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Preprint ARTICLE | doi:10.20944/preprints202306.0291.v1

Measurement of Abdominal Fat by Nutritional Ultrasound as a Risk Factor for Non-alcoholic Hepatic Steatosis (Nash) in Obese Children

Sandra Maeso Mendez, Ainhoa Sarasua-Miranda, Zuriñe Garcia Casares, Ariane Calvo Saez, Erika Santos Corraliza, Ainara Gamarra CAbrerizo, Ignacio Diez Lopez

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: obesity NASH

Online: 5 June 2023 (09:38:13 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.1906.v2

Congenital Cytomegalovirus (cCMV) From Non-Primary Maternal Infection: Still a Problem?

Victoria Malherbe, Stefanie Celen, Katherine Carkeek³, Evelina Carapancea, Cinzia Auriti, Fiammetta Piersigilli

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Congenital cytomegalovirus; hypothermia; status epilepticus; universal screening

Online: 31 May 2023 (08:46:42 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202305.1906.v1

Congenital Cytomegalovirus (cCMV) From Non-Primary Maternal Infection: Still a Problem?

Victoria Malherbe, Stefanie Celen, Katherine Carkeek³, Evelina Carapancea, Cinzia Auriti, Fiammetta Piersigilli

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Congenital cytomegalovirus; hypothermia; status epilepticus; universal screening

Online: 26 May 2023 (09:51:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1899.v1

The Effect of Caffeine on the Heart Rate Variability in Newborns: A Pilot Study

Helena Lenasi, Eva Rihar, Jerneja Filipič, Matjaž Klemenc, Petja Fister

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; heart rate variability; caffeine; apnoea; apnea; autonomic nervous system

Online: 26 May 2023 (09:36:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1715.v1

Human Milk Feeding Could Protect Extremely Preterm Infants from Bronchopulmonary Dysplasia

Sergio Verd, Roser Porta, Gemma Ginovart, Alejandro Ávila Alvarez, Fermín García-Muñoz Rodrigo, Montserrat Izquierdo Renau, Paula Sol Ventura

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: bronchopulmonary dysplasia; extremely preterm infants; human milk; breastfeeding

Online: 25 May 2023 (02:28:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1489.v1

Clinical Impact of Systematic Assessment and Psychoeducation in Specialized Treatment of Adolescents with Severe Functional Somatic Disorders: Results from the AHEAD Study

Karen Hansen Kallesøe, Kaare Bro Wellnitz, Eva Ørnbøl, Charlotte Ulrikka Rask

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Adolescents; Assessment; Functional Somatic Disorders; Functional Somatic Syndromes; Psychoeducation

Online: 22 May 2023 (09:44:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1199.v1

Malnutrition and the Microbiome Across the Four Trimesters of Pregnancy and the Post-Partum Period

Katie M. Strobel, Sandra Juul, D. Taylor Hendrixson

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Parental nutrition; Obesity; Pregnancy; Microbiome

Online: 17 May 2023 (05:43:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1157.v1

Evaluation of Anal Sphincter With High Resolution Anorectal Manometry and 3D Reconstruction in Patients With Anorectal Malformation

Anna Maria Caruso, Denisia Bommarito, Vincenza Girgenti, Glenda Amato, Ugo Calabrese, Adele Figuccia, Fabio Baldanza, Francesco Grasso, Emanuela Giglione, Alessandra Casuccio, Mario Pietro Marcello Milazzo, Maria Rita Di Pace

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: anorectal malformations; high resolution anorectal manometry; fecal incontinence; bowel management

Online: 16 May 2023 (10:48:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1131.v1

Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis and Clinically Diagnosed Postnatal Infection

Jordan T. Ewald, Baiba Steinbrekera, Jennifer R. Bermick, Donna A. Santillan, Tarah T. Colaizy, Mark K. Santillan, Robert D. Roghair

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: adipokine; chemokine (C-C motif) ligand 2; interleukin-6; leptin; neonatal; preeclampsia

Online: 16 May 2023 (09:00:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0591.v1

Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology

Nilesh Dankhara, Ira Holla, Sumana Ramarao, And Renjithkumar Kalikkot Thekkeveedu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 1. Bronchopulmonary dysplasia; 2. Sepsis; 3. Mechanical ventilation; 4. Pathogenesis; 5. Inflammation; 6. PDA

Online: 9 May 2023 (08:03:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0017.v1

Use of Newer and Repurposed Antibiotics Against Gram-negative Bacteria in Neonates

Angeliki Kontou, Maria Kourti, Elias Iosifidis, Kosmas Sarafidis, Emmanuel Roilides

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: neonates; ceftazidime/avibactam; ceftolozane/tazobactam; imipenem/cilastatin-relebactam; meropenem/vaborbactam; colistin; tigecycline; fosfomycin

Online: 8 May 2023 (04:59:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0198.v1

A Study of Gastric Fluid and Urine Metabolomics for the Prediction of Survival in Severe Prematurity

Konstantia Besiri, Olga Begou, Olga Deda, Evmorfia Bataka, Christos Nakas, Helen Gika, Angeliki Kontou, Eleni Agakidou, Kosmas Sarafidis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: gastric fluid; urine; metabolite; GC-MS; prematurity; survival

Online: 4 May 2023 (05:21:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0048.v1

Feeding VLBWs with Mother’s Own Milk. Italian Monocentric Analysis

Pasqua Anna Quitadamo, Federica Zambianco, Giuseppina Palumbo, Massimiliano Copetti, Maria Assunta Gentile, Antonio Mondelli

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Mothers' Own Milk; Preterm feeding; VLBW

Online: 2 May 2023 (03:09:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1190.v1

Early Prediction of Mortality after Birth Asphyxia with the nSOFA

Anne-Kathrin Dathe, Anja Stein, Nora Bruns, Elena-Diana Craciun, Laura Tuda, Johanna Bialas, Maire Brasseler, Ursula Felderhoff-Müser, Britta Hüning

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Birth asphyxia; nSOFA; outcome prediction; neonate; Hypoxic-ischemic encephalopathy (HIE); therapeutic hypothermia; resuscitation; organ dysfunction; biomarker; mortality

Online: 29 April 2023 (02:52:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0946.v1

Association of the Bacteria of the Vermiform Appendix and the Peritoneal Cavity with Complicated Acute Appendicitis in Children

Konstantinos Zachos, Fevronia Kolonitsiou, Antonios Panagidis, Despoina Gkentzi, Sotirios Fouzas, Vasileios Alexopoulos, Eirini Kostopoulou, Stylianos Roupakias, Aggeliki Vervenioti, Theodore Dassios, George Georgiou, Xenophon Sinopidis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acute appendicitis; bacterial culture; children; appendiceal lumen; peritoneal cavity; complicated appendicitis

Online: 26 April 2023 (03:41:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0652.v1

Chromosome 22q11.2 Deletion Syndrome: A Comprehensive Review of Molecular Genetics in the Context of Multidisciplinary Cinical Approach

Aleksandra Szczawińska-Popłonyk, Eyal Schwartzmann, Zuzanna Chmara, Antonina Głukowska, Tomasz Krysa, Maksymilian Majchrzycki, Maurycy Olejnicki, Paulina Ostrowska, Joanna Babik

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 22q11.2 deletion; microdeletion; DiGeorge syndrome; velocardiofacial syndrome; dysmorphism; inborn errors of immunity; thymus; congenital heart defect; hypocalcemia

Online: 20 April 2023 (10:41:14 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202304.0453.v1

An Infant Case of Coronary Artery Aneurysms with No Systemic Symptoms after Treatment for Kawasaki Disease

Yumiko Asai, Takanori Suzuki, Midori Yamada

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Coronary artery abnormalities; Infants; Kawasaki disease

Online: 17 April 2023 (10:45:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0408.v1

Prevalence of Active Primitive Reflexes and Craniosacral Blocks in Apparently Healthy Children and Relationships With Neuro-Development Disturbances

Gema León-Bravo, Irene Cantarero-Carmona, Javier Caballero-Villarraso

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: primitive reflexes; craniosacral dysfunction; neurodevelopment; early diagnosis; screening

Online: 17 April 2023 (05:32:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0386.v1

Caffeine Citrate Increases Ciliary Beat Frequency in Human Respiratory Epithelial Cells

Sandra Cindrić, Laura Bodenbeck, Rim Hjeij, Niki Tomas Loges, Christine Edelbusch, Petra Pennekamp, Esther Rieger-Fackeldey, Heymut Omran

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: caffeine citrate; bronchopulmonary dysplasia; neonates; ciliary beat frequency; air-liquid interface culture; mucociliary clearance; ryanodine receptor

Online: 17 April 2023 (03:39:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0265.v1

Neonatal Drug Formularies: a Global Scope

Dotan Shaniv, Srinivas Bolisetty, Thomas E. Young, Barry Mangum, Sean Ainsworth, Linda Elbers, Petra Schultz, Melanie Cucchi, Saskia N De Wildt, Tjitske M Van der Zanden, Neil Caldwell, Anne Smits, Karel Allegaert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Drug information; drug database; drug formulary; neonatal; pediatric

Online: 12 April 2023 (09:32:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0498.v1

A Machine Learning Algorithm Predicting Infant Psychomotor Developmental Delay Using Medical and Social Determinants

David Waynforth

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Developmental milestones; artificial intelligence; classification algorithms; infant growth

Online: 29 March 2023 (03:06:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0307.v1

Predictors of eHealth Literacy Among Turkish Adolesents: Perspectives From Preventive Health Practices And Health Promotion Activities

Gulay Yilmazel

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Adolescents; eHealth; health promotion; healthy lifestyle; preventive health

Online: 16 March 2023 (11:34:57 CET)

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Objective: This study aimed to determine impact of eHealth literacy on health promotion activities and preventive health practice among adolescents. Methods: This cross-sectional study was conducted between March and May 2022 with 706 adolescents in Çorum, Turkey. A face to face questionnaire form including socio demographic characteristics, preventive health practices, eHealth Literacy scale and Adolescent Health Promotion Scale were used. The data of the research were analyzed with the SPSS 22.0 program. Percentage, mean, Pearson Correlation analysis and multiple regression analysis were used in the analyzes. The p<0.05 value was considered statistically significant in the evaluations. Results: In the study, 55.8% were female and the mean age of the whole group was 16.09±2.63 years. The mean score of eHealth Literacy scale was 29.40±6.29. The mean of the total scores obtained from the Adolescent Health Promotion Scale was 137.97±21.87. Among the adolescents 96.0% didn’t use alcohol and 81% didn’t smoke. The rate of annual weight measure was 68.8%. Measurements of annual blood pressure, annual blood iron, annual cholesterol, annual dental examination and regular exercise rate were below 50%. There was a significant positive correlation between eHealth literacy and the Adolescent Health Promotion Scale (p<0.001). Multiple linear regression analysis was performed to predict eHealth literacy using the variables of Adolescent Health Promotion and preventive health practices. eHealth literacy was positively and significantly predicts health promotion behaviors (β= 0.27, t (695)= 7.54, p<0.001). eHealth literacy increased annual weight measurement by more than 0.13 (β=0.13), the annual blood iron measurement by more than 0.16 (β=0.16), annual dental examination by more than 0.11 (β=0.11). Conclusions: Adolescents ehealth literacy was high and effected via health promotion activities and preventive health practices. Developing eHealth litracy interventions will be important for environments with a high concentration of adolescents (schools, courses). Also, primary health care services should be entegrated with school environment.

Preprint ARTICLE | doi:10.20944/preprints202303.0259.v1

Correlation of Plasmatic Profiles of Inflammatory Cytokines/Chemokines and GFAP with Brain Damage Detected at MRI in Neonates with Hypoxic Ischemic Encephalopathy (HIE) Treated with Therapeutic Hypothermia: A Preliminary Study

Cinzia Auriti, Fiammetta Piersigilli, Vito Mondì, Laura Timelli, Tamara Del Pinto, Giusi Prencipe, Giulia Lucignani, Daniela Longo, Iliana Bersani

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Asphyxia; therapeutic hypothermia; newborns; glial fibrillary acidic protein (GFAP); cytokines; chemokines; neuroinflammation

Online: 14 March 2023 (13:22:48 CET)

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Background & Objective. Perinatal hypoxia acutely triggers the release of cytokines and chemokines from neurons, astrocytes and microglia. In response to hypoxia-ischemia resting/ramified microglia proliferate and undergo activation, with the production of proinflammatory molecules. The brain damage extension seems to be related with both the severity of hypoxia and the balance between pro and anti-inflammatory host response. Methods: In this preliminary study we compared in 10 neonates with hypoxic ischemic encephalopathy (HIE), during therapeutic hypothermia (TH), plasmatic cytokines and other inflammatory molecules levels: monocytic chemotactic-protein-1 (CCL2/MCP-1), CXCL8, glial fibrillary acidic protein (GFAP), Interferon gamma (IFN y), Interleukin 10 (IL-10), IL-18, IL-6, CCL3, ENOLASE2, Colony Stimulating Factor(GM-CSF), IL-1b, IL-12p70, IL-33, Tumor Necrosis Factor alpha(TNF), collected at four different time points during TH (24 hours, 25-48 hours, 49-72 hours) , and after the rewarming (7-10 days from birth). Five of enrolled babies had pathological brain MRI (“cases”) and 5 had a normal examination (“controls”). Cytokines were measured by Magnetic Luminex Assay (Luminex SV 013-17 (14), instrument Biorad Bio-Plex 100 s.n. LX 10005039304). MRI images were classified according to the Barkovich score. Results: Mean levels of all cytokines and molecules at time T1 were not significantly different in the two groups of patients. Comparing samples paired by day of collection, the greatest differences between cases and controls were found at times T2 and T3, during TH. After rewarming, some molecules showed an upward trend. At T4, levels tended to be close again (with the exception of IL-6, IL10 and IL18). Infants with worse MRI showed plasmatic GFAP levels higher than those with normal MRI, while their IL-18 was lower. Mean levels of CCL3MIP1alpha, GMCSF, IL1BETA overlapped throughout the observation period in both the groups of neonates. Conclusion. In children with worse brain MRI we found high levels of GFAP and of IL-10 at T4, considered respectively an early biomarker of brain damage and a predictor of adverse outcome, according to the literature, and a trend towards low IL-18 levels. We found the greatest, although not significant, difference between molecules levels in cases and controls at time points T2 and T3, during TH. With the rewarming some molecules showed an upward trend. We cannot exclude that the small sample size may prevent significance in the differences from being achieved.

Preprint ARTICLE | doi:10.20944/preprints202303.0198.v1

The Effects of COVID-19 Lockdown on the Sleep Quality of Children

Roberto Lopez-Iracheta, Laura Moreno-Galarraga, Jose Manuel Moreno Villares, Oscar Emilio Bueso-Asfura, Miguel Angel Martínez-González, Nerea Martín-Calvo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Covid-19 lockdown; sleep quality; parental education; SENDO project

Online: 10 March 2023 (13:36:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0150.v1

The Outcome of a Caregiver Potential Support Program on Anemia Prevention Among Children Six Months to Two Years in Thasala District, Nakhon Si Thammarat Province, Thailand

Suphaphorn Saipaen, Kiatkamjorn Kusol, Thidarat Eksirinimit

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: support caregivers’ potential; food consumption; iron supplement; anemia prevention

Online: 8 March 2023 (08:41:09 CET)

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Children under two years old are at risk for anemia because young children have an increased need for iron for their physical growth and brain development. The purpose of this study was designed to evaluate the effects of a caregiver potential support program on anemia prevention in children six months to two years old attending the subdistrict health-promoting hospital in Thasala District, Nakhon Si Thammarat Province. This study was quasi-experimental. The sample included children aged six months to two years old and their caregivers, who were selected by random sampling and allocated to either the experimental or control group, with 40 pairs per group. The experimental group received a potential support program, while the control group received regular care. Both groups were followed for 12 weeks. The instruments used were the potential caregiver assessment, children’s anemia assessment, and a program to support the potential of primary caregivers. Descriptive statistics, chi-square, and t-tests were used to analyze the data. The results revealed that 11.4% of the children had anemia, and a hematocrit count of less than 33% (range = 30-40, M = 34.89, SD = 1.97). The mean scores of knowledge about anemia and iron supplementation after using the program in the experimental group and control group were significantly different (p < 0.001). The mean scores of knowledge about anemia in the experimental and control group were 15.75, SD = 0.54, and 13.28, SD = 1.43 respectively. The mean scores of knowledge about iron supplementation in the experimental and control group were 10.75, SD = 0.49, and 8.15, SD = 1.54 respectively. It was found that the experimental group had a higher mean score on food care behaviors than the control group for 6-11 months and 1-2 years, with statistical significance. The experimental group also had a higher mean score of care behaviors concerning children’s consumption of medicine than the control group (M = 58.20, SD = 4.05; M = 45.78, SD = 9.66, respectively), (p < 0.001). The mean score of the hematocrit level for the experimental group was found to be higher than the control group after receiving the program (M = 35.80, SD = 1.55; M = 34.83, SD = 2.14, respectively), (p < 0.05). Therefore, healthcare providers should support caregivers' capacity to provide continued care for children to prevent anemia.

Preprint REVIEW | doi:10.20944/preprints202303.0027.v1

Assessing Adverse Childhood Experiences in Young Refugees: A Systematic Review of Available Questionnaires

Shaymaa Abdelhamid, Eline Kraaijenvanger, Joachim Fischer, Maria Steinisch

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Adverse Childhood Experiences (ACEs); Refugee children; Systematic review; Questionnaires

Online: 2 March 2023 (01:42:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0470.v1

A Systematic Review on the Clinical Diagnosis of Transient Hypogammaglobulinemia of Infants

Angel Justiz-Vaillant, Nikao Davis, Candice Deonarinesingh, Amir De Silva, Dylan Dhanpaul, Chloe Dookhoo, Justin Doorpat, Alexei Dopson, Joash Durgapersad, Clovis Palmer, Odalis Asin-Milan, Trudee Hoyte

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: clinical diagnosis; immunodeficiency; systematic review; immunoglobulins

Online: 27 February 2023 (10:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0384.v1

Physical Activity, Sedentary Behaviour and Cardiovascular Risk Factors in Overweight Low-Income Schoolchildren: A Complex System Perspective

Thaynã Bezerra, Anastácio Souza Filho, Natália Quirino, Paulo Bandeira, Luciana Cabral, Cézane Reuter, Clarice Martins, Ferdinando Carvalho

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Cardiovascular factors; Network analysis; Obese children; Physical activity; Sedentary behaviour.

Online: 22 February 2023 (10:45:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0255.v1

Validation of Aspartylglucosaminidase Activity Assay for Human Serum Samples: Establishment of a Biomarker for Diagnostics and Clinical Studies

Antje Banning, Minna Laine, Ritva Tikkanen

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Aspartylglucosaminuria; lysosomal storage disorders; biomarkers; protein glycosylation; enzymes

Online: 15 February 2023 (07:54:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0219.v1

Surgical Informed Consent in Elective Pediatric Surgery: Medical Inadequacy or Parental Scotomization?

Bianca Stefani, Daniela Codrich, Maria Rita Caputo, Edoardo Guida, Maria-Grazia Scarpa, Alessandro Boscarelli, Jurgen Schleef

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Informed consent; Pediatrics; Elective Surgery; Quality improvement; Activity questionnaire

Online: 13 February 2023 (14:36:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0053.v1

Assessment of Determinants of Paediatric Diarrhoea Case Management Adherence in Pakistan

ASIF KHALIQ, River Holmes-Stahlman, Danish Ali, Shamshad Karatela, Zohra Lassi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: adherence; case management; determinants; diarrhoea; paediatrics

Online: 3 February 2023 (03:04:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0475.v1

Perceptions and Intention of Healthcare Workers’ to Vaccinate Their Children Aged <18 Years against COVID-19 from A Tertiary Care Institute of Eastern Uttar Pradesh (U.P.), India

Imran Ahmed Khan, MD. Abu Bashar, Rupam Kumar

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Parents; Healthcare workers; Children; C0VID-19 vaccine; Perception; Intention; Attitude

Online: 26 January 2023 (08:43:10 CET)

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Abstract Background COVID-19 vaccination program among Adults in India is one of the highly successful vaccination drives globally. Indian children aged 15–18 years old became eligible for COVID-19 vaccination on 3rd January, 2022 followed by 12-14 years old children on 16th March, 2022. As parents are primary decision-makers for their children, we aimed to assess parents' perceptions and intentions regarding COVID-19 vaccination for children in India. Aim To assess parental perceptions and intention to get COVID-19 vaccination for their children (aged<18 years), Materials and Methods A cross-sectional anonymous web-based survey was designed. Healthcare workers of a tertiary care institute in Eastern U.P. having any children aged <18 years were the study population. They were recruited through snowball sampling and were sent the study questionnaire in Google form through email and WhatsApp. Cross-tabulation was performed by parents' intention to vaccinate their children against COVID-19 virus with socio-demographic characteristics and their risk perception toward COVID-19, trust in the healthcare system, and their history of vaccine hesitancy behavior routine childhood immunization. Bi-variate analysis was performed to find out the predictors of child vaccination intention among the parents. Results A total of 388 healthcare workers parents (HCWPs) having A child < 18 years of age completed the survey. Mean age of the parents were 40.28 ±11.34 years with majority(97.0%) completing recommended 2 doses of COVIID-19 vaccine. Around 91% of the parents agreed that COVID-19 vaccines are important for child’s health whereas about 89% agreed to the statement that COVID-19 vaccines are effective. A total 356 (91.7%) participants were willing to vaccinate their child against COVID-19, 91.3% of them liked to do so as soon as possible. The factors significantly associated with the stated likelihood of child vaccination among the participants were younger age, female gender, urban residence, absence of any chronic illness, lower monthly income, history of COVID-19 in child and the child/children completed with routine childhood vaccines. Parental concerns mainly centered around vaccine need, safety and side effects. Conclusion The healthcare worker parents(HCWPs) have good knowledge and positive attitude towards COVID-19 vaccination for children. Around 92% of them were willing to vaccinate their children with COVID vaccine currently, which implies very low vaccine hesitancy among the HCWPs . Further longitudinal studies are required to be conducted to assess the trend of parental acceptance of COVID vaccine.

Preprint ARTICLE | doi:10.20944/preprints202301.0347.v1

Newborn Care Practices and Associated Factors Influencing their Health in a Northern Rural Area of India

Md Islam Arfin, Md Suhail Khan, Anas Ahmad Khan, Bayapa Reddy Narapureddy, Nazim Nasir, Lingala Kalyan Viswanath Reddy, Khursheed Muzammil, Irfan Ahmad, Adam Dawria, Faheem Ahmed, Ali Mohieldin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; cord care; newborn bathing; home deliveries; institutional deliveries; birth attendants; breastfeeding

Online: 19 January 2023 (08:41:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0317.v1

Serum 25-hydroxyvitamin D Levels and Youth-onset Type 2 Diabetes: A Two-sample Mendelian Randomization Study

Benjamin De La Barrera, Despoina Manousaki

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: vitamin D; pediatric type 2 diabetes; Mendelian randomization; GWAS; causal inference

Online: 18 January 2023 (03:40:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0210.v1

Morphological Medial Gastrocnemius Muscle Growth in Ambulant Children with Spastic Cerebral Palsy: A Prospective Longitudinal Study

Nathalie De Beukelaer, Ines Vandekerckhove, Ester Huyghe, Geert Molenberghs, Nicky Peeters, Britta Hanssen, Els Ortibus, Anja Van Campenhout, Kaat Desloovere

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: cerebral palsy; ultrasound; piecewise model; muscle volume; cross-sectional area; GMFCS

Online: 12 January 2023 (04:51:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0139.v1

Recent Trends in Antisense Therapies for Duchenne muscular dystrophy

Harry Wilton-Clark, Toshifumi Yokota

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: eteplirsen; golodirsen; viltolarsen; casimersen; WVE-N531; SRP-5051; DS-5141B; NS-089/NCNP-02; SCAAV9.U7.ACCA; ATL1102

Online: 9 January 2023 (04:18:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0576.v1

TiNi-based Material with Shape Memory Effect for Surgical Treatment of Diseases of Small Intestine in Newborn and Young Children

Sergey Anikeev, Maria Kaftaranova, Valentina Hodorenko, Stanislav Ivanov, Nadezhda Artyukhova, Anastasiia V. Shabalina, Sergei A. Kulinich, Grigory Slizovsky, Anatolii V. Mokshin, Viсtor Gunther

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: TiNi; structure; martensitic transformations; strength; double-barreled enterostomy; compression anastomosis

Online: 30 December 2022 (08:53:45 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202212.0513.v1

Case Report and a Review of Increased IgE in Patients with Transient Hypogammaglobulinemia of Infancy Who Received Immunoglobulins

Tareef Fadhil Raham

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: immunoglobulin; atopic dermatitis; atopy; IVIG

Online: 27 December 2022 (08:32:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0154.v1

Risk Factors for Neonatal Hypothermia at Arba Minch General Hospital, Ethiopia

Tilahun Ferede Asena, Tegenu Tento, Meseret Alemayehu, Asmare Wube

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Mean sojourn time; Multi-state Markov model; Transition rate

Online: 8 December 2022 (09:55:34 CET)

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Background: The first few minutes after birth are the most dangerous for the survival of an infant. Babies in neonatal intensive care units are either under heated or overheated, and hypothermic infants remain hypothermic or develop a fever. As a result, special attention must be paid to monitoring and maintaining the time of recovery from hypothermia states. Despite numerous studies, only a few have examined the transition from neonatal hypothermia and associated risk factors in depth. Method: A retrospective observational study was conducted to track axillary temperatures taken at the time of neonatal intensive care unit admission, which were then tracked every 30 minutes until the newborn's temperature stabilized. All hypothermic neonates admitted to the neonatal intensive care unit between January 2018 and December 2020 was included in the study. Temperature data were available at birth and within the first three hours of admission for 391 eligible hypothermic neonates. The effect of factors on the transition rate in different states of hypothermia was estimated using a multi-state Markov model. Result: The likelihood of progressing from mild to severe hypothermia was 5%, while the likelihood of progressing to normal was 34%. The average time spent in a severe hypothermia state was 48, 35, and 24 minutes for three different levels of birth weight, and 53, 41, and 31 minutes for low, moderate, and normal Apgar scores, respectively. Furthermore, the mean sojourn time in a severe hypothermia state was 48, 39, and 31 minutes for three different levels of high, normal, and low pulse rate, respectively. Conclusion: For hypothermic survivors within the first three hours of life, very low birth weight, low Apgar, and high pulse rate had the strongest association with hypothermia and took the longest time to improve/recover. As a result, there is an urgent need to train all levels of staff dealing with maintaining the time of recovery from neonatal hypothermia.

Preprint ARTICLE | doi:10.20944/preprints202212.0110.v1

Antibiotic Stewardship in Nonoperative Management of Perforated Appendicitis: Oral Antibiotics Are an Alternative

Alvaro Eduardo Galvis, Robert Bucayu, Rebecca John, Yigit Guner MD, Antonio C. Arrieta, Delma J. Nieves

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: discharge antibiotics; complicated Appendicitis; nonoperative management; antimicrobial treatment

Online: 7 December 2022 (02:22:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0078.v1

Assessment of Needs and Expectations of Expectant and New Parents as a Fundamental Step in Co-design of a mHealth Application Supporting the First 1000 Days of Life

Laura Brunelli, Sofia Bussolaro, Raffaella Dobrina, Chiara De Vita, Elena Mazzolini, Giuseppa Verardi, Maura Degrassi, Maria Piazza, Andrea Cassone, Anja Starec, Giuseppe Ricci, Sara Zanchiello, Tamara Stampalija

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: mHealth; pregnancy; app; first 1000 days; co-design; expectant parents

Online: 5 December 2022 (14:43:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0036.v1

COVID-19 in Infants and Children under 2 years – Lung Ultrasound Score Correlated with Biomarkers and Symptoms

Emil Robert Stoicescu, Jovan Lovrenski, Roxana Iacob, Simona Cerbu, Daniela Iacob, Emil Radu Iacob, Septimiu Radu Susa, Ioana Mihaiela Ciuca, Andreea Ciornei-Hoffman, Cristian Oancea, Diana Luminita Manolescu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: lung ultrasound; infants; children; COVID-19; SARS-CoV-2; multisystem inflammatory syndrome.

Online: 2 December 2022 (02:29:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0562.v1

Influencing Factors for the Implementation of School-based Interventions Promoting Obesity Prevention Behaviors in Children with Low Socioeconomic Status: A Systematic Review

Friederike Butscher, Jan Ellinger, Monika Singer, Christoph Mall

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: health equity; implementation; obesity; systematic review; CFIR; qualitative review; school-based interventions; children; facilitators

Online: 30 November 2022 (03:59:34 CET)

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Background: Health inequity (HI) remains a major challenge in public health. Improving the health of children with low socioeconomic status (SES) can help to reduce overall HI in children. Childhood obesity is a global problem, entailing several adverse health effects. It is crucial to assess influencing factors for adoption, implementation and sustainment of interventions. This review aims to identify articles reporting about influencing factors for the implementation of school-based interventions promoting obesity prevention behaviors in children with low SES. It aims to critically appraise the articles’ quality, assess influencing factors, categorize and evaluate them, and to discuss possible implications. Methods: A systematic search was conducted in 7 databases with the following main inclusion criteria: 1) school-based interventions and 2) target group aged 5–14 years. The Consolidated Framework for Implementation Research, its five domains (intervention characteristics, inner setting, outer setting, characteristics of individuals, process) along with 39 constructs within these domains were used to deductively analyze the data. We grouped the articles with regard to the characteristics of the interventions in simple and complex interventions. For each domain, and for the groups of simple and complex interventions, the most commonly reported influencing factors are identified. Results: 6452 articles were screened, and 16 met all eligibility criteria. Included articles applied mixed methods (n=10), qualitative (n=5) and quantitative design (n=1). Of these, five were considered to report simple interventions and eleven were considered to report complex interventions. In total, 295 influencing factors were assessed. Aspects of the inner setting were reported in every study, aspects of the outer setting were the least reported domain, and in the group of simple interventions not reported at all. In the inner setting, most reported influencing factors were time (n=7), scheduling (n=6) and communication (n=6). Conclusion: This review found a wide range of influencing factors for implementation. Most important influencing factors need to be assessed for every setting. Including all stakeholders involved in the implementation process enhances the prioritization of the most important influencing factors for the specific setting. More empirical research and practical guidance are needed to promote obesity prevention behaviors among children with low SES.

Preprint BRIEF REPORT | doi:10.20944/preprints202211.0436.v1

Multiplex PCR Detects Respiratory Viruses at A Much Higher Rate in Kawasaki Disease

Masayuki Nagasawa, Teruyoshi Shimoyama, Sayuri Hashimoto, Ryuichi Nakagawa, Haruna Yokoyama, Mari Okada, Tomohiro Udagawa, Akihiro Oshiba

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Kawasaki disease; febrile convulsions; respiratory virus; filmarray; multiplex PCR

Online: 23 November 2022 (07:02:54 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202211.0294.v1

Zoonotic Infection with Rabies Virus Leading to Fatal Encephalitis in Pediatric Patient – Case Report

Gheorghita Jugulete, Madalina Maria Merisescu, Alexandra Bastian, Sabina Andrada Zurac, Carmen Pavelescu, Monica Luminita Luminos

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: rabies children postexposure profilaxis; children; zoonotic disease; vaccine

Online: 16 November 2022 (03:12:04 CET)

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Rabies is a life-threatening and vaccine-preventable infectious disease and is triggered by an RNA virus, part of the Rhabdoviridae family, Lyssavirus genus. It is transmitted from infected saliva due to biting, but also from contact with infected blood or organs from rabid animals to humans. Children are at high risk due to their inability to defend themselves from infected animals and most deaths occur with a particularly high incidence in this category (under the age of 15 years). Postexposure prophylaxis (PEP) is standard and life-saving if given early after exposure. We are reporting the case of a ten-year-old female child, who was bitten by an unvaccinated cat ten days before admission to the Paediatric Intensive Care Unit at National Institute for Infectious Diseases „Prof. Dr Matei Bals”, Bucharest. The child had category III cat bites and did not receive PEP. Suggestive clinical manifestations such as an altered general state, psychomotor agitation, auditory and visual hallucinations, and hypersomnia followed by aerophobia and hydrophobia were present. Despite the maximal treatment introduced from early admission (Human Rabies Immunoglobulin, anti-rabies vaccination, orotracheal intubation plus mechanical ventilation, vital functions’ support, parenteral feeding, symptomatic drugs) the evolution of the patient was unfavourable, namely death two months after admission. The diagnosis was established in both pre-mortem by identifying the rabies virus in the cerebrospinal fluid based on reverse transcription-polymerase chain reaction (RT-PCR) and post-mortem by a histopathological examination (which reveals the presence of Babes-Negri bodies in the hippocampus). The objective is to understand the mechanism of infection and mortality from rabies virus in children. Conclusion: The most effective prevention methods are early administration of specific prophylaxis (immunoglobulin and vaccination) and, most importantly, early elimination of animal rabies outbreaks, while rapid diagnosis is helpful in the management of human rabies in humans. The rate of human exposure may be significantly decreased by controlling rabies through pet immunization programs.

Preprint ARTICLE | doi:10.20944/preprints202211.0198.v1

Finding the Proportion of Females with Autistic Spectrum Disorder Who Develop Anorexia Nervosa, the True Prevalence of Female ASD and Its Clinical Significance.

Robert McCrossin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: autistic spectrum disorder; anorexia nervosa; female; prevalence; Bayes’ Theorem; diagnosis; management; generalized joint hypermobility.

Online: 10 November 2022 (11:02:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0196.v1

Opportunities for Comprehensive Medication Management (CMM) for Children with Special Healthcare Needs and Medical Complexity (CSHCN-CMC): The Methodology of a Prospective Case Series within a Collaborative Practice Agreement (CPA)

Jena Quinn, Heather Monk Bodenstab, Catherine Kuhn, Richard H Parrish II

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: CSHCN; CMC; care coordination; case series; collaboration; medical complexity; medication management; methodology; pediatrics

Online: 10 November 2022 (10:04:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0158.v1

Grouping of Ankyloglossia According to Coryllos Anatomical Classification and Follow-Up Results for Breastfeeding: Single Center, Cross-Sectional Study

Mehmet Ali Narsat, Abdulvahab Beygirci, Gökçen Tuğçe Özdönmez, Eren Yıldız

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: ankyloglossia; breastfeeding; Coryllos; frenotomy; lingual frenulum; newborn; tongue tie

Online: 8 November 2022 (16:07:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0139.v1

Chorioamnionitis and Fetal Lung: from Animal Models to Human Fetuses

Vasiliki Kymioni, Kosmas Sarafidis, Theodora Papamitsou, Antonia Sioga

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: chorioamnionitis; fetal lung; vascularization; alveolarization; lung inflammation

Online: 8 November 2022 (02:33:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0116.v1

Possible Relationship between Respiratory Diseases and Urinary Concentrations of Polycyclic Aromatic Hydrocarbon Metabolites

Kateřina Urbancová, Veronika Vondraskova, Ivo Solansky, Anna Pastorkova, Jana Pulkrabova, Radim J. Sram

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 2-year-old children; respiratory diseases; influenza; OH-PAHs; metabolites; urine

Online: 7 November 2022 (10:12:30 CET)

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Aim: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been in the past associated with adverse effects on human health among which belong also respiratory diseases. Our study is focused on the evaluation of PAH exposure by measuring the concentrations of their monohydroxylated metabolites (OH-PAHs) in urine and comparing their concentrations with the incidence of respiratory diseases in 2-year-old children from two locations of the Czech Republic – a control locality Ceske Budejovice and a previously highly contaminated mining district Most. Methods: The total number of 248 participants were sampled for urine samples that were analysed for the presence of 11 OH-PAHs using liquid-liquid extraction with ethyl acetate and clean-up employing dispersive solid phase extraction with a sorbent Z-Sep. Separation, identification and quantification of the target compounds was achieved by ultra-high performance liquid chromatography coupled to tandem mass spectrometry. The incidence of respiratory diseases was evaluated according to the questionnaires provided by the paediatricians. Results and discussion: The concentrations of measured OH-PAHs were higher in the urine samples collected from 2-year-old children living in Most compared to 2-year-old children from Ceske Budejovice. The same trend was observed also when the urine samples were analysed when these children were studied as newborns in our previous study. From all of the monitored respiratory diseases, only influenza due to unidentified influenza virus showed a difference between tested locations where the 2-year-old children living in Most were more frequently diagnosed with this disease. Conclusion: Even though the air pollution and lifestyle in both cities is very similar, we have observed higher incidence of respiratory diseases as well as higher concentration of OH-PAHs in urine of the 2-year-old children from Most. Therefore, we hypothesize that the population living in this previously highly contaminated location (in 1970s and 1980s) can carry some long-term health burden.

Preprint ARTICLE | doi:10.20944/preprints202210.0471.v1

High Seroprevalence of Anti-SARS-CoV-2 Antibodies in Children in Vietnam: An Observational, Hospital-based Study

Dien Minh Tran, Uyen Tu Vu, Canh Ngoc Hoang, Ha Thu Thi Nguyen, Phu Huy Nguyen, Mai Chi Thi Tran, Anh Ngoc Chu, Phuc Huu Phan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: children; seroprevalence; antibodies; SARS-CoV-2; Vietnam

Online: 31 October 2022 (07:37:55 CET)

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Background: The robustness of sero-surveillence has delineated the high burden of SARS-CoV-2 infection in children; however, these existing data showed wide variation. This study aimed to identify the serostatus of antibodies against SARS-CoV-2 and associated factors among children following the fourth pandemic wave in Vietnam. Methods: A cross-sectional study was conducted at Vietnam National Children’s Hospital (VNCH) between March 13 and April 3, 2022. 4,032 eligible children seeking medical care for any medical condition not related to acute Covid-19 infections was tested for IgG SARS-CoV-2 Antibodies by ADVIA Centaur® SARS-CoV-2 IgG (sCOVG) assay using the residuals of routine blood samples. Results: The median age of enrolled children was 39 (IQR=14-82) months. The overall seropositive prevalence was 59.2%, and the median antibody titer was 4.78 [IQR 2.38-9.57] UI/mL. The risk of seropositivity and the median antibody titer was not related to gender (58.6% versus 60.1%, 4.9 versus 4.6 UI/mL, all p>0.05). Among age groups, the highest seroprevalence was reported in the children aged 13 to <36 months old. Children aged ≤12 months were likely to be seropositive compared to children aged 36 to <60 months (59.2% versus 57.5%, p=0.49) and those aged ≥144 months (59.2% versus 65.5%, p=0.16). Children aged ≥144 months exhibited a significantly higher titer of protective COVID-19 antibodies than other age groups (p <0.001). In multivariate logistic regression, we observed independent factors associated with SARS-CoV-2 seropositivity, including the age 13 to <36 months (OR=1.29, 95%CI=1.06-1.56, p=0.01), 60 to <144 months (OR=79, 95%CI=0.67-0.95, p=0.01), ≥144 months (OR=1.84, 95%CI=1.21-2.8, p=0.005), the presence of infected household members (OR=2.36, 95%CI=2.06–2.70, p<0.001), participants from Hanoi (OR=1.54, 95%CI=1.34-1.77, p<0.001), underlying conditions (OR=0.71, 95%CI=0.60-0.85, p<=0.001), and using corticosteroids or immunosuppressants (OR=0.64, 95%CI=0.48-0.86, p=0.003). Conclusions: This study highlights a high seroprevalence of antibodies against SARS-CoV-2 among children seeking medical care for non-COVID-19-related conditions in a tertiary children’s hospital in Hanoi, Vietnam. In the context of reopening in-person schools and future emerged COVID-19 variants, this point will also be a key message about the necessity of “rush-out” immunization coverage for children, especially those under the age of three years.

Preprint ARTICLE | doi:10.20944/preprints202210.0278.v1

Association between Knowledge about Anemia, Food Consumption Behaviors, and Hematocrit Level among School-Age Children in Nakhon Si Thammarat Province, Thailand

Pastraporn Kaewpawong, Kiatkamjorn Kusol, Onuma Bunkarn, Sirigran Sutthisompohn

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: knowledge; food consumption behaviors; hematocrit level; school-age children

Online: 19 October 2022 (10:06:28 CEST)

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Anemia is a significant public health problem among children, especially school-age children because their body quickly produces red blood cells to provide sufficient blood volume with plasma expansion to maintain blood concentration. This research aimed to study the anemia situation, knowledge about anemia, food consumption behaviors, and the association between knowledge, food consumption behaviors, and hematocrit level among school-age children in primary school, in Thasala district, Nakhon Si Thammarat Province. This is a descriptive study among 408 students, Grades 4 to 6, aged 9-12 years. Research instruments included the demographic data of the children and their knowledge about anemia, food consumption behaviors, and hematocrit assessment. Data were analyzed using descriptive, Spearman’s rank correlation coefficient, and logistic regression statistics. The results revealed that 23.2% of the samples had anemia, whereas 22.22% had mild anemia and 0.98% had moderate anemia. The children knew about anemia, where the mean score was at a moderate level (Mean= 6.63; SD= 2.51) out of 10. The mean score on food consumption behaviors was in the moderate level (Mean= 17.49; SD= 3.68) out of 24. There were significantly positive correlations between the knowledge about anemia and the hematocrit level at a moderate level (r= 0.45, p< 0.001). Correlation analysis revealed moderate food consumption behaviors with the hematocrit level (r= 0.40, p< 0.001). When confirm with Logistic regression found that knowledge about anemia (OR = 9.15, 95% CI: 4.57-18.34), and food consumption behaviors (OR = 19.09, 95% CI: 9.71-37.53) were significantly associated with the hematocrit level. Conclusions: This study showed that knowledge and appropriate food consumption behaviors are associated with hematocrit levels. Enhancing knowledge about anemia and food consumption behaviors may be reduced the prevalence of anemia in school-age children. The health care providers in primary care should be encouraged children to have health education and eat sufficient food.

Preprint ARTICLE | doi:10.20944/preprints202210.0251.v1

Impact of Prenatal Health Conditions and Health Behaviors in Pregnant Women on Infant Birth Defects in the United States Using CDC-PRAMS 2018 survey.

Girish Shelke, Rochisha Marwaha, Pankil Shah, Suman Challa

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Pregnancy; Birth-defect; National; PRAMS (Pregnancy Risk Assessment Monitoring System); Smoking; Diabetes; Depression

Online: 18 October 2022 (05:48:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0225.v1

Qtc Interval Reference Values and Their (Non)-Maturational Factors in Neonates and Infants: A Systematic Review

Lisa De Smet, Nathalie Devolder, Thomas Salaets, Anne Smits, Karel Allegaert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: QTc interval; Torsades de Pointes; neonates; infants; maturational changes; pharmacovigilance

Online: 17 October 2022 (04:09:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0084.v2

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

Sarah Werner, Claus Doerfel, Richard Biedermann, Michael Lorenz, Marius Rasche, Hans Proquitté, Lars Newman, Daniel Vilser

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: long COVID; Post COVID-19 condition; sleep disorders, SARS-CoV-2; Coronavirus; children

Online: 14 October 2022 (10:13:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0441.v1

Accumulation of Postoperative Unexpected Events Assessed by the Comprehensive Complication Index Are Prognostic Outcome Parameters After Kasai Procedure

Omid Madadi-Sanjani, Julia Brendel, Marie Uecker, Eva-Doreen Pfister, Ulrich Baumann, Johanna Ohlendorf, Joachim F Kuebler

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: biliary atresia; complications; clavien-dindo classification; comprehensive complication index; cci

Online: 28 September 2022 (12:19:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0185.v1

Role of Chest Radiographs and Electrocardiograms in Predicting the Hemodynamics of Congenital Heart Disease

Romila Chimoriya, Gaurav Kumar, Kritika Rana, Ritesh Chimoriya, Reena Anand, Kulbhusan S. Dagar, Neeraj Awasthy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital heart disease; chest radiograph; electrocardiogram; echocardiography

Online: 14 September 2022 (02:55:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0258.v2

Neonatal Intra-Ventricular-Hemorrhage Prevention in Premature at < 30 Weeks Gestational Age. A 12 years experience

Angela Hoyos, Pablo Vasquez-Hoyos

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Intraventricular Hemorrhage; Very preterm infants; Epiclatino registry; Obstetric trauma; Minimal manipulation protocol.

Online: 13 September 2022 (13:28:31 CEST)

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Introduction: Intraventricular Hemorrhage (IVH) is a devastating condition mostly in preterm infants at < 30 weeks GA with large morbidities and mortality usually in the first 72 hours after birth. Prevention seems to be the only way to completely deal with this problem. The IVH prevention in this age group has been studied and includes some strategies such as prenatal corticosteroids, cesarean delivery, careful extraction among others, but still, it has an unacceptably high incidence in this population. A protocol with the name Drive to Zero IVH Prevention Project that was presented in one of EpicLatino conferences some years ago. As with any quality improvement in practices, we adapted this project to our unit. Objective: To compare the IVH incidence in our unit after the protocol implementation with and historic cohort from the same unit and with all other units un the epilactino network. Material and method: In October 2017 we begun to implement a neuro protection protocol. For this analysis we include every patient born <30 weeks of GA, inborn or outborn but less than 2 days old, that survived at least three days and had a neuroimaging preformed. We include cases until July 2022, and we use the EpicLatino, a Latin-American database, from 2018 to 2020 excluding our own unit for comparison as well as an historical cohort from our unit from 2010-2017. The protocol consists of: Minimal manipulation, low volume ventilation, one routine fiscal exam a day, neutral head position, one blood pressure measured per shift, no keel stick measurements, continuous dim light and low noise level, minimal touch, no vasoactive therapy except in extreme cases, temperature and humidity at 80%, catheters, when possible, fluid restriction followed with diuresis, no PDA therapy or Echo if possible and routine therapy with hydrocortisone, erythropoietin, caffeine, parenteral nutrition, and trophic feeding. e performed a univariate analysis for IVH and groups and a logistic regression model with variables that had statistical significance in the univariate analysis. Results: The study group included 64 cases, the historic cohort 123 and the EpicLatino 1029. Demographic characteristics were similar with few statistically significant differences. We found four grade 1-2 and six grade 3-4 IVH in the study group (some caused by very traumatic delivery with multiples hematomas in head, body, and extremities), all significantly lower that the other two groups. The logistic regression model confirmed the independent statistically significant result in the study group. Conclusion: The hemorrhage during delivery must be prevented by the obstetric team. Afterwards, a set of interventions like very gentle handling with minimal manipulation and unnecessary strict lab managing seams to decrease the incidence of IVH.

Preprint ARTICLE | doi:10.20944/preprints202209.0087.v1

Association of Infant Feeding Indicators and Infant Feeding Practices with Coexisting Forms of Malnutrition in Children under Six Months of Age

Asif Khaliq, Darren Wraith, Yvette D. Miller, Smita Nambiar

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Malnutrition; association; feeding; practice; infants; Pakistan

Online: 6 September 2022 (10:13:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0084.v1

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

Sarah Werner, Claus Doerfel, Richard Biedermann, Michael Lorenz, Marius Rasche, Hans Proquitté, Lars Newman, Daniel Vilser

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: long COVID; Post COVID-19 condition; sleep disorders, SARS-CoV-2; Coronavirus; children

Online: 6 September 2022 (10:01:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0407.v2

Decrease in the Use of Parenteral Fluids in Premature Infants from 30 to 34 Weeks of Gestation at Birth

Angela Hoyos, Pablo Vasquez-Hoyos

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Parenteral fluids in premature infants; late premature infants; infections associated with the use of lines; early oral feeds

Online: 5 September 2022 (13:05:52 CEST)

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Introduction: Some of the practices in medicine are carried out of habit without proven benefits. This is the case of premature babies from 30 to 34 weeks of gestation who are always given parenteral fluids, even though this practice has been associated with an increase incidence of infection. At the end of 2017, we started a protocol of rationalization in the use of parenteral fluid. To administer nutrition/fluids, we used oral fluids by suction if this was possible or otherwise by oral/nasogastric tube at volumes of 70-80 mL/Kg/day divided every 3 hours, with 5 mL increments every 12-24 hours until 200 mL/K/day was achieved, always using breast milk when possible. Material and methods: The present study sought to compare results before and after this new policy. For this work, we review all premature babies between 30-34 weeks of gestation in two time periods, the first from 01/01/2010 to 12/31/2017 and the second from 01/01/2018 to 08/15/2022. The number of cases with and without parenteral fluids (PF), the incidence of infection, the weight at admission and discharge, and the change in the weight Z score between birth and discharge were compared. Both the anthropometric and outcome variables were compared using the different statistical methods according to each variable. Results: were found 920 cases with the described characteristics. The groups before and after the intervention did not show significant differences in their general demographic characteristics. We observed a decrease use of PF in the second period, from 425 cases (82.0%) before to 297 (26.2%) after implementation, p <0.0001 and fewer days of use (4.1 days/average before vs 1.3 after, p <0.0001) of PF. The weight at discharge and the change in weight Z-score were the same in both groups. Infections went from nine cases before to two cases after but it was not statistically significant. There were no complications due to less use of PF. Discussion: This study showed that the use of PF is not associated with significant changes in outcomes of interest, which reinforces that its use does not generate any benefit for the patient. Larger number of cases is required to detect differences in low incidence events such as infections.

Preprint ARTICLE | doi:10.20944/preprints202209.0002.v1

Brazilian Adults' Attitudes and Practices toward the Mandatory Vaccination for COVID-19 and the Hesitancy about Childhood Vaccination

Edson Zangiacomi Martinez, Miriane Lucindo Zucoloto, Vânia Pinheiro Ramos, Carla Daiane Costa Dutra, Giselle Juliana de Jesus, Arinete Véras Fontes Esteves, Isabella Schroeder Abreu, Monica Augusta Mombelli, Roberta Alvarenga Reis, Marilia Marcondes Campoamor, Wanderson Roberto da Silva, Claudia Benedita dos Santos

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; vaccine hesitancy; children; pediatrics; public health

Online: 1 September 2022 (02:25:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0532.v1

Perceived Vaccine Access Issues and the Uptake of Measles Vaccine in Sudan: The Mediating Role of Vaccination Hesitancy

Majdi M. Sabahelzain, Ahmed Tagelsir, Yasir Ahmed Mohammed Elhadi, Omayma Abdalla

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Vaccine access issues; vaccine uptake; vaccine hesitancy; vaccination hesitancy; measles; media-tion analysis

Online: 31 August 2022 (03:53:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0516.v1

Burden of Pediatric SARS-CoV-2 Hospitalizations during the Omicron Wave in Germany

Maren Doenhardt, Christin Gano, Anna-Lisa Sorg, Natalie Diffloth, Tobias Tenenbaum, Rüdiger von Kries, Reinhard Berner, Jakob P. Armann

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: SARS-CoV-2; COVID-19; Omicron; children; hospitalization

Online: 30 August 2022 (09:00:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0494.v1

Partial Obstruction of Ventricular Catheters Affects Performance in a New Catheter Obstruction Model of Hydrocephalus

Seunghyun Lee, Michael Vinzani, Bianca Romero, Alvin Y. Chan, Leandro Castaneyra-Ruiz, Michael Muhonen

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: hydrocephalus; shunt failure; catheter occlusion; ventricular phantom; flow/pressure performance

Online: 29 August 2022 (12:45:35 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202208.0379.v1

Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy

Elisenda Moliner-Calderón, Sergio Verd, Alfonso Leiva, Jaume Ponce-Taylor, Gemma Ginovart, Pia Moll-McCarthy, Catian Gelabert, Josep Figueras-Aloy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn infant; sepsis; premature infant; oxygen therapy; oxidative stress; ventilation support

Online: 22 August 2022 (08:11:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0371.v1

Maternal COVID-19 Vaccine May Reduce the Risk of MIS-C in Infants: A Narrative Review

Chetna Mangat, Siva Naga Srinivas Yarrarapu, Gagandeep Singh, Pankaj Bansal

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19 vaccine; pregnancy; infant; MIS-C

Online: 22 August 2022 (04:00:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0312.v1

Intranasal Dexmedetomidine as Sedative for Medical Imaging in Young Children: A Systematic Review to Provide a Roadmap for an Evidence-guided Clinical Protocol

Kato Hermans, Larissa Ramaekers, Jaan Toelen, Koen Vanhonsebrouck, Karel Allegaert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: procedural sedation; children; dexmedetomidine; imaging

Online: 17 August 2022 (09:44:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0277.v1

Pathogenesis and Etiology of Hearing Loss in Children

Srijan Singh, Roya Huseynova, Yahya Ethawi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Hearing loos; conductive; sensorineural; outer ear; middle ear; inner ear; SNHL; Cochlear; auditory; physical examination; history

Online: 16 August 2022 (04:04:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0261.v1

Fetal Macrosomia and Associated Factors to Perinatal Adverse Outcomes, in Yaounde, Cameroon : A Case Control Study

Anne Esther Njom Nlend, Josepha Gwodog, Arsene Brunelle Sandie

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: fetal macrosomia; gestational diabetes; maternal obesity; birth weight; fetal growth

Online: 15 August 2022 (11:56:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0257.v1

Fetal Macrosomia and Associated Factors to Perinatal Adverse Outcomes, in Yaounde, Cameroon : A Case Control Study

Anne Esther Njom Nlend, Josepha Gwodog, Arsene Brunelle Sandie

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: fetal macrosomia; gestational diabetes; maternal obesity; birth weight; fetal growth

Online: 15 August 2022 (11:25:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0447.v1

Impact of COVID-19 Pandemic on School-aged Children’s Physical Activity, Screen Time and Sleep in Hong Kong: a Cross-sectional Repeated Measures Study

Hung-Kwan So, Gilbert T Chua, Ka-Man Yip, Keith TS Tung, Rosa S Wong, Lobo HT Louie, Winnie WY Tso, Ian Wong, Jason Yam, Mike Kwan, Gary KK Lau, Judy Kong, Wilfred HS Wong, Patrick Ip

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19 pandemic; school closures; school-aged children; physical activity; screen time; sleep; Hong Kong

Online: 29 July 2022 (03:57:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0418.v1

Intent among Parents to Vaccinate Children before Pediatric Vaccine Recommendations, Minnesota and Los Angeles County, California--May-September 2021

Kara A. Suvada, Stuart F. Quan, Matthew D. Weaver, Meera Sreedhara, Mark É. Czeisler, Kathy Como-Sabetti, Ruth Lynfield, Prabhu Grounder, Elizabeth Traub, Aryana Amoon, Chandresh Ladva, Mark E. Howard, Charles A. Czeisler, Shantha Rajaratnam, Donatus U. Ekwueme, Brendan Flannery, Rashon I. Lane

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; vaccination; adolescents; parents; school

Online: 27 July 2022 (10:00:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0384.v1

Clinical and Evolutionary Features of SARS Cov-2 Infection (COVID-19) in Children, A Romanian Perspective

George Jugulete, Daniela Pacurar, Mirela Luminita Pavelescu, Mihaela Safta, Elena Gheorghe, Bianca Borcos, Carmen Pavelescu, Mihaela Oros, Madalina Merisescu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: SARS-CoV-2; COVID-19; children; clinical features; comorbidities; male genderSARS-CoV-2, COVID-19, children, clinical features, comorbidities, male gender

Online: 26 July 2022 (04:43:02 CEST)

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Background: Given the potential for additional development to clarify a better knowledge of the overall impact of COVID-19 on the pediatric population, the clinical symptoms of SARS-CoV-2 infection in children and adolescents are still being explored. Morbidity in children is characterized by a variable clinical course. Our study's goal was to compare clinical aspects of 230 pediatric patients who tested positive for SARS-CoV-2 and were hospitalized between April 2020 and March 2022. Methods: In a retrospective analysis, we compared two groups hospitalized in the infectious diseases clinical ward IX at the National Institute for Infectious Diseases "Prof. Dr. Matei Bals," Bucharest, Romania. The first group of 88 patients was admitted between (April–December 2020) and their clinical manifestations were compared with the second group of 142 children followed between July 2021 and March 2022. Results: Of 230 children, the median age was 4.5 (interquartile range 0.6-17) years, 53.9% were male. 88 (36.21%) patients (first group) were admitted during the second wave in Romania, mostly aged < 5 years old, and experienced digestive manifestations like fever (p=0.001), and diarrhoea (p=0.004). The second group experienced different clinical signs when compared with the first group, with higher temperature and increased respiratory symptoms analogous to those of acute respiratory viral infections. The proportion in the second group increased, and 64.5% had symptoms for a median interval of 5 days; age (0-4 -years old) and length of stay were both proportionally inversely (p<0.01) and with correlation with hospital admission (p = 0.04). We report two Paediatric Inflammatory Multisystem Syndrome (PIMS) in the second group, with favourable evolution under treatment. Comorbidities were risk factors for complications appear (p < 0.001) in both groups. All paediatric cases admitted to our clinic evolved favourably and no death was recorded. Conclusions: In the first group children experienced digestive symptoms, whereas the second group experienced mild and moderate respiratory symptoms. We confirmed risk factors for severe cases as manifestations across the age spectrum, 0-4 (digestive symptoms) and 5-12 years old (for respiratory symptoms), associated comorbidities, fever, and male gender. The potential effects of COVID-19 infection in children older than 5 years should encourage caregivers to vaccinate and improve the prognosis among pediatric patients at risk.

Preprint REVIEW | doi:10.20944/preprints202207.0251.v1

Adenovirus Infection in Pediatric Hematopoietic Cell Transplantation: A Challenge Still Open for Survival

Simone Cesaro, Fulvio Porta

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: adenovirus infection; adenovirus disease; cidofovir; preemptive therapy; risk factors; survival

Online: 18 July 2022 (08:13:46 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202206.0324.v1

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Ruth Diez, Sergio Verd, Jaume Ponce-Taylor, Antonio Gutierrez, Maria Llull, Maria-Isabel Martin-Delgado, Olga Cadevall, Jan Ramakers

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: circadian clock; otitis media; late dinner; common cold; Mediterranean diet; oxidative stress; chronotype

Online: 23 June 2022 (10:37:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0206.v1

Evaluation of Baseline Characteristics and Prognostic Factors in Multisystemic Inflammatory Syndrome in Children: Is It Possible to Foresee the Prognosis in the First Step?

Benhur Sirvan Cetin, Ayşenur Paç Kısaarslan, Sedanur Tekin, Merve Basol Goksuluk, Ali Baykan, Başak Nur Akyıldız, Yılmaz Seçilmiş, Hakan Poyrazoglu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; multisystem inflammatory syndrome in children (MIS-C); risk classification; prognosis

Online: 14 June 2022 (11:12:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0203.v1

Nupur Parakh, Puneet Sahi, Jagdish Chandra

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Gilbert Syndrome; Deferiprone; bone deformity

Online: 14 June 2022 (10:18:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0228.v1

Reactogenicity of mRNA and non-mRNA Based COVID-19 Vaccines Among Lactating Mother and Baby Dyads

Beth Jacob-Chow, Vasundhara Kandarpa Lakshmi, Hon Kit Cheang, Le Ye Lee, Jia Ming Low, Amin Zubair

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19 vaccines; SARS-CoV2; lactation; mother-child dyads; reactogenicity

Online: 17 May 2022 (10:31:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0044.v1

The Typology and Topography of Child Abuse and Neglect: The Experience of a Tertiary Children’s Centre

Geoff Debelle, Nikolaos Efstathiou, Rafiyah Khan, Annette Williamson, Manjit Summan, Julie Taylor

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: child maltreatment; administrative data; domestic violence/abuse; physical abuse; burns; neglect; emotional abuse; poverty

Online: 5 May 2022 (15:47:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0011.v1

Tanning Bed Legislation for Minors: A Comprehensive International Comparison

Katharina Diehl, Karla S. Lindwedel, Sonja Mathes, Tatiana Görig, Olaf Gefeller

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: tanning bed; sunbed; legislation; ban; adolescent; minors; ultraviolet radiation

Online: 4 May 2022 (13:19:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202204.0285.v1

Progressive Respiratory Insufficiency in a Teenager with Diaphragmatic Hypomotility Due to a Novel Combination of Gliomedin Gene Variants

Benjamin Eurich, Catharina Nitsche, Margot Lau, Britta Hanker, Juliane Spiegler, Guido Stichtenoth

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: GLDN variant; gliomedin; juvenile progressive respiratory insufficiency; diaphragmatic hypomotility; scoliosis; arthrogryposis; LCCS11; axonopathy; FADS

Online: 29 April 2022 (03:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0014.v1

Prevalence and Determinants of Excessive Screen Viewing Time in Children and its Effects on Physical Activity, Sleep, Eye Symptoms and Headache

Shilpa Jain, Shreya Shrivastava, Aditya Mathur, Deepali Pathak, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: screen view time; children; risk factors; India

Online: 4 April 2022 (10:57:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0398.v1

Rubella Virus Research in the Years 2000–2022: A Bibliometric Analysis

Hafiz Zeeshan, Ashina Sadiq, Hina Kirn

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: bibliometric analysis; Pubmed; rubella virus; research output; research collaboration; Biblioshiny; Bibliometrix; R-package

Online: 31 March 2022 (07:37:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0224.v2

Excessive Use of Paracetamol (Acetaminophen) during Early Development and Difficulties in Retrospective Analyses of Risks

Dillan Bono-Lunn, Maragatha Kuchibhatla, Antara Palkar, Jasmine Cendejas-Hernandez, Joshua T. Sarafian, Victoria G. Lawton, Lauren G. Anderson, John P. Jones III, William Parker

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acetaminophen; paracetamol; autism; pediatrics; safety

Online: 30 March 2022 (05:47:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0296.v1

A Non-Invasive Neonatal Signature Predicts Later Development of Atopic Diseases

Sereme Youssouf, Michel Moise, Mezouar Soraya, Guindo Oumar Cheick, Kaba Lanceï, Grine Ghiles, Mura Thibault, Mège Jean-Louis, Tran Tu Anh, Corbeau Pierre, Filleron Anne, Vitte Joana

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: preterm birth; fecal mediator and cytokine; methanogenic Archaea; allergy; atopy

Online: 22 March 2022 (07:33:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0296.v1

Managing Care during the COVID-19 Pandemic: The Point of View and Fears of Pediatric Cancer Patients’ Families

Olga Nigro, Giovanna Sironi, Andrea Ferrari, Gabriele Tinè, Gabriele Infante, Francesco Barretta, Matteo Silva, Carlo Alfredo Clerici, Stefano Chiaravalli, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Cristina Meazza, Filippo Spreafico, Michela Casanova, Monica Terenziani, Roberto Luksch, Maura Massimino

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; pediatric cancer; managing care

Online: 23 February 2022 (13:57:46 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202202.0288.v1

A Case of Focal Segmental Glomerulosclerosis in a Young Girl with a Very Low Birth Weight

Yasuyo Kashiwagi, Kazushi Agata, Gaku Yamanaka, Hisashi Kawashima

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: chronic kidney disease; low birth weight; focal segmental glomerulosclerosis; two-hit theory

Online: 23 February 2022 (08:26:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0115.v1

Available Evidence Indicates That Pediatric Use of Acetaminophen Adversely Affects Neurodevelopment in Susceptible Babies and Children

William Parker, Esha Patel, John Jones, Zacharoula Konsoula

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acetaminophen; autism; infant; paracetamol; neurodevelopment

Online: 8 February 2022 (13:42:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0011.v1

Leveraging Beneficial Off-target Effects Of Live-attenuated Rotavirus Vaccines

Prisca Benedicto-Matambo, Julie Bines, Chikondi Malamba-Banda, Isaac Tom Shawa, Kayla Barnes, Arox Wadson Kamn’gona, Daniel Hungerford, Kondwani Charles Jambo, Miren Iturriza-Gomara, Nigel A. Cunliffe, Katie L Flanagan, Khuzwayo Chidiwa Jere

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Rotavirus; off-target effects; neonatal; live attenuated; RV3-BB; epigenetic modulation

Online: 1 February 2022 (12:34:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0358.v1

Which Examination Is Most Useful in Assessing the Phenotype of Left Ventricular Noncompaction Cardiomyopathy in Children – Echocardiography, Cardiovascular Magnetic Resonance, or Both?

Agata Paszkowska, Jędrzej Sarnecki, Alicja Mirecka-Rola, Monika Kowalczyk-Domagala, Łukasz Mazurkiewicz, Lidia Ziółkowska

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: left ventricular noncompaction; cardiomyopathy; imaging; echocardiography; cardiovascular magnetic resonance; children

Online: 24 January 2022 (13:59:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0285.v1

Comparing Measurement Properties of the English EQ-5D-Y Three-Level Version with the Five-Level Version in South Africa

Janine Verstraete, Razia Amien, Des Scott

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Health Related Quality of Life, EQ-5D-Y-3L, EQ-5D-Y-5L, Youth, children, orthopaedic

Online: 20 January 2022 (07:23:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0264.v1

Disease Severity and Risk Factors of 30-Day Hospital Readmission in Pediatric Hospitalizations for Pneumonia

Motomori O. Lewis, Phuong T. Tran, Yushi Huang, Raj A. Desai, Yun Shen, Joshua D Brown

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: pediatric pneumonia; hospital readmission; healthcare quality; hospital costs

Online: 18 January 2022 (16:08:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0148.v1

CSF Upward Motion Is Crucial for ETV Success

Hans Ludwig, Steffi Dreha-Kulaczewski, Christoph Bock

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neuroendoscopy; ETV; Hydrocephalus; ETVSS; T2 flow void; Real-time MRI; Inspiration

Online: 11 January 2022 (14:08:02 CET)

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Purpose: ETV is indicated for treating obstructions of major CSF pathways. The outcome evaluation often yields success rates of only +- 70% for shunt independency. Hence, compromised CSF absorption seems to occur more often than expected. We searched for parameters suitable to assess the involved CSF dynamics. Material and Methods: This was a prospective study in 58 paediatric patients (7.7 yrs. mean age) between 2000 and 2020 with aqueductal stenosis (11/58), obstruction of the aqueduct due to tumor growth (22/58),and connatal hydrocephalus (9/58). The average follow-up interval was 4.7 years. Head circumferences, Evans- and fronto-occipital horn ratios before and 3 months after ETV were obtained as Delta-indices. Furthermore ETV success score (ETVSS), the patency of the aqueduct pre- and postoperatively as well as of the stoma were assessed by flow void signs on MRI. Evaluation on MRI also included the shape of the floor of the 3^rd ventricle and whether or not the septum pellucidum showed signs of perforation. Four patients were analysed pre- and postoperatively via real-time MRI. At least the educational status regarding protected or unprotected education was analyzed. Results:The prevalence of a bowing of the floor of the 3^rd ventricle was 72%, and the ETVSS was 71.0%. In 26 children a septal perforations or an open aqueduct prior to ETV (19) could be identified. Mean ER and FOHR were reduced by 0.03 and 0.05 , respectively. Maintained open (flow void on postop MRI) or perforation could successfully be carried out during endoscopic surgery in 44 patients (79%). The disproportionate increase of head circumference abated in 79.4% of patients. New shunt insertion occurred in 16 patients (27.5%). Intraoperatively upward CSF flow was detected in all cases. Statistical analyses(ANOVA) showed significant results for unprotected education, postoperative ER and FOHR but not for open stoma. Conclusion: The identification of flow through the stoma on postoperative MRI seems to be a necessary but not sufficient condition for ETV success. In our study, ventricular volumes were used as parameters to determine success rates as well as unprotected education. Furthermore, enabling upward CSF flow driven by inspiration seems crucial for successful ETV.

Preprint ARTICLE | doi:10.20944/preprints202201.0034.v1

Estimating the Male to Female Ratio in Autistic Spectrum Disorder, Defining and Calculating the Biases and Finding the True Number of Girls.

Robert McCrossin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: autistic spectrum disorder, male to female ratio, biases, young women.

Online: 5 January 2022 (10:57:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0017.v1

Inclusion and Withdrawal Criteria for Growth Hormone (GH) Therapy in Children with Idiopathic GH Deficiency—Towards Following the Evidence but Still with Unresolved Problems

Joanna Smyczyńska

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: short stature; growth hormone deficiency; insulin-like growth factor-1; growth hormone stimulation tests; neurosecretory dysfunction; final height; retesting

Online: 4 January 2022 (18:05:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0516.v1

The Role of the Global Solar UV Index for Sun Protection of Children in German Kindergartens

Olaf Gefeller, Sonja Mathes, Wolfgang Uter, Annette B. Pfahlberg

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: health attitudes; health knowledge; skin cancer; sun protection; ultraviolet radiation; UV index

Online: 31 December 2021 (11:56:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0407.v1

Decrease in the Use of Parenteral Fluids in Premature Infants from 31 to 34 Weeks of Gestation at Birth

Angela Hoyos, Pablo Vasquez-Hoyos

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Parenteral fluids in premature infants; late premature infants; infections associated with the use of lines; early oral feeds

Online: 24 December 2021 (14:43:57 CET)

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Introduction: Some of the practices in medicine are carried out of habit without proven benefits. This is the case of premature babies from 31 to 34 weeks of gestation who are always given parenteral fluids, even though this practice has been associated with an increase incidence of infection. In 2017, we started a protocol of parenteral fluid restriction. To administer nutrition/fluids, we used oral fluids by suction if this was possible or otherwise by oral/nasogastric tube at volumes of 15-20 mL intake every 3 hours, with 5 mL increments every 12-24 hours until 200 mL/K/day was achieved, always using breast milk when possible.Material and methods: The present study sought to compare cases before and after this new policy. For this work, we review all premature babies between 31-34 weeks of gestation discharged home in two periods of time, the first from 01/01/2012 to 12/31/2017 and the second from 01/01/2018 to 08/31/2021. The number of cases with and without parenteral fluids (PF), the incidence of infection, the weight at admission and discharge, and the fall in the weight Z score between birth and discharge were compared. Both the anthropometric and outcome variables were compared using the different statistical methods according to each variable.Results: 725 cases were found with the described characteristics. The groups before and after the intervention did not show significant differences in their general demographic characteristics. A lower use of PF was observed in the second period from 348 cases (79%) to 70 (24%), p <0.001 and fewer days of use (4.1 days/case vs 1.3, p <0.0001) of PF. The weight at discharge and the change in weight Z-score were the same in both groups. Infections went from three cases to zero but it was not statistically significant. There were no complications due to less use of PF.Discussion: This study showed that the use of PF is not associated with significant changes in outcomes of interest, which reinforces that its use does not generate any benefit for the patient. Larger number of cases is required to detect differences in low incidence events such as infections.

Preprint ARTICLE | doi:10.20944/preprints202112.0391.v1

Meta Analysis of Variant Predictions in Congenital Adrenal Hyperplasia Caused by Mutations in CYP21A2

Mayara Jorgens Prado, Rodrigo Ligabue-Braun, Arnaldo Zaha, Maria Lucia Rosa Rossetti, Amit Pandey

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: online prediction; CYP21A2; mutation analysis; pathogenicity prediction

Online: 23 December 2021 (12:00:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0312.v1

Factors Affecting the Knowledge and Motivation of Health Cadres on Stunting Prevention in Children in Indonesia

Henny Suzana Mediani, Sri Hendrawati, Tuti Pahria, Ati Surya Mediawati, Mira Suryani

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Health cadres; knowledge; motivation; stunting children; stunting prevention

Online: 20 December 2021 (12:40:36 CET)

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Medicine and Pharmacology