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Preprint ARTICLE | doi:10.20944/preprints201709.0143.v1

A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of a Reciprocal Activation System Based on a Single Chain Urokinase-Type Plasminogen Activator and Plasminogen

Guo Ruihua, Duan Dong, Shaotong Hong, Yu Zhou, Fang Wang , Shujun Wang, Wenhui Wu, Bin Bao

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: fibrinolytic acticity; FGFC1; plasminogen activator; plasminogen; enzymatic kinetic

Online: 28 September 2017 (09:17:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0611.v1

Doxycycline and Minocycline act as Positive Allosteric Modulators of the PAC1 Receptor and Induce Plasminogen Activators in RT4 Schwann Cells

Sarah Thomas Broome, Giuseppe Musumeci, Alessandro Castorina

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pituitary adenylate cyclase-activating peptide (PACAP); PAC1 receptor; doxycycline; minocycline; positive allosteric modulator; Schwann cells; tissue plasminogen activator (tPA); urokinase plasminogen activator (uPA)

Online: 27 July 2021 (21:51:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0293.v1

Safety and Efficacy of Adjunctive Catheter-Directed Thrombolysis During Primary PCI for ST-segment Elevation Myocardial Infarction With High Thrombus Burden

Satsuki Noma, Hideki Miyachi, Isamu Fukuizumi, Junya Matsuda, Hideto Sangen, Yoshiaki Kubota, Yoichi Imori, Yoshiyuki Saiki, Yusuke Hosokawa, Shuhei Tara, Yukichi Tokita, Koichi Akutsu, Wataru Shimizu, Takeshi Yamamoto, Hitoshi Takano

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: high coronary thrombus burden; tissue plasminogen activator; catheter-directed thrombolysis

Online: 20 October 2021 (12:53:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0048.v1

Clinical Risk Factors that Predict Functional Recovery in Ischemic Stroke Patients with Pre-Stroke Depression

Leah Wormack, Brice Blum, Benjamin Bailes, Thomas Nathaniel

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Ambulation, Ischemic stroke, pre-stroke depression, recombinant tissue plasminogen activator (rtPA)

Online: 6 June 2019 (10:37:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0994.v1

The Curious Role of PAI‐1 in Severe OSA

Tea Friščić, Edvard Galić, Domagoj Vidović, Petrana Brečić, Igor Alfirević

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: plasminogen activator inhibitor-1; obstructive sleep apnea; continuous positive airway pressure; atherogenesis; fibrinolytic capacity

Online: 16 April 2024 (07:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1086.v2

A High-Throughput Small-Angle X-ray Scattering Assay to Determine the Conformational Change of Plasminogen

Adam J Quek, Nathan P Cowieson, Tom T Caradoc-Davies, Paul J Conroy, James C Whisstock, Ruby HP Law

Subject: Biology And Life Sciences, Biophysics Keywords: SAXS; conformational change; plasminogen; fibrinolysis; structure-function; lysine binding site; lysine analogue; kringle domain

Online: 23 August 2023 (09:57:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1455.v1

Nebulized recombinant tissue plasminogen activator (rt-PA) for acute COVID-19-induced severe respiratory failure: an exploratory proof of concept trial

Pratima Chowdary, Banwari Agarwal, Maria Rita Peralta, Sanjay Bhagani, Simon Lee, James Goldring, Marc Lipman, Emal Waqif, Mark Phillips, Helen Philippou, Jonathan H Foley, Nicola J Mutch, Robert Ariens, Kathleen A Stringer, Federico Ricciardi, Marie Watissée, Derralynn Hughes, Amit Nathwani, Anne Riddell, David Patch, Jim Buckley, Mark De Neef, Rahul Dimber, Cecilia Diaz-Garcia, Honey Patel, Aarti Nandani, Upuli Dissanayake, Nick Chadwick, Ahmed Alkhatip, Peter Watkinson, Eamon Raith, Suveer Singh, Tony Wolff, Rajeev Jha, Simon E Brill, Ameet Bakhai, Alison Evans, Farhat Gilani, Keith Gomez

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Acute respiratory illness; critical care; recombinant tissue plasminogen activator; nebulization, fibrinolytics, COVID-19 pandemic, inhaled medication, targeted therapy

Online: 20 June 2023 (14:59:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0382.v1

New Immunohistochemical Markers for Pleural Mesothelioma Subtyping

Iosè Di Stefano, Greta Alì, Anello Marcello Poma, Rossella Bruno, Agnese Proietti, Cristina Niccoli, Carmelina Cristina Zirafa, Franca Melfi, Maria Giovanna Mastromarino, Marco Lucchi, Gabriella Fontanini

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: pleural mesothelioma; subtypes; immunohistochemistry; Mesothelin; Claudin-15; Complement Factor B (CFB); Plasminogen Activator Inhibitor 1 (PAI1); p21-activated kinase 4 (PAK4).

Online: 4 August 2023 (12:34:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0463.v1

Molecular Docking, Computational and Antithrombotic Studies of Novel 1,3,4-oxadiazole Derivatives

Majda Batool, Affifa Tajammal, Firdous Farhat, Francis Verpoort, Zafar A. K. Khattak, Mehr-un- Nisa, Muhammad Shahid, Hafiz Adnan Ahmed, Munawar Ali Munawar, Muhammad Zia ur. Rahman, Muhammad Asim Raza Basra

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Factor Xa ( F-Xa), Cardiovascular diseases (CD), Coronary heart disease (CHD), Tissue plasminogen activator (t-PA), Urokinase (UK), Streptokinase (SK), N,N-Dimethyl formamide (DMF)

Online: 27 August 2018 (14:54:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0165.v1

The Importance and Effectiveness of Carotid Endarterectomy in Ischaemic Stroke or TIA with Significant Carotid Stenosis

Muhammad Shohel Almamun, Mobashshereen Khan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco encephalopathy (CADASIL); Carotid Endarterectomy (CEA); Modified Rankin Scale (MRS); Computed Tomography(CT); Tissue plasminogen activator (tPA); Diffusion weighted Imaging (DWI); Recognition of Stroke in the Emergency Room (ROSIER) scale; Magnetic resonance Imaging (MRI); Internal Carotid Artery (ICA)

Online: 26 February 2018 (11:46:47 CET)

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