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Preprint REVIEW | doi:10.20944/preprints202306.0355.v1

Use of Polyelectrolyte Complexes Chitosan-Based for Its Potential Application in Active Food Packaging. A Review of Recent Literature

Nancy Alvarado, Romina L Abarca, Cristian Linares-Flores

Subject: Chemistry And Materials Science, Biomaterials Keywords: chitosan; polyelectrolyte complexes; food packaging

Online: 5 June 2023 (16:38:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0308.v1

Antibacterial Thermo-Sensitive Silver Hydrogel Nanocomposite Improves Wound Healing

Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Kilani, Frank Ko, Aziz Ghahary, Dirk Lange

Subject: Chemistry And Materials Science, Biomaterials Keywords: Wound healing; Antibacterial; Hydrogel; Meshfill; Silver nanocomposite

Online: 5 June 2023 (10:34:40 CEST)

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Introduction: Among the many factors that may limit effective wound healing in patients with chronic ulcers, bacterial infection and poor cell recruitment are primary causes that contribute to prolonged healing. Thus, a novel strategy that aims to prevent bacterial infection within the wound, while at the same time providing structural scaffolding that promotes endogenous tissue repair, would be of great interest. Here, we developed a thermo-sensitive silver nanoparticle hydrogel composite as an antibacterial nutritional scaffold for the wound that contains all nutrients required for cell growth while preventing bacterial infection with the ability to fill up all the cavities and void areas in wounds regardless of their geometry. Methods: Silver nanoparticles (AgNPs) were synthesized by chemical reduction. After characterization, silver hydrogel nanocomposite was developed by reconstitution of collagen-based hydrogel powder in a nanoparticle suspension of varying AgNPs concentrations (200, 400, and 600 ppm). The antibacterial activity of the formulations was examined in vitro and in vivo in subcutaneous implant infected model. The wound healing efficacy of the hydrogel nanocomposite was also evaluated using a splinted wound model in rats through comparison of clinical wound measurements and histological assessments. Cytocompatibility assay and biochemical analysis of blood at the end of in vivo wound healing study were performed to evaluate the safety of formulations. Results: The synthesized nanoparticles were spherical and stable. While hydrogel alone did not show any bacterial reduction in vitro, the inhibition of bacterial growth was significant in all silver hydrogel nanocomposites compared to controls (p <0.05) and was dose-dependent, with maximum reduction observed in the 600 ppm group (4.56±0.26 LOG CFU/mL, P<0.001). All concentrations of AgNPs hydrogel composites showed significant antibacterial activity in vivo as well (P<0.0001). Treatment of splinted wounds with AgNPs hydrogel composite resulted in faster wound closure and accelerated wound re-epithelialization. The formulations were non-cytotoxic and did not differ significantly in hematological and biochemical factors from the control group in in vivo study. Conclusions: By presenting promising antibacterial and wound healing activity, silver hydrogel nanocomposite offers a safe therapeutic option that can be used as a functional scaffold for an acceleration of wound healing.

Preprint ARTICLE | doi:10.20944/preprints202306.0302.v1

Formation of the Hydroxyapatite-based Hybrid Materials in Presence of Platelet-Poor Plasma Additive

Ilya Evgen'evich Glazov, Valentina Konstantinovna Krut’ko, Tatiana Viktorovna Safronova, Nikita Aleksandrovich Sazhnev, Natalia Rustemovna Kil'deeva, Roman Alekseevich Vlasov, Olga Nikolaevna Musskaya, Anatoly Iosifovich Kulak

Subject: Chemistry And Materials Science, Biomaterials Keywords: hybrid material; hydroxyapatite formation; amorphous calcium phosphate; platelet-poor plasma; phase composition

Online: 5 June 2023 (10:14:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0246.v1

On the Safety of Implanted Breast Prostheses in Accidental Impacts

Gerardus Janszen, Michela Arnoldi, Valeriano Vinci, Marco Klinger, Luca Di landro

Subject: Chemistry And Materials Science, Biomaterials Keywords: breast implants; silicone prosthesis aging; accidental impacts; crash test; compression tests

Online: 5 June 2023 (05:38:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0220.v1

Hydrogel-Forming Microneedles for Transdermal Drug Delivery

Xiaolin Hou, Jiaqi Li, Hang Ruan, Meng Long, Yongyu Hong, Nianping Feng, Yongtai Zhang

Subject: Chemistry And Materials Science, Biomaterials Keywords: hydrogel-forming microneedles; transdermal drug delivery; controlled release; permeation pathway; environmental response

Online: 2 June 2023 (15:57:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0211.v1

Placental-Derived Biomaterials and Their Application to Wound Healing: A Review

Nicole M. Protzman, Yong Mao, Desiree Long, Raja Sivalenka, Anna Gosiewska, Robert J. Hariri, Stephen A. Brigido

Subject: Chemistry And Materials Science, Biomaterials Keywords: biomaterials; decellularization; extracellular matrix; placenta; placental-derived biomaterials; wound healing

Online: 2 June 2023 (14:14:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0091.v1

Functionalized Collagen/Poly(Ethylene Glycol) Diacrylate Interpenetrating Network Hydrogel Enhances Beta-Pancreatic Cell Sustenance

Natalia Moreno-Castellanos, Elías Cuartas-Gomez, Oscar Vargas-Ceballos

Subject: Chemistry And Materials Science, Biomaterials Keywords: Collagen; hydrogel; interpenetrating network; beta pancreatic cells; vascular endothelial factor; biomaterial

Online: 1 June 2023 (12:48:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2168.v1

Antibacterial Films of Silver Nanoparticles Embedded into Carboxymethylcellulose/Chitosan Multilayers on Nanoporous Silicon: a Layer-by-Layer Assembly Approach Comparing Dip and Spin Coating

Nelson Naveas, Ruth Pulido, Vicente Torres-Costa, Fernando Agulló-Rueda, Mauricio Santibanez, Francisco Malano, Gonzalo Recio-Sánchez, Karla Garrido-Miranda, Miguel Manso-Silván, Jacobo Hernandez-Montelongo

Subject: Chemistry And Materials Science, Biomaterials Keywords: antibacterial films; carboxymethylcellulose; chitosan; silver nanoparticles; nanoporous silicon; composite material; layer-by-layer

Online: 31 May 2023 (03:58:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2142.v1

Recent Developments in Edible Films and Coatings for Fruits and Vegetables

Anuradhi Liyanapathiranage, Rohan S. Dassanayake, Ashoka Gamage, Rama Rao Karri, Asanga Manamperi, Philippe Evon, Yasasvi Jayakodi, Terrence Madhujith, Othmane Merah

Subject: Chemistry And Materials Science, Biomaterials Keywords: biopolymers; Edible films and coatings; food packaging; polysaccharides; proteins

Online: 30 May 2023 (12:41:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2101.v1

Zn-Doped Calcium Magnesium Phosphate Bone Cements Based on Struvite and Their Antibacterial Properties

Polina A. Krokhicheva, Margarita A. Goldberg, Alexander S. Fomin, Dinara R. Khayrutdinova, Olga S. Antonova, Alexander S. Baikin, Aleksander V. Leonov, Ekaterina M. Merzlyak, Ivan V. Mikheev, Valentina A. Kirsanova, Irina K. Sviridova, Suraya A. Akhmedova, Natalia S. Sergeeva, Sergey M. Barinov, Vladimir S. Komlev

Subject: Chemistry And Materials Science, Biomaterials Keywords: calcium phosphate; magnesium phosphate; bone cement; antibacterial properties; ; cytocompatibility

Online: 30 May 2023 (09:45:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2064.v1

Freeze-Drying Process for the Fabrication of Collagen-Based Sponges as Medical Devices in Biomedical Engineering

Chrysoula Katrilaka, Niki Karipidou, Nestor Petrou, Chris Manglaris, George Katrilakas, Anastasios Nektarios Tzavellas, Maria Pitou, Eleftherios E. Tsiridis, Theodora Choli-Papadopoulou, Amalia Aggeli

Subject: Chemistry And Materials Science, Biomaterials Keywords: freeze-drying; biomaterials; collagen; gelatin; alignment; medical devices; biomedical engineering; modeling; Artificial Intelligence

Online: 30 May 2023 (07:23:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1870.v1

Modulation of Cell Response Through the Covalent Binding of Fibronectin to Titanium Substrates

Parsa Rezvanian, Aroa Alvarez-Lopez, Raquel Tabraue, Rafael Daza, Luis Colchero, Manuel Elices, Gustavo V. Guinea, Daniel González-Nieto, José Pérez-Rigueiro

Subject: Chemistry And Materials Science, Biomaterials Keywords: fibronectin; functionalization; activated vapor silanization (AVS); mesenchymal stem cells (MSC); biomaterial.

Online: 26 May 2023 (05:50:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1803.v1

Fabrication, Characterization, and Microbial Biodegradation of Transparent Nanodehydrated-Bioplastic (NDBs) Membranes Using Novel Casting, Dehydration, and Peeling Techniques

Sherif S. Hindi, Mona Othman I. Albureikan

Subject: Chemistry And Materials Science, Biomaterials Keywords: bioplastic; gum arabic; polyvinyl alcohol; dehydration; FTIR; XRD; TGA; DTA; AFM; microbial biodegradation

Online: 25 May 2023 (10:46:48 CEST)

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NDBs were fabricated from gum arabic (GA) and polyvinyl alcohol (PVA) in different ratios using novel techniques (casting, dehydration, and peeling). The GA/PVA blends were cast with a novel vibration-free horizontal flow (VFHF) technique, producing membranes free of air bubble defects with a homogenous texture, smooth surface, and constant thickness. The casting process was achieved on a self-electrostatic template (SET) made of poly-(methyl methacrylate), which made peeling the final product membranes easy due to its non-stick behavior. After settling of the cast membranous blind, sheets were dried using nanometric dehydration under a mild vacuum stream using a novel stratified nanodehydrator (SND) loaded with P2O5. After drying the TBM, the dry, smooth membranes were peeled easily without scratching defects. The physicochemical properties of the NDBs were investigated using FTIR, XRD, TGA, DTA, and AFM to ensure that the novel techniques did not distort the product quality. The NDBs retained their virgin characteristics, namely, their chemical functional groups (FTIR results), crystallinity index (XRD data), thermal stability (TGA and DTA), and ultrastructural features (surface roughness and permeability), as well as their microbial biodegradation ability. Comparing the two TBM’ s precursors, PVA had a higher crystallinity index (CI), more mass loss at higher temperatures, greater thermal stability due to higher heat resistance, and a higher clearance of surface roughness due to its large particle size (PS), as well as its higher permeability parameters, namely pore diameter (PD) and void volume (VV), than those for GA. Accordingly, increasing the PVA allocation in the bioplastic blends can enhance their properties except for mass loss, whereby increasing the GA allocation in the TBM blend reduces its mass loss at an elevated temperature. In addition, there is no statistical difference between the NDBs and ordinary air-dried NDBs in PS, PD, and VV, indicating that the novel procedures used did not distort their parent properties examined, as well as their ability for biodegradation. In comparison to control samples, the separated bacteria and fungus destroyed the NDBs. Pseudomonas spp. and Bacillus spp. were the two main strains of isolated bacteria, and Rhizobus spp. was the main fungus. The nanodehydration method gave the best solution for the prompt drying of water-based biopolymers free of manufacturing defects, with simple and easily acquired machinery required for the casting and peeling tasks, in addition to its wonderful biodegradation behavior when buried in wetted soil.

Preprint ARTICLE | doi:10.20944/preprints202305.1711.v1

Multiscale Modelling of Milk Proteins Adsorption on Metallic Iron Surfaces

Parinaz Mosaddeghi Amini, Julia Subbotina, Vladimir Lobaskin

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanoparticle; potential of mean force; protein adsorption; proteins corona; bionano interface; multiscale modelling

Online: 24 May 2023 (12:57:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1681.v1

Recognition Mechanisms of Hemoglobin Particles by Monocytes – CD163 May Just Be One

Jonathan-Gabriel Nimz, Pichayut Rerkshanandana, Chiraphat Kloypan, Ulrich Kalus, Saranya Chaiwaree, Axel Pruß, Radostina Georgieva, Yu Xiong, Hans Bäumler

Subject: Chemistry And Materials Science, Biomaterials Keywords: hemoglobin sub-micron particles; CD163; monocytes; scavenger receptors

Online: 24 May 2023 (04:04:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1660.v1

Quality of Raspberry Fruit (Rubus idaeus L.) Cultivated under Balanced Fertilization Conditions: Commodity Evaluation

Barbara Sawicka, Piotr Barbaś, Dominika Skiba, Barbara Krochmal-Marczak, Piotr Pszczółkowski

Subject: Chemistry And Materials Science, Biomaterials Keywords: raspberry fruit; cultivated; balanced fertilization; conditions, commodity evaluation; quality of fruit

Online: 23 May 2023 (14:02:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1651.v1

Enhanced Antibacterial Properties of Chitosan Fibres

Cesar Hernandez, Zbigniew Draczyński, Dominik Borkowski, Dorota Kaźmierczak

Subject: Chemistry And Materials Science, Biomaterials Keywords: Chitosan, Fibres, Ursolic acid, antibacterial, Chitosan Fibres.

Online: 23 May 2023 (11:07:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1531.v1

Hybrid materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields

Martina Casarin, Martina Todesco, Chiara Giulia Fontanella, Alessandro Morlacco, Fabrizio Dal Moro, Andrea Bagno

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biomaterials; Hybrid Materials; Tissue Engineering; Regenerative Medicine

Online: 22 May 2023 (16:19:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1508.v1

Chitosan-Based Biomaterials for Hemostatic Applications: A Review on Recent Advances

Daniela Gheorghita, Horatiu Moldovan, Alina Robu, Ana-Iulia Bita, Elena Grosu, Aurora Antoniac, Iuliana Corneschi, Iulian Antoniac, Alin Danut Bodog, Ciprian Ionut Bacila

Subject: Chemistry And Materials Science, Biomaterials Keywords: hemostasis; topical hemostatic agents; chitosan-based composites; blood-material interaction

Online: 22 May 2023 (10:51:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1428.v1

Study on Cubic-Orientation Settlement of Angiotensin Converting Enzyme II Immobilized on Polystyrene by Molecular Dynamics Simulation

Yang Ma, Yong J. Yuan

Subject: Chemistry And Materials Science, Biomaterials Keywords: Angiotensin converting enzyme II; Polystyrene; Molecular dynamics simulation; Adsorption behaviors; Biochips

Online: 19 May 2023 (10:20:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1359.v1

On the Deformation Behavior of Composite “Hen’s Eggshell – Polymer Plomb” under Bending

Peter Panfilov, Dmitry Zaytsev, Maxim Mezhenov, Sergei Grigoriev

Subject: Chemistry And Materials Science, Biomaterials Keywords: hen’s eggshell; polymer coating; mechanical properties

Online: 19 May 2023 (02:33:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1261.v1

Injectable Hydrated Calcium Phosphate Bone-Like Paste: synthesis, In Vitro and In Vivo Biocompatibility Assessment

Anastasia Yu. Teterina, Vladislav V. Minaychev, Polina V. Smirnova, Margarita I. Kobiakova, Igor V. Smirnov, Roman S. Fadeev, Alexey A. Egorov, Artem A. Ashmarin, Kira V. Pyatina, Anatoliy S. Senotov, Irina S. Fadeeva, Vladimir S. Komlev

Subject: Chemistry And Materials Science, Biomaterials Keywords: biocompatible materials; calcium phosphates; hydrated pastes; bone tissue

Online: 18 May 2023 (03:07:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1225.v1

Dual-Step Controlled Release of Berberine Hydrochloride from the Trans-scale Hybrids of Nanofibers and Microparticles

Jianfeng Zhou, Yelin Dai, Junhao Fu, Chao Yan, Deng-Guang Yu, And Tao Yi

Subject: Chemistry And Materials Science, Biomaterials Keywords: dual-step release; berberine hydrochloride; hybrid; electrospinning; nanofibers; electrospraying; microparticle

Online: 17 May 2023 (10:17:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1204.v1

Enhancement of Mechanical Properties of Chitosan Fibres

César Hérnandez, Zbigniew Draczynski

Subject: Chemistry And Materials Science, Biomaterials Keywords: Chitosan; tripolyphosphate; TPP; tensile strength; Chitosan Fibres

Online: 17 May 2023 (07:42:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1139.v1

A Polymer Instigated Path in the Engineering of Sensors and Biosensors for Effective Amelioration of Therapeutics

Mohzibudin Z. Quazi, Jimin Hwang, Youngseo Song, Nokyoung Park

Subject: Chemistry And Materials Science, Biomaterials Keywords: DNA-based hydrogels; biosensors; stimuli-responsive; Progesterone detection; mRNA quantification; sensors

Online: 16 May 2023 (09:34:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0985.v1

Effects of Hydrophobic Gold Nanoparticles on Structure and Fluidity of SOPC Lipid Membranes

Poornima Budime Santhosh, Tihomir Tenev, Luka Šturm, Nataša Poklar Ulrih, Julia Genova

Subject: Chemistry And Materials Science, Biomaterials Keywords: gold nanoparticles; phospholipids; biomedical applications; membrane fluidity; infrared spectroscopy

Online: 15 May 2023 (07:09:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0832.v1

Bioactive Calcium Phosphate Coatings for Bone Implant Applications: A Review

Richard Drevet, Joël Fauré, Hicham Benhayoune

Subject: Chemistry And Materials Science, Biomaterials Keywords: biomaterials; coatings; calcium phosphates; hydroxyapatite; bone implant; biocompatibility; bioactivity; hard tissue repair

Online: 11 May 2023 (09:03:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0724.v1

Gellan Gum/Alginate Microparticles As Drug Delivery Vehicles: Doe Production Optimization and Drug Delivery

Henrique Carrêlo, Maria Teresa Cidade, João Paulo Borges, Paula Soares

Subject: Chemistry And Materials Science, Biomaterials Keywords: Microparticles; Gellan Gum; Alginate; Design of Experiments; Coaxial airflow

Online: 10 May 2023 (09:53:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0451.v1

PGS/Gelatin Nanocomposite Electrospun Wound Dressing

Mahyar Naseri, Aysan Hedayatnazari, Lobat Tayebi

Subject: Chemistry And Materials Science, Biomaterials Keywords: Electrospun wound dressing; Skin tissue engineering; Regenerative medicine; Gelatin; Poly (glycerol sebacate); Diabetic wound

Online: 8 May 2023 (05:15:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0300.v1

Synthesis, Characterization, Properties, and Biomedical Application of Chitosan-Based Hydrogels

Ruixi Ye, Siyu Liu, Wenkai Zhu, YuRong Li, Long Huang, Guozheng Zhang, Yeshun Zhang

Subject: Chemistry And Materials Science, Biomaterials Keywords: Chitosan; Hydrogel; biomedical application; stimuli-responsive hydrogels; synthesis methods; characterization methods

Online: 5 May 2023 (04:50:52 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0126.v1

Spontaneous Osteogenic Differentiation of Human Mesenchymal Stem Cells by Tuna Bone-Derived Hydroxyapatite Composites with Green Tea Polyphenol-Reduced Graphene Oxide

Moon Sung Kang, Rowoon Park, Hyo Jung Jo, Yong Cheol Shin, Chang-Seok Kim, Suong-Hyu Hyon, Suck Won Hong, Junghwan Oh, Dong-Wook Han

Subject: Chemistry And Materials Science, Biomaterials Keywords: bone tissue engineering; hydroxyapatite; reduced graphene oxide; human mesenchymal stem cell; osteogenic differentiation

Online: 3 May 2023 (09:54:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0033.v1

Manufacturing and Characterization of Three Modified Vegetable Oils Added Polylactic Composites

İbrahim Şen, Metehan Atagür, Sibel Tuna, Murat Eroğlu, Meral Akkoyun, Kutlay Sever

Subject: Chemistry And Materials Science, Biomaterials Keywords: polylactic acid(PLA); modified vegetable oils (MVO); maleinization; mechanical properties

Online: 2 May 2023 (01:09:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1001.v1

Development of Foam Dressing Containing Eclipta prostrata Leaf Extract and Gelatin

Sukhontha Hasatsri, Jariya Suthi, Nattaporn Siriwut, Onjira Charoensappakit

Subject: Chemistry And Materials Science, Biomaterials Keywords: Eclipta prostrata; gelatin; foam dressing; wound dressing; physical property; absorption; dehydration; pH environment

Online: 26 April 2023 (15:23:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0820.v1

Organic Luminescent Sensor for Mercury(II) and Iron(III) Ions in Aqueous Solutions

Sofian Kanan, Aysha Shabnam, Ahmed A Mohamed, Imad a Abu-Yousef

Subject: Chemistry And Materials Science, Biomaterials Keywords: luminescent sensors; mercury ions; iron ions; binding affinity; selective detection; adsorption capacity

Online: 24 April 2023 (04:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0595.v1

Polyvinylpyrrolidone Nanofibers Incorporating Mesoporous Bioactive Glass for Bone Tissue Engineering

Ricardo J. R. Matos, Jorge C. Silva, Paula I. P. Soares, João Paulo Borges

Subject: Chemistry And Materials Science, Biomaterials Keywords: Electrospun polyvinylpyrrolidone; polymeric scaffolds; bone regeneration; mesoporous bioactive glass

Online: 19 April 2023 (13:36:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0325.v1

Characterisation of Agarose Gels in Solvent and Non-solvent Media

Denis C. D. Roux, Isabelle Jeacomine, Guillaume Maîtrejean, François Caton, Marguerite Rinaudo

Subject: Chemistry And Materials Science, Biomaterials Keywords: agarose; methyl substituent; DSC; NMR; water retention; rheology; gelation hysteresis; gel in ethanol

Online: 13 April 2023 (12:49:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0286.v1

Self-Assembled CNF/rGO/Tannin Composite: Study of the Physicochemical and Wound Healing Properties

Katherina Fernández, Ayleen Llanquileo, Monserrat Bustos, Valentina Aedo, Isleidy Ruiz, Sebastián Carrasco, Mauricio Tapia, Miguel Pereira, Manuel Francisco Melendrez, Claudio Aguayo, Leonard I. Atanase

Subject: Chemistry And Materials Science, Biomaterials Keywords: graphene oxide; nanocellulose; reduced graphene oxide; polydopamine; wound healing

Online: 13 April 2023 (03:21:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0026.v1

Understanding the Role of M13 Bacteriophage Thin Films on a Metallic Nanostructure Through a Standard and Dynamic Model

Thanh Mien Nguyen, Cheol Woong Choi, Ji-Eun Lee, Damun Heo, Eun Jeong Choi, Jong-Min Lee, Vasanthan Devaraj, Jin-Woo Oh

Subject: Chemistry And Materials Science, Biomaterials Keywords: M13 bacteriophage; Metallic nanoparticles; Plasmonics; Dynamic response; Self-assembly; Simulations

Online: 3 April 2023 (11:13:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0378.v1

Comparative Metabolomics Profiling Reveals Key Metabolites and Associated Pathways Regulating Tuber Dormancy in White Yam (Dioscorea rotundata)

Jeremiah S. Nwogha, Abtew G. Wosene, Muthurajan Raveendran, Jude E. Obidiegwu, Cynthia A. Chilaka, Happiness O. Oselebe, Rohit Kambale, Veera Ranjani R.

Subject: Chemistry And Materials Science, Biomaterials Keywords: Yam tuber; metabolomics; pathways; molecular-mechanism; dormancy; regulation

Online: 21 March 2023 (13:55:59 CET)

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;Yams are economic and medicinal crops with a long growth cycle, spanning between 9-11 months due to the prolonged tuber dormancy. Tuber dormancy has constituted a major constraint in yam production and genetic improvement. In this study, we performed non-targeted comparative metabolomic profiling of tubers of two white yam genotypes, (Obiaoturugo and TDr1100873), to identify metabolites and associated pathways that regulate yam tuber dormancy using gas chromatography-mass spectrometry (GC-MS). Yam tubers were sampled between 42 days after physiological maturity (DAPM) till tuber sprouting. The sampling points include 42-DAPM, 56-DAPM, 87DAPM, 101-DAPM, 115-DAPM, and 143-DAPM. A total of 949 metabolites were annotated, 559 in TDr1100873 and 390 in Obiaoturugo. 39 differentially accumulated metabolites (DAMs) were identified across the studied tuber dormancy stages in the two genotypes. 27 DAMs were conserved between the two genotypes, whereas, 5 DAMs were unique in the tubers of TDr1100873 and 7 DAMs were in the tubers of Obiaoturugo. The differentially accumulated metabolites (DAMs) spread across 14 major functional chemical groups. Amines and biogenic polyamines, amino acids and derivatives, Alcohols, flavonoids, alkaloids, phenols, esters, coumarins and phytohormone positively regulated yam tuber dormancy induction and maintenance, whereas, fatty acids, lipids, nucleotides, carboxylic acids, sugars, terpenoids, benzoquinones, and benzene derivatives positively regulated dormancy breaking and sprouting in tubers of both yam genotypes. Metabolite set enrichment analysis (MSEA) revealed that 12 metabolisms were significantly enriched during yam tuber dormancy stages. Metabolic pathway topology analysis further revealed that six metabolic pathways (linoleic acid metabolic pathway, phenylalanine metabolic pathway, galactose metabolic pathway, starch and sucrose metabolic pathway, alanine-aspartate-glutamine metabolic pathways and purine metabolic pathway) exerted significant impact on yam tuber dormancy regulation. This result provides vital insights into molecular mechanisms regulating yam tuber dormancy.

Preprint ARTICLE | doi:10.20944/preprints202302.0472.v1

Combining Digital Image Correlation and Acoustic Emission to Characterize the Flexural Behavior of Flax Biocomposites

Mohamed Habibi, Luc Laperrière

Subject: Chemistry And Materials Science, Biomaterials Keywords: Flax; Flexural behavior; Damage behavior; Acoustic Emission; Digital Image Correlation

Online: 27 February 2023 (10:13:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0449.v1

Novel Strategy for Surface Modification of Titanium Implants towards the Improvement of Osseointegration Property and Antibiotic Local Delivery

Isabela da Rocha Silva, Aline Tavares da Silva Barreto, Renata Santos Seixas, Paula Nunes Guimarães Paes, Juliana do Nascimento Lunz, Rossana Mara da Silva Moreira Thiré, Paula Mendes Jardim

Subject: Chemistry And Materials Science, Biomaterials Keywords: titanium; hydrothermal treatment; surface modification; local drug delivery system; osseointegration

Online: 27 February 2023 (06:41:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0431.v1

Biomineralization Process in Three-Dimensional Scaffolds Based on Bacterial Nanocellulose for Bone Tissue Engineering: Chemi-Cal and Morphological Features, and Stem Cell Differentiation

Ana Cañas-Gutiérrez, Lenka Toro, Cristina Fornaguera, Salvador Borrós, Marlon Osorio, Cristina Castro-Herazo, David Arboleda-Toro

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanocomposites; bacterial nanocellulose; microporosity; biomineralization process and bone regeneration

Online: 27 February 2023 (02:29:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0371.v1

Recent Approaches of Collagen Biomatrix Modification as a Corneal Biomatrix and its Cellular Interaction

Nur Amalia Ra’oh, Rohaina Che Man, Mh Busra Fauzi, Norzana Abd Ghafar, Muhammad Ramdzan Buyong, Ng Min Hwei, Wan Haslina Wan Abdul Halim

Subject: Chemistry And Materials Science, Biomaterials Keywords: collagen biomatrix; optimization; modification; corneal epithelial cells; limbal epithelial stem cells; biocompatibility

Online: 22 February 2023 (03:03:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0314.v1

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

Javier Mauricio Anaya-Mancipe, Vanessa de Moura Queiroz, Rafael Ferreira Dos Santos, Rosane Nora Castro, Veronica da Silva Cardoso, Alane Beatriz Vermelho, Marcos Lopes Dias, Rossana. Mara da Silva Moreira Thiré

Subject: Chemistry And Materials Science, Biomaterials Keywords: Electrospinning; Nanofibers; Polycaprolactone; Plantago Major L; Drug delivery; Wound dressing

Online: 20 February 2023 (01:32:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0061.v2

Structural Strategies of Supramolecular Hydrogels and Their Applications

José Sánchez-Fernández

Subject: Chemistry And Materials Science, Biomaterials Keywords: Supramolecular hydrogels; hydrogel chemistry; self-healing hydrogels; adhesive hydrogels; conductive hydrogels; clays; 3D structures

Online: 6 February 2023 (10:32:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0058.v1

Porous Thermoplastic Molded Regenerated Silk Crosslinked by the Addition Of Citric Acid

Alessio Bucciarelli, Nicola Vighi, Alessandra Maria Bossi, Brunella Grigolo, Devid Maniglio

Subject: Chemistry And Materials Science, Biomaterials Keywords: Bone Tissue Engineering; Bone Scaffold; Citric Acid; Silk Resin; Compression Molding

Online: 4 January 2023 (03:37:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0332.v1

Effect of Aging of Orthodontic Aligners in Different Storage Media on Force and Torque Generation: An in vitro Study

Tarek Elshazly, Diva Nang, Bijan Golkhani, Hanaa Elattar, Christoph Bourauel

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biomechanics; Orthodontic force; Torque; Tooth Movement; Removable Thermoplastic Appliance; Aging; Aligners

Online: 19 December 2022 (09:10:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0266.v1

Production of Biomodified Bleached Kraft Pulp by Catalytic Conversion Using Penicillium verruculosum Enzymes: Composition, Properties, Structure and Application

Aleksandr R. Shevchenko, Irina V. Tyshkunova, Alexey V. Malkov, Evgeniy A. Toptunov, Vadim D. Telitsin, Alexandra M. Rozhkova, Olga A. Sinitsyna, Iosif V. Gofman, Andrey S. Aksenov

Subject: Chemistry And Materials Science, Biomaterials Keywords: enzymatic hydrolysis; biomodified kraft pulp; cellulose; xylan; cryogel; crystallinity

Online: 15 December 2022 (06:23:58 CET)

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The global development of bioeconomy is impossible without technologies for comprehensive processing of plant renewable resources. The use of proven pretreatment technologies raises the possibility of industrial implementation of enzymatic conversion of polysaccharides from lignocellulose considering the process complexity. For instance, a well-tuned kraft pulping produces a substrate easily degraded by cellulases and hemicelulases. Enzymatic hydrolysis of bleached hardwood kraft pulp was carried out using an enzyme complex of endoglucanases, cellobiohydrolases, b-glucosidases and xylanases produced by recombinant strains of Penicillium verruculosum at a 10 FPU/g mixture rate and a 10 % substrate concentration. As a result of biocatalysis the following products are obtained: sugar solution, mainly glucose, xylobiose, xylose, as well as other minor reducing sugars; modified complex based on cellulose and xylan. The composition of biomodified kraft pulp was determined involving the use of HPLC. The method for determining the degree of crystallinity on an X-ray diffractometer was used to characterize the properties. The article shows the possibility of producing modified cellulose cryogels by amorphization with concentrated 85 % H3PO4 followed by precipitation with water and supercritical drying. Analysis of the enzymatic hydrolysate composition reveals the predominance of glucose (55...67 %) in reducing sugars with a maximum content of up to 6 % in the solution after 72 hours. The properties and structure of modified kraft pulp were shown to change during biocatalysis, in particular, the degree of crystallinity increased by 5 % after 3 hours of enzymatic hydrolysis. We obtained cryogels based on the initial and biomodified kraft pulp with conversion rates of 35, 50 and 70 %. The properties of these cryogels are not inferior to those based on industrial microcrystalline cellulose, as confirmed by the specific surface area, degree of swelling, porosity and SEM images. Thus, kraft pulp enzymatic hydrolysis offers prospects not only for producing sugar-rich hydrolysates for microbiological synthesis, but also for producing cellulose powders and cryogels with specified properties.

Preprint REVIEW | doi:10.20944/preprints202212.0115.v1

Gelatin and Bioactive Glass Composites for Tissue Engineering: A Review

Maria E. V. Barreto, Rebeca P. Medeiros, Adam Shearer, Marcus V. L. Fook, Maziar Montazerian, John C. Mauro

Subject: Chemistry And Materials Science, Biomaterials Keywords: bioactive glass; gelatin; tissue engineering; bone; composite

Online: 7 December 2022 (04:30:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0048.v1

Novel Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review

A. Jorge Guiomar, Ana M. Urbano

Subject: Chemistry And Materials Science, Biomaterials Keywords: poly(hexamethylene biguanide); polyhexamethylene biguanide; polyhexanide; PHMB; membrane; controlled drug release; wound dressing; antimicrobial; cytotoxicity; wound healing

Online: 2 December 2022 (10:31:38 CET)

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The prevalence for chronic, non-healing skin wounds in the general population, most notably diabetic foot ulcers, venous leg ulcers and pressure ulcers, is approximately 2% and is expected to increase, driven mostly by an aging population and the steady rise in obesity and diabetes. Non-healing wounds often become infected, increasing the risk of life-threatening complications, which poses a significant socioeconomic burden. Aiming at an improved management of infected wounds, a variety of wound dressings incorporating antimicrobials (AMDs), namely polyhexanide (poly(hexamethylene biguanide); PHMB), have been introduced in the wound care market. However, many wound care professionals agree that none shows comprehensive and optimal antimicrobial activity. This manuscript summarizes and discusses studies on novel PHMB-releasing membranes (PRMs) for wound dressings, detailing their preparation, physical properties relevant in the context of AMDs, drug loading and release, antibacterial activity, biocompatibility, wound healing capacity, and clinical trials conducted. Some of these PRMs were able to improve wound healing in in vivo models, with no associated cytotoxicity, but significant differences in study design make it difficult to compare overall effi-cacies. It is hoped that this review, which includes, whenever available, international standards for testing AMDs, will provide a framework for future studies.their preparation, physical properties relevant in the context of AMDs, drug loading and release, antibacterial activity, biocompatibility, wound healing capacity, and clinical trials conducted. Some of these PRMs were able to improve wound healing in in vivo models, with no associated cytotoxicity, but significant differences in study design make it difficult to compare overall efficacies. It is hoped that this review, which includes, whenever available, international standards for testing AMDs, will provide a framework for future studies.

Preprint ARTICLE | doi:10.20944/preprints202211.0256.v1

Choline Chloride: Lactic Acid as a Green Solvent for the Extraction of Eugenol, Eugenol Acetate, and β-Caryophyllene of Clove Buds

Petra Strižincová, Igor Šurina, Veronika Majová, Aleš Ház, Katarína Hroboňová

Subject: Chemistry And Materials Science, Biomaterials Keywords: clove buds; choline chloride: lactic acid; extraction; design of experiment; eugenol

Online: 14 November 2022 (11:08:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0191.v1

Stress Relaxation Analysis in Bulk and Porous Ultra-High Molecular Weight Polyethylene (UHMWPE)

Eugene S. Statnik, Alexey I. Salimon, Yulia E. Gorshkova, Natallia S. Kaladzinskaya, Ludmila V. Markova, Alexander M. Korsunsky

Subject: Chemistry And Materials Science, Biomaterials Keywords: UHMWPE; relative density; porosity; stress relaxation; operando analysis; Prony series; X-ray to-mography; Small Angle X-ray Scattering (SAXS); Dyben 1.0 miniature 1 kN universal mechanical testing

Online: 10 November 2022 (05:58:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0092.v1

Physicochemical, Morphological and Cytotoxic properties of Brazilian Jackfruit (Artocarpus Eterophyllus) Starch Scaffold loaded with Silver Nanoparticles

José Filipe Bacalhau Rodrigues, Valeriano Soares Azevedo, Rebeca Peixoto Medeiros, Gislaine Bezerra de Carvalho Barreto, Maria Roberta de Oliveira Pinto, Marcus Vinicius Lia Fook, Maziar Montazerian

Subject: Chemistry And Materials Science, Biomaterials Keywords: Jackfruit; Silver; Nanoparticles; Scaffold; Biomaterials

Online: 4 November 2022 (13:14:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0081.v1

Influence of Reinforcing Efficiency of Clay on the Mechanical Properties of Poly(butylene terephthalate) Nanocomposite

Maria A.S. Colombo, Francisco R.V. Díaz, Deepa Kodali, Vijaya Rangari, Olgun Güven, Esperidiana A.B. Moura

Subject: Chemistry And Materials Science, Biomaterials Keywords: clay; polymer-matrix; nanocomposites; mechanical properties; morphology

Online: 4 November 2022 (01:06:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0069.v1

Cell/Tissue based Reconstituted Lipid Nanoparticles as Versatile Drug Delivery Carrier

Cheng Wang

Subject: Chemistry And Materials Science, Biomaterials Keywords: reconstituted lipid nanoparticles; drug delivery systems; solvent diffusion method

Online: 3 November 2022 (03:57:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0325.v2

Streptavidin-Modified Iron Oxide Hybrid Nanozymes for Magnetic Enrichment and Bioelectrocatalytic Sensing of Circulating Tumor RNA

Kevin M. Koo

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanozymes; circulating tumor nucleci acid; liquid biopsy; magnetic enrichment; minimal residual disease; cell-free RNA

Online: 24 October 2022 (10:33:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0354.v1

Mini-Spidroin Filamentation in Different Methanol Concentration Coagulation Bath

Jie Zhang, Meng xin Gong, Qiu pin Jia, Qing Meng

Subject: Chemistry And Materials Science, Biomaterials Keywords: Spidroin; wet spinning; methanol

Online: 24 October 2022 (07:14:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0325.v1

Streptavidin-Modified Iron Oxide Hybrid Nanozymes for Magnetic Enrichment and Bioelectrocatalytic Sensing of Circulating Tumor RNA

Kevin M. Koo

Subject: Chemistry And Materials Science, Biomaterials Keywords: nanozymes; circulating tumor nucleci acid; liquid biopsy; magnetic enrichment; minimal residual disease; cell-free RNA

Online: 21 October 2022 (09:35:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0471.v1

Manufacturing of Bio–Grease Vegetable Oil from Sugarcane Filter Mud for Lubrication System with Environment Friendly for Friction Reduction

Demeke Girma Wakshume, Venkata Ramayya Ancha, Johnson Santhosh

Subject: Chemistry And Materials Science, Biomaterials Keywords: biodegradable lubricating grease; friction; energy; penetration; sugar cane filter cake mud oil; temperature and wear

Online: 30 September 2022 (02:28:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0365.v1

Pineapple Agro-Industrial Biomass to Produce Biomedical Applications in a Circular Economy Context in Costa Rica

Valeria Amores-Monge, Silvia Goyanes, Laura Ribba, Mary Lopretti, Manuel Sandoval-Barrantes, Melissa Camacho, Yendry Corrales-Ureña, José Roberto Vega-Baudrit

Subject: Chemistry And Materials Science, Biomaterials Keywords: pineapple; wastes; biorefinery; COVID-19; circular economy; biomedical.

Online: 23 September 2022 (09:22:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0356.v1

Influence of Molecular Weight and Grafting Density of PEG on the Surface Properties of Polyurethanes and Their Effect on the Viability and Morphology of Fibroblasts and Osteoblasts

Antonio David Abreu Rejón, Wilberth Antonio Herrera Kao, Alejandro May Pat, Alejandro Ávila Ortega, Nayeli Rodríguez Fuentes, Jorge Alonso Uribe Calderón, José Manuel Cervantes Uc

Subject: Chemistry And Materials Science, Biomaterials Keywords: PEG; viability; osteoblasts; fibroblasts; pH; polyurethane; polyethylene glycol

Online: 23 September 2022 (03:52:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0352.v1

TEGDMA-Functionalized Dicalcium Phosphate Dihydrate Resin-Based Composites Prevent Secondary Caries in An In-Vitro Biofilm Model

Andrei Cristian Ionescu, Sebastian Hahnel, Marina D.S. Chiari, Andreas König, Paolo Delvecchio, Roberto Ruggiero Braga, Vanessa Zambelli, Eugenio Brambilla

Subject: Chemistry And Materials Science, Biomaterials Keywords: bioreactor; secondary caries; caries model; DCPD; micro-CT

Online: 23 September 2022 (03:00:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0222.v1

All-Polymeric Electrode based on PEDOT:PSS for In-Vivo Neural Recording

Gilberto Martins Filho, Cláudio José Mendes Júnior, Bruno Guedes Spinelli, Igor Zumba Damasceno, Felipe Porto Fiuza, Edgard Morya

Subject: Chemistry And Materials Science, Biomaterials Keywords: PEDOT:PSS; Neural recording; Immune response; BMI

Online: 15 September 2022 (08:04:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0144.v1

Short Silk Fiber Reinforced PETG Biocomposite for Biomedical Applications

Vijayasankar K. N., Sumanta Mukherjee, Falguni Pati

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biocomposites (A); Natural fibres (A); Thermomechanical properties (B); Annealing (E); Biocompatibility

Online: 12 September 2022 (09:58:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0128.v1

Development and Characterization of Garlic Loaded Chitosan and Chondroitin Sulfate Based Hydrogels for potential Wound Healing/Skin Regeneration Applications

Fatima Masood, Muhammad Atif Makhdoom, Iftikhar Ahmed Channa, Sadaf Jamal Gilani, Ahmad Khan, Rabia Hussain, Syeda Ammara Batool, Kiran Konain, Saeed Ur Rahman, Abdul Wadood, May Nasser Bin-Jumah, Muhammad Atiq ur Rehman

Subject: Chemistry And Materials Science, Biomaterials Keywords: Hydrogels; polymers; regeneration; antibacterial; drug release; garlic; alicin

Online: 9 September 2022 (03:56:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0534.v1

A Novel Piggyback Strategy for mRNA Delivery Exploiting Adenovirus Entry Biology

Myungeun Lee, Paul J. Rice-Boucher, Logan Thrasher Collins, Ernst Wagner, Lorenzo Aulisa, Jeffrey Hughes, David T Curiel

Subject: Chemistry And Materials Science, Biomaterials Keywords: Targeted Adenoviral Vectors (Ad), Streptavidin-Polylysine (STAVpLys), messenger Ribonucleic Acid (mRNA)

Online: 31 August 2022 (05:08:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0066.v1

pH-Sensitive Polyacrylic Acid-Gated Mesoporous Silica Nanocarrier Incorporated with Calcium Ions for Controlled Drug Release

Jungwon Kong, Sung Soo Park, Chang-Sik Ha

Subject: Chemistry And Materials Science, Biomaterials Keywords: Mesoporous silica; Polyacrylic acid; Calcium ion; 5-Fluorouracil; Drug delivery

Online: 2 August 2022 (12:15:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0203.v1

Optimization of Lignin-Nanofiber-Filled Thermoplastic Starch Composite Film Production for Potential Application in Food Packaging

Tawakaltu AbdulRasheed-Adeleke, Evans Chidi Egwim, Ayo Samuel Afolabi, Emmanuel Rotimi Sadiku, Stephen S Ochigbo

Subject: Chemistry And Materials Science, Biomaterials Keywords: lignin; nanocomposite; nanofiber; optimization; percent elongation; starch; tensile strength; Young’s modulus

Online: 14 July 2022 (03:50:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0073.v1

Biocompatibility of Ceramic Materials in CaO-P2O5 System, Obtained via Heat Treatment of Cement-Salt Stone

Otabek Toshev, Tatiana Safronova, Maksim Kaimonov, Tatiana Shatalova, Elena Klimashina, Yulia Lukina, Konstantin Malyutin

Subject: Chemistry And Materials Science, Biomaterials Keywords: calcium pyrophosphate; calcium polyphosphate; biocompatibility; bone implants; regenerative medicine

Online: 5 July 2022 (13:13:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0023.v1

Nanostructured Electrospun Polycaprolactone - Propolis Films Composed of Different Morphologies for Potential Use in Wound Healing

Agnes Chacor De Figueiredo, Javier Mauricio Anaya Mancipe, Aline Oliveira da Silva De Barros, Ralph Santos-Oliveira, Marcos Lopes Dias, Rossana Mara da Silva Moreira Thiré

Subject: Chemistry And Materials Science, Biomaterials Keywords: electrospinning; morphology structures; propolis; polycaprolactone; drug delivery

Online: 1 July 2022 (17:39:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0013.v1

Inorganic Powders Prepared from Fish Scales

Tatiana V. Safronova, Viktor I. Vorobyov, Natalia R. Kildeeva, Tatiana B. Shatalova, Otabek U. Toshev, Yaroslav Yu. Filippov, Artem O. Dmitrienko, Olga Т. Gavlina, Olga P. Chernega, Elena V. Nizhnikova, Marat M. Akhmedov, Konstantin A. Lysenko

Subject: Chemistry And Materials Science, Biomaterials Keywords: fish scale powder; high-speed grinding; heat treatment; hydroxyapatite; magnesium whitlockite; nanosized grain

Online: 1 July 2022 (10:05:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0338.v1

Is Wood a Material?

Stephen M. Walley, Samuel J. Rogers

Subject: Chemistry And Materials Science, Biomaterials Keywords: wood; size effect; Weibull; weakest link; strength; timber; lumber

Online: 24 June 2022 (10:41:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0183.v1

Explore Novel Biomarkers and Associated Key Pathways to Perform as Potential Prognostic Biomarkers and Therapeutic Targets in Oral Cancer

Fatema Akhter, Fawzia Haif Al Kahtani, Zainah Mohammed Sambawa, Deema Abdulrahman Alhassan, Reema Abdulaziz AlSaif, Tahsinul Haque, Mohammad Khursheed Alam, Md. Tanvir Hasan, Md. Rakibul Islam, Kawsar Ahmed, Rehana Basri

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biomarkers; Drug Signature Identification; Key pathways; Oral Cancer; Oral Squamous Cell Carcinoma

Online: 13 June 2022 (10:14:58 CEST)

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Background: Oral cancer (OC) is serious health concerning issue that has a high fatality rate. The oral cavity has seven kinds of OC, including the lip, tongue, and floor of the mouth, as well as the buccal, hard palate, alveolar, retromolar trigone, and soft palate. The goal of this study is to look into new biomarkers and important pathways that might be used as diagnostic biomarkers and therapeutic candidates in OC. Methods: Publicly available repository the Gene Expression Omnibus (GEO) was responsible to collect OC-related datasets. GSE74530, GSE23558, and GSE3524 microarray datasets were collected to apply analysis. Minimum cut-off criteria of |log fold-change (FC)| > 1 and adjusted p < 0.05 were applied to figure out the up-regulated and down-regulated differential expression genes (DEGs) from the three datasets. After that only common DEGs in all three datasets were collected to apply further analysis. Gene ontology (GO) and Pathway analysis were implemented to explore the functional behaviors of DEGs. Then protein-protein interaction (PPI) networks were built to identify the most performed genes, clustering algorithm was also implemented to identify complex parts of PPI. TF-miRNA networks were also constructed to study deeply about OC-associated DEGs. Finally, top gene performers from PPI networks were used to apply drug signature analysis. Results: After applying filtration and cut-off criteria 2508, 3377, and 670 DEGs were found for GSE74530, GSE23558, and GSE3524 respectively, and 166 common DEGs were found in every dataset. The GO annotation remarks that most of the DEGs were associated with the terms of type I interferon signaling pathway. The pathways of KEGG reported that the common DEGs are related to the Cell cycle and Influenza A. The PPI network holds 88 nodes and 492 edges and CDC6 had the highest number of connections. 4 clusters were identified from the PPI. Drug signatures doxorubicin and resveratrol showed high significance according to the hub genes. We anticipate that our bioinformatics research will aid in the definition of the pathophysiology and the development of new therapies for OC.

Preprint ARTICLE | doi:10.20944/preprints202205.0396.v1

Customizable Collagen Vitrigel Scaffolds and Preliminary Results in Corneal Engineering

María Dolores Montalvo-Parra, Wendy Ortega-Lara, Denise Loya-García, Andres Bustamante-Arias, Guillermo Isaac Guerrero-Ramírez, César E. Calzada-Rodríguez, Guiomar Farid Torres-Guerrero, Bestabé Hernández-Sedas, Italia Tatnaí Cárdenas-Rodríguez, Sergio E. Guevara-Quintanilla, Marcelo Salán-Flores, Miguel Angel Hernández-Delgado, Salvador Garza-González, Mayra G Gamboa-Quintanilla, Luis Guillermo Villagómez-Valdez, Judith Zavala, Jorge Eugenio Valdez-García

Subject: Chemistry And Materials Science, Biomaterials Keywords: scaffold; collagen vitrigel; tissue engineering; cornea; corneal endothelium

Online: 30 May 2022 (11:25:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0348.v1

Influence of the Surface Chemistry Differences between Zirconia and Titanium with the Same Surface Topographies on Bone Formation

Yoshiki Tokunaga, Masatsugu Hirota, Tohru Hayakawa

Subject: Chemistry And Materials Science, Biomaterials Keywords: zirconia; molecular precursor method; dental-implant; osseointegration; bone-to-implant contact

Online: 25 May 2022 (10:10:35 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202205.0159.v1

Characterization and In Vivo Toxicity Assay of Uncoated Silicon Nanoparticles

Konstantin V. Zolotarev, Anton N. Mikhailov, Valeriya I. Nakhod, Maxim A. Sanzhakov, Elena G. Tikhonova, Marina V. Mikhailova

Subject: Chemistry And Materials Science, Biomaterials Keywords: uncoated silicon nanoparticles; aggregation; in vivo toxicity; LC50 for Danio rerio larvae

Online: 12 May 2022 (07:39:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0284.v1

Production of Various Monomer-Ratio Biodegradable Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Films for Wide Range of Applications

Aneta Pospíšilová, Juraj Vodicka, Monika Trudicova, Zuzana Juglova, Jiri Smilek, Přemysl Menčík, Jiří Másilko, Eva Slaninova, Veronika Melčová, Michal Kalina, Stanislav Obruča, Petr Sedlacek

Subject: Chemistry And Materials Science, Biomaterials Keywords: Polyhydroxyalkanoates (PHA); P(3HB-co-4HB); Aneurinibacillus sp. H1; mechanical properties; surface morphology; crystallinity; active ingredients release

Online: 28 April 2022 (10:56:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0259.v1

Degradation of P(3HB-co-4HB) films in Simulated Body Fluids

Juraj Vodicka, Monika Wikarska, Monika Trudicova, Zuzana Junglova, Aneta Pospisilova, Michal Kalina, Eva Slaninova, Stanislav Obruca, Petr Sedlacek

Subject: Chemistry And Materials Science, Biomaterials Keywords: Polyhydroxyalkanoates (PHA); Aneurinibacillus sp. H1; PHA copolymers; biodegradation; simulated body fluids

Online: 27 April 2022 (10:45:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0192.v1

Pineapple Agro-Industrial Wastes to Produce Biomedical Applications Post-COVID-19 Pandemic: Biorefinery and the Circular Economy

Valeria Amores-Monge, Silvia Goyanes, Laura Ribba, Mary Lopretti, Manuel Sandoval-Barrantes, Melissa Camacho, Yendry Corrales-Ureña, José Roberto Vega-Baudrit

Subject: Chemistry And Materials Science, Biomaterials Keywords: pineapple; wastes; biorefinery; COVID-19; circular economy; biomedical

Online: 21 April 2022 (07:54:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0026.v2

Elastomer-Hydrogel Systems: From Bio-Inspired Interfaces to Medical Applications

Miroslawa El Fray, Gokhan Demirci, Malwina Niedźwiedź, Nina Kantor-Malujdy

Subject: Chemistry And Materials Science, Biomaterials Keywords: elastomers; hydrogels; elastomer-hydrogel systems; injectable biomaterials; adhesive surfaces; tissue engineering

Online: 20 April 2022 (11:39:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0148.v1

Nanofiber Cellulose Grafted with Lauric Acid as a New Phase Change Material (PCM) used in Buildings for Thermal Energy Storage

Soumaya Zormati, Fadhel Aloulou, Habib Sammouda

Subject: Chemistry And Materials Science, Biomaterials Keywords: Cellulose Nanofiber; Organoclay; PCM; Thermal Energy Storage; Building; Composite materials

Online: 15 April 2022 (14:55:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0142.v1

A Review on the Recent Advancements on Therapeutic Effects of Metallic Ions in the Physiological Environments

Muhammad Awais, Aqsa Aziz, Arooba Nazneen, Qurat ul Ain Bhatti, Abdul Wadood, Muhammad Atiq Ur Rehman

Subject: Chemistry And Materials Science, Biomaterials Keywords: metallic ions; biomedical; antibacterial; osteoporosis; therapeutic

Online: 15 April 2022 (10:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0049.v1

Immobilization and Characterization of L-Asparaginase over Carbon Xerogels

Rita A.M. Barros, Raquel O. Cristóvão, Sónia A.C. Carabineiro, Márcia C. Neves, Mara G. Freire, Joaquim L. Faria, Valéria C. Santos-Ebinuma, Ana P.M. Tavares, Cláudia G. Silva

Subject: Chemistry And Materials Science, Biomaterials Keywords: L-asparaginase; Enzyme immobilization; Carbon xerogels; Physical adsorption; Central Composite Design

Online: 6 April 2022 (13:49:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0041.v1

Magnetoliposomes Containing Multicore Nanoparticles and a New Thienopyridine Antitumor Compound for Chemo/Thermotherapy

Fábio A. C. Lopes, André V. F. Fernandes, Juliana M. Rodrigues, Maria-João R. P. Queiroz, Bernardo G. Almeida, Ana Pires, André M. Pereira, João P. Araújo, Ana Rita O. Rodrigues, Elisabete M. S. Castanheira, Paulo J. G. Coutinho

Subject: Chemistry And Materials Science, Biomaterials Keywords: multicore magnetic nanoparticles; magnetoliposomes; magnetic hyperthermia; antitumor thienopyridine derivative; chemotherapy

Online: 6 April 2022 (10:27:22 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202203.0035.v1

Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses such as SARS-CoV-2

Alba Cano-Vicent, Rina Hashimoto, Kazuo Takayama, Ángel Serrano-Aroca

Subject: Chemistry And Materials Science, Biomaterials Keywords: calcium alginate; SARS-CoV-2; bacteriophage; phi 6; biomaterials; films; hydrogels

Online: 2 March 2022 (07:17:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0290.v1

Bioceramics Based on Calcium Pyrophosphate

Tatiana V. Safronova, Andrey S. Kiselev, Irina I. Selezneva, Tatiana B. Shatalova, Yulia S. Lukina, Yaroslav Yu Filippov, Otabek U. Toshev, Snezhana A. Tikhonova, Olga S. Antonova, Alexander V. Knotko

Subject: Chemistry And Materials Science, Biomaterials Keywords: calcium lactate pentahydrate; monocalcium phosphate monohydrate; mechanical activation; powder; brushite; monetite; calcium pyrophosphate; ceramics; biocompatibility

Online: 23 February 2022 (12:07:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0262.v1

Hydrophilic CO-releasing material of PEGlyated Ruthenium Carbonyl Complex

Xiao Zhang, Nan Guo, Shuhong Yang, Huma Khan, Weiqiang Zhang

Subject: Chemistry And Materials Science, Biomaterials Keywords: Ruthenium complex; Carbon monoxide releasing molecule; Hydrophilicity, PEGylation

Online: 22 February 2022 (03:38:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0244.v1

A Comparative Evaluation of Combustion Characteristics of Araucaria Cunninghamii, Intsia Bijuga and Pometia Pinnata for Bio-Energy Source

Benson K. Gusamo, Koniel A. Towalis

Subject: Chemistry And Materials Science, Biomaterials Keywords: wood combustion; sawdust pellets; solid woods; heat calorific value; ash content; bio-energy; Papua New Guinea

Online: 21 February 2022 (03:23:34 CET)

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Burning woody biomass for energy is gaining attention due to environmental issues associated with fossil fuels and carbon emission. The carbon released from burning wood is absorbed by plants and is carbon neutral. The purpose of this study was to investigate the combustion characteristics (heat calorific values and ash contents) of three timbers: Araucaria cunninghamii, Instia bijuga and Pometia pinnata and recommend for fuelwood. The test samples were sawdust particles (treatment) and solid woods (control) extracted from the heartwoods. The sawdust particles were oven-dried, sieved and pelletized into pellets using a hand-held pelletizing device, thus, forming cylindrical dimension (volume 1178.57 mm3, oven dry density 0.0008 g/mm3). While the solid woods were cubed and oven-dried (volume 1000.00 mm3, oven dry density 0.001 g/mm3). Prior to combustion in a semi-automatic bomb calorimeter, 90 test specimens (15 replicates per treatment and control per species) were conditioned to 14 % moisture content (at temperature 105 ºC) and weighed to a constant (unit) mass (1.0 g). The heat energy outputs and ash residues (of treatments) were analyzed statistically. The results indicated variability in heat energy outputs and ash residues between test specimens of the three species. Comparatively, the treatment specimens of A. cunninghamii produced higher calorific value (18.546 kJ/g) than the control (18.376 kJ/g) whilst the treatment specimens of I. bijuga and P. pinnata generated lower heat calorific values (17.124 kJ/g and 18.822 kJ/g) than the control (18.415 kJ/g and 20.659 kJ/g), respectively. According to ash content analysis, A. cunninghamii generated higher residues (6.3%) followed by P. pinnata (4.5%) and I. bijuga (2.8%). The treatment specimens of the three species could not meet the standard heat energy requirement (20.0 kJ/g) and thus, were unsuitable for fuelwood. However, the control specimens of P. pinnata generated equivalent heat energy (20.659 kJ/g) and could be a potential fuelwood.

Preprint ARTICLE | doi:10.20944/preprints202202.0039.v1

Powder Mixture for the Production of Microporous Ceramics Based on Hydroxyapatite

Tatiana V. Safronova, Stepan Chichulin, Tatiana B. Shatalova, Yaroslav Yu. Filippov

Subject: Chemistry And Materials Science, Biomaterials Keywords: hydroxyapatite; oxalic acid; powder, whewellite, weddellite, calcium oxalate monohydrate, brushite, calcium hydrophosphate dihydrate, heterophase reaction, ceramics, microporosity

Online: 2 February 2022 (15:45:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0135.v1

Recent Advances in Wearable Optical Sensors Automation Powered by Battery Versus Skin-Like Battery-Free Devices for Personal Healthcare - A Review

Nikolay L Kazanskiy, Muhammad A Butt, Svetlana N Khonina

Subject: Chemistry And Materials Science, Biomaterials Keywords: Wearable sensors; skin-like; heart rate monitoring; continuous glucose monitoring; battery-free sensors

Online: 11 January 2022 (12:18:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0081.v1

Recrystallization of Triple Superphosphate Produced From Oyster Shell Waste for Agronomic Performance and Environmental Issue

Somkiat Seesanong, Chaowared Seangarun, Banjong Boonchom, Chuchai Sronsri, Nongnuch Laohavisuti, Kittichai Chaiseeda, Wimonmat Boonmee

Subject: Chemistry And Materials Science, Biomaterials Keywords: Ca(H2PO4)2·H2O; Triple superphosphate; Fertilizer; Recrystallization; Oyster shell; Thermal decomposition

Online: 6 January 2022 (11:48:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0035.v1

A Review on Cellulose-based Materials for Biomedicine

Hani Nasser Abdelhamid, Aji P. Mathew

Subject: Chemistry And Materials Science, Biomaterials Keywords: Cellulose; Biomedical; Wound healing; Drug delivery; Antibacterials; Tissue engineering

Online: 5 January 2022 (11:00:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0233.v1

Up-Conversion Nanomaterial Doped With Au Nanoparticles With Photothermal Conversion for Multi-Modality Imaging

Wei Zhang, Yanli Lu, Yang Zang, Qingyun Xiong, Jinping Xiong

Subject: Chemistry And Materials Science, Biomaterials Keywords: up-conversion; nanomaterials; photothermal conversion; multi-modality imaging

Online: 14 December 2021 (12:15:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0178.v1

Chitosan/alginate Hydrogel Dressing Loaded FGF/VE-cadherin: To Accelerate Full-thickness Skin Regeneration and More Normal Skin Repairs

Lai Wei, Jianying Tan, Li Li, Sainan Liu, Huanran Wang, Junying Chen, Yajun Weng, Tao Liu

Subject: Chemistry And Materials Science, Biomaterials Keywords: hydrogel dressing; full-thickness skin regeneration; 3D cell culture; VE-cadherin; FGF

Online: 10 December 2021 (13:10:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0566.v2

Degradation Analysis of Thin Mg-xAg Wires Using X-Ray Near-Field Holotomography

Sebastian Meyer, Andreas Wolf, Daniela Sanders, Kamila Iskhakova, Hanna Ćwieka, Stefan Bruns, Silja Flenner, Imke Greving, Johannes Hagemann, Regine Willumeit-Römer, Björn Wiese, Berit Zeller-Plumhoff

Subject: Chemistry And Materials Science, Biomaterials Keywords: X-ray computed tomography; magnesium-silver alloy; wire; degradation; near-field holotomography

Online: 8 December 2021 (14:26:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0486.v1

Pectin: New Science and Forthcoming Applications of the Most Valued Hydrocolloid

Rosaria Ciriminna, Alexandra Fidalgo, Antonino Scurria, Laura Ilharco, Mario Pagliaro

Subject: Chemistry And Materials Science, Biomaterials Keywords: Pectin; Food hydrocolloid; Green extraction; Heteropolysaccharide; Citrus; Bioeconomy

Online: 25 November 2021 (16:09:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0456.v1

SiO2 Coated Up-conversion Nanomaterial Doped with Ag Nanoparticles for Micro-CT Imaging

Wei Zhang, Yanli Lu, YANG ZANG, Jinhui Han, Qingyun Xiong, Jinping Xiong

Subject: Chemistry And Materials Science, Biomaterials Keywords: up-conversion; nanomaterials; CT imaging

Online: 24 November 2021 (13:04:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0389.v1

Emerging Fabrication Techniques for Engineering Extracellular Matrix Biomimetic Materials

Samuel Ogbeide Ebhodaghe, Farnaz Sadat Fattahi, Henry Ndibe, Ojeaga Evans Imanah

Subject: Chemistry And Materials Science, Biomaterials Keywords: 3D Bioprinting; Extracellular Matrix; Extrusion; Biomaterials; Tissue Engineering

Online: 22 November 2021 (12:26:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0360.v1

3D Printed SiOC(N) Ceramic Scaffolds for Bone Tissue Regeneration: Improved Osteogenic Differentiation of Human Bone Marrow‐Derived Mesenchymal Stem Cells

Yuejiao Yang, Apoorv Kulkarni, Gian Domenico Soraru, Joshua M Pearce, Antonella Motta

Subject: Chemistry And Materials Science, Biomaterials Keywords: 3D printing; polymer derived ceramics; osteogenic differentiation; human mesenchymal stem cells; Fused Filament Fabrication; SiOC(N); cellular structure; scaffolds; Bone regeneration

Online: 19 November 2021 (14:33:05 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202111.0294.v1

Flexible, Biocompatible PET Sheets: a Platform for Attachment, Proliferation and Differentiation of Eukaryotic Cells

Soumen Samanta, Diana Gaad, Eva Cabet, Alain Lilienbaum, Ajay Singh, Dinesh Kumar Aswal, Mohamed Chehimi

Subject: Chemistry And Materials Science, Biomaterials Keywords: Flexible materials; diazonium salts; surface modification; biocompatible polymers; adhesive; adhesion; eukaryotic cells; muscle fibers

Online: 16 November 2021 (14:36:25 CET)

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Chemistry and Materials Science