Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression

Rosaria Maria Pipitone; Rossella Zito; Giuditta Gambino; Gabriele Di Maria; Ayesha Javed; Giulia Lupo; Giuseppe Giglia; Pierangelo Sardo; Giuseppe Ferraro; Francesca Rappa; Daniela Carlisi; Danila Di Majo; Stefania Grimaudo

doi:10.20944/preprints202305.0680.v1

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202305.0680.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression

Rosaria Maria Pipitone

^* ,

Version 1 : Received: 9 May 2023 / Approved: 10 May 2023 / Online: 10 May 2023 (04:01:08 CEST)

How to cite: Pipitone, R.M.; Zito, R.; Gambino, G.; Di Maria, G.; Javed, A.; Lupo, G.; Giglia, G.; Sardo, P.; Ferraro, G.; Rappa, F.; Carlisi, D.; Di Majo, D.; Grimaudo, S. Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression. Preprints 2023, 2023050680. https://doi.org/10.20944/preprints202305.0680.v1 Pipitone, R.M.; Zito, R.; Gambino, G.; Di Maria, G.; Javed, A.; Lupo, G.; Giglia, G.; Sardo, P.; Ferraro, G.; Rappa, F.; Carlisi, D.; Di Majo, D.; Grimaudo, S. Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression. Preprints 2023, 2023050680. https://doi.org/10.20944/preprints202305.0680.v1

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MDPI and ACS Style

Pipitone, R.M.; Zito, R.; Gambino, G.; Di Maria, G.; Javed, A.; Lupo, G.; Giglia, G.; Sardo, P.; Ferraro, G.; Rappa, F.; Carlisi, D.; Di Majo, D.; Grimaudo, S. Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression. Preprints 2023, 2023050680. https://doi.org/10.20944/preprints202305.0680.v1

APA Style

Pipitone, R.M., Zito, R., Gambino, G., Di Maria, G., Javed, A., Lupo, G., Giglia, G., Sardo, P., Ferraro, G., Rappa, F., Carlisi, D., Di Majo, D., & Grimaudo, S. (2023). Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression. Preprints. https://doi.org/10.20944/preprints202305.0680.v1

Chicago/Turabian Style

Pipitone, R.M., Danila Di Majo and Stefania Grimaudo. 2023 "Red and Golden Tomato Administration Improves Fat Di-Et-Induced Hepatic Steatosis in Rats by Modulating HNF4, Lepr and GK Expression" Preprints. https://doi.org/10.20944/preprints202305.0680.v1

Abstract

Abstract: Nonalcoholic fatty liver disease, characterized by the lipid accumulation within hepatocytes exceeding 5% of liver weight, is strictly related to metabolic disorders and to obesity and diabetes and represents a health emergency worldwide. Being not available any standard therapy for NAFLD, a key role is ascribed to lifestyle intervention including phytonutrient intake to prevent NAFLD development and progression. We have used a rat model of NAFLD to evaluate the effect of dietary supplementation with red tomato and golden tomato, patented mix of fruit with different degrees of ripeness, particularly rich in naringenin and chlorogenic acid, after steatosis development. We have assessed the ef-fects on body weight, metabolic profile, and hepatic steatosis and a correlation between the amelioration of all the parameters and the liver gene expression was evidenced. We found that the genes mainly up regulated by tomatoes administration were HNF4, Lepr and GK, able to condition metabolic homeostasis. Our results suggest that there is a role for red and golden tomatoes, dietary intake as a nutraceutical approach of NAFLD prevention and therapy.

Keywords

Nonalcoholic Fatty Liver Disease; Golden Tomato; Red Tomato; Lepr; NFH4a; GK; lipid homeo-stasis; steatosis

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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