Version 1
: Received: 13 August 2020 / Approved: 14 August 2020 / Online: 14 August 2020 (08:56:53 CEST)
Version 2
: Received: 23 November 2020 / Approved: 25 November 2020 / Online: 25 November 2020 (14:47:29 CET)
How to cite:
Wit, J.; Dilks, C.; Andersen, E. Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints2020, 2020080313. https://doi.org/10.20944/preprints202008.0313.v1
Wit, J.; Dilks, C.; Andersen, E. Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints 2020, 2020080313. https://doi.org/10.20944/preprints202008.0313.v1
Wit, J.; Dilks, C.; Andersen, E. Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints2020, 2020080313. https://doi.org/10.20944/preprints202008.0313.v1
APA Style
Wit, J., Dilks, C., & Andersen, E. (2020). Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes. Preprints. https://doi.org/10.20944/preprints202008.0313.v1
Chicago/Turabian Style
Wit, J., Clayton Dilks and Erik Andersen. 2020 "Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes" Preprints. https://doi.org/10.20944/preprints202008.0313.v1
Abstract
Parasitic nematode infections impact human and animal health globally, especially in the developing world. Anthelmintic drugs are the major line of defense against these infections, but the arsenal is limited. Additionally, anthelmintic resistance is widespread in veterinary parasites and an emerging threat in human parasites. Discoveries of the mode of action of these drugs and mechanisms of resistance have predominantly come from studies of a related non-parasitic nematode species, Caenorhabditis elegans, and the parasitic nematode Haemonchus contortus. Here, we discuss recent progress understanding anthelmintic resistance using these two species and how that progress relates to laboratory and field-based studies of veterinary helminths. We present a powerful approach enabled by the strengths of both nematode species to understand mechanisms of resistance and modes of action of anthelmintic drugs.
Keywords
drug resistance; natural diversity; C. elegans; anthelmintics
Subject
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
