Xu, W.; Yang, Y.; Li, N.; Hua, J. Interaction between Mesenchymal Stem Cells and Immune Cells during Bone Injury Repair. Int. J. Mol. Sci.2023, 24, 14484.
Xu, W.; Yang, Y.; Li, N.; Hua, J. Interaction between Mesenchymal Stem Cells and Immune Cells during Bone Injury Repair. Int. J. Mol. Sci. 2023, 24, 14484.
Xu, W.; Yang, Y.; Li, N.; Hua, J. Interaction between Mesenchymal Stem Cells and Immune Cells during Bone Injury Repair. Int. J. Mol. Sci.2023, 24, 14484.
Xu, W.; Yang, Y.; Li, N.; Hua, J. Interaction between Mesenchymal Stem Cells and Immune Cells during Bone Injury Repair. Int. J. Mol. Sci. 2023, 24, 14484.
Abstract
Fractures are the most common large organ trauma in humans. The initial inflammatory re-sponse promotes bone healing during the initial post-fracture phase, but chronic and persistent inflammation due to infection or other factors does not contribute to the healing process. The precise mechanisms by which immune cells and their cytokines are regulated in bone healing remain unclear. The use of mesenchymal stem cells (MSCs) for cellular therapy of bones injury is a novel clinical treatment approach. Bone progenitor MSCs not only differentiate into bone, but also interact with the immune system to promote the healing process. We review in vitro and in vivo studies on the role of the immune system and bone marrow MSCs in bone healing and their interactions. A deeper understanding of this paradigm may provide clues to potential therapeu-tic targets in the healing process, thereby improving the reliability and safety of clinical applica-tions of MSCs to promote bone healing.
Keywords
bone fracture; MSCs; immune cells
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
