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Preprint ARTICLE | doi:10.20944/preprints202404.1177.v1

Association between the Use of Macrolides in Food-Producing Animals and Mycoplasma pneumoniae Macrolide Resistance: A Global Ecological Analysis

Chris Kenyon

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Macrolide resistance; Mycoplasma pneumoniae

Online: 17 April 2024 (14:33:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1071.v1

Managing Patients with Immune-Mediated Inflammatory Diseases on Disease-Modifying Antirheumatic Drug Therapy in a COVID-19 Endemic World: A Narrative Review and Expert Insights

Kok Ooi Kong, Pinyo Rattanaumpawan, Nguyen Chau Tuan, Cao Thanh Ngoc, Yee-Chun Chen, Ahlam Al Marzooqi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; SARS-CoV-2; DMARDs; immunocompromised; immune-mediated inflammatory disease; rheumatic disease ;

Online: 16 April 2024 (17:29:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0903.v1

Retrospective Analysis of Clostridioides difficile Infection Rates in Hospitalized Patients during COVID-19 Pandemic. A Unicenter Study in Reus, Spain

Simona Iftimie, Ana F. López-Azcona, Mireia Corchero-Valverde, Antonio Peralta-Vázquez, Laia Revuelta López-Cordón, Carles García-Cervera, Luís Manuel Fernández-Domínguez, Jordi Camps, Jorge Joven, Antoni Castro

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Cancer; Clostridioides difficile; COVID-19; Infectious diseases; Pandemic; Risk factors

Online: 15 April 2024 (05:37:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1075.v4

Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus

Rima Obeid, Emmanuel Andrès, Richard Češka, Babak Hooshmand, Rosa-Maria Guéant-Rodriguez, Gabriel Ioan Prada, Jarosław Sławek, Latchezar Traykov, Binh Van Ta, Tamás Várkonyi, Karlheinz Reiners

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Diagnosis; neuropathy; cognitive decline; anemia; treatment; vitamin B12 deficiency

Online: 9 April 2024 (10:26:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1075.v3

Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus

Rima Obeid, Emmanuel Andrès, Richard Češka, Babak Hooshmand, Gabriel Ioan Prada, Jarosław Sławek, Latchezar Traykov, Binh Van Ta, Tamás Várkonyi, Karlheinz Reiners

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Diagnosis; neuropathy; cognitive decline; anemia; treatment; vitamin B12 deficiency

Online: 27 March 2024 (06:39:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1075.v2

Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus

Rima Obeid, Emmanuel Andrès, Richard Češka, Babak Hooshmand, Gabriel Ioan Prada, Jarosław Sławek, Latchezar Traykov, Binh Van Ta, Tamás Várkonyi, Karlheinz Reiners

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Diagnosis; neuropathy; cognitive decline; anemia; treatment; vitamin B12 deficiency

Online: 26 March 2024 (07:27:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1075.v1

Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus

Rima Obeid, Emmanuel Andrès, Richard Češka, Babak Hooshmand, Gabriel Ioan Prada, Jarosław Sławek, Latchezar Traykov, Van Binh Ta, Tamás Várkonyi, Karlheinz Reiners

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Diagnosis; neuropathy; cognitive decline; anemia; treatment; vitamin B12 deficiency

Online: 19 March 2024 (08:06:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0776.v1

Protocol and Characteristics of the Basel Postpartum Hypertension Cohort (Basel-PPHT-Cohort): an Interim Analysis

Thenral Socrates, Céline Wenker, Annina Vischer, Christina Schumacher, Fiona Pugin, Andreas Schötzau, Michael Mayr, Irene Hösli, Beatrice Mosimann, Olav Lapaire, Thilo Burkard

Subject: Medicine And Pharmacology, Internal Medicine Keywords: maternal health, hypertensive disorders of pregnancy, postpartum hypertension, hypertension, arterial hypertension, ambulatory blood pressure, telemedicine

Online: 13 March 2024 (10:43:43 CET)

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Introduction: Postpartum hypertension (PPHT) is hypertension that persists or develops directly after pregnancy. PPHT affects 10% of pregnancies and is the most common cause for re-hospitalization after giving birth. In general, PPHT stems from hypertensive disorders of pregnancy (HDP). The aim of the current interim report of the Basel PPHT registry is to describe the cohort, and to determine feasibility and acceptance of a home-based telemonitoring management strategy (HBTMS) in women with PPHT. Methods: Enrollment in the cohort began in June 2020 during the SARS-CoV-2 pandemic at the University Hospital Basel. Women in the maternity ward were screened for preexisting hypertension, HDP, and de novo postpartum hypertension and after consenting, were enrolled. In this pragmatic non-randomized prospective trial, women in the PPHT cohort could choose, between a HBTMS or usual care which consisted of in-hospital appointments at the hypertension clinic. HBTMS was defined as a smartphone application or a programmed spreadsheet to report blood pressure followed by telephone consultations. Standard of care was hospital-based visits as clinically needed after discharge. All participants were assessed three months after delivery with a standardized clinical visit including a 24-hour blood pressure measurement, blood, biomarker, and urine analysis. Results: 311 participants were enrolled from 06/20-08/23. Mean age was 34±5.3 years. Regarding pregnancy-related medical history: 10 % had preexisting hypertension, 27.3 % gestational hypertension, 53% preeclampsia (PE), 0.3% eclampsia, 6% HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) and 18.3% had de novo PPHT. More than one diagnosis was possible. Family history of cardiovascular disease was seen in 49.5%, 7.5% had a family history of PE. 23.3% were determined as high risk for PE during pregnancy. The most common type of delivery was C-Section (68.5%), mean hospital stay was 6.3 days (±3.9) and IUGR (intrauterine growth restriction) was seen in 21% of the newborns. 99% of participants chose a home-based management strategy. Conclusion: This first description of the Basel PPHT Cohort showed that a HBTMS is well accepted. This is particularly relevant in the direct postpartum period and even more pertinent when the exposure of hospital visits should be avoided when possible.

Preprint ARTICLE | doi:10.20944/preprints202402.1615.v1

Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis – a Pilot Prospective Observational Cohort Study

Lazar A. Chisavu, Viviana M. Ivan, Adelina Mihaescu, Flavia Chisavu, Oana Schiller, Luciana Marc, Flaviu Bob, Adalbert Schiller

Subject: Medicine And Pharmacology, Internal Medicine Keywords: hemodialysis; mortality; cardio-vascular disease; novel biomarkers; cardiac function and structure

Online: 28 February 2024 (13:52:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1623.v1

Prevalence of Type 1 and 2 Diabetes among Chronic Kidney Disease Patients and Laboratorial Differences between Them

Abdullah Shyah, Ahmad Almouselli, Taghreed Hmoud

Subject: Medicine And Pharmacology, Internal Medicine Keywords: diabetes; chronic kidney disease; diabetic nephropathy; MDRD

Online: 28 February 2024 (10:43:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1606.v1

System-wide Thromboprophylaxis Interventions for Hospitalized Patients at Risk of Venous Thromboembolism: Focus on Cross-Platform Clinical Decision Support

Nikolaos Tsaftaridis, Mark Goldin, Alex C Spyropoulos

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Venous Thromboembolism; Clinical Decision Support Tools; Thromboprophylaxis; Hospitalized Patients; Electronic Health Records

Online: 28 February 2024 (08:06:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1444.v1

Intersecting Crises: Exploring the Impact of Climate Change on the Burgeoning Burden of Non-Communicable Diseases

Henry Sutanto

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Climate change; pollution; global warming; human health; non-communicable diseases; food security

Online: 26 February 2024 (14:09:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1435.v1

A Comprehensive Review of Secondary Movement Disorders

Eduardo R. Santos

Subject: Medicine And Pharmacology, Internal Medicine Keywords: secondary movement disorders; dystonia; chorea; athetosis; myoclonus; tics; tremor; drug-induced movement disorders; post-infectious movement disorders; metabolic disorders

Online: 26 February 2024 (11:45:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1258.v1

Understanding Drug-Induced Movement Disorders: Causes, Symptoms, and Treatment

Eduardo R. Santos

Subject: Medicine And Pharmacology, Internal Medicine Keywords: DIMD; DIP; Review; parkinsonism; DID; dyskinesia; tardive syndromes

Online: 22 February 2024 (07:49:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1171.v1

Influence of Hypovolemia on Cardiac Function Measured by Transpulmonary Thermodilution. A Retrospective Cohort Study

Cecilia Gonzalez, Jesica Rodriguez Louzan, Agustin Traverso, Emanuele Papini, Agostina Giordana, Diana Latasa, Carlos Lovesio, Arnaldo Dubin

Subject: Medicine And Pharmacology, Internal Medicine Keywords: cardiac function; GEF limitation; global ejection fraction; TPTD; transpulmonary thermodilution; hypovolemic shock

Online: 21 February 2024 (08:05:51 CET)

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Background and Objectives Transpulmonary thermodilution has gained interest in recent years. It measures cardiac output (CO), stroke volume (SV), but also calculates global end diastolic indexed volume (GEDVI), and global ejection fraction (GEF). GEDVI is a static variable of cardiac preload. GEF provides information regarding cardiac function. GEF algorithm depends on SV and GEDVI. Therefore, in hypovolemic patients with decreased preload, SV or GEDVI could be decreased, and lead to altered GEF. The aim of our work was to evaluate whether impairment in GEDVI and SV may constitute a limitation for the interpretation of GEF in hypovolemic patients. A secondary objective was to determine factors independently associated with impaired GEF. Materials and Methods A retrospective study was conducted. Statistical analysis was performed by means of Mann Whitney and student t test. To determine correlation between GEF with SV, or GEF with GEDVI Pearson's coefficient was used. To determine factors independently associated with the presence of impaired GEF, binary logistic regression was performed. Results We included 113 patients with shock. Differences in mortality were detected in GEF (21[16-28] survivors versus 18 in non survivors[11-26]; p= 0.01). 38(34%) patients had hypovolemia. 44(39%) of them had depressed GEF values. Hypovolemic patients had lower GEF values than non-hypovolemic patients (16 [12-22] vs 20 [15-27]; p=0.01). Both SV and GEDVI had a statistically significant correlation with GEF (SV (Pearson's r 0.74; (p=0.00)) and GEDVI (Pearson's r -0.25; (p=0.00)). The only factors independently associated with low GEF were low SV and low GEDVI. Conclusion Hypovolemic patients frequently show low GEF values. We found correlation between SV and GEDVI with GEF. Low SV and low GEDVI were associated with low GEF. This could constitute a limitation in the interpretation of GEF and cardiac pump function. Hypovolemic patients could have low GEF without implying disorders in cardiac contractility.

Preprint SHORT NOTE | doi:10.20944/preprints202402.1063.v1

C4d in IgA Nephropathy; a Personal Experience

Hamid Nasri

Subject: Medicine And Pharmacology, Internal Medicine Keywords: IgA nephropathy; Immunoglobulin A; C4d; Tubulointerstitial fibrosis

Online: 20 February 2024 (04:38:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0674.v1

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Katarzyna Napiórkowska-Baran, Paweł Treichel, Marta Czarnowska, Magdalena Drozd, Kinga Koperska, Agata Węglarz, Oskar Schmidt, Samira Darwish, Zbigniew Bartuzi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type 2 diabetes; immunomodulation; immune system; nutrients; macroelements; microelements; vitamins; omega-3 acids; coenzyme Q10; alpha-lipoic acid

Online: 12 February 2024 (13:24:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0632.v1

Mycobacterium paratuberculosis: A HERV Turn-On for Autoimmunity, Neurodegeneration, and Cancer?

Coad Thomas Dow, Ellen S. Pierce, Leonardo A. Sechi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Mycobacterium avium ss. paratuberculosis (MAP); Human endogenous retrovirus; HERV; Type 1 Diabetes; Multiple Sclerosis; Rheumatoid Arthritis; Amyotrophic lateral sclerosis (ALS); Alzheimer’ s disease (AD); Parkinson’ s disease (PD); Glioblastoma; Bromoepiandros-terone (BEA); Temelimab; BNN27

Online: 12 February 2024 (08:53:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0449.v1

Reactivation of Varicella‐Zoster Virus in Patients with Lung Cancer Receiving Immune Checkpoint Inhibitors: Retrospective Nationwide Population‐ Based Cohort Study of the Health Insurance Review and Assessment Database in South Korea

Jiyun Jung, Seong Yeon Park, Jae Yoon Park, Dalyong Kim, Kyoungmin Lee, Sungim Choi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: herpes zoster; immune checkpoint inhibitors; standardized incidence ratio; cancer patients

Online: 7 February 2024 (14:34:28 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0056.v1

The Effect of Whole-Body Electromyostimulation on Visceral Adipose Tissue Volume in Overweight to Obese Adults with Knee Osteoarthritis. A Randomized Controlled Study

Benazir Burkhardt, Oliver Chaudry, Stephanie Kast, Simon Von Stengel, Matthias Kohl, Frank W. Roemer, Klaus Engelke, Michael Uder, Wolfgang Kemmler

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Electromyostimulation; exercise; intra-abdominal fat; visceral fat; magnetic resonance imaging; obesity; adults

Online: 1 February 2024 (14:06:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2128.v1

Influence of the COVID-19 Pandemic on the Treatment of immune mediated Rheumatic and Musculoskeletal Diseases during the first pandemic period: A Systematic Review

Marco Schlegel, Stefan Bachmann

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Covid-19, pandemic, influence, rheumatic diseases, treatment

Online: 30 January 2024 (15:16:59 CET)

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Background and Objectives: The COVID-19 pandemic influenced the management of patients with immune mediated rheumatic and musculoskeletal diseases (imRMDs) in various ways. The goal of our systematic review was to determine the influence of the first period of the COVID-19 pandemic on the management of imRMDs. Materials and Methods: Systematic literature search of PubMed, Cochrane and Embase databases, including studies with adult patients on the influence of the COVID-19 pandemic on management of imRMDs. There were no restrictions regarding to study-design except for systematic reviews and case reports that were excluded as well as articles on the disease outcomes in case of SARS-CoV-2 infection. Two reviewers screened the studies for inclusion, and, in case of disagreement, consensus was reached after discussion. Results: A total of 5969 potentially relevant studies were found, and, after title, abstract and full-text screening, 35 studies were included with data from 182’746 patients and 2018 rheumatologists. Non-availability of drugs, e.g., hydroxychloroquine and tocilizuab, was frequent (16–69% of patients). Further, medication non-adherence was reported among patients with different RMDs and between different drugs in 4–46% of patients. Changes to preexisting medication were reported in up to 33% of patients (e.g. reducing dose of steroids or cessation of biological disease-modifying antirheumatic drugs). Physical in-office consultations and laboratory testing decreased and as a consequence newly implemented remote consultations increased greatly with an increase of up to 80%. Conclusion: The COVID-19 pandemic influenced the management of imRMDs, especially at the beginning. Influences were wide-ranging, affecting availability of pharmacies, adherence to medication or medication changes, doctor visits and laboratory testing. New systems of care were set up, including virtual clinics and video consultations. These new forms of health care delivery should be spread and implemented worldwide to routine clinical practice to be ready for future pandemics.

Preprint REVIEW | doi:10.20944/preprints202401.1910.v1

Cytokine Storm Fatal Acute Kidney Infection Triggered by COVID-19 (SARS CoV-2) Infection: A Review

Hailemeleak Regassa, Kasahun Gudeta, Ankeet Bhagat, Rachna Chaturvedi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: cytokine storm, COVID-19, Acute kidney infection, SARS-CoV-2, pro-inflammatory cytokines

Online: 29 January 2024 (02:10:24 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1490.v1

Liver-Kidney-Heart Axis – A Clinical Challenge

Dina Fernandes Neto, Iago Blanco, María Melendo Viu, David Dobarro Perez, Andrés Iñiguez Romo

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type-5 cardio-renal syndrome; heart failure; cirrhosis; Liver-Kidney-Heart axis

Online: 19 January 2024 (13:11:37 CET)

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Cirrhosis is a chronic disease with multiple etiologies, multiple manifestations, and multi-organ involvement. Affects about 200 million people worldwide. Its main complication is Portal hypertension (PHT). Cirrhotic cardiomyopathy is a consequence of PHT, with heart failure (HF) being the main manifestation. On the other hand, for people with cardiopathy due to other reasons beyond cirrhosis, the presence of the last could act as a trigger to acute HF. Finally, when HF and cirrhosis coexist, the renal system suffers the most, originating from type-5 cardio-renal syndrome, a complex entity with many challenges in diagnosis and treatment. This entity was recently defined and there is a lack of data on the epidemiology of this syndrome. A 77-year-old woman, with cardiovascular risk factors; heart failure with reduced ejection fraction (HFrEF), secondary ischemic and valvular cardiopathy, chronic Kidney disease (CKD), and stable decompensated cirrhosis, went to the emergency department after progressive abdominal perimeter augmentation, legs’ edema and hematochezia. It was assumed acute decompensated cirrhosis and acute decompensated chronic kidney disease, had triggered digestive bleeding and the patient stayed hospitalized. Intravenous diuretic therapy was started but, the ascites and kidney function got worse, the Nt pro-BNP grew until 1125000 pg/ml, and a transthoracic echocardiography showed important signs of congestion, isolated right ventricular dysfunction, with normal cardiac output. After teamwork’s discussion, a type-5 cardio-renal syndrome was assumed deciding not to act on tricuspid regurgitation due to the maladaptive RV remodeling. Hepatorenal syndrome treatment was begun (oral terlipressin and intravenous albumin), followed by decongestion therapy, resulting in a marked improvement in clinical presentation. The kidney, heart, and liver recovered to these basal states. With this clinical case, the authors want to show how multidisciplinary management is important to face tricuspid regurgitation and right ventricular dysfunction.

Preprint ARTICLE | doi:10.20944/preprints202311.1689.v2

No Association between Antimicrobial Consumption and Antimicrobial Resistance in a PrEP Population: A Cross Sectional Study

Thibaut Vanbaelen, Jolein Laument, Tessa De Block, Christophe Van Dijck, Sheeba Santhini Manoharan-Basil, Chris Kenyon

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Antimicrobial resistance; PrEP; saturation; Neisseria gonorrhoeae; gonorrhoea; stewardship

Online: 16 January 2024 (14:32:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1062.v1

Anti-inflammatory Effect of Atorvastatin and Rosuvastatin on Monosodium Urate-Induced Inflammation through IL-37/Smad3 Complex Activation

Seong-Kyu Kim, Jung-Yoon Choe, Ji-Won Kim, Ki-Yeun Park, Boyoung Kim

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Monosodium urate; Interleukin-37; Statin; Smad3; Caspase-1

Online: 15 January 2024 (03:18:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0984.v1

Clinical Efficacy of Sitafloxacin-Colistin-Meropenem and Colistin-Meropenem among Carbapenem-Resistant and Multidrug-Resistant Acinetobacter baumannii Hospital-Acquired Pneumonia (Hap) / Ventilator-Associated Pneumonia (Vap) Patients in One Super-ter

Manasawee Wantanatavatod, Panuwat Wongkulab

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Acinetobacter baumannii HAP/VAP, carbapenem-resistant, sitafloxacin

Online: 12 January 2024 (09:21:49 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.0376.v1

Increase in Antibody Titer and Change over Time Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection after mRNA Vaccination: Consideration of the Significance of Additional Vaccination

Hiroshi Kusunoki, Michiko Ohkusa, Rie Iida, Ayumi Saito, Mikio Kawahara, Kazumi Ekawa, Nozomi Kato, Masaharu Motone, Hideo Shimizu

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; SARS-CoV-2; vaccines; breakthrough infection; SARS-CoV-2 antibody

Online: 5 January 2024 (02:04:00 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.0170.v1

Unveiling the Mystery of Adult-Onset Still's Disease: a Compelling Case Report

Daniele Sola†, Carlo Smirne, Francesco Bruggi, Chiara Bottino Sbaratta, Aubin Cardin Tamen Njata, Guido Valente, Maria Cristina Pavanelli, Rosetta Vitetta, Mattia Bellan, Lorenzo De Paoli, Mario Pirisi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: adult-onset Still's disease; macrophage activation syndrome; hemophagocytic lymphohistiocytosis; autoimmunity; autoinflammatory diseases; immune system; inflammation; steroids; fever of unknown origin; monocytes/macrophages

Online: 3 January 2024 (09:44:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2339.v1

Dermatologic Changes in Experimental Model of Long-COVID

Hussain Hussain, Michael J Paidas, Ramamoorthy Rajalakshmi, Aya Fadel, Misha Ali, Pingping Chen, Arumugam R. Jayakumar

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Dermatologic manifestation; fibrosis; inflammation; long-COVID; murine hepatitis virus-1.

Online: 30 December 2023 (16:21:00 CET)

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The COVID-19 pandemic, declared in early 2020, is an unprecedented global health crisis, causing over 7.0 million deaths and ongoing challenges. While the pharmaceutical industry expedited vaccine development, mutant SARS-CoV-2 strains remain a major fear. Moreover, concerns regarding the long-term health repercussions of COVID-19-affected individuals persist since individuals affected by mild and moderate to severe SARS-CoV-2 infection experience long-term cardiovascular complications, liver dysfunction, pulmonary afflictions, kidney impairments, and most importantly neurocognitive deficits. In recent studies, we documented pathophysiological changes in various organs following the post-acute infection of mice with murine hepatitis virus-1 (MHV-1), a coronavirus, at both 7 days and 12 months after infection. One part of the body that can be drastically affected by SARS-CoV-2 is the skin. Studies have shown major changes in the skin post-acute SARS CoV-2 infection in humans. However, long-term dermatologic changes post-COVID have never been explored. For the first time, we show several cutaneous findings both at the acute stages and long-term post-infection of mice with MHV-1 coronavirus (a promising experimental model to study acute and long-COVID). Precisely, we found destruction of the epidermal layer, an increase in the number of hair follicles, extensive collagen deposition in the dermal layer, and hyperplasticity of the sebaceous glands at the acute stages, along with thinning of the panniculus carnosus, as well as the adventitial layer, which corresponds well with studies in humans. In contrast, the cutaneous investigation in the long-COVID phase shows the absence of hair follicles from both the epidermal and dermal layers, the destruction of adipose tissues, and the devastation of the epidermal layer. Further, treatment of these mice with a 15 amino acid synthetic peptide, SPIKENET (SPK), which was effective in preventing Spike glycoprotein-1 binding with host receptors, as well as has a potent anti-inflammatory response to severe inflammatory stimulus) restored the loss of hair follicles and re-architected the epidermal and dermal layers. Additionally, destruction in fatty tissue in the infected mice was successfully restored post-treatment with SPK. These findings suggest that SARS-CoV-2 initiates the changes early post-infection, leading to devastating skin alterations in the long term which can be prevented by our newly identified peptide drug SPK.

Preprint SHORT NOTE | doi:10.20944/preprints202312.2248.v1

The Ultimate Shake Down: Epilepsy vs. Syncope

Vernon Davis Jr., Dev Desai, Bhavika Udernani

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Epilepsy; Seizure; Syncope; Loss of Consciousness

Online: 29 December 2023 (11:31:57 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.2162.v1

Visceral Proliferation of Kaposi Sarcoma in a 49-year-old African American Male

Shirley P Parraga, Revanth Reddy Bandaru

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Kaposi sarcoma; disseminated KS; HHV-8

Online: 29 December 2023 (01:15:05 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.2212.v1

Exploring the Link Between Diabetes and Striatopathy: A Case Report

Janushee Modi, Vismit Gami, Tushar Teraiya, Sahil Shah, Dev Desai

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Diabetes; Striatopathy; Chorea; Hyperglycaemia

Online: 28 December 2023 (15:56:21 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1997.v1

Measles Reawakening: A Rare Case of Subacute Sclerosing PanEncephalitis

Zeal Soni, Vismit Gami, Tushar Teraiya, Sahil Shah, Dev Desai

Subject: Medicine And Pharmacology, Internal Medicine Keywords: ; Central Nervous System, Measles, MRI, Adolescents, Cerebrospinal fluid.

Online: 26 December 2023 (13:05:41 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202312.1908.v1

Pain or Pressure? Delineating between Primary and Secondary Headache

Vernon Davis Jr., Dev Desai, Maria Eleni Malafi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Headache; Migraine; Management; Intervention

Online: 26 December 2023 (04:02:18 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0735.v1

Lyme Disease in an Indian Male: A Rare Case of a Common Western Disease

Zeal Soni, Tushar Teraiya, Vismit Gami, Sahil Shah, Dev Desai

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Lyme Disease; Indian male; Treatment

Online: 11 December 2023 (19:21:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0436.v1

Association of GLIM-Defined Malnutrition in Kidney Dysfunction With Increased All-Cause Mortality from Infections in Hospitalized Older Adults: A Retrospective Cohort Study

Makoto Yamaguchi, Hirokazu Sugiyama, Asai Akimasa, Keisuke Kamiya, Fumiya Kitamura, Hiroshi Kinashi, Takayuki Katsuno, Shogo Bannno, Takuji Ishimoto, Takahiro Imaizumi, Keisuke Maeda, Yuria Ishida, Naoharu Mori, Yasuhiko Ito

Subject: Medicine And Pharmacology, Internal Medicine Keywords: infection; Global Leadership Initiative on Malnutrition; malnutrition; mortality

Online: 7 December 2023 (07:39:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0470.v1

Adipose Stromal Cells-Derived Secretome Attenuates Cisplatin-Induced Injury In Vitro Surpassing the Intricate Interplay Between Proximal Tubular Epithelial Cells and Macrophages

Erika Rendra, Stefanie Uhlig, Isabell Moskal, Corinna Thielemann, Harald Klüter, Karen Bieback

Subject: Medicine And Pharmacology, Internal Medicine Keywords: MSC secretome; proximal tubular epithelial cells; cisplatin; macrophages; acute kidney injury; oxidative stress; crosstalk; phagocytosis

Online: 7 December 2023 (07:14:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1521.v1

The Prevalence of Cardiovascular Comorbidities In Patients with Rheumatoid Arthritis

Marius Rus, Claudia Judea Pusta, Simina Crisan, Paula Marian, Oana Lilliana Pobirci, Veronica Huplea, Alina Stanca Osiceanu, Adrian Gheorghe Osiceanu, Felicia Liana Andronie-Cioara, Madalina Ioana Guler

Subject: Medicine And Pharmacology, Internal Medicine Keywords: rheumatoid arthritis; cardiovascular complications; atherogenesis; cardiac arrhythmias; inflammation; disease, traditional factors; “non-traditional” factors

Online: 23 November 2023 (11:06:55 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202309.2109.v2

Long COVID: A Chronic Shortage of Blood. Pathophysiology and Treatment Proposal

Pieter A. Molenaar

Subject: Medicine And Pharmacology, Internal Medicine Keywords: blood volume; blood osmolality; haematocrit; albumin; ferritin; vascular constriction; arteriolovenous anastomosis; venous blood buffer

Online: 22 November 2023 (14:24:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1358.v1

A Study on Mortality Predictors in Hemodialysis Patients Infected with COVID-19: Impact of Vaccination Status

Voin Brkovic, Gorana Nikolic, Marko Baralić, Milica Kravljava, Marija Milinkovic, Jelena Pavlovic, Mirjana Lausevic, Milan Radovic

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Covid-19; vaccines; chronic kidney disease; hemodialysis; lymphocytopenia

Online: 22 November 2023 (07:39:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0298.v1

The Evolving Landscape of Gout in the Female: A Narrative Review

Jennifer Lee, Nicholas Sumpter, Tony R. Merriman, Ru Liu-Bryan, Robert Terkeltaub

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Gout; Hyperuricemia; ABCG2; SLC2A9; Urate transporter; Alcohol; Fructose; COVID-19; Chronic kidney disease; Hypertension

Online: 6 November 2023 (08:18:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1835.v1

Review of Post-discharge Thromboprophylaxis Practices and Outcomes in COVID-19 Patients

Der Lor, Amanda Meyers, Laura Hubbard, Joel Peterson, Yun Lu

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID 19; thrombosis, DOAC; Anticoagulant

Online: 30 October 2023 (07:15:21 CET)

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Patients hospitalized with COVID-19 are at a higher risk of thrombotic events following discharge, however the role of extended thromboprophylaxis remains controversial. The purpose of this study is to evaluate current extended post-discharge thromboprophylaxis practice and its outcomes.This study was a single-center, retrospective chart review of patients within Hennepin Healthcare hospitalized with COVID-19 from April 1^st 2020 to December 31^st 2021 with increased risk of thrombotic event based on D-dimer. The primary outcome was to describe current prescribing practices based on the number of patients who were eligible and received anticoagulants on discharge. Secondary outcomes included comparing the patient’s risk for thromboembolism based on a modified International Medical Prevention Registry on Venous Thromboembolism (IMPROVE-VTE) score to the current internal prescribing practice guideline, evaluating efficacy outcomes based on new thromboembolic events, and assessing safety of extended-thromboprophylaxis using the International Society of Thrombosis and Hemostasis criteria for major bleeding within 30 days of hospitalization discharge.Of 1984 patients who were hospitalized with COVID-19 infection, 961 patients were eligible to receive thromboprophylaxis at discharge, with a total of 191 patients who received anticoagulation according to the Hennepin Healthcare practice guideline. However, using the IMPROVE-VTE score, only 206 patients qualified for post-discharge thromboprophylaxis, and 63 total patients received anticoagulation. A new thromboembolic event occurred in 20 patients (5.8%) and 14 patients (4.1%) experienced major bleeding.The Hennepin Healthcare guideline for extended thromboprophylaxis at discharge encompassed more patients compared to the IMPROVE-VTE score. The incidence of a new thromboembolic event and major bleeding were low in both groups, although venous thrombotic events occurred more in thromboprophylaxis group than in patients who did not receive anticoagulation at discharge, more clinical data are needed for a conclusion.

Preprint REVIEW | doi:10.20944/preprints202310.1078.v1

From Non-Alcoholic Steatohepatitis (NASH) to Hepatocellular Carcinoma (HCC): Epidemiology, Incidence, Predictions, Risk Factors and Prevention

Benedetta Maria Motta, Mario Masarone, Pietro Torre, Marcello Persico

Subject: Medicine And Pharmacology, Internal Medicine Keywords: NAFLD; NASH; HCC; SNP.

Online: 17 October 2023 (10:51:11 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202309.2109.v1

Long COVID: A Chronic Shortage of Blood. Pathophysiology and Treatment Proposal

Pieter A. Molenaar

Subject: Medicine And Pharmacology, Internal Medicine Keywords: blood volume; blood osmolality; haematocrit; albumin; ferritin; vascular constriction; arteriolovenous anastomosis; venous blood buffer

Online: 16 October 2023 (09:09:17 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202310.0919.v1

Rapid Progressive Systemic Sclerosis Following mRNA COVID-19 Vaccination

Lídia Caley, Priscila Flores, André Matos Gonçalves, André Real, Jorge Nepomuceno

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; mRNA-based vaccine; systemic sclerosis

Online: 16 October 2023 (03:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0861.v1

Antineutrophil Cytoplasmic Antibody-associated Vasculitis and the Risk of Developing Incidental Tuberculosis: A Population-based Cohort Study

Shan-Ho Chan, Ming-Feng Li, Shih-Hsiang Ou, Mei-Chen Lin, Jen-Hung Wang, Po-Tsang Lee, Hsin-Yu Chen

Subject: Medicine And Pharmacology, Internal Medicine Keywords: antineutrophil cytoplasmic antibody-associated vasculitis; tuberculosis; population-based study

Online: 13 October 2023 (08:10:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0627.v1

Scoping Review of Helicobacter pylori Infection in Somalia: Epidemiology and Risk Factors

Mohamed Jayte

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Helicobacter pylori; epidemiology; prevalence; Somalia

Online: 11 October 2023 (06:51:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0604.v1

Bone Microarchitecture Alterations Are Associated With the TP53 Arg72Pro Polymorphism

Ricardo Usategui-Martín, Nadia Galindo-Cabello, Salvador Pastor-Idoate, José María Fernandez-Gómez, Alvaro del Real, Diego Ferreño, Rebeca Lapresa, Francisco Martín-Rodriguez, José A Riacho, Angeles Almeida, Jose-Luis Pérez-Castrillón

Subject: Medicine And Pharmacology, Internal Medicine Keywords: metabolic bone diseases; osteoporosis; TP53; p53; apoptosis and gene polymorphism

Online: 10 October 2023 (10:41:06 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202310.0401.v1

Progressive Lower extremity Paralysis Caused by Intrathecal MTX-induced Myelopathy mimicking Guillain-Barre Syndrome: A Case Report

Eun Chae Lee, Don Gyu Lee

Subject: Medicine And Pharmacology, Internal Medicine Keywords: intrathecal; methotrexate; myelopathy; Guillain-Barre syndrome

Online: 7 October 2023 (09:51:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1818.v3

Is modern medicine in need of an overhydration marker in kidney failure? The accuracy of available fluid overload markers and the potential of the new ones.

Barbara Emilia Nikitiuk, Alicja Rydzewska-Rosołowska, Katarzyna Kakareko, Irena Głowińska, Tomasz Hryszko

Subject: Medicine And Pharmacology, Internal Medicine Keywords: fluid status; overhydration; hydration status; renal failure; kidney failure; heart failure; Ca-125; NT-pro-BNP; VEXUS; BIS

Online: 5 October 2023 (14:28:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0165.v1

The Prevalence of Mental Health Illness among Jordanian Patients during COVID-19 Pandemic: A Cross-Sectional Study

Mahmoud Alali, Maher Al-Hajjaj, Wasan Al-Dalabeeh, Abdullah Alwahkyan, Obada Alsakaji, Mohammad Salameh, Qusai Hamdan, Abdallah Arabiat, Saed Alhamawi, Amjad Al-Shdaifat

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; mental health; Anxiety

Online: 4 October 2023 (07:50:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2082.v1

Failure of Non-invasive Respiratory Support in Patients with SARS-Cov-2 with the Different Therapies

Juan Javier García-Fernández, José Andrés Sánchez-Nicolás, Sonia Galicia-Puyol, Isabel Gil-Rosa, Juan Jose Guerras Conesa, Enrique Bernal-Morell, César Cinesi-Gómez

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Non-invasive respiratory support 1; SARS-CoV-2 2; Hospitalization 3; CPAP 4; HFNO 5; Bilevel 6

Online: 29 September 2023 (10:41:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2020.v1

45 Years of Tetracycline Post Exposure Prophylaxis for STIs and the Risk of Tetracycline Resistance: A Systematic Review and Meta-Analysis

Vanbaelen Thibaut., Sheeba Manoharan-Basil, Chris Kenyon

Subject: Medicine And Pharmacology, Internal Medicine Keywords: doxycycline PEP, tetracycline, minocycline, AMR, PrEP, gonorrhoea

Online: 29 September 2023 (04:50:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1475.v1

Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome

Cristina Elena Bita, Ion Romulus Scorei, Ananu Florentin Vreju, Anca Emanuela Muşetescu, George Dan Mogoşanu, Andrei Biţă, Venera Cristina Dinescu, Ştefan Cristian Dinescu, Cristina Criveanu, Andreea Lili Bărbulescu, Alesandra Florescu, Paulina Lucia Ciurea

Subject: Medicine And Pharmacology, Internal Medicine Keywords: complex regional pain syndrome, microbiota, boron-containing compounds, prebiotic boron, gut–brain axis, gut–musculoskeletal axis, gut–immune system axis

Online: 21 September 2023 (11:27:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1818.v2

Is Modern Medicine in Need of an Overhydration Marker in Kidney Failure? The Accuracy of Available Fluid Overload Markers and the Potential of the New Ones

Barbara Emilia Nikitiuk, Alicja Rydzewska-Rosołowska, Katarzyna Kakareko, Irena Głowińska, Tomasz Hryszko

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Fluid status 1; overhydration 2; hydration status 3; renal failure 4; kidney failure 5; heart failure 6; Ca-125 7; NT-pro-BNP 8; VEXUS 9; BIS 10

Online: 15 September 2023 (11:01:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0845.v1

Linking Migraine to Gut Dysbiosis And Chronic Non-Communicable Diseases

Manuela Di Lauro, Cristina Guerriero, Kevin Cornali, Maria Albanese, Micaela Costacurta, Nicola Biagio Mercuri, Nicola Di Daniele, Annalisa Noce

Subject: Medicine And Pharmacology, Internal Medicine Keywords: migraine; chronic non-communicable diseases; gut microbiota; nutritional approaches; lifestyle changes

Online: 13 September 2023 (10:02:42 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.0638.v1

A Case of Polymyositis Associated with Cytomegalovirus Infection in a Patient with Hashimoto’s Thyroiditis

Ergeta Ktona, Blerta Budani, Ioannis Kostas- Agnantis, Alma Idrizi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Polymyositis; Cytomegalovirus infection; Hashimoto`s thyroiditis, association, coexistence, autoimmune diseases

Online: 11 September 2023 (09:31:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0659.v1

PET-CT spectrum of large vessel vasculitis (LVV) in a tertiary center: differences in FDG uptake between LVV with predominant cranial and extracranial giant cell arteritis phenotypes

Elena Heras-Recuero, Laura Cristina Landaeta-Kancev, Marta Martínez de Bourio-Allona, Arantxa Torres-Rosello, Teresa Blázquez-Sánchez, Iván Ferraz-Amaro, Santos Castañeda, Juan Antonio Martínez-López, Luis Martínez-Dhier, Raquel Largo, Miguel Angel González-Gay

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Positron emission computed tomography (PET-CT) with 18F-fluorodeoxyglucose (FDG), large vessel vasculitis, vasculitis, giant cell arteritis, polymyalgia rheumatica

Online: 11 September 2023 (09:22:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2126.v1

Echocardiographic-Fluoroscopic Fusion Imaging Improves Interventionalists´ Learning Curve for Percutaneous Left Atrial Appendage Closure

Dominika Anna Kanschik, Houtan Heidari, Kathrin Klein, Amin Polzin, Verena Veulemans, Jürgen Leick, Malte Kelm, Christian Jung, Tobias Zeus, Shazia Samreen Afzal

Subject: Medicine And Pharmacology, Internal Medicine Keywords: structural heart disease; left atrial appendage closure; fusion imaging; learning curve

Online: 31 August 2023 (10:36:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1997.v1

Circulating СD8+ T Cells Subsets in Primary Sjögren’s Syndrome

Igor Kudryavtsev, Stanislava Benevolenskaia, Maria Serebriakova, Irina Grigor’yeva, Evgeniy Kuvardin, Darina Zammoeva, Dmitri Motorin, Anna Budkova, Artem Rubinstein, Alexey Golovkin, Olga Kalinina, Ekaterina Zaikova, Sergey Vladimirovich Lapin, Alexey Maslyanskiy

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Sjögren's syndrome; T cell subsets; СD8+ T Cells

Online: 30 August 2023 (08:15:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1657.v1

Metachronous Mucinous Breast Carcinoma and Mucinous Pancreatic Cystadenoma in a Patient With Metabolic Comorbidities- Case Report and Minireview

Teodora-Gabriela Alexescu, Irina Obada, Angela Cozma, Mirela Alb, Olga Hilda Orăsan, Vasile Negrean, Iacob Domsa, Simina Felicia Tarmure

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Mucinous breast carcinoma; pancreatic cancer; diabetes mellitus type 2; obesity; metabolic syndrome; postmenopausal women

Online: 23 August 2023 (11:22:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1613.v1

Albumin: A Biomarker to Be Repurposed

Elisa Gremese, Dario Bruno, Valentina Varriano, Simone Perniola, Luca Petricca, Gianfranco Ferraccioli

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Albumin levels; pre-Albumin levels; Emergency Department; Nephrology; Cardiology; Oncology; Infectious Diseases; Intensive Care Units; Rheumatologig Autoimmune Diseases.

Online: 23 August 2023 (09:14:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0922.v2

Effect of Cuff-Inflation on Blood Pressure, Arousals, Sleep Efficiency, and Desaturations: Sub-Analysis of the VAST Pilot Study

Thenral Socrates, Philipp Krisai, Andrea Meienberg, Michael Mayr, Thilo Burkard, Annina Salome Vischer

Subject: Medicine And Pharmacology, Internal Medicine Keywords: arterial hypertension; sleep arousal; cuff-based blood pressure measurement; nocturnal hypertension; pulse transit time

Online: 15 August 2023 (08:48:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0991.v1

Antiphospholipid Antibodies and Vascular Thrombosis in Patients with Severe Forms of COVID-19

Mirjana Zlatković-Švenda, Milica Ovuka, Manca Ogrič, Saša Čučnik, Polona Žigon, Aleksandar Radivčev, Marija Zdravković, Goran Radunović

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; antiphospholipid syndrome; vascular thrombosis; antiphospholipid antibodies; anticardiolipin antibodies (aCLA); anti-β2-glycoprotein I antibodies (anti-β2GPI); anti phosphatidylserine-prothrombin (aPS/PT) antibodies

Online: 14 August 2023 (10:22:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0948.v1

Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study

F. Pietrantonio, F. Rosiello, M. Ruggeri, Marco Materazzo, Vincenzo Mirco La Fazia, Nicola Pierucci, Rosa Iodice, G. Granvillano, Lamberto mc Cicerchia, Massimo Maurici, Michela Delli castelli, Fabio Vinci, Angela Ciamei, Marise Sabato, Aurelio Sparta, Davide Acco, Luca Fortunato, Maria sofia Cattaruzza, Antonio Vinci, M. Lordi, Enrica Cipriano

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Molnupiravir; SARS-CoV-2; COVID-19; Nirmatrelvir; oral antiviral

Online: 11 August 2023 (13:23:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0922.v1

Effect of Cuff-Inflation on Blood Pressure, Arousals, Sleep Efficiency, and Desaturations: Sub-Analysis of the VAST Pilot Study

Thenral Socrates, Philipp Krisai, Andrea Meienberg, Michael Mayr, Thilo Burkard, Annina Salome Vischer

Subject: Medicine And Pharmacology, Internal Medicine Keywords: arterial hypertension; sleep arousal; cuff-based blood pressure measurement; nocturnal hypertension; pulse transit time

Online: 11 August 2023 (10:42:43 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202308.0687.v1

Comparison of Cefazolin/Metronidazole versus Ampicillin-Sulbactam as Preoperative Antibiotics in Colorectal Surgery: Retrospective, Single-Center Cohort Study

Jae Hyoung Im, Dong Yeop Lee, Ji Hyeon Baek, Se-joo Lee, Sungtaek Jung, Eunjung Kim, Dong Yoon Kang, Jin-Soo Lee

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Ampicillin; Antibiotics prophylaxis; cefazolin; Colorectal surgery

Online: 9 August 2023 (02:59:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0370.v1

Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma

Alessio Cimmino, Giovanni Francesco Fasciglione, Magda Gioia, Stefano Marini, Chiara Ciaccio

Subject: Medicine And Pharmacology, Internal Medicine Keywords: osteosarcoma; phytoestrogens; anticancer effects; estrogen receptors

Online: 4 August 2023 (11:00:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1979.v1

Novel Risks of Unfavorable Corticosteroid Response in Patients with COVID-19 Identified by Artificial Intelligence-Assisted Analysis of Chest Radiographs

Min Hyung Kim, Hyun Joo Shin, Jaewoong Kim, Sunhee Jo, Eun-Kyung Kim, Yoon Soo Park, Taeyoung Kyong

Subject: Medicine And Pharmacology, Internal Medicine Keywords: artificial intelligence; chest radiograph; corticosteroid responsiveness; COVID-19

Online: 28 July 2023 (11:50:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1966.v1

Coronary Event Risk Test (CERT) as Risk Predictor for the 10-Year Clinical Outcome of Patients with Peripheral Artery Disease

Andreas Leiherer, Axel Muendlein, Christoph H Saely, Kathrin Geiger, Eva-Maria Brandtner, Christine Heinzle, Stella Gaenger, Reijo Laaksonen, Peter Fraunberger, Heinz Drexel

Subject: Medicine And Pharmacology, Internal Medicine Keywords: peripheral artery disease; biomarker; ceramides; CERT; mortality; MACE; risk factors; statin

Online: 28 July 2023 (11:43:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1933.v1

Utility of the Serum Protein Electrophoresis in the Opportunistic Screening for the Deficiency of Alpha-1 Antitrypsin

Beatriz Fernández-Gomez, Sebastian Menao-Guillén, Ayala Fernandez Gonzalez, Maria Arruebo Muñio, Monica Ramos Alvarez, Mercedes Inda Landaluce, Maria Angeles Castillo Arce, Miguel-Angel Torralba-Cabeza

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Alpha-1 Antitrypsin; Protein electrophoresis; SERPINA1; screening; genetic counseling

Online: 28 July 2023 (10:24:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1694.v1

The Preventive Effects of Statin on Lung Cancer Development in Patients with Idiopathic Pulmonary Fibrosis Using the National Health Insurance Service Database in Korea

Yoo Jung Lee, Nayoon Kang, Junghyun Nam, Eung Gu Lee, Jiwon Ryoo, Soon Seog Kwon, Yong Hyun Kim, Hye Seon Kang

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Database

Online: 25 July 2023 (10:01:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1056.v1

Micro- and Macrovascular Effects of Inflammation in Peripheral Artery Disease – Pathophysiology and Translational Therapeutic Approaches

Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski

Subject: Medicine And Pharmacology, Internal Medicine Keywords: atherosclerosis; inflammation; peripheral artery disease; glycocalyx; endothelial dysfunction

Online: 17 July 2023 (05:31:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0005.v1

The Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Long Covid: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog

Francesco Menichetti

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Long Covid; Covid-19; post-COVID syndrome; neuroendocrine disorders; chronic fatigue; brain fog; phospholipids; phospholipid liposome; phosphatidylserine

Online: 4 July 2023 (03:10:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1654.v1

Serum Level of Cytokeratin 18 (M65) as Prognostic Marker of High Cardiovascular Disease Risk in Non-alcoholic Fatty Liver Disease Individuals

Sabrina Pagano, Stephan J.L. Bakker, Catherine Juillard, Robin P.F. Dullaart, Nicolas Vuilleumier

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Cytokeratin 18; Non-Alcoholic Fatty Liver Disease; Fatty liver index; Framingham risk score; Systematic COronary Risk Evaluation 2

Online: 23 June 2023 (10:36:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0690.v1

The Spectrum of Hyperferritinemic Syndromes

Marilena Stoian, Gabriel Scarlat

Subject: Medicine And Pharmacology, Internal Medicine Keywords: hyperferritinemic syndrome; hyperinflammatory state; hypercitokinemia; immunosupression

Online: 9 June 2023 (09:10:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0659.v1

SARS-CoV-2 Infection: Molecular Mechanisms of Endothelial Dysfunction in COVID-19 Patients

Laurence Bouillet, Alban DEROUX, Meryem BENMARCE, Chloé GUERIN, Laura BOUVET, Olivia GARNIER, Donald K. MARTIN, ISABELLE VILGRAIN

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Endothelium; VE-cadherin; ACE2; SARS-CoV2 infection; Long COVID syndrome

Online: 9 June 2023 (03:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0626.v1

Could Systemic Inflammatory Index Predict Diabetic Kidney Injury in Type 2 Diabetes Mellitus?

Tuba Taslamacioglu Duman, Buse Balci, Feyza Nihal Ozkul

Subject: Medicine And Pharmacology, Internal Medicine Keywords: diabetic kidney injury; inflammation; systemic inflammatory index

Online: 8 June 2023 (10:26:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0446.v1

Who Let the Dogs Out ? Unmasking the Neglected : A Com-prehensive Review on the Enduring Impact of Toxocarosis, a Prevalent Zoonotic Infection

Katrin Henke, Sotirios Ntovas, Aristomenis K. Exadaktylos, Jolanta Klukowska-Rötzler, Mairi Ziaka

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Toxocara canis; Toxocara cati; Toxocarosis; Parasitic infection; Visceral larva migrans; albendazole

Online: 6 June 2023 (11:29:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0204.v1

Methadone Maintenance and QT-interval: Prevalence and Risk Factors. Is it Effective to Switch Therapy to Levomethadone?

Laura Santin, Giuseppe Verlato, Ahmad Tfaily, Roberto Manera, Giuseppe Zinfollino, Francesca Fusina, Lugoboni Fabio

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Methadone; levomethadone; QTc; prolongation; treatment; heroin; therapy-switch

Online: 2 June 2023 (12:24:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0202.v1

Serum C-Reactive Protein to Albumin Ratio as a Reliable Marker of Diabetic Neuropathy in Type 2 Diabetes Mellitus

Gulali Aktas

Subject: Medicine And Pharmacology, Internal Medicine Keywords: type 2 diabetes mellitus; diabetic neuropathy; inflammation; C reactive protein to albumin ratio

Online: 2 June 2023 (12:07:42 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.0122.v1

Preexposure Prophylaxis against COVID-19 with Tixagevimab/Cilgavimab in Slovenian National Cohort of Kidney Transplant Recipients

Špela Borštnar, Miha Arnol, Željka Večerić Haler, Gregor Mlinšek

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID 19; pre-exposure prophylaxis; kidney transplantation, tixagevimab/cilgavimab

Online: 2 June 2023 (03:58:07 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.1962.v1

Elucidating the Effects of Methotrexate Therapy on Serum Cytokeratin-18 Levels in Rheumatology

Kanimoliyaal Balakrishnan, Sakthiswary Rajalingham, Chew Chia Hsian Deborah, Asrul Abdul Wahab, Yazmin Yaacob, Rosnah Sutan

Subject: Medicine And Pharmacology, Internal Medicine Keywords: methotrexate (MTX); rheumatoid arthritis (RA); cytokeratin -18 ( CK -18)

Online: 29 May 2023 (08:56:15 CEST)

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Background: CK-18 is a serological marker of apoptosis that has been widely associated with fibrosis and steatosis in NASH. Many studies have showed association CK-18 levels with NAFLD. To date, there is a profound lack of rheumatology studies on the effect of MTX therapy with regard to CK-18 levels. The relationship between CK-18 levels and cumulative MTX dose, MTX treatment duration, weekly MTX dose is not available in the literature. Objectives: The main purpose of this study was to determine the relationship between serum cytokeratin-18 (CK-18) and cumulative methotrexate dose in rheumatology patients on methotrexate (MTX) therapy. Besides, we studied the correlations between CK-18 and clinical parameters including age, disease duration , duration of MTX therapy, cumulative steroid dose and biochemical parameters such as alanine transaminase (ALT) and aspartate aminotransferase AST). Methods : We recruited 79 rheumatology patients on methotrexate (MTX) therapy as MTX group and 38 patients not on MTX therapy as non-MTX group . All subjects were tested for their serum CK-18 levels using an enzyme-linked immunosorbent assay (ELISA) test. We identified 20 patients with the highest CK-18 levels and 20 patients with the lowest CK-18 levels and had ultrasound liver performed on them. Results : The median serum CK-18 levels were marginally higher among the patients on MTX (1.20 ng/mL [0.19-37.15]) compared to the non-MTX group (1.17 ng/mL [0.37-34.32]). There was a significantly positive relationship between serum CK-18 levels and cumulative MTX dose (r = 0.329, p = 0.003) and total duration of MTX therapy (r = 0.284, p = 0.011). Apart from the above-mentioned variables, the CK-18 levels in MTX group significantly correlated with age (r = 0.265, p = 0.018), ALT (r = 0.440, p = <0.001) and AST (r = 0.478, p= 0.004). Ultrasound liver findings showed median CK-18 levels was higher among patients with abnormal liver findings although statistical significance was not reached. Conclusion : Among patients on MTX therapy, serum CK-18 levels correlated positively with cumulative MTX dose , total duration of MTX treatment , ALT and AST levels. These findings are preliminary and requires validation by future studies in the field of rheumatology.

Preprint REVIEW | doi:10.20944/preprints202305.1835.v1

COVID-19 and COVID-19 Vaccine in Japan—A Review from a General Physician's Perspective

Hiroshi Kusunoki

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; SARS-CoV-2; vaccines; breakthrough infection; hybrid immunity; SARS-CoV-2 antibody

Online: 26 May 2023 (04:05:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1753.v1

A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management

Ashish Shetty, Gayathri Delanerolle, Chunli Deng, Heitor Cavalini, Xiaojie Yang, Anish Thillainathan, Yassine Bouchareb, Amy Boyd, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Chronic pain; Medical Devices; Neuromodulation; Clinical trials; Bayesian

Online: 25 May 2023 (07:27:31 CEST)

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Chronic non-cancer pain is a highly debilitating condition affecting approximately 20% of the global population. Chronic pain may lead to significant physical disability, emotional distress, social isolation and financial burden. Whilst^.pharmacological therapies remain the cornerstone of pain management in non-cancerous chronic pain, factors including the current opioid epidemic have led to non-pharmacological techniques becoming a more attractive proposition. We explored the prevalence of medical device use and their treatment efficacy in non-cancer pain management. A systematic methodology was developed, peer reviewed and published in PROSPERO (CRD42021235384). Key words of medical device, pain management devices, chronic pain, lower back pain, back pain, leg pain and chronic pelvic pain using Science direct, PubMed, Web of Science, PROSPERO, MEDLINE, EMBASE, PorQuest and ClinicalTrials.gov. All clinical trials, epidemiology and mixed methods studies that reported the use of medical devices for non-cancer chronic pain management published between the 1^st of January 1990 and the 30^th of April 2022 were included. 13 studies were included in systematic review, of these 6 were used in the meta-analysis with 173 participants. Our meta-analysis for pain reduction in each study showed that transcutaneous electrical nerve stimulation combined with instrument-assisted soft tissue mobilization treatment and pulsed electromagnetic therapy produced significant treatment on chronic lower back pain patients. Pooled evidence revealed the use of medical device related interventions resulted in 0.7 degree of pain reduction under a 0-10 scale. Significant improvement in disability scores, with a 7.44 degree reduction in disability level compared to a placebo using a 50 score range was also seen. The application of medical devices in patients with chronic pain has gained popularity due to increasingly cost effective techniques, minimally invasiveness and greater awareness of risks associated with pharmacological management. Our analysis has shown that the optimal use of medical devices in a sustainable manner requires further extensive research, needing larger cohort studies with greater gender parity, in a more diverse range of geographical locations.

Preprint REVIEW | doi:10.20944/preprints202305.1557.v1

Conducting and Reporting Meta-analysis: A Checklist for Reviewers

SAMIT GHOSAL

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Meta-analysis; heterogeneity; reviewer; checklist

Online: 23 May 2023 (04:09:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0896.v1

Liver Involvement in Patients With Systemic Sclerosis: Role of Transient Elastography in the Assessment of Hepatic Fibrosis and Steatosis

Giovanna Cuomo, Carlo Iandoli, Raffaele Galiero, Alfredo Caturano, Claudio Di Vico, Danilo Perretta, Pier Vincenzo Adamo, Roberta Ferrara, Luca Rinaldi, Ciro Romano, Ferdinando Carlo Sasso

Subject: Medicine And Pharmacology, Internal Medicine Keywords: fibroscan, liver fibrosis, systemic sclerosis

Online: 25 April 2023 (07:14:28 CEST)

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Background Systemic sclerosis (SSc) is a rare, multisystemic disorder of connective tissue, characterized by widespread inflammation, vascular abnormalities, and both skin and visceral organ fibrosis. Tissue fibrosis is the final phase of a complex biological process of immune activation and vascular damage. Objectives The aim of study was to assess hepatic fibrosis and steatosis in SSc patients by transient elastography (TE). Methods Fifty-nine SSc patients, satisfying the 2013 ACR/EULAR classification criteria, were recruited. Clinical and laboratory findings, modified Rodnan skin score (mRSS), ac-tivity index, video-capillaroscopy, echocardiography, and lung function data were ana-lyzed. Liver stiffness (LS) was measured by transient elastography (TE), with 7 kPa used as the cut-off value for significant liver fibrosis and steatosis. Specifically, values ≥ 238 CAP ≤ 259 dB/m were considered consistent with mild steatosis (S1), 260 ≥ CAP ≤ 290 dB/m with moderate steatosis (S2) and ≥291 dB/m with severe steatosis (S3) Results The median age of patients was 51 years, with a median disease duration of 6 years. Median LS was 4.5 (2.9–8.3) kPa; 41 patients (69.5%) had no evidence of fibrosis (F=0), 16 (27.1%) displayed LS values between 5.2 and 7 kPa; only 2 patients (3.4%) had LS values >7 kPa (F3). The median CAP value for liver steatosis was 223 dB/m (IQR: 164–343). Overall, 39 patients (66.1%) did not show evidence of steatosis (CAP values <238 dB/m); 9 patients (15.2%) showed values consistent with mild (S1) steatosis (CAP value ≥238 ≤259 dB/m); 8 patients (13.5%) had moderate (S2) steatosis (CAP value ≥260 ≤290 dB/m); 3 patients (5.1%) were deemed to have severe steatosis (S3) due to CAP values ≥291 dB/m. Conclusions Only 3.4% of our patient population showed evidence of marked liver fibrosis, which is the same prevalence as that expected in the general population. Likewise, the prevalence of significant steatosis was low (5.1%) and depending on the same variables associated with fatty liver in the general population. TE was shown to be an easy and valuable method for detection and screening of liver fibrosis in SSc patients with no additional risk factors for liver disease.

Preprint REVIEW | doi:10.20944/preprints202304.0516.v1

SGLT -2 Inhibitors and the Inflammasome: What's next in the 21st century?

Dimitris Kounatidis, Natalia Vallianou, Angelos Evangelopoulos, Ioannis Vlachodimitris, Eugenia Grivakou, Evangelia Kotsi, Krystalia Dimitriou, Alexandros Skourtis, Iordanis Mourouzis

Subject: Medicine And Pharmacology, Internal Medicine Keywords: SGLT-2 Inhibitors; Inflammasome; NLRP3; reno-protective effects; Cardio-protective effects; neuro-protective effects.

Online: 18 April 2023 (10:33:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0298.v1

D-dimer Trends Predicts COVID-19 Patient’s Prognosis: A Retrospective Chart Review Study

Raeed Kabir, Iyana Malik, Reena Chen, Jebun Nahar, Xiongying Chen, Mahfouz Hoq, Azad Kabir

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; SARS-CoV-2; anticoagulation; enoxaparin; bleeding risk; prognosis; oxygen; vaccination; D-dimer; non-critically ill

Online: 13 April 2023 (05:32:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0335.v1

Twitter Sentiment Analysis of Lagos State 2023 Gubernatorial Election using BERT

Ashiribo Senapon Wusu, Olusola Aanu Olabanjo, Rebecca Maulome Padonu, Manuel Mazzara

Subject: Medicine And Pharmacology, Internal Medicine Keywords: NLP; NLU; Twitter; Sentiment Analysis; Opinion Mining; Nigeria; Election; Machine Learning; BERT; LSTM; SVM

Online: 20 March 2023 (02:52:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0392.v1

The Effect of Giving Avocado Leaf Boiled Water on Lowering Blood Pressure in the Elderly with Hypertension in the Work Area Gambut Health Center

Khusnul Mar'iyah, Aman Rohman, Ismul Fajar, Chandra Negara

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Keywords: Hypertension; Avocado leaves; Blood pressure; seniors

Online: 26 October 2022 (02:13:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0460.v1

Access to Health Services and Its Influence on Adherence to Treatment of Arterial Hypertension During the COVID-19 Pandemic in a Hospital in Callao, Peru

Oriana Rivera-Lozada, Isabel Cristina Rivera-lozada, Cesar Antonio Bonilla-Asalde

Subject: Medicine And Pharmacology, Internal Medicine Keywords: adherence; COVID-19; arterial hypertension; health services

Online: 26 August 2022 (11:37:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0416.v1

Diverse CT Findings of Pulmonary Infection in Patients with Kidney Diseases under Immunosuppressive Therapy or on Maintenance Hemodialysis

Shuai Zhou, XiaoMing Liu, PeiHua Hu, HuiNing Liu, Yong Wang, LiHong Zhang, Tao Wang

Subject: Medicine And Pharmacology, Internal Medicine Keywords: kidney disease; hemodialysis; immunosuppression; pulmonary infections; computed tomography

Online: 24 August 2022 (08:30:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0017.v3

Effectiveness of High-Intensity Interval Training and Continuous Moderate-Intensity Training on Blood Pressure in Physically Inactive Pre-Hypertensive Young Adults

Anil T. John, Moniruddin Chowdhury, Rabiul Islam, Imtiyaz Ali Mir, Md Zobaer Hasan, Chao Yi Chong, Syeda Humayra, Yukihito Higashi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: High-intensity interval training; Continuous aerobic training; Systolic blood pressure; Diastolic blood pressure; Pre-hypertension

Online: 13 July 2022 (09:21:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0017.v2

Effectiveness of High-Intensity Interval Training and Continuous Moderate-Intensity Training on Blood Pressure in Young Physically Inactive Pre-Hypertensive Adults

Anil T. John, Moniruddin Chowdhury, Rabiul Islam, Imtiyaz Ali Mir, Md Zobaer Hasan, Chao Yi Chong, Syeda Humayra, Yukihito Higashi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: High-intensity interval training; Continuous aerobic training; Systolic blood pressure; Diastolic blood pressure; Pre-hypertension

Online: 3 June 2022 (11:08:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0017.v1

Effectiveness of High-Intensity Interval Training and Continuous Moderate-Intensity Training on Blood Pressure in Young Physically Inactive Pre-Hypertensive Adults

Anil T John, Moniruddin Chowdhury, Rabiul Islam, Imtiyaz Ali Mir, Md Zobaer Hasan, Chao Yi Chong, Syeda Humayra, Yukihito Higashi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: High-intensity interval training; Continuous aerobic training; Systolic blood pressure; Diastolic blood pressure; Pre-hypertension

Online: 1 June 2022 (11:11:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0278.v1

Usefulness of Multi-Organ Point-Of-Care Ultrasound as a Complement to the Decision-Making Process in Internal Medicine

Irene Casado-López, Yale Tung-Chen, Marta Torres-Arrese, Davide Luordo-Tedesco, Arantzazu Mata-Martínez, Jose Manuel Casas-Rojo, Esther Montero-Hernández, Gonzalo García De Casasola-Sánchez

Subject: Medicine And Pharmacology, Internal Medicine Keywords: point-of-care ultrasound; internal medicine; lung ultrasound; echocardiography; abdominal ultrasound

Online: 21 March 2022 (08:39:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0459.v1

Non-invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

John G. Jones

Subject: Medicine And Pharmacology, Internal Medicine Keywords: in vivo magnetic resonance; liver metabolism; hyperpolarization; stable isotopes

Online: 23 August 2021 (15:34:21 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202007.0178.v2

Brief Report: Rapid Clinical Recovery from Critical COVID-19 with Respiratory Failure in a Lung Transplant Patient Treated with Intravenous Vasoactive Intestinal Peptide

Jihad Georges Youssef, Faisal Zahiruddin, Mukhtar Al-Saadi, Simon Yau, Ahmad Goodarzi, Howard J. Huang, Jonathan C. Javitt

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Aviptadil; Vasoactive Intestinal Peptide; VIP; SARS-CoV-2; COVID-19; Corona Virus; Acute Respiratory Distress Syndrome; ARDS; Acute Lung Injury; ALI; surfactant; Alveolar Type II; ATII

Online: 2 August 2020 (18:16:20 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202007.0178.v1

Brief Report: Rapid Clinical Recovery from Critical COVID-19 with Respiratory Failure in a Lung Transplant Patient Treated with Intravenous Vasoactive Intestinal Peptide

Jihad Georges Youssef, Faisal Zahiruddin, Mukhtar Al-Saadi, Simon Yau, Ahmad Goodarzi, Howard J. Huang, Jonathan C. Javitt

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Aviptadil; Vasoactive Intestinal Peptide; VIP; SARS-CoV-2; COVID-19; Corona Virus; Acute Respiratory Distress Syndrome; ARDS; Acute Lung Injury; ALI; surfactant; Alveolar Type II; ATII

Online: 9 July 2020 (07:54:22 CEST)

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Medicine and Pharmacology