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Preprint ARTICLE | doi:10.20944/preprints202208.0301.v1

Simultaneous Motor and Visual Intraoperative Neuromonitoring in Asleep Parietal Lobe Surgery: Dual Strip Technique

Devika Rajashekar, José Pedro Lavrador, Prajwal Ghimire, Hannah Keeble, Lauren Harris, Noemia Pereira, Sabina Patel, Ahmad Beyh, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: corticospinal tract; optic radiations; tractography; transcranial magnetic stimulation; subdural strip electrodes; intra-operative neuro-monitoring; parietal lobe

Online: 17 August 2022 (05:08:09 CEST)

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Background: The role played by the non-dominant parietal lobe in motor cognition, attention and spatial awareness networks has potentiated the use of awake surgery. When this is not feasible, asleep monitoring and mapping techniques should be used to achieve an onco-functional balance. Objective: This study aims to assess the feasibility of a dual-strip method to obtain direct cortical stimulation for continuous real-time cortical monitoring and subcortical mapping of motor and visual pathways simultaneously in parietal lobe tumour surgery. Methods: Single-centre prospective study between May’19-November’20 of patients with intrinsic non-dominant parietal-lobe tumours. Two subdural strips were used to simultaneously map and monitor motor and visual pathways. Results: Fifteen patients were included. With regards to motor function, a large proportion of patients had abnormal interhemispheric resting motor threshold ratio (iRMTr) (71.4%), abnormal Cortical Excitability Score (CES) (85.7%), close distance to the corticospinal tract – Lesion-To-Tract Distance (LTD) – 4.2mm, Cavity-To-Tract Distance (CTD) – 7mm and intraoperative subcortical distance - 6.4mm. Concerning visual function, the LTD and CTD for optic radiations (OR) were 0.5mm and 3.4mm, respectively; the mean intensity for positive subcortical stimulation of OR was 12mA±2.3mA and 5/6 patients with deterioration of VEPs>50% had persistent hemianopia and transgression of ORs. 12 patients remained stable, one patient had a de-novo transitory hemiparesis, and two showed improvements in motor symptoms. A higher iRMTr for lower limbs was related with a worse motor outcome (p=0.013) and a longer CTD to OR was directly related with a better visual outcome (p=0.041). At 2 weeks after hospital discharge, all patients were ambulatory at home and all proceeded to have oncological treatment. Conclusion: We propose motor and visual function boundaries for asleep surgery of intrinsic non-dominant parietal tumours. Pre-operative abnormal cortical excitability of the motor cortex, deterioration of the VEP recordings and CTD<2mm from the OR were related to poorer outcomes.

Preprint REVIEW | doi:10.20944/preprints202207.0432.v2

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Manish Kumar

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: mutation; gastric cancer; p53; K-Ras; c-Myc; cancer genomics; targeted therapy; immunotherapy

Online: 16 August 2022 (10:35:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0260.v1

Financial Costs of Pediatric Cancer Management in Africa: Systematic Review and Meta-Analysis

Criss Koba Mjumbe, Desiré Kulimba Mashinda, Oscar Numbi Luboya, Murielle Nkumuyaya, Chadrack Diyoka Kabeya, Benjamin Ilunga Kabyla

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Childhood cancer; financial costs; Africa; systematic review; meta-analysis

Online: 15 August 2022 (11:53:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0220.v1

Promoting Oncolytic Vector Replication With Switches That Detect Ubiquitous Mutations

Michael Renteln

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Molecular switches; oncolytic vectors; patient-specific ubiquitous mutations; targeted therapy; multi-region sequencing; molecular biology

Online: 11 August 2022 (11:50:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0208.v1

Plasma Cell-free RNA PD-L1 Expression and Overall Survival of Immune Checkpoint Inhibitor Therapy in Advanced Non-Small Cell Lung Cancer

Paul R. Walker, Mahvish Muzzafar, Sriraksha Jayananda, Praveen Namireddy, Nitika Sharma, Teresa Parent, Cynthia Cherry, Richard B. Lanman

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Plasma PD-L1; liquid biopsy; cfRNA; immune checkpoint inhibitor; predictive immune biomarker; NSCLC

Online: 11 August 2022 (06:10:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0182.v1

The Effects of a Mediterranean Diet Intervention on Cancer-Related Fatigue for Patients undergoing Chemotherapy: A Pilot Randomized Controlled Trial

Amber S. Kleckner, Jennifer E. Reschke, Ian R. Kleckner, Allison Magnuson, Andrea M. Amitrano, Eva Culakova, Michelle Shayne, Colleen S. Netherby-Winslow, Susan Czap, Michelle C. Janelsins, Karen M. Mustian, Luke J. Peppone

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: oncology; nutrition; supportive care; integrative oncology; metabolism; mitochondria

Online: 9 August 2022 (15:02:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0147.v1

Incorporation of Alternative Ultrasound Biomarkers into Myometrial Invasion-based Model better Predicts Lymph Node Metastasis in Endometrial Cancer: Evidence and Future Prospects

Marcin Liro, Marcin Śniadecki, Ewa Wycinka, Szymon Wojtylak, Michał Brzeziński, Joanna Jastrzębska, Dariusz Wydra

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: endometrial cancer; ultrasound; lymph nodes; staging; metastases; biomarkers; model; COVID-19

Online: 8 August 2022 (10:24:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0286.v3

Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells

Wei Yang, Yong Liang, Yuan Yuan Zheng, Hai Tao Luo, Xiao Fei Yang, Fu Rong Li

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: novel ncRNAs; DE landscape; LSCs and LTCs; LncRNA; MiRNA; CircRNA; ceRNA networks; molecular mechanism

Online: 4 August 2022 (16:29:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0105.v1

Breast Cancer in Asia: Incidence, Mortality, Early Detection, Mammography Programmes, and Risk-based Screening Initiatives

Yu Xian Lim, Zi Lin Lim, Peh Joo Ho, Jingmei Li

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: asian breast cancers; mammography screening; risk-based screening

Online: 4 August 2022 (06:20:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0088.v1

Manipulation of Amino Acid Levels With Artificial Diets Induces Anticancer Activity in Mice With Renal Cell Carcinoma

José Manuel Calderón-Montaño, Emilio Guillén-Mancina, Julio José Jiménez-Alonso, Víctor Jiménez-González, Estefania Burgos-Morón, Alfonso Mate, María Concepción Pérez-Guerrero, Miguel López-Lázaro

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Amino acids; cancer; cancer metabolism; cancer therapy; kidney cancer; renal adenocarcinoma; renal cancer; metastasis; selective amino acid restriction therapy; restriction

Online: 3 August 2022 (11:16:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0071.v1

A Treatment Paradigm Shift: Targeted Radionuclide Therapies for Metastatic Castrate Resistant Prostate Cancer

Ephraim Parent, Adam M. Kase

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Prostate cancer; radionuclide therapy; bone; PSMA; GRPR; Somatostatin

Online: 3 August 2022 (03:51:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0432.v1

Precision Oncology-Based Targeting of Signaling Pathways toward a Holistic Approach to Cancer Therapeutics

Manish Kumar

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: mutation; gastric cancer; p53; K-Ras; c-Myc; cancer genomics; targeted therapy; immunotherapy

Online: 28 July 2022 (08:16:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0371.v1

Trastuzumab Biosimilar ABP 980 Plus Pertuzumab and Docetaxel in the Therapy of Metastatic Breast Cancer: Real World Experiences from the National Research Institute of Oncology in Warsaw

Karolina Miacz, Agnieszka Jagiełło-Gruszfeld, Michal Kunkiel, Izabela Lemanska, Anna Gorniak, Anna Niwinska, Zbigniew I. Nowecki

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: biosymilars; metastatic breast cancer; trastuzumab; cost; her2; PTH

Online: 25 July 2022 (10:05:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0370.v1

Dynamic Weight Agnostic Neural Networks and Medical Microwave Radiometry (MWR) for Breast Cancer Diagnostics

Jolen Li, Christopher Galazis, Illarion Popov, Lev Ovchinnikov, Sergey Vesnin, Alexander Losev, Igor Goryanin

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: breast cancer; passive microwave radiometry (MWR); cascaded correlation neural network (CCNN); weight agnostic neural network (WANN); CMA-ES algorithm.

Online: 25 July 2022 (10:04:03 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202207.0304.v1

Successful Treatment of Acute Uric Acid Nephropathy with Rasburicase in a Primary Central Nervous System Lymphoma Patient Showing Dramatic Response to Methotrexate – Case Report

Yoshihiro Mouri, Manabu Natsumeda, Noritaka Okubo, Taro Sato, Taiki Saito, Shibuya Kohei, Shiori Yamada, Jotaro On, Yoshihiro Tsukamoto, Masayasu Okada, Makoto Oishi, Takeyoshi Eda, Junko Murai, Hiroshi Shimizu, Akiyoshi Kakita, Yukihiko Fujii

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: PCNSL; high-dose methotrexate; acute uric acid nephropathy; rasburicase

Online: 20 July 2022 (11:52:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0262.v1

How Is the Exposure of a Sarcoma Surgeon Defined?

Carlo Theus-Steinmann, Georg Schelling, Philip Heesen, Stefan Breitenstein, Mario F. Scaglioni, Bruno Fuchs

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: sarcoma; multidisciplinary team / MDT; sarcoma surgery; orthopedic oncology; real-world data registry; exposure; experience

Online: 18 July 2022 (10:18:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0256.v1

Adverse Renal Effects of Anticancer Immunotherapy: A Review

Maciej Borówka, Stanisław Łącki-Zynzeling, Michał Nicze, Sylwia Kozak, Jerzy Chudek

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cancer; immunotherapy; adverse events; immune checkpoints inhibitors; chimeric antigen receptor therapy; bispecific antibodies; toxicity; renal; oncology

Online: 18 July 2022 (09:21:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0253.v1

Abnormal in LMNA Triggers a Shift in Intracellular Metabolic Homeostasis Via AMPK Activation

Ying Zhou, Jia-jie Yang, Yuan Cheng, Ge-xuan Feng, Rong-hui Yang, Yuan Yuan, Li-yong Wang, Lu Kong

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: LMNA; AMPK; lipid metabolism; cancer

Online: 18 July 2022 (08:59:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0211.v1

Particle Swarm Optimization and Two-Way Fixed-Effects Analysis of Variance for Efficient Brain Tumor Segmentation

Naoual Atia, Amir Benzaoui, Sébastien Jacques, Madina Hamiane, Kaouther El Kourd, Ayache Bouakaz, Abdeldjalil Ouahabi

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Brain tumor; Image segmentation; PSO; ANOVA, K-means.

Online: 14 July 2022 (11:28:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0141.v1

Real World Evidence – Current Developments and Perspectives

Friedemann Schad, Anja Thronicke

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: review; real -world evidence; real -world data; randomized controlled trials; registry; digital health technology; early drug approval

Online: 8 July 2022 (11:09:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0124.v1

Diagnostics of Ovarian Tumors in Postmenopausal Patients

Chingis Mustafin, Arran Turnbull, Sergey Vesnin, Mike Dixon, Igor Goryanin

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: microwave radiometry; postmenopausal; cancer biomarker

Online: 7 July 2022 (09:46:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0072.v1

High IGKC Expressing Intratumoral Plasma Cells Predict Response to Immune Checkpoint Blockade

Juan Luis Onieva, Qingyang Xiao, Miguel Berciano-Guerrero, Aurora Laborda-Illanes, Carlos De Andrea, Patricia Cháves, Pilar Piñeiro, Alicia Garrido-Aranda, Elena Gallego, Belén Sojo, Laura Gálvez, Rosario Chica-Parrado, Daniel Prieto, Elisabeth Pérez-Ruiz, Angela Farngren, María José Lozano, Martina Álvarez, Pedro Jiménez, Alfonso Sánchez, Javier Oliver, Manuel Cobo-Dols, Emilio Alba, Isabel Barragán

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Immunotherapy; Biomarkers; Melanoma

Online: 5 July 2022 (12:21:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0033.v1

A Circulating Serum miRNA-Based Model to Predict Early Mortality in Multiple Myeloma Patients Treated with Bortezomib-Based Regimens

Anna Puła, Paweł Robak, Dariusz Jarych, Damian Mikulski, Małgorzata Misiewicz, Izabela Drozdz, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: multiple myeloma; early mortality; blood plasma; circulating miRNA; hematological malignancies; molecular biomarker; multiparametric model; prognosissurvival

Online: 4 July 2022 (05:59:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0015.v1

Retroviral Replicating Vector Toca 511 (vocimagene amiretrorepvec) for Prodrug Activator Gene Therapy of Lung Cancer

Hiroki Kushiya, Kei Hiraoka, Tomohiro Suzuki, Kazuho Inoko, Akihito Inagaki, Hiroki Niwa, Katsunori Sasaki, Toru Nakamura, Takahiro Tsuchikawa, Toshiaki Shichinohe, Douglas J. Jolly, Noriyuki Kasahara, Satoshi Hirano

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: lung cancer; gene therapy; retrovirus vector

Online: 1 July 2022 (15:28:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0420.v1

Role of Diffusion-weighted MRI in Differentiation between Benign and Malignant Anterior Mediastinal Masses

Tran Thi Mai Thuy, Nguyen Truong Hoang Trang, Tran Thanh Vy, Vo Tan Duc, Nguyen Hoang Nam, Phan Cong Chien, Le Huu Hanh Nhi, Le Huu Nhat Minh

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: anterior mediastinal lesions; diffusion weighted imaging; diffusion magnetic resonance imaging; gadolinium; thyroma; lymphoma; thymus neoplasms; biopsy

Online: 30 June 2022 (08:19:29 CEST)

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Background. To describe the characteristics of anterior mediastinal masses on conventional magnetic resonance imaging (MRI) and to assess the role of the Apparent Diffusion Coefficient (ADC) value in distinguishing benign from malignant mediastinal lesions. Methods. We conducted a retrospective cross-sectional study on 55 patients with anterior mediastinal mass who performed MRI before treatment. Biopsy and histopathological assessments were done after that. A radiologist evaluates the changes of signal intensity on these sequences: T1- weighted VIBE DIXON pre and post-contrast with Gadolinium, T2 HASTE, T2 TIRM, DWI/ADC, to determine the size, margin of the lesion, the presence of fat, cystic in it. ADCs values were calculated from the ADC maps which were constructed from b = 0 and b = 2000 Results. The study was composed of 55 patients, with 5 benign lesions and 50 malignant lesions. The ADCmean, ADCmedian, ADC10, and ADC90 in the histogram-based approach and hot-spot-ROI-based mean ADC for the malignant lesions was significantly lower than those found in benign lesions (P-value <0.05). The hot-spot-ROI-based mean ADC had the highest value in differentiation between benign and malignant mediastinal lesions, between group A (benign lesions, thymoma A, AB, B1) and group B (thymoma B2, B3 and other malignant lesions). The cut-off point of the ADC value differentiating malignant from benign mediastinal lesions was 1,17x10-3mm2/s with sensitivity of 80%, and specificity of 80%. The cut off point of the ADC value differentiating group A from group B was 0.99 x10-3mm2/s with sensitivity of 78,4%, and specificity of 88.9%. The cut-off point of the ADC value differentiating lymphoma from other malignant lesions was 0,91 x10-3mm2/s with sensitivity of 100%, and specificity of 60.5%. Conclusion. Diffusion-weighted MRI and measurement of ADC value in histogram-based approach and hot-spot-ROI-based mean ADC are very helpful in the differentiation between benign and malignant anterior mediastinal lesions.

Preprint ARTICLE | doi:10.20944/preprints202206.0394.v1

Improving Clinical Prediction of Later Occurrence of Breast Cancer Metastasis Using Deep Learning and Machine Learning with Grid Search

Xia Jiang, Chuhan Xu

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: deep learning; DNN; machine learning; breast cancer; metastasis, metastatic breast cancer, distant recurrence of breast cancer metastasis; prediction; clinical; EHR

Online: 29 June 2022 (04:06:16 CEST)

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ABSTRACT Background It is important to be able to predict, for each individual patient, the likelihood of later metastatic occurrence, because the prediction can guide treatment plans tailored to a specific patient to prevent metastasis and to help avoid under- or over-treatment. Deep Neural Network (DNN) learning, commonly referred to as deep learning, has become popular due to its success in image detection and prediction, but questions such as whether deep learning outperforms other machine learning methods when using non-image clinical data remain unanswered. Grid search has been introduced to deep learning hyperparameter tunning for the purpose of improving its prediction performance, but the effect of grid search on other machine learning methods are under-studied. In this research, we take the empirical approach to study the performance of deep learning and other machine learning methods when using non-image clinical data to predict the occurrence of breast cancer metastasis (BCM) 5, 10, or 15-years after the initial treatment. We developed DNN models as well as models using 9 other machine learning methods including Naive Bayes (NB), Logistic Regression (LR), Support Vector Machine (SVM), LASSO, Decision Tree (DT), k-Nearest Neighbors (KNN), Random Forrest (RF), AdaBoost (ADB), and XGBoost (XGB). We used grid search to tune hyperparameters for all methods. We then compared the deep learning models to the models trained using the 9 other machine learning methods. Results Based on the mean test AUC results, DNN ranks 6th, 4th, and 3rd when predicting 5-year, 10-year, and 15-year BCM respectively, out of 10 machine learning methods. The top performing methods in predicting 5-year BCM are XGB(1^st), RF(2^nd), and KNN(3^rd). For predicting 10-year BCM the top performers are XGB (1^st), RF(2^nd), and NB(3^rd) . Finally, for 15-year BCM the top performers are SVM (1^st), LR and LASSO (tied for 2^nd), and DNN (3^rd). The ensemble methods RF and XGB outperform other methods when data are less balanced, while SVM, LR, LASSO, and DNN outperform other methods when data are more balanced. Our statistical testing results show that at a significance level of 0.05 DNN overall performs no worse than other machine learning methods when predicting 5-year, 10-year, and 15-year BCM. Conclusions Our results show that deep learning with grid search overall performs at least as well as other machine learning methods when using non-image clinical data. It is interesting to note that some of the other machine learning methods such as XGB, RF, and SVM are very strong competitors of DNN when incorporating grid search. It is also worth noting that the computation time required to do grid search with DNN is way more than that required to do grid search with the other 9 machine learning methods.

Preprint HYPOTHESIS | doi:10.20944/preprints202201.0171.v3

Targeted Anti-mitochondrial Therapy: The Future of Oncology

Farzad Taghizadeh-Hesary, Babak Behnam, Hassan Akbari, Moslem Bahadori

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: ATP; Cancer cell; Cancer Treatment; Mitochondria; T cell

Online: 27 June 2022 (05:07:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0186.v1

Developing An Over-the-Counter Screening Model for Breast Cancer among the Asian Women Population

Tengku Muhammad Hanis, Nur Intan Raihana Ruhaiyem, Wan Nor Arifin, Juhara Haron, Wan Faiziah Wan Abdul Rahman, Rosni Abdullah, Kamarul Imran Musa

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: screening model; breast cancer; explainable model; machine learning; Asian women

Online: 13 June 2022 (11:06:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0160.v1

Targeted Therapeutic Options and Future Perspectives for HER2-Positive Breast Cancer

Angelica Ferrando-Díez, Eudald Felip, Anna Pous, Milana Bergamino Sirven, Mireia Margelí

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: breast cancer; HER2-positive; estrogen receptor positive; triple-positive; HER2-targeted therapy; immunotherapy

Online: 10 June 2022 (11:03:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0046.v1

Epigenetic Modifications and Targeted Therapy in Pediatric Acute Myeloid Leukemia

Huan Xu, Yuxi Wen, Runming Jin, Hongbo Chen

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Acute myeloid leukemia; Pediatric; Epigenetics; DNA methylation; Histone modification; Non-coding RNAs; Therapy

Online: 3 June 2022 (10:59:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0368.v1

Finding Waldo: The Evolving Paradigm of Circulating Tumor DNA (ctDNA)-Guided Minimal Residual Disease (MRD) Assessment in Colorectal Cancer (CRC)

Sakti Chakrabarti, Anup Kasi, Aparna Raj Parikh, Amit Mahipal

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: circulating tumor DNA; colon cancer; colorectal cancer; minimal residual disease; adjuvant chemotherapy

Online: 27 May 2022 (03:52:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0342.v1

Predictive and Prognostic Value of Non-coding RNA in Breast Cancer

Navid Sobhani, Richard Chahwan, Raheleh Roudi, Rachel Morris, Stefano Volinia, Dafei Chai, Alberto D'Angelo, Daniele Generali

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: noncoding RNA; biomarkers; breast cancer; prognostic; diagnostic

Online: 25 May 2022 (05:09:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0336.v1

LncRNA Prostate Androgen-Regulated Transcript 1 (Part-1) Promotes the Non-small-Cell Lung Cancer Progression via Regulating miR-204-3p/IGFBP-2 pathway

Kenfen Li, Yanping Zhang, Yunfeng Wang, Xin Guo, Xianhui Dai, And Li Song

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Long non-coding RNA; Prostate androgen-regulated transcript 1; miR-204-3p; insulin-like growth factor binding protein 2

Online: 24 May 2022 (11:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0332.v1

Toxicity of Dose-Escalated Radiotherapy up to 84 Gray for Prostate Cancer

Johannes Rosenbrock, Christian Baues, Marius Kreis, Redouane Fouassi, Eren Celik, Pia Paffenholz, David Pfister, Axel Heidenreich, Simone Marnitz

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: prostate cancer; radiotherapy; toxicity; dose escalation

Online: 24 May 2022 (10:47:08 CEST)

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Introduction The outcome of radiotherapy (RT) for prostate cancer (PCA) depends on the delivered dose. While the evidence for dose-escalated RT up to 80 Gy is well established, there have been only few studies examining dose escalation above 80 Gy. We initiated the presented study to assess the safety of dose escalation up to 84 Gy. Patients and methods In our retrospective analysis, we included patients who received dose-escalated RT for PCA at our institution between 2016 and 2021. We evaluated acute genitourinary (GU) and gastrointestinal (GI) toxicity as well as late GU and GI toxicity. Results A total of 86 patients could be evaluated, of whom 24 patients had received 80 Gy and 62 patients had received 84 Gy (35 without pelvis- and 27 with pelvis-radiotherapy). Regarding acute toxicities, no adverse events > grade 2 occurred. 12.5% of patients treated with 80Gy, in 25.7% of patients treated with 84 Gy excluding pelvis, and in 51.9% of patients treated with 84Gy including pelvis suffered from Grade 2 GU acute toxicity (80 Gy versus 84 Gy: p=0.186; with pelvis versus without pelvis: p=0.032). Grade 2 GI toxicity occurred in 12.5% of patients irradiated with 80Gy, in 14.3% of patients treated with 84 Gy excluding pelvis, and in 12.9% of patients treated with 84Gy including pelvis (80 Gy versus 84 Gy: p=0.582; with pelvis versus without pelvis: p=0.510).GU late toxicity of grade ≥ 2 occurred in 4.2% of patients treated with 80 Gy, in 7.1% of patients treated with 84 Gy excluding pelvic RT, and in 18.2% of patients treated with 84 Gy including pelvic RT (logrank-test p=0.237). 8.3% of patients treated with 80 Gy, in 3.6% of patients treated with Gy excluding pelvic RT, and in 0% of patients treated with 84 Gy including pelvic RT suffered from GI late toxicity of grade ≥ 2(logrank-test p=0.358). Conclusion We were able to show that dose-escalated RT in PCA up to 84 Gy is feasible and safe without asubstantial increase in toxicity. Further follow up is needed to assess survival.

Preprint REVIEW | doi:10.20944/preprints202205.0328.v1

An Update on the General Features of Breast Cancer in Male Patients- a Literature Review

Sinziana Ionescu, Alin Nicolescu, Marian Marincas, Octavia Luciana Madge, Laurentiu Simion

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: male; breast; cancer; diagnosis; treatment; prognosis

Online: 24 May 2022 (09:34:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0218.v1

Endocrine Disruptors in Food, Estrobolome and Breast Cancer

Alessio Filippone, Cristina Rossi, Maria Maddalena Rossi, Annalisa Di Micco, Claudia Maggiore, Luana Forcina, Maria Natale, Lara Costantini, Nicolò Merendino, Alba Di Leone, Gianluca Franceschini, Riccardo Masetti, Stefano Magno

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Microbiome; Endocrine disruptors; Estrobolome; Personalized medicine; Oncobiotic

Online: 17 May 2022 (03:25:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0286.v2

Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells

Wei Yang, Yong Liang, Yuanyuan Zheng, Haitao Luo, Xiaofei Yang, Furong Li

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: novel ncRNAs; DE landscape; LSCs and LTCs; LncRNA; MiRNA; CircRNA; ceRNA networks; molecular mechanism

Online: 16 May 2022 (10:56:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0201.v1

A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies

Céline Hervieu, Mireille Verdier, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cancer stem cells; colorectal cancer; label-free cell sorting; chemoresistance; intratumoral cellular heterogeneity

Online: 16 May 2022 (09:11:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0142.v1

Development of in Vitro Assays for Advancing Radioimmunotherapy Against Brain Tumors

Yohan Walter, Anne Hubbard, Allie Benoit, Erika Jank, Olivia Salas, Destiny Jordan, Andrew Ekpenyong

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: glioblastoma; immunotherapy; radiotherapy; brain cancers; radioimmunotherapy; immune checkpoint inhibitors; temozolomide; durvalumab; immunoradiotherapy.

Online: 10 May 2022 (13:22:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0120.v1

Mathematical Modeling of the Growth Suppression of HER2+ Breast Cancer Colonies Under the Effect of Trastuzumab and PD-1/PD-L1 Inhibitor

Regina Padmanabhan, Hadeel Kheraldine, Ishita Gupta, Nader Meskin, Anas Hamad, Semir Vranic, Ala-Eddin Al Moustafa

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: HER2; PD-1/PD-L1; Mathematical model; HER2/PD-1 Interaction; Breast cancer

Online: 9 May 2022 (14:06:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0091.v1

Using the Prediction Model Risk of Bias Assessment Tool (PROBAST) to Evaluate Melanoma Prediction Studies

Isabelle Kaiser, Sonja Mathes, Annette B. Pfahlberg, Wolfgang Uter, Carola Berking, Markus V. Heppt, Theresa Steeb, Katharina Diehl, Olaf Gefeller

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: risk prediction; prediction models; risk of bias; PROBAST; melanoma

Online: 7 May 2022 (03:50:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0084.v1

Incidence, Mortality, Disability-Adjusted Life Years, and Trends of Prostate Cancer in Mexico from 2000 to 2019: Results from the Global Burden of Disease Study 2019

Saul A. Beltran-Ontiveros, Martha A. Fernandez-Galindo, Jose M. Moreno-Ortiz, Jose A. Contreras-Gutierrez, Jesus Madueña-Molina, Elyakim Arambula-Meraz, Emir Leal-Leon, Delia M. Becerril-Camacho, Veronica J. Picos-Cardenas, Carla Angulo-Rojo, Diana Z. Velazquez, Francisco Jimenez-Trejo, Francisco Gallardo-Vera, Daniel Diaz

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Age-standardized rate; Burden of disease; Cancer epidemiology; Malign neoplasm; Sociodemographic index; Subnational heterogeneity

Online: 6 May 2022 (14:47:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0068.v1

Mechanisms and Therapeutic Perspectives of Chemotherapy-Induced Peripheral Neuropathy: An Update

Antonio Avallone, Sabrina Bimonte, Claudia Cardone, Cira Antonietta Forte, Marco Cascella, Arturo Cuomo

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Chemotherapy-induced peripheral neuropathy; pain management; target therapy; immuno-therapy

Online: 6 May 2022 (09:14:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0042.v1

RAS, BRAF and EGFR Related Genetic Mutations as Predictive Biomarkers in Colorectal Cancer

Adriana Ionescu, Liviu Bilteanu, Ovidiu Ionut Geicu, Florin Iordache, Loredana Stanca, Aurelia Magdalena Pisoschi, Adrian Miron, Andreea Iren Serban, Valentin Calu

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Colorectal cancer; ddPCR; KRAS; NRAS; BRAF; EGFR

Online: 5 May 2022 (15:24:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0308.v1

Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells

Najla Santos Pacheco de Campos, Adriano de Oliveira Beserra, Pedro Henrique Barbosa Pereira, Alexandre Silva Chaves, Fernando Luiz Affonso Fonseca, Tiago da Silva Medina, Tiago Goss dos Santos, Yufei Wang, Wayne Anthony Marasco, Eloah Rabello Suarez

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: adoptive T cell therapy; hypoxic tumors; immune checkpoint blockade; CAR T; solid tumors; T cell exhaustion; co-stimulatory domains; CD28; 4-1BB; CD137

Online: 29 April 2022 (15:14:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0306.v2

Cancer clinic redesign: Opportunities for Resource Optimization

Michael Fung-Kee-Fung, Rachel S. Ozer, Bill Davies, Stephanie Pick, Kate Duke, David J. Stewart, M. Neil Reaume, Marcus Ward, Katelyn Balchin, Robert M. MacRae, Shannon Nelson, Julie Renaud, Dennis Garvin, Suzanne Madore, Jason R. Pantarotto

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: learning health system; ambulatory clinic; block schedule; disease site teams; interdisciplinary care; cancer operations; oncology value stream

Online: 26 April 2022 (04:37:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0207.v1

Prostate Cancer as a Channelopathy

Minas Sakellakis

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: prostate; cancer; proliferation; ion; channels

Online: 21 April 2022 (13:58:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0183.v1

Sensitization of Resistant Breast Cancer Cells with a Jumonji Family Histone Demethylase Inhibitor

Balraj Singh, Vanessa N. Sarli, Anthony Lucci

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: resistant TNBC; intra-tumoral heterogeneity; breast cancer relapse; breast cancer epigenome; me-tastasis prevention; intrinsic resistance of cancer; tumor adaptability; targeting resistant cancer

Online: 20 April 2022 (04:16:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0136.v1

Altitude Effect on Cutaneous Melanoma Epidemiology in the Veneto Region (Northern Italy): A Pilot Study

Paolo Del Fiore, Irene Russo, Alessandro Dal Monico, Jacopo Tartaglia, Beatrice Ferrazzi, Marcodomenico Mazza, Francesco Cavallin, Saveria Tropea, Alessandra Buja, Rocco Cappellesso, Lorenzo Nicolè, Vanna Chiarion-Sileni, Chiara Menin, Antonella Vecchiato, Angelo Paolo Dei Tos, Mauro Alaibac, Simone Mocellin

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cutaneous melanoma; altitude; coast-plain-hill gradient

Online: 14 April 2022 (14:54:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0132.v1

Sentinel Lymph Node in Breast Cancer: An Innovative Techniques

Paolo Izzo, Sara Izzo, Simone Sibio, Luigi Basso, Andrea Polistena, Gabriele Raimondo, Massimo Codacci-Pisanelli, Gaetano Gallo, Daniela Messineo, Luciano Izzo

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: SLNB; SPIO; ALND; LS; superparamagnetic iron oxide nanoparticles

Online: 14 April 2022 (10:51:37 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202204.0076.v1

[18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression

Teodoro Rudolphi-Solero, Eva María Triviño-Ibáñez, Jose Pablo Martínez-Barbero, Nicolás Cordero-Tous, Clara Eurgenia Chamorro-Santos, Antonio Rodríguez-Fernández, Manuel María Gómez-Río

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Foreign Body Reaction; deshydroxy-(18F) fluorocholine; Positron Emission Tomography; Low-grade glioma; Haemostatic material

Online: 8 April 2022 (08:48:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0391.v1

Preclinical models in Head and Neck Squamous Cell Carcinoma

Patricia Chaves, María Garrido, Javier Oliver, Elisabeth Pérez-Ruiz, Isabel Barragán, Antonio Rueda-Domínguez

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: HNSCC; preclinical model; cancer therapy

Online: 30 March 2022 (14:49:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0309.v1

Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma

Frances Byrne, Ellen Olzomer, Nina Lolies, Kyle Lee Hoehn, Marthe-Susanna Wegner

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: glycolysis; GEMs; oxidative phosphorylation; UGCG; glucosylceramide; normal liver cells; gangliosides; lacto/neo-lacto series GSLs; sulfatides

Online: 23 March 2022 (04:39:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0297.v1

The Effect of Intratumoral Interrelation among FOXP3+ Regulatory T cells on Treatment Response and Survival in Triple-Negative Breast Cancer

Noriko Goda, Chika Nakashima, Ichiro Nagamine, Sunao Otagaki

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: regulatory T cell; tumor-infiltrating lymphocyte; neoadjuvant chemotherapy; triple-negative breast cancer

Online: 22 March 2022 (07:50:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0156.v1

Breathing Exercises for Pain Management in Cancer Survivors: A Systematic Review

Haiying Wang, Xian-Liang Liu, Tao Wang, Jing-Yu (Benjamin) Tan, Houqiang Huang

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: breathing exercises; pain; cancer survivors

Online: 10 March 2022 (15:17:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0139.v1

CD15 and CD15s in The Anticancer Therapy

Wojciech Szlasa, Karol Wilk, Klaudia Knecht-Gurwin, Adam Gurwin, Anita Froń, Natalia Sauer, Jolanta Saczko, Tomasz Szydełko, Julita Kulbacka, Bartosz Małkiewicz

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: CD15; Lewis X; Lex; Cancer; Therapy

Online: 10 March 2022 (04:15:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0107.v1

The Potential Implementation of Biosensors for the Diagnosis of Biomarkers of Various Cancer

Sameer Quazi

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Nanobiotechnology; Biomarkers; Biosensors; Lung cancer; Skin Cancer; Colorectal Cancer

Online: 7 March 2022 (15:03:00 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202203.0091.v1

Characteristic of Uterine Rhabdomyosarcoma by Algorithm of Potential Biomarkers for Uterine Mesenchymal Tumor

Saya Tamura, Takuma Hayashi, Tomoyuki Ichimura, Nobuo Yaegashi, Kaoru Abiko, Ikuo Konishi

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: rhabdomyosarcoma; leiomyoma; leiomyosarcoma; mesenchymal tumor

Online: 7 March 2022 (08:50:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0060.v1

Viability of Glioblastoma Cells and Fibroblasts in the Presence of Imidazol-Containing Compounds

Christiane Seidel, Claudia Birkemeyer, Rainer Baran-Schmidt, Jürgen Meixensberger, Henry Oppermann, Frank Gaunitz

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: carnosine; glioblastoma; fibroblasts; imidazole-containing compounds; cell viability; high per-formance liquid chromatography coupled mass spectrometry

Online: 3 March 2022 (10:31:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0059.v1

Effect of Vitamin D on Graft-Versus-Host Disease

Alfonso Rodríguez Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Pérez-Simón

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: vitamin D; calcifediol; cailcitriol; graft-versus-host disease; vitamin D receptor (VDR)

Online: 3 March 2022 (10:02:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0018.v1

Investigating the Potential Use of Chemical Biopsy Devices to Characterize Brain Tumor Lipidomes

Joanna Bogusiewicz, Bogumiła Kupcewicz, Paulina Zofia Goryńska, Karol Jaroch, Krzysztof Goryński, Marcin Birski, Jacek Furtak, Dariusz Paczkowski, Marek Harat, Barbara Bojko

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: brain tumor; glioma; SPME; heterogeneity; lipids; chemical biopsy

Online: 1 March 2022 (11:13:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0015.v1

Development of a Novel Anti-CD44 Monoclonal Antibody C44Mab-46 for Multiple Applications against Esophageal Squamous Cell Carcinomas

Nohara Goto, Hiroyuki Suzuki, Tomohiro Tanaka, Teizo Asano, Mika K. Kaneko, Yukinari Kato

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: CD44; monoclonal antibody; esophageal cancer

Online: 1 March 2022 (10:32:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0268.v2

Preclinical Studies of Granulysin-Based Anti-Tn Immunotoxins as A New Antitumoral Treatment

Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: immunotoxins; granulysin; Tn antigen; MUC1

Online: 1 March 2022 (07:51:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0316.v1

The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

Kamari Weaver, Rachid Skouta

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Selenoprotein Glutathione Peroxidase 4 (GPX4); Reduced Glutathione (GSH); ferroptosis; lipid peroxidation; ferroptosis modulators; small molecules targeting GPX4

Online: 24 February 2022 (12:05:30 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202201.0171.v2

Anti-mitochondrial Therapy: A Potential Therapeutic Approach in Oncology

Farzad Taghizadeh-Hesary, Hassan Akbari, Moslem Bahadori

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: ATP; Cancer cell; Cancer Treatment; Mitochondria; T cell

Online: 22 February 2022 (10:48:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0268.v1

Preclinical Studies of Granulysin-Based Anti-Tn Immunotoxins as a New Antitumoral Treatment

Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: immunotoxins; granulysin; Tn antigen; MUC1

Online: 22 February 2022 (10:25:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0242.v1

Current Targeted Therapy for Metastatic Colorectal Cancer

Tomokazu Ohishi, Mika K. Kaneko, Yukihiro Yoshida, Yukinari Kato, Manabu Kawada

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Colorectal cancer; Targeted therapy; Clinical trial

Online: 21 February 2022 (03:05:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0218.v1

Lactobacillus on Recovering of Immune-Damage by Chemotherapy (Cancer Treatment)

Shousong Yue, Zhenzhong Zhang, Fei Bian, Yan Zhang, Gao Chen, Jun Li, Jean-François Picimbon

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Illumina MiSeq sequencing; gut microflora; Lactobacilli; immunostimulant; anticancer

Online: 17 February 2022 (17:31:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0090.v1

Establishment of Novel Neuroendocrine Carcinoma Patient-Derived Xenograft Models for Receptor Peptide-Targeted Therapy

Catherine G Tran, Luis C Borbon, Jacqueline L Mudd, Ellen Abusada, Solmaz AghaAmiri, Sukhen C Ghosh, Servando H. Vargas, Guiying Li, Gabriella V Beyer, Mary McDonough, Rachel Li, Carlos HF Chan, Paul F Cliften, Susan A Walsh, Thaddeus J Wadas, Thomas M O’Dorisio, M Sue O'Dorisio, Ramaswamy Govindan, Ali Azhdarinia, Andrew M Bellizzi, Ryan C Fields, James R Howe, Po Hien Ear

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Gastroenteropancreatic neuroendocrine neoplasms; patient-derived xenograft; tumor spheroids; somatostatin receptor-2; Near infrared-labelled octreotide analog

Online: 7 February 2022 (13:12:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0078.v1

At the Intersection of Cardiology and Oncology: TGFβ as a Clinically Translatable Therapy for TNBC Treatment and as a Major Regulator of Post-Chemotherapy Cardiomyopathy

Andrew Sulaiman, Jason Chambers, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri, Sarah McGarry, Sung Kim

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Cardiology; Oncology; CSC; TNBC; TGF-β

Online: 7 February 2022 (11:19:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0066.v1

Does Leptin Cause Proximal Gastric Cancer in the Obese? The role of Serum Leptin in the Etiology of Proximal Gastric Cancer

Tomaz Jagric, Gaja Hladnik, Rok Kolaric, Marjeta Dugonik, Evgenija Homsak

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: serum leptin; proximal gastric cancer

Online: 4 February 2022 (07:31:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0052.v1

New Targeted Therapies and Combinations of Treatments for Cervical, Endometrial and Ovarian Cancers: A Year in Review

Adelina Silvana Dragomir, Elena Adriana Dumitrescu, Isabela Anda Komporaly, Raluca Ioana Mihăilă, Cristian Virgil Lungulescu, Dana Lucia Stănculeanu

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cervical cancer; endometrial cancer; ovarian cancer; 2021 update; novel targeted therapies; immunotherapy

Online: 3 February 2022 (13:02:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0426.v1

Prognostic Role of p16 Overexpression in Sinonasal Squamous Cell Carcinoma: A Retrospective Analysis of Alberta Patients

Jill Querney, Adrian Mendez, Jacob Wihlidal, Fatemeh Ramazani, Moses Fung, Vincent Biron, David Côté

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Sinonasal squamous cell carcinoma; Head and neck; HPV; p16; Survival

Online: 28 January 2022 (07:20:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0390.v1

Analytic and clinical validation of a pan-cancer NGS liquid biopsy test for the detection of copy number amplifications, fusions and exon skipping variants.

Audrey Audetat, Cherie Tschida, Sarah Kreston, Adam Stephen, Brittany D'Alessio, Brittany D’Alessio, Leisa Jackson, John Williamson, Hestia Mellert, Niki Givens, Ubaradka G. Sathyanarayana, Gary A. Pestano

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: non-small cell lung cancer (NSCLC); liquid biopsy; cell-free nucleic acid (cfNA); next generation sequencing (NGS); CNA (copy number amplifications); fusions, exon-skipping.

Online: 26 January 2022 (03:21:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0380.v1

Circulating Tumor Cell Assay to Non-Invasively Evaluate PD-L1 and Other Therapeutic Targets in Multiple Cancers

Raymond Page, Darshana Patil, Dadasaheb Akolkar, Sudha S Murthy, Kiran Bendale, Revati Patil, Pradeep Fulmali, Pooja Fulmali, Archana Adhav, Sneha Puranik, Sachin Apurwa, Vineet Datta, Chirantan Bose, Stefan Schuster, Jinumary John, Ajay Srinivasan, Rajan Datar

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Therapeutic biomarkers; circulating tumor cells; Immunocytochemistry; targeted therapy; Fluorescence in situ hybridization (FISH); Immune Checkpoint Inhibitors; Liquid Biopsy; Hormonal Treatments; Breast Cancer; Lung Cancer

Online: 25 January 2022 (11:31:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0366.v1

Minimal Residual Disease Using Liquid Biopsies in Hematological Malignancies

Rafael Colmenares, Noemí Álvarez, Santiago Barrio, Joaquín Martínez-López, Rosa Ayala

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cell-free DNA; liquid biopsy; cancer; next-generation sequencing (NGS); minimal residual disease; measurable residual disease; molecular residual disease (MRD); leukemia; lymphoma; myeloma; myeloproliferative neoplasms; myelodysplastic syndrome

Online: 25 January 2022 (08:13:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0346.v1

Zhao YI Liu, Yong Chang Chen, Nayiyuan Wu, He Li, Jing Wang

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: pyroptosis; ovarian cancer; prognosic; immune microenvironment; signature

Online: 24 January 2022 (11:19:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0292.v2

Frutalin Affinity Chromatography on Sepharose Gel as a Strategy for the Identification of Possible Tumor Markers in Myelodysplastic Syndromes

José Camilo Torres-Romero, Adolfo I. B. Romo., Márcio de Souza Cavalcante, Ana Cristina Monteiro-Moreira, Marina Duarte Pinto Lobo, Ronald Feitosa Pinheiro, Renato Moreira, Yulian Sepúlveda-Casadiego

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Cancer biomarker; Proteomic analysis; Myelodysplastic syndromes; Frutalin; MDS-RS; MDS-EB

Online: 24 January 2022 (10:53:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0327.v1

Imaging Cancer-Associated Fibroblasts (CAFs) with FAPi PET

Laura Gilardi, Lighea Simona Airò Farulla, Emre Demirci, Ilaria Clerici, Emanuela Omodeo Salé, Francesco Ceci

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cancer-associated-fibroblast; fibroblast activation protein; FAPi; Positron emission tomography; FAPi PET; theranostics

Online: 21 January 2022 (13:31:31 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202201.0298.v1

A Rare Case of Hepatic Vanishing Bile Duct Syndrome Occurring After Combination Therapy With Nivolumab and Cabozantinib in a Patient With Renal Carcinoma

Karim Gourari, Julien Catherine, Soizic Garaud, Joseph Kerger, Antonia Lepida, Aspasia Georgala, Fabienne Lebrun, Maria Gomez Galdon, Thierry Gil, Karen Willard-Gallo, Mireille Langouo Fontsa

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Checkpoint inhibitors; Immune related adverse events; Cholestasis; Severe ductopenia; Vanishing bile duct syndrome

Online: 20 January 2022 (11:07:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0292.v1

Frutalin Affinity Chromatography on Sepharose Gel as a Strategy for the Identification of Possible Tumor Markers in Myelodysplastic Syndromes

José Camilo Torres-Romero, Adolfo Barros-Romo, Márcio de Souza Cavalcante, Ana Cristina Monteiro-Moreira, Marina Duarte Pinto Lobo, Ronald Feitosa Pinheiro, Renato Moreira, Yulian Sepúlveda-Casadiego

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Cancer biomarker; Proteomic analysis; Myelodysplastic syndromes; Frutalin; MDS-RS; MDS-EB

Online: 20 January 2022 (09:46:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0286.v1

Identification of Novel Multi-Omics Expression Landscapes and Meta-Analysis of Landscape-Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells

Wei Yang, Yong Liang, Yuan Yuan Zheng, Hai Tao Luo, Xiao Fei Yang, Fu Rong Li

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: novel ncRNAs; DE landscape; LSCs and LTCs; LncRNA; MiRNA; CircRNA; ceRNA networks; molecular mechanism

Online: 20 January 2022 (07:49:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0280.v1

Roles of Podoplanin in Malignant Progression of Tumor

Hiroyuki Suzuki, Mika K Kaneko, Yukinari Kato

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: podoplanin, PDPN, tumor malignancy, tumor marker, antibody therapy, cancer-specific monoclonal antibody, CasMab

Online: 19 January 2022 (16:05:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0261.v1

Orphan Receptors in Prostate Cancer

Minas Sakellakis

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Orphan; receptors; nuclear; olfactory; prostate; cancer

Online: 18 January 2022 (15:08:22 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202201.0171.v1

Immune Cells vs. Cancer Cells: A Microscopic Energy Battle

Farzad Taghizadeh-Hesary, Hassan Akbari, Moslem Bahadori

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: ATP; Cancer cell; Mitochondria; T cell

Online: 12 January 2022 (14:18:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0164.v1

Neoadjuvant Pertuzumab plus Trastuzumab in Combination with Docetaxel and Carboplatin in Patients with HER2 Positive Breast Cancer: Real-World Data from a National Institute of Oncology in Poland.

Agnieszka Irena Jagiełło-Gruszfeld, Magdalena Rosinska, Malgorzata Meluch, Katarzyna Pogoda, Anna Niwińska, Renata Sienkiewicz, Aleksander Grous, Pawel Winter, Zbigniew I. Nowecki

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: breast cancer,; neoadjuvant chemotherapy; elederly; HER2- positive; pathological complete response; safety

Online: 12 January 2022 (13:31:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0082.v1

The Cationic Amphiphilic Drug Hexamethylene Amiloride Eradicates Bulk Breast Cancer Cells and Therapy-Resistant Subpopulations With Similar Efficiencies

Anastasia L Berg, Ashley Rowson-Hodel, Michelle Hu, Michael Keeling, Hao Wu, Kacey VanderVorst, Jenny J Chen, Jason Hatakeyama, Joseph Jilek, Courtney A Dreyer, Madelyn R Wheeler, Ai-Ming Yu, Yuanpei Li, Kermit L Carraway

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: breast cancer; cancer stem cell; therapy resistance; cationic amphiphilic drug; lysosome-dependent cell death

Online: 6 January 2022 (11:51:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0020.v1

Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer

Shengliang Zhang, Lindsey Carlsen, Liz Hernandez Borrero, Attila A. Seyhan, Xiaobing Tian, Wafik S. El-Deiry

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: P53; mutant p53; targeting therapy; immunotherapy; cancer

Online: 4 January 2022 (20:34:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0525.v1

Immunotherapy for Colorectal Cancer: Mechanisms and Predictive Biomarkers

Lindsey Carlsen, Kelsey E. Huntington, Wafik S. El-Deiry

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: colorectal cancer; immunotherapy; checkpoint blockade; adoptive cell therapy; monoclonal antibodies; oncolytic viruses; anti-cancer vaccines; cytokine; T cell; NK cell

Online: 31 December 2021 (15:14:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0482.v1

A Bayesian Network Meta-Analysis of First-Line Treatments for Non-Small Cell Lung Cancer with High Programmed Death-Ligand 1 Expression

Jung Han Kim, Soo Young Jeong, Jae-Jun Lee, Sung Taek Park, Hyeong Su Kim

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: non-small-cell lung cancer; immune checkpoint inhibitor; Bayesian meta-analysis; Review

Online: 30 December 2021 (12:13:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0447.v1

Cancer Immunotherapy Biomarkers of Response and Toxicity; Current Limitations and Future Promise

Brian Richard Healey Bird, Ken Nally, Karine Ronan, Gerard Clarke, Sylvie Amu, Anna S. Almeida, Richard Flavin, Stephen Finn

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cancer; immunotherapy; biomarker; microenvironment; microbiome; flow cytometry; cytokine

Online: 28 December 2021 (11:13:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0602.v3

Biochemistry, Not Oncogenes, may Demystify and Defeat Cancer

Jay Kulsh

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: carcinogenesis; cancer treatment; cervical cancer; DNA synthesis; free-radical; retinoblastoma; ribonucleotide reductase; somatic mutation theory (SMT)

Online: 28 December 2021 (10:53:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0441.v1

Determining the Factors Predicting the Response to Anti-HER2 Therapy in HER2-Positive Breast Cancer Patients

Ji Young You, Kyong Hwa Park, Eunsook Lee, Youngmee Kwon, Kyungtae Kim, Seungyoon Nam, Donghee Kim, Jeoung Won Bae

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: HER2; neoadjuvant; pathologic complete response; trastuzumab

Online: 28 December 2021 (09:58:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0396.v1

Novel Repositioning Therapy for Drug-Resistant Glioblastoma: In vivo Validation Study of Clindamycin Treatment Targeting the mTOR Pathway and Combination Therapy with Temozolomide

Takeyoshi Eda, Masayasu Okada, Ryosuke Ogura, Yoshihiro Tsukamoto, Yu Kanamaru, Jun Watanabe, Jotaro On, Hiroshi Aoki, Makoto Oishi, Nobuyuki Takei, Yukihiko Fujii, Manabu Natsumeda

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: glioblastoma; signal transduction; xenograft model; drug repositioning

Online: 23 December 2021 (16:53:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0306.v1

Cancer Clinic Redesign: Opportunities for Resource Optimization

Michael Fung-Kee-Fung, Rachel S. Ozer, Bill Davies, Stephanie Pick, Kate Duke, David J. Stewart, M. Neil Reaume, Marcus Ward, Katelyn Balchin, Robert M. MacRae, Julie Renaud, Dennis Garvin, Suzanne Madore, Jason R. Pantarotto

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: learning health system; ambulatory clinic; block schedule; disease site teams; interdisciplinary care; cancer operations; oncology value stream

Online: 20 December 2021 (10:35:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0282.v1

The Role of Bruton’s Kinase Inhibitors in Chronic Lymphocytic Leukemia: Current Status and Future Directions

Tadeusz Robak, Magda Witkowska, Piotr Smolewski

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Acalabrutinib; Bruton’s tyrosine kinase; BTK; CLL; Covalent inhibitors; COVID-19; Ibrutinib; Non-covalent inhibitors; Fenebrutinib; MK1026; Pirtobrutinib; Spebrutinib; Tirabrutinib; Zanubrutinib

Online: 16 December 2021 (16:13:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0236.v1

Canine and Feline Cutaneous Lymphocytosis: Reactive Process or Indolent Neoplastic Disease?

Francesco Albanese, Francesca Abramo, Michele Marino, Maria Massaro, Laura Marconato, Lucia Minoli, Valeria Martini, Luca Aresu

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cat; cutaneous lymphocytosis; dog; immunohistochemistry; lymphoma; PARR; skin

Online: 14 December 2021 (13:01:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0145.v1

Management of Oligoprogression in Patients with Metastatic NSCLC Harboring ALK Rearrangements

Chiara Pisano, Marco De Filippis, Francesca Jacobs, Silvia Novello, Maria Lucia Reale

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: oligoprogression; NSCLC; ALK rearrangement

Online: 9 December 2021 (08:36:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0137.v1

Effect of 5-Azacitine Treatment on Redox Status and Inflammatory Condition in MDS Patients

Paola Montes, Ana Guerra-Librero, Paloma García, Mª Elena Cornejo-Calvo, Mª del Señor López, Tomás de Haro, Laura Martínez-Ruiz, Germaine Escames, Darío Acuña-Castroviejo

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: myelodysplastic syndrome (MDS); oxidative stress; cytokines; inflammation; 5-Azacitidine; somatic alterations

Online: 8 December 2021 (14:36:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0018.v1

Machine-Learning to Discern Interactive Clusters of Risk Factors for Late Recurrence of Metastatic Breast Cancer

Juan Luis Gomez Marti, Adam Brufsky, Alan Wells, Xia Jiang

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: metastatic breast cancer; metastasis; causal learning; machine learning

Online: 1 December 2021 (13:40:33 CET)

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Background: Risk of metastatic recurrence of breast cancer after initial diagnosis and treatment depends on the presence of a number of risk factors. Although most univariate risk factors have been identified using classical methods, machine-learning methods are also being conducted to tease out non-obvious contributors to a patient’s individual risk of developing late distant metastasis. Bayesian-network algorithms may predict not only risk factors but also interactions among these risks, which consequently lead to metastatic breast cancer. We proposed to apply a previously developed machine-learning method to predict risk factors of 5-, 10- and 15-year metastasis. Methods: We applied a previously validated algorithm named the Markov Blanket and Interactive risk factor Learner (MBIL) on the electronic health record (EHR)-based Lynn Sage database (LSDB) from the Lynn Sage Comprehensive Breast Cancer at Northwestern Memorial Hospital. This algorithm provided an output of both single and interactive risk factors of 5-, 10-, and 15-year metastasis from LSDB. We individually examined and interpreted the clinical relevance of these interactions based on years to metastasis and the reliance on interactivity between risk factors. Results: We found that with lower alpha values (low interactivity score), the prevalence of variables with an independent influence on long term metastasis was higher (i.e., HER2, TNEG). As the value of alpha increased to 480, stronger interactions were needed to define clusters of factors that increased the risk of metastasis (i.e., ER, smoking, race, alcohol usage). Conclusion: MBIL identified single and interacting risk factors of metastatic breast cancer, many of which were supported by clinical evidence. These results strongly recommend the development of further large data studies with different databases to validate the degree to which some of these variables impact metastatic breast cancer in the long term.

MEDICINE & PHARMACOLOGY