Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly IsoniazidRifapentine Regimen in Bangladesh: A CommunityBased Implementation Study

Md. Toufiq Rahman; Farzana Hossain; Rupali Sisir Banu; Md. Shamiul Islam; Shamsher Alam; Abu Jamil Faisel; Hamid Salim; Oscar Cordon; Pedro Suarez; Hamidah Hussain; Tapash Roy

doi:10.20944/preprints202311.0155.v1

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202311.0155.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly IsoniazidRifapentine Regimen in Bangladesh: A CommunityBased Implementation Study

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Version 1 : Received: 2 November 2023 / Approved: 2 November 2023 / Online: 2 November 2023 (09:58:42 CET)

A peer-reviewed article of this Preprint also exists.

Rahman, M.T.; Hossain, F.; Banu, R.S.; Islam, M.S.; Alam, S.; Faisel, A.J.; Salim, H.; Cordon, O.; Suarez, P.; Hussain, H.; Roy, T. Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study. Trop. Med. Infect. Dis. 2024, 9, 4. Rahman, M.T.; Hossain, F.; Banu, R.S.; Islam, M.S.; Alam, S.; Faisel, A.J.; Salim, H.; Cordon, O.; Suarez, P.; Hussain, H.; Roy, T. Uptake and Completion of Tuberculosis Preventive Treatment Using 12-Dose, Weekly Isoniazid–Rifapentine Regimen in Bangladesh: A Community-Based Implementation Study. Trop. Med. Infect. Dis. 2024, 9, 4.

Abstract

Background: The UNHLM pledged to enroll 30 million in TB preventive treatment (TPT) by 2022, necessitating TPT expansion to all at TB risk. We assessed uptake and completion of a 12-dose, weekly isoniazid-rifapentine (3HP) TPT regimen. Methods: Between February 2018 - March 2019 in Dhaka, community-based TPT using 3HP targeted household contacts of 883 confirmed drug-sensitive pulmonary TB patients. Adhering to WHO guidelines, contacts underwent active TB screening before TPT initiation. Results: Of 3,193 contacts who advised health facility visits for screening, 67% (n=2,149) complied. Among these, 1,804 (84%) received chest X-rays. Active TB was diagnosed in 39 (2%) contacts; they commenced TB treatment. Over 97% of 1,216 contacts began 3HP TPT, with completion rates higher among females, those with more education and income, non-slum residents, and those without 3HP-related adverse events. Adverse events, mainly mild, occurred in 5% of participants. Conclusions: The 3HP weekly regimen, with its short duration, self-administered option, and minimal side effects, achieved satisfactory completion rates. A community-focused 3HP TPT approach is feasible, scalable nationally, and aligns with UNHLM targets.

Keywords

TB preventive treatment; UNHLM; End TB; TPT; 3HP; Bangladesh

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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