Version 1
: Received: 5 December 2022 / Approved: 7 December 2022 / Online: 7 December 2022 (02:26:58 CET)
How to cite:
Kothawade, S.; Pande, V.; Bole, S.; Autade, K.; Sumbe, R.; Albhar, S.; Raut, K. A Floating System for Drug Delivery using Microballoons. Preprints2022, 2022120112. https://doi.org/10.20944/preprints202212.0112.v1
Kothawade, S.; Pande, V.; Bole, S.; Autade, K.; Sumbe, R.; Albhar, S.; Raut, K. A Floating System for Drug Delivery using Microballoons. Preprints 2022, 2022120112. https://doi.org/10.20944/preprints202212.0112.v1
Kothawade, S.; Pande, V.; Bole, S.; Autade, K.; Sumbe, R.; Albhar, S.; Raut, K. A Floating System for Drug Delivery using Microballoons. Preprints2022, 2022120112. https://doi.org/10.20944/preprints202212.0112.v1
APA Style
Kothawade, S., Pande, V., Bole, S., Autade, K., Sumbe, R., Albhar, S., & Raut, K. (2022). A Floating System for Drug Delivery using Microballoons. Preprints. https://doi.org/10.20944/preprints202212.0112.v1
Chicago/Turabian Style
Kothawade, S., Shubhangi Albhar and Kunal Raut. 2022 "A Floating System for Drug Delivery using Microballoons" Preprints. https://doi.org/10.20944/preprints202212.0112.v1
Abstract
Gastro-retentive floating microspheres were developed as a result of the recent advancements in floating delivery systems for drugs (FDDS), which included the uniform dispersion of multiparticulate dosage forms along the GIT. This could lead to more consistent drug absorption and a lower risk of local irritation. Microballoons (MB), a multi-unit extended release with a sphere-shaped cavity encased in a tough polymer shell, have been developed as a dosage form with exceptional buoyancy in the stomach. This preparation for constrained intestinal absorption is made to float on top of gastric acid, that has a relative density lower than 1.By using enteric acrylic polymers and the emulsion solvent diffusion method, microballoons are prepared and filled to drug in one‘s outer polymer casings. Enteric acrylic plastics are used to generate microballoons that are drug-loaded in one‘s external polymer casings and dissipate in a solution of dichloromethane and ethanol. Cavity development in microparticles seems to be particularly correlated with dichloromethane evaporation. Microballoons with a drug distributed or dispersed all through the particle-matrix have the potential for a controlled drug release and float continuously for more than 12 hours in vitro out over the surface of an acidified dissolution medium with surfactant. The drug is released slowly and at the desired rate as the microballoons glide over the components of the stomach, increasing gastro-retention time and lowering fluctuations in plasma concentration.
Keywords
Gastro retentive drug delivery systems; non-effervescent systems; floating drug delivery systems; microballoons; CRDDS
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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