Version 1
: Received: 22 May 2023 / Approved: 24 May 2023 / Online: 24 May 2023 (02:30:24 CEST)
How to cite:
Valdiviezo-Campos, J. E.; Rodriguez Aredo, C. D.; Ruiz-Reyes, S. G.; Venegas-Casanova, E. A.; Ganoza-Yupanqui, M. L.; Bussmann, R. W. In Silico Potential Antiviral Activity of Polyphenols From Plants Used in Traditional Medicine in La Libertad Región, Peru. Preprints2023, 2023051669. https://doi.org/10.20944/preprints202305.1669.v1
Valdiviezo-Campos, J. E.; Rodriguez Aredo, C. D.; Ruiz-Reyes, S. G.; Venegas-Casanova, E. A.; Ganoza-Yupanqui, M. L.; Bussmann, R. W. In Silico Potential Antiviral Activity of Polyphenols From Plants Used in Traditional Medicine in La Libertad Región, Peru. Preprints 2023, 2023051669. https://doi.org/10.20944/preprints202305.1669.v1
Valdiviezo-Campos, J. E.; Rodriguez Aredo, C. D.; Ruiz-Reyes, S. G.; Venegas-Casanova, E. A.; Ganoza-Yupanqui, M. L.; Bussmann, R. W. In Silico Potential Antiviral Activity of Polyphenols From Plants Used in Traditional Medicine in La Libertad Región, Peru. Preprints2023, 2023051669. https://doi.org/10.20944/preprints202305.1669.v1
APA Style
Valdiviezo-Campos, J. E., Rodriguez Aredo, C. D., Ruiz-Reyes, S. G., Venegas-Casanova, E. A., Ganoza-Yupanqui, M. L., & Bussmann, R. W. (2023). In Silico Potential Antiviral Activity of Polyphenols From Plants Used in Traditional Medicine in La Libertad Región, Peru. Preprints. https://doi.org/10.20944/preprints202305.1669.v1
Chicago/Turabian Style
Valdiviezo-Campos, J. E., Mayar Luis Ganoza-Yupanqui and Rainer W. Bussmann. 2023 "In Silico Potential Antiviral Activity of Polyphenols From Plants Used in Traditional Medicine in La Libertad Región, Peru" Preprints. https://doi.org/10.20944/preprints202305.1669.v1
Abstract
Traditional medicine is one of the main bases for studying and discovering natural sources of phytometabolites with antiviral properties. This research aims to demonstrate that the medicinal plants used as a treatment of viral diseases in the La Libertad region have, in fact, antiviral ac-tivity. The study evaluated the ethnobotany of the 8 most widely used medicinal plants in the region (Azadirachta indica A. Juss. “paraíso”, Caesalpinia spinosa (Molina) Kuntze “tara”, Citrus limon (L.) Osbeck “limón”, Clinopodium pulchellum (Kunth) Govaerts “panizara”, Cordia lutea Lam. “overo”, Ocimum basilicum L. “albahaca”, Schinus molle L. “molle”, and Taraxacum campylodes G.E. Haglund “diente de león”). The phytometabolites responsible for the antiviral activity were identified by LC-MS and evaluated in silico against the viral proteins NS2B/NS3 (DENV-2), NS5B (HCV), and ICP27 (HSV-1) using molecular docking in Autodock Vina and UCSF Chimera. The presence of five polyphenols (chlorogenic acid, gallic acid, caffeic acid, rosmarinic acid, and rutin) was found and, in the in silico test, the antiviral activity of chlorogenic acid stood out against DENV-2 and HCV, rutin against HCV and HSV-1, rosmarinic acid against DENV-2 and HCV. Therefore, it is verified that the medicinal plants studied have antiviral activity, which supports their use in traditional medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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