Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Zhe Wang
ORCID logo ,
Xinpei Wang
,
Wanting Xu
,
Yongxiao Li
,
Ruizhi Lai
,
Xiaohui Qiu
,
Xu Chen
,
Zhidong Chen
,
Bobin Mi
* ,
Meiying Wu
* ORCID logo ,
Junqing Wang
* ORCID logo
Version 1 : Received: 26 September 2023 / Approved: 27 September 2023 / Online: 28 September 2023 (03:21:20 CEST)

A peer-reviewed article of this Preprint also exists.

Wang, Z.; Wang, X.; Xu, W.; Li, Y.; Lai, R.; Qiu, X.; Chen, X.; Chen, Z.; Mi, B.; Wu, M.; Wang, J. Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems. Pharmaceutics 2023, 15, 2623. Wang, Z.; Wang, X.; Xu, W.; Li, Y.; Lai, R.; Qiu, X.; Chen, X.; Chen, Z.; Mi, B.; Wu, M.; Wang, J. Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems. Pharmaceutics 2023, 15, 2623.

Abstract

Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages in therapeutic delivery. These systems, encompassing platforms such as liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, and enhanced therapeutic outcomes. However, the translation of BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, and rigorous efficacy and safety evaluations. Furthermore, the innovative nature of BDSs demands a reevaluation and evolution of existing regulatory and ethical frameworks. This review provides an overview of BDSs, delve into the multifaceted translational challenges and present emerging solutions, underscored by real-world case studies. Emphasizing the potential of BDSs to redefine healthcare, we advocate for sustained interdisciplinary collaboration and research. As our understanding of biological systems deepens, the future of BDSs in clinical translation appears promising, with a focus on personalized medicine and refined patient-specific delivery systems.

Keywords

biomimetic; bioinspired; nanodiscs; liposomes; virus-like particles; albumin; ferritin; polysaccharides; extracellular vesicles

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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