Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Windows into Canine Leishmaniasis: From Veterinary Diagnosis to Promising In Vitro Models to Target Parasite-Secreted Lipid Bound Vesicles

Áurea Gabriel
* ORCID logo ,
Gilvando Rodrigues Galvão
,
Adan Galué-Parra
,
Lívia Medeiros Neves Casseb
ORCID logo ,
Washington Luiz Assunção Pereira
ORCID logo ,
Ketil Winther Pedersen
,
Delia Cristina Figueira Aguiar
ORCID logo ,
Evonnildo Costa Gonçalves
,
Edilene Oliveira Da Silva
ORCID logo
Version 1 : Received: 18 January 2024 / Approved: 18 January 2024 / Online: 19 January 2024 (03:14:14 CET)

How to cite: Gabriel, Á.; Galvão, G.R.; Galué-Parra, A.; Casseb, L.M.N.; Pereira, W.L.A.; Pedersen, K.W.; Aguiar, D.C.F.; Gonçalves, E.C.; Da Silva, E.O. Windows into Canine Leishmaniasis: From Veterinary Diagnosis to Promising In Vitro Models to Target Parasite-Secreted Lipid Bound Vesicles. Preprints 2024, 2024011406. https://doi.org/10.20944/preprints202401.1406.v1 Gabriel, Á.; Galvão, G.R.; Galué-Parra, A.; Casseb, L.M.N.; Pereira, W.L.A.; Pedersen, K.W.; Aguiar, D.C.F.; Gonçalves, E.C.; Da Silva, E.O. Windows into Canine Leishmaniasis: From Veterinary Diagnosis to Promising In Vitro Models to Target Parasite-Secreted Lipid Bound Vesicles. Preprints 2024, 2024011406. https://doi.org/10.20944/preprints202401.1406.v1

Abstract

Leishmaniases are zoonotic vector-borne diseases caused by a wide variety of Leishmania species with complex transmission cycles involving different reservoirs, potential new hosts and vectors. Similarly, to other eukaryotes, Leishmania release extracellular vesicles (LEVs) to play important initial interactions that are crucial to modulate the subsequent systemic immune response on the establishment of infection in humans and others hosts like dogs. Recent studies in endemic areas of Brazil concluded that canine infections were predominantly due to L. amazonensis and not restricted to L. infantum (syn. Leishmania chagasi). Under these premises, the diagnosis of leishmaniasis needs to be improved with the identification of current etiological agent and the histopathologic features, highlighting the differential diagnosis and the molecular components of LEVs. In this way, the dual aim of that study is to register collected observations of natural canine infections, enhancing the relevance of differential diagnosis in companion animals and inserting in vitro results in the field of LEVs that still research gaps to be filled to understand the mechanisms and biological aspects involving the parasite-host interactions. Therefore, improve these studies of Parasitology research is important for diagnostic, prognostic, treatment advances and continuing need for global prevention, control, elimination/eradication of these parasitic infections.

Keywords

Leishmania infectivity in mammalian hosts; inserts of leishmaniases and coinfections in companion animals; clinical and histopathologic features of natural zoonotic canine leishmaniasis; cell communication by parasite-derived extracellular vesicles; in vitro models advance to target parasite-secreted lipid bound vesicles

Subject

Biology and Life Sciences, Parasitology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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