Version 1
: Received: 29 February 2024 / Approved: 29 February 2024 / Online: 29 February 2024 (08:24:55 CET)
Version 2
: Received: 29 March 2024 / Approved: 29 March 2024 / Online: 29 March 2024 (17:10:04 CET)
How to cite:
Tachibana, M.; Hamayasu, H.; Yokota, A.; Matsushita, M. Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions. Preprints2024, 2024021700. https://doi.org/10.20944/preprints202402.1700.v1
Tachibana, M.; Hamayasu, H.; Yokota, A.; Matsushita, M. Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions. Preprints 2024, 2024021700. https://doi.org/10.20944/preprints202402.1700.v1
Tachibana, M.; Hamayasu, H.; Yokota, A.; Matsushita, M. Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions. Preprints2024, 2024021700. https://doi.org/10.20944/preprints202402.1700.v1
APA Style
Tachibana, M., Hamayasu, H., Yokota, A., & Matsushita, M. (2024). Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions. Preprints. https://doi.org/10.20944/preprints202402.1700.v1
Chicago/Turabian Style
Tachibana, M., Akihiko Yokota and Masahiro Matsushita. 2024 "Most Colorectal Hyperplastic Nodules Represent Polypoid Colitis Nucleomigrans - A New Challenge in Classifying Colorectal Mucosal Tumor-Like Lesions" Preprints. https://doi.org/10.20944/preprints202402.1700.v1
Abstract
Hyperplastic nodules (HNs) are benign polypoid lesions of the colorectal mucosa reportedly caused by hyperplasia of the crypt epithelial cells. They differ from hyperplastic polyps because the crypts do not have histologically serrated changes. HNs often occur in the rectal mucosa and tend to be multifocal. We have proposed a new colitis nucleomigrans (CN) concept as the third type of microscopic colitis. Our histopathological criteria of CN include: i) chained nuclear migration to the middle part of the surface-lining columnar epithelium, ii) apoptotic nuclear debris scattered in the eosinophilic cytoplasm underneath the nuclei, and iii) mild to moderate chronic inflammation in the lamina propria. Immunostaining for cleaved-caspase 3 revealed apoptotic bodies. In this study, we report that most HN lesions share the histological features with CN, representing polypoid CN. We evaluated 108 lesions of HN in total, and 94 (87%) were reclassified as polypoid CN. In the polypoid CN, the lamina propria mucosae were uniformly edematous, suggesting that accelerated apoptosis of the mucosal surface epithelium may cause osmotic dysregulation to form localized mucosal elevations.
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
