Aung, W.W.; Krongrawa, W.; Limmatvapirat, S.; Kulpicheswanich, P.; Okonogi, S.; Limmatvapirat, C. Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract. Polymers2024, 16, 183.
Aung, W.W.; Krongrawa, W.; Limmatvapirat, S.; Kulpicheswanich, P.; Okonogi, S.; Limmatvapirat, C. Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract. Polymers 2024, 16, 183.
Aung, W.W.; Krongrawa, W.; Limmatvapirat, S.; Kulpicheswanich, P.; Okonogi, S.; Limmatvapirat, C. Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract. Polymers2024, 16, 183.
Aung, W.W.; Krongrawa, W.; Limmatvapirat, S.; Kulpicheswanich, P.; Okonogi, S.; Limmatvapirat, C. Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract. Polymers 2024, 16, 183.
Abstract
Single-fluid electrospinning creates nanofibers from molten polymer solutions with active ingredients. The study utilized a combination of a fractional factorial design and a Box-Behnken design to examine crucial factors among a multitude of parameters and to optimize the electrospinning conditions that impact the fiber mats' morphology and entrapment efficiency of the Senna alata leaf extract. The findings indicated that the shellac content had the greatest impact on both fiber diameter and bead formation. The optimum electrospinning conditions were identified as a voltage of 24 kV, a solution feed rate of 0.8 mL/h, and a shellac-extract ratio of 38.5:3.8. These conditions produced nanosized fibers with a diameter of 306 nm, a low bead-to-fiber ratio of 0.29, and an extract entrapment efficiency of 96% within the fibers. The biphasic profile of optimized nanofibers was confirmed through an in vitro release study. This profile consisted of an initial burst release of 88% within the first hour, which was succeeded by a sustained release pattern surpassing 90% for the next 12 h, as predicted by zero-order release kinetics. The optimized nanofibers demonstrated antimicrobial efficacy against diverse pathogens, suggesting promising applications in wound dressings and protective textiles.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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