Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Antibacterial Films of Silver Nanoparticles Embedded into Carboxymethylcellulose/Chitosan Multilayers on Nanoporous Silicon: a Layer-by-Layer Assembly Approach Comparing Dip and Spin Coating

Version 1 : Received: 29 May 2023 / Approved: 31 May 2023 / Online: 31 May 2023 (03:58:13 CEST)

A peer-reviewed article of this Preprint also exists.

Naveas, N.; Pulido, R.; Torres-Costa, V.; Agulló-Rueda, F.; Santibáñez, M.; Malano, F.; Recio-Sánchez, G.; Garrido-Miranda, K.A.; Manso-Silván, M.; Hernández-Montelongo, J. Antibacterial Films of Silver Nanoparticles Embedded into Carboxymethylcellulose/Chitosan Multilayers on Nanoporous Silicon: A Layer-by-Layer Assembly Approach Comparing Dip and Spin Coating. Int. J. Mol. Sci. 2023, 24, 10595. Naveas, N.; Pulido, R.; Torres-Costa, V.; Agulló-Rueda, F.; Santibáñez, M.; Malano, F.; Recio-Sánchez, G.; Garrido-Miranda, K.A.; Manso-Silván, M.; Hernández-Montelongo, J. Antibacterial Films of Silver Nanoparticles Embedded into Carboxymethylcellulose/Chitosan Multilayers on Nanoporous Silicon: A Layer-by-Layer Assembly Approach Comparing Dip and Spin Coating. Int. J. Mol. Sci. 2023, 24, 10595.

Abstract

The design and engineering of antibacterial materials is key for preventing bacterial adherence and proliferation in biomedical and house-hold instruments. Silver nanoparticles (AgNPs) and chitosan (CHI) are broad-spectrum antibacterial materials with different properties, whose combined application is currently under optimization. This study proposes the formation of antibacterial films with AgNPs embedded in carboxymethylcellulose/chitosan multilayers by the layer-by-layer (LbL) method. The films were deposited onto nanoporous silicon (nPSi), an ideal platform for bioengineering applications, due to its biocompatibility, biodegradability, and bioresorbability. We focus on two alternative multilayer deposition processes: cyclic dip coating (CDC) and cyclic spin coating (CSC). The physicochemical properties of the films were the subject of microscopic, microstructural and surface-interface analyses. The antibacterial activity of each film was investigated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria strains as model microorganisms. According to the findings, CDC technique produced multilayer films with higher antibacterial activity for both bacteria compared to the CSC method. Bacteria adhesion inhibition was observed from only 3 cycles. The developed AgNPs-multilayer composite film offers advantageous antibacterial properties for biomedical applications.

Keywords

antibacterial films; carboxymethylcellulose; chitosan; silver nanoparticles; nanoporous silicon; composite material; layer-by-layer

Subject

Chemistry and Materials Science, Biomaterials

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