk factor and influenced by many factors such as eating habits, physical activity, diabetes and obesity. The objective of this study was to identify cardiometabolic factors that predict changes in blood pressure induced by a one-year lifestyle intervention in primary care settings involving a collaboration between family physicians, dietitians, and exercise specialists. Patients with metabolic syndrome diagnosis were recruited by family physicians participating in primary care lifestyle intervention among several family care clinics across Canada. Participants for whom all cardiometabolic data at the beginning (T0) and the end (T12) of the intervention were available were included in the present analysis (n=101). Patients visited the dietitian and the exercise specialist weekly for the first three months and monthly for the last nine months. Diet quality, exercise capacity, anthropometric indicators, and cardiometabolic variables were evaluated at T0 and at T12. The intervention induced a significant decrease in waist circumference (WC), systolic (SBP) and diastolic (DBP) blood pressure, and plasma triglycerides and an increase in cardiorespiratory fitness (estimated VO2max). Body weight (p<0.001), body mass index (BMI) (p<0.001), and plasma glucose (p=0.006) reduction and VO2max increase (p=0.048) were all related to changes in SBP. WC was the only variable for which changes were significantly correlated with those in both SBP (p<0.0001) and DBP (p=0.0004). Variations in DBP were not associated with changes in other cardiometabolic variables to a statistically significant extent. Twelve participants were identified as adverse responders in both SBP and DBP and displayed less favorable changes in WC. The beneficial effects of a lifestyle intervention on blood pressure were significantly associated with cardiometabolic variables, especially WC. These findings suggest that a structured lifestyle intervention in primary care can help improve cardiometabolic risk factors in patients with metabolic syndrome.

Preprint ARTICLE | doi:10.20944/preprints202206.0085.v1

Facilitation of Insulin Effects by Ranolazine in Astrocytes in Primary Culture

Adrián Jordá, Martin Aldasoro, Ignacio Campo Palacio, Jose Mª Vila, Contanza Aldasoro, Juan Campos Campos, Carlos Colmena, Sandeep Kumar Singhb, Elena Obrador, Soraya L. Valles

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Ranolozine; Insuline; astrocytes; inflammation; antioxidants

Online: 6 June 2022 (10:14:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0285.v1

Environmental Pollution to Blame for Depressive Disorder?

Mariana Segovia-Mendoza, Margarita Isabel Palacios-Arreola, Lenin Pavón, Enrique Becerril, Karen Elizabeth Nava-Castro, Omar Amador, Jorge Morales-Montor

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: depression; serum levels; phthalates; bisphenols

Online: 16 November 2021 (09:53:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1390.v1

VLDL Biogenesis and Secretion: It Takes a Village

Willemien van Zwol, Bart van de Sluis, Henry Ginsberg, Jan Albert Kuivenhoven

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Very low density lipoproteins; biogenesis; dyslipidemia

Online: 20 June 2023 (05:24:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0019.v1

Construction and Analysis of an Enzyme‐constrained Metabolic Model of Corynebacterium glutamicum

Jinhui Niu, Zhitao Mao, Yufeng Mao, Ke Wu, Zhenkun Shi, Qianqian Yuan, Jingyi Cai, Hongwu Ma

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: enzyme-constrained model; Corynebacterium glutamicum; metabolic engineering

Online: 1 September 2022 (09:54:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0129.v1

The Modification of Detrimental Biochemical Anomalies May Reduce the Rate of Development of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Subhasish Pramanik, Kaustav Banerjee, Lakshmi Kanta Mondal

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Diabetic retinopathy; Oxidative stress; Advanced glycation end products (AGEs); Antioxidant enzymes; Vascular endothelial growth factor; B-vitamins; Vitamin-C; Vitamin- E

Online: 8 June 2022 (12:40:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0223.v1

Premier Obesogenic Factors: Overeating and Food Addiction

Muhammad Aslam, Mubashir Abbas

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Obesity; Hyperpalatability; Adipose tissue; Hormonal imbalance

Online: 14 February 2023 (02:17:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0081.v1

Increased LRG1 Levels in Overweight and Obese Adolescents and Its Association with Obesity Markers including Leptin, Chemerin and High Sensitivity C-reactive Protein

Rashed Alhammad, Mohamed Abu-Farha, Maha M. Hammad, Thangavel Alphonse Thanaraj, Arshad Channanath, Nada Alam-Eldin, Reem Al-Sabah, Lemia Shaban, Abdulrahman Alduraywish, Fahd Al-Mulla, Abdur Rahman, Jehad Abubaker

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: adolescents; high sensitivity C-reactive protein; Interleukin 6; Leucine-rich α-2 glycoprotein 1; obesity; TNF-α

Online: 6 July 2022 (03:25:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0227.v1

Application of Multiblock Analysis on Small Metabolomic Multi-Tissue Dataset

Frida Torell, Tomas Skotare, Johan Trygg

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Data integration; Metabolomics; Multi-tissue; Multiblock; Joint and unique multiblock analysis (JUMBA), OnPLS; Multiblock Orthogonal Component Analysis (MOCA)

Online: 11 July 2020 (04:01:03 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0211.v2

Metabolic Heat in Microbial Conflict and Cooperation

Steven A. Frank

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Thermoregulation; microbial metabolism; overflow metabolism; biofilms; public goods; social evolution; ecological competition; fever; bacteriophage defense

Online: 17 July 2020 (09:35:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0159.v1

Phosphatidylethanolamine N-methyltransferase Knockout Modulates Metabolic Changes in Aging Mice

Qishun Zhou, Fangrong Zhang, Jakob Kerbl-Knapp, Melanie Korbelius, Katharina B. Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolomics; NMR; PEMT; knockout; aging; mice; liver; intestine; white/brown adipose tissue

Online: 8 August 2022 (13:36:04 CEST)

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Working Paper ARTICLE

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial: Assessing the Effects of Angelica gigas Nakai Extract on Blood Triglycerides

Su-Jin Jung, Woo-Rim Kim, Mi-Ra Oh, Youn-Soo Cha, Byung-Hyun Park, Soo-Wan Chae

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Angelica gigas Nakai; triglycerides; VLDL-C; TG/HDL-C; atherogenic index

Online: 22 December 2019 (13:56:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1240.v1

Diabetic Neuropathic Pain: Pathophysiology & Treatment

Johannes Geeso, Cinthya Galan

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: DNP; PNS; Diabetic neuropathic pain; Peripheral pain; Distal symmetric polyneuropathy; diabetic neuropathy; diabetes mellitus; DM; T1D; T2D; DPN; DPNP; Diabetic peripheral neuropathic pain; Diabetic peripheral neuropathy

Online: 17 May 2023 (10:55:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0146.v1

Basal Metabolism, Body Composition and Physical Activity with Central Obesity in Adults: A Systematic Review

Génesis Chen, Claudia Lora, Diana Rodríguez, Victoria Valdés, Fabiana Pirán, Alex Brito, Israel Ríos-Castillo

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: central obesity; waist circumference; physical activity; basal metabolic rate; body composition

Online: 12 September 2022 (11:36:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0120.v1

Metabolomic Profiles of Mice Tissues Reveals an Interplay Between Aging and Energy Metabolism

Qishun Zhou, Jakob Kerbl-Knapp, Fangrong Zhang, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: aging; NMR spectroscopy; mice; energy metabolism; fat; intestine; metabolomics

Online: 8 December 2021 (12:03:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0185.v1

Constitutive Activating and Inactivating Mutants of Eel Luteinizing Hormone Receptor

Munkhzaya Byambaragchaa, Dong-An Kim, Dae-Jung Kim, Sun-Mee Hong, Myung-Hwa Kang, Kwan-Sik Min

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: eel luteinizing hormone receptor; constitutively activating mutation; inactivating mutation; cyclic adenosine monophosphate response; cell surface loss of receptor

Online: 8 September 2020 (10:56:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1651.v1

Insulin Resistance Develops Due to an Imbalance in the Synthesis of Cyclic AMP and the Natural Cyclic AMP Antagonist Prostaglandyl-Inositol Cyclic Phosphate (Cyclic PIP)

Heinrich K Wasner

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: cyclic AMP; cyclic PIP; insulin resistance; prostaglandylinositol cyclic phosphate; protein phosphorylation; protein kinase A; protein ser/thr phosphatase; type 2 diabetes

Online: 25 September 2023 (11:05:29 CEST)

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Dear Ladies and Gentlemen, I thank you for suggesting to submit the manuscript with the title “Insulin resistance develops due to an imbalance in the synthesis of cyclic AMP and the natural cyclic AMP antagonist prostaglandylinositol cyclic phosphate (cyclic PIP)” to the Editorial Board of the MDPI journal Stresses, and I ask for consideration to publish it in the journal Stresses. It was previously submitted to the MDPI journal Int. J. Mol. Sci. (IJMS-195 6513), but it was found that 1) it would not fit within the scope of this special edition and 2) it would primarily deal with cyclic PIP and would have not enough literature citation on the topic insulin resistance. The present version of the manuscript is improved, but the content is the same. The goal of this review is not to write again a summary on nearly all reports on insulin resistance as this was done by Dr. Petersen and Dr. Shulman, whose review has 961 literature citations. The present manuscript compiles what is known on cyclic PIP in relation to insulin resistance and the reason of writing this manuscript was that the discovered facts on cyclic PIP synthesis allow to suggest how insulin resistance most likely starts. Hitherto, reports on insulin resistance did not come close to this question. I am convinced that the manuscript makes an essential contribution to the question what causes the development of insulin resistance, and I have to say that stress overload is one of the reasons. Unfortunately, I have to mention a topic, about which I do not like to talk. Years ago, research groups postulated with rigor that the mediator of insulin action would be a peptide and then they suggested various, extracellularly synthesized glycans as mediators. They caused confusions and a high degree of disbelief in the matter of mediators of insulin action. In my review on cyclic PIP in IUBMB Life from 2020, I wrote in the introduction that cyclic PIP should not be confused with these mediators. But I cannot write this in the introduction of every report. I am keeping fingers crossed so that the editor in charge will find fair and openminded reviewers. Last not least I confirm that neither the manuscript nor any part of its content is currently under consideration or published in another journal. Kind regards, Henrich Wasner, PhD, BioReg Biopharm, TiLab; University of Illinois at Chicago; 2242 West Harrison St., Ste. 201, Chicago, Il 60612; USA

Preprint ARTICLE | doi:10.20944/preprints202112.0237.v1

Metabolic Response to Daytime Dry Fasting in Bahá’í Volunteers

Anja Mähler, Carmen Jahn, Lars Klug, Caroline Klatte, Andreas Michalsen, Daniela Koppold-Liebscher, Michael Boschmann

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: religious fasting; daytime dry fasting; energy expenditure; body composition; microdialysis

Online: 14 December 2021 (13:06:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0436.v1

«Enzymatic Landscape» of the Gut Microbiome in Obese Patients

Olga Petrovna Shatova, Tatyana Vladimirovna Grigorieva, Svetlana Alexandrovna Appolonova, Valentin Vladimirovich Makarov, Sergey Mikhailovich Yudin, Sergey Aleksandrovich Roumiantsev, Andrey Mikhailovich Gaponov, Alexander Vyacheslavovich Shestopalov

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: tryptophan metabolites; microbiome; obesity; enzymatic landscape

Online: 25 August 2022 (13:21:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0317.v1

Loss Of Protein Stability And Function Caused By POR-Rs17853284 Linked To Lower Testosterone Levels

Maria Natalia Rojas Velazquez, Mathias Noebauer, Amit V Pandey

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Cytochrome P450; POR; Congenital adrenal hyperplasia; metabolic disorders; CYP3A4; protein stability; drug metabolism

Online: 17 August 2022 (10:02:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0073.v1

Palmitic Acid Impedes Extravillous Trophoblast Activity by Increasing MRP1 Expression and Function

Yunali Ashar, Qiuxu Teng, John N. D. Wurpel, Zhe-Sheng Chen, Sandra E Reznik

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: extravillous trophoblast; placenta; saturated fatty acid; in-utero environment; MRP1

Online: 3 August 2022 (04:21:58 CEST)

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Working Paper ARTICLE

Anti-Diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance

Eunjung Son, Hye Jin Choi, Seung-Hyung Kim, Dong-Gyu Jang, Jimin Cha, Jeong June Choi, Mee Ree Kim, Dong-Seon Kim

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Glycine soja seed; Type 2 diabetes mellitus; Antidiabetic; AMPK; Akt; PPAR-γ

Online: 25 August 2020 (11:47:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0263.v1

Research on Recent Progress in the Treatment of Thin Endometrium

Tao Xu, Na Kong

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Thin Endometrium; stem cells; Granulocyte colony-stimulating factor; Acupuncture treatment; Physical therapy

Online: 15 November 2022 (01:12:22 CET)

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Biology and Life Sciences