Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Therapeutic Potential of Alternanthera Brasiliana and Fridericia Platyphylla Plants on Bone Healing in Rats

Camila Silva de Morais Pinheiro
* ,
Vicente pinheiro Neto
,
Joice Cortez de Sá Sousa
,
José Ribamar Da Silva Júnior
,
Cláudia Quintino da Rocha Oliveira
ORCID logo ,
Ellen Caroline da Silva Penha
,
Thalisson Kaynan Reis Silva
,
Ícaro Rodrigo Dutra Cunha
,
Antônio Carlos Romão Borges
,
Fábio Henrique Evangelista De Andrade
,
Marilene Oliveira da Rocha Borges
ORCID logo
Version 1 : Received: 25 January 2023 / Approved: 27 January 2023 / Online: 27 January 2023 (06:31:59 CET)

How to cite: Pinheiro, C.S.D.M.; Neto, V.P.; Sousa, J.C.D.S.; Da Silva Júnior, J.R.; Oliveira, C.Q.D.R.; Penha, E.C.D.S.; Silva, T.K.R.; Cunha, Í.R.D.; Borges, A.C.R.; De Andrade, F.H.E.; Borges, M.O.D.R. Therapeutic Potential of Alternanthera Brasiliana and Fridericia Platyphylla Plants on Bone Healing in Rats. Preprints 2023, 2023010491. https://doi.org/10.20944/preprints202301.0491.v1 Pinheiro, C.S.D.M.; Neto, V.P.; Sousa, J.C.D.S.; Da Silva Júnior, J.R.; Oliveira, C.Q.D.R.; Penha, E.C.D.S.; Silva, T.K.R.; Cunha, Í.R.D.; Borges, A.C.R.; De Andrade, F.H.E.; Borges, M.O.D.R. Therapeutic Potential of Alternanthera Brasiliana and Fridericia Platyphylla Plants on Bone Healing in Rats. Preprints 2023, 2023010491. https://doi.org/10.20944/preprints202301.0491.v1

Abstract

Medicinal plants for bone grafts are promising because they are free from infecting microorganisms and biocompatible. We report a novel study evaluating osteoregeneration of bone grafts from extracts of Alternanthera brasiliana and Fridericia platyphylla after bone injury induced by radius fracture in rats. Grafts were obtained using 2% chitosan gel and 0.5% hydroalcoholic extract. The rats were randomly divided into four experimental groups (N= 12): Negative control (NC) - Chitosan gel; Positive control (PC) - bovine mineral bone graft (Lumina Bone®, fine powder 0.5); F. platyphylla Graft (FRID) - 0.5% bone graft; A. brasiliana Graft (ABRA) - 0.5% bone graft. The animals were evaluated for three periods, 30, 60, and 90 days after fracture induction. Bone alkaline phosphatase (BSAP) and radiographic and histological evaluations were followed. After 90 days, there was an increase in BSAP for the ABRA group on the newly formed bone matrix but not for FRID, indicating the presence of active osteoblasts. Additionally, mature bone tissue and bone remodeling were observed, and a conspicuous presence of type I collagen for both FRID and ABRA. We demonstrated that FRID and ABRA grafts produced early bone neoformation. New perspectives for these species as a graft are suggested.

Keywords

Bone healing; bone fracture; herbal medicine; osteogenesis; bone alkaline phosphatase

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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