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Preprint ARTICLE | doi:10.20944/preprints202401.0409.v1

The Biochemical Composition and Quality of Adult Chinese Mitten Crab Eriocheir sinensis Reared in Carbonate Alkalinity Water

Shihui Wang, Liang Luo, Rui Zhang, Kun Guo, Zhigang Zhao

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Eriocheir sinensis; saline-alkaline; aquaculture; edible yield; mineral element

Online: 4 January 2024 (11:16:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1534.v1

Summary of Document Image Binarization

Zhengxian Yang, Rui Zhang, Yanxi Zhou, Jinlong He, Jianwen Shi, Shikai Zuo

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: degraded document images; binarization; threshold processing; deep learning

Online: 22 January 2024 (04:32:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1359.v1

Multiscale spatiotemporal variations of GNSS-derived precipitable water vapor over Yunnan

Minghua Wang, Zhuochen Lv, Weiwei Wu, Du Li, Rui Zhang, Chengzhi Sun

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Global Navigation Satellite System; Precipitable Water Vapor; Secular Trend; Annual Cycle; Diurnal Variation; Radiosonde

Online: 19 December 2023 (09:33:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0377.v1

3D Printed Tooth Model with Root Canal Ledge: A Novel Educational Tool for Endodontic Training

Rui Zhang, Renjie Tang, Sebastian Spintzyk, Yuting Tian, Yong Xiang, Yichen Xu, Tao Hu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: 3D printing; additive manufacturing; dental education; educational models; root canal therapy; ledge; endodontics

Online: 4 August 2023 (08:23:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1403.v1

Oilfield Reservoir Parameter Inversion Based on Ground Deformation 2D Measurements Acquired by Msbas Time Series InSAR Method

Anmengyun Liu, Rui Zhang, Yunjie Yang, Tianyu Wang, Ting Wang, Age Shama, Runqing Zhan, Xin Bao

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: oilfield deformation; MSBAS-InSAR; the Qaidam Basin; geophysical models

Online: 22 November 2023 (07:32:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0134.v2

Same Brain, Different Look? – the Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters

Ronja Thieleking, Rui Zhang, Maria Paerisch, Kerstin Wirkner, Alfred Anwander, Frauke Beyer, Arno Villringer, A. Veronica Witte

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Diffusion Magnetic Resonance Imaging; White Matter; Fractional anisotropy; Multi-centre; Reproducibility; Imaging artefacts; Ageing

Online: 6 September 2021 (13:20:18 CEST)

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Working Paper ARTICLE

Chromosome-Level Genome Assembly of The Humpback Puffer, Tetraodon palembangensis

Rui Zhang, Chang Li, Mengjun Yu, Xiaoyun Huang, Mengqi Zhang, Shanshan Liu, Shanshan Pan, Weizhen Xue, Congyan Wang, Chunyan Mao, He Zhang, Guangyi Fan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tetraodon palembangensis; chromosome-level genome; genomic annotation; gene family

Online: 31 August 2020 (04:28:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0631.v1

Text-to-Image Segmentation with Open-Vocabulary and Multitasking

Lihu Pan, Yunting Yang, Zhengkui Wang, Rui Zhang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: image segmentation; open vocabulary; multitask; multi-modal interaction

Online: 9 April 2024 (11:43:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201812.0156.v1

The Report of Marine Life Genomic Research

Guangyi Fan, Jianwei Chen, Tao Jin, Chengcheng Shi, Xiao Du, He Zhang, Yaolei Zhang, Hanbo Li, Ting Luo, Pengxu Yan, Guang Liu, Xiangqun Chi, Xiaoxuan Tan, Liangwei Li, Guilin Liu, Xiaochuan Liu, Shijie Hao, Kai Han, Xiaoyun Huang, Shuai Sun, Jing Zhou, Mengjun Yu, Lingfeng Meng, Yue Chang, Rui Zhang, Kaiqiang Liu, Mengqi Zhang, Yong Zhao, Chang Li, Jiao Guo, Xinyu Guo, Jiahao Wang, Meiqi Lv, Haoyang Gao, Yujie Liu, Yue Song, Shengjun Wang, Yang Deng, Binjie Ouyang, Jinzhong Lin, Yingjia Yu, lynn Fink, Xianwei Yang, Xun Xu, Xin Liu

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Marine microorganisms, marine fungi, algae, marine plants, marine invertebrates, marine vertebrates, genome, metagenome

Online: 12 December 2018 (15:44:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1623.v1

Increasing Endoglin Deletion in Endothelial Cells Exacerbates the Severity of Brain Arteriovenous Malformation in Mouse

zahra Sshabani, Leandro Barbosa Do Prado, Rui Zhang, Wan Zhu, Sonali S Shaligram, Alka Yadav, Calvin Wang, hua su

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Arteriovenous malformations; Endothelial cells; Endoglin; Hereditary Hemorrhagic Telangiectasia

Online: 24 June 2024 (11:05:52 CEST)

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Abstract: Endoglin (ENG) is a causative gene of type 1 hereditary hemorrhagic telangiectasia (HHT1). HHT1 patients have arteriovenous malformations (AVMs) in multiple organs, including the brain. In mice, Eng deletion induced by R26RCreER or SM22aCre leads to AVM development in the brain and other organs. We have reported that the severity of brain AVM in mice with activin receptor-like kinase 1 (Alk1, an HHT2 causative gene) mutation is correlated with the number of Alk1 negative endothelial cells (ECs). We hypothesized that increase of Engnegative ECs will enhance AVM severity. To increase EC Eng deletion, we used a codon improved cre (icre), which is more potent in recombination of floxed alleles than the wild type (WT) cre. R26RCreER;Eng^f/f mice that have Rosa promoter driving and tamoxifen (TM) inducible WT cre expression globally and PdgfbiCreER;Eng^f/f that have Pdgfb promoter driving and TM inducible icre expression in ECs were treated with 3 intra-peritoneal injections of TM (2.5 mg/25g of body weight) to delete Eng globally or in the ECs. AAV-VEGF was stereotactically injected into the brain to induce brain focal angiogenesis and brain AVM. We found that iCre caused more Eng deletion in the brain indicated by lower level of Eng proteins (p<0.001) and fewer Eng positive ECs (p=0.01) than mice with WT cre. Mice with iCre mediated Eng deletion have more abnormal vessels (p=0.02), CD68⁺ macrophages (p=0.002), and hemorrhage (p=0.04), and less vascular pericyte and smooth muscle coverage than mice with WT cre. In addition, arteriovenous shunts were detected in the intestines of icre mice, a phenotype that have not been detected in WT cre mice before. RNAseq analysis showed that 8 out of the 10 top upregulated pathways identified by Gene Ontology (GO) analysis are related to the inflammation. Therefore, increase of Eng deletion in ECs exacerbates AVM severity, which is associated with enhanced inflammation. Strategies that can reduce Eng negative ECs could be used to develop new therapies to reduce AVM severity for HHT1 patients.

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