Hajimehdipoor, H.; Tahmasvand, Z.; Nejad, F.G.; Maresca, M.; Rajabi, S. Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells. Nutrients2023, 15, 2884.
Hajimehdipoor, H.; Tahmasvand, Z.; Nejad, F.G.; Maresca, M.; Rajabi, S. Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells. Nutrients 2023, 15, 2884.
Hajimehdipoor, H.; Tahmasvand, Z.; Nejad, F.G.; Maresca, M.; Rajabi, S. Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells. Nutrients2023, 15, 2884.
Hajimehdipoor, H.; Tahmasvand, Z.; Nejad, F.G.; Maresca, M.; Rajabi, S. Rutin Promotes Proliferation and Orchestrates Epithelial–Mesenchymal Transition and Angiogenesis in MCF-7 and MDA-MB-231 Breast Cancer Cells. Nutrients 2023, 15, 2884.
Abstract
Rutin has been reported as a potential anti-cancer agent for several decades. This study evaluated the effects of rutin on the proliferation, metastasis, and angiogenesis of MDA-MB-231 and MCF-7 breast cancer cell lines. Increasing concentrations of rutin significantly stimulated the proliferation of MDA-MB-231 and MCF-7 cells compared to controls. Wound scratch assay demonstrated that rutin had an inducing effect on the migration of the cells. In MDA-MB-231 and MCF-7 cells, rutin upregulated MKI67, VIM, CDH2, FN1, and VEGFA and downregulated CDH1 and THBS1 genes. It also increased N-cadherin and VEGFA and decreased E-cadherin and thrombospondin 1 protein expression. Our data indicated that rutin could stimulate proliferation, migration, and pro-angiogenic activity in two different breast cancer cell lines. This phytoestrogen induced invasion and migration of both cell lines by a mechanism involving the EMT process. This suggests that rutin may act as a breast cancer-promoting phytoestrogen.
Keywords
Breast cancer; Rutin; Epithelial-Mesenchymal Transition; Metastasis; Angiogenesis
Subject
Biology and Life Sciences, Other
Copyright:
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