MSMEs play an important role in the global economy, employing nearly 90% of the workforce and contributing nearly 50% of the world's gross domestic product. However, many MSMEs have difficulty finding and retaining repeat customers, which is one of the main challenges for small businesses. This study aims to find out how customer data can be used to improve marketing strategies and meet customer needs and preferences more effectively. This research also aims to provide solutions and recommendations for MSMEs to improve their marketing through personalizing the experience for their customers. This study uses the SEM-PLS method with a quantitative approach. The population is taken from SMEs operating in the city of Semarang. 100 Samples are determined through Quota Sampling. Personalized marketing involves using customer data to customize the customer experience, which can create a closer relationship between customers and MSMEs. This research is still limited to the effectiveness of Personalized Marketing on customer loyalty in MSMEs. There have been many studies that discuss MSME customer loyalty with the marketing communication method. However, there are not many studies that specifically discuss personalized marketing for MSMEs.

Background: The seventh novel human infecting Betacoronavirus that causes pneumonia (2019 novel coronavirus, 2019-nCoV) originated in Wuhan, China. The evolutionary relationship between 2019-nCoV and the other human respiratory illness-causing coronaviruses is unclear. We sought to characterize the relationship of the translated proteins of 2019-nCoV with other species of Orthocoronavirinae.Methods: A phylogenetic tree was constructed from the genome sequences. A cluster tree was developed from the profiles retrieved from the presence and absence of homologs of ten 2019-nCoV proteins. The combined data were used to characterize the relationship of the translated proteins of 2019-nCoV to other species of Orthocoronavirinae.Results: Our analysis reliably suggests that 2019-nCoV is most closely related to BatCoV RaTG13 and belongs to subgenus Sarbecovirus of Betacoronavirus, together with SARS coronavirus and Bat-SARS-like coronavirus. The phylogenetic profiling cluster of homolog proteins of one annotated 2019-nCoV protein against other genome sequences revealed two clades of ten 2019-nCoV proteins. Clade 1 consisted of a group of conserved proteins in Orthocoronavirinae comprising Orf1ab polyprotein, Nucleocapsid protein, Spike glycoprotein, and Membrane protein. Clade 2 comprised six proteins exclusive to Sarbecovirus and Hibecovirus. Two of six Clade 2 nonstructural proteins, NS7b and NS8, were exclusively conserved among 2019-nCoV, BetaCoV_RaTG, and BatSARS-like Cov. NS7b and NS8 have previously been shown to affect immune response signaling in the SARS-CoV experimental model. Thus, we speculate that knowledge of the functional changes in the NS7b and NS8 proteins during evolution may provide important information to explore the human infective property of 2019-nCoV.

Islamic banks (IBs) have been criticized as not being genuinely Islamic, and the methods in measuring their performances have been debatable. While the literature on IBs performance has been emerging, such studies precisely assess its recent development remains absent. Therefore, we aim to evaluate the development of scholarly articles that measure IBs’ performances. We employ bibliometric analysis and sample related articles from the Scopus database. We find that the development of IBs performance literature may be understood by 111 peer-reviewed journal articles, 4 conference papers, 1 book, and 1 book series. We analyze these materials based on publication sources, country and institution affiliation, keywords association, and cluster dendrogram. Our model that quantifies the keywords association and cluster dendrogram provides a novelty in assessing IBs performance literature development. Future studies may replicate our model to cluster and identify the keyword associations from the unstructured data sources.

Spodoptera frugiperda is a relatively new invasive polyphagous insect pest in Indonesia. So far, S. frugiperda infestation has only been reported in corn, however in other countries S. frugiperda has been known to attack many commercial crops. To date, information on biological parameters of S. frugiperda is limited in Indonesian ecologies. Since host plants are a critical factor for insect life-history and has the potential to be used for pest control strategies, it is important to study the biology and survival of S. frugiperda on different host plants. This research was aimed to study the survival, life cycle, and fecundity of S. frugiperda on different host plants and how it affects pest management. The study was conducted by rearing S. frugiperda on 14 common cultivated host plant species in Indonesia. Survival rate, development time, fecundity, and potential attack rate of S. frugiperda on various tested host plants were analyzed in this study. The findings re-vealed that corn was the main host for S. frugiperda. The ability of S. frugiperda to survive on pa-paya, water spinach, banana, spinach, cucumber, and coco grass indicates that these plants are potential alternate host for S. frugiperda. Long beans, bok choy, choy sum, and beans might be in-dicated as a shelter for S. frugiperda. Meanwhile, inappropriate hosts for S. frugiperda include cabbage, broccoli, and cauliflower due to their low survival rate on these plants. This research implies that these plants have the potential to be used as a hedge, trap, or bunker plant in S. frugi-perda management strategies. However, to prevent a detrimental damage, control methods are needed in integrated manner, including monitoring pest populations, environmental engineering, and conservation of natural enemies.

The year 2022 was characterized by several major events that impacted the business world in Indonesia and even globally after the COVID-19 pandemic devastated all business sectors in Indonesia and the world. The current business environment is experiencing accelerating turbulence characterized by increasing intensity of business competition, rapid changes in the market, and industrial connections climate. The industrial connection climate of an institution can be measured by the pattern of relationships that occur between workers and management. Industrial connections are fundamental to the sustainability of an organization and are understood as an important factor in influencing institutional performance. This research aims to look at the impact of the existence of industrial connections instruments, turbulence in the business environment on the industrial connections climate. Besides, how the industrial connections climate relates to firm performance. The research design is an inferential quantitative, using sampling and snowball sampling methods with total sample are 406. The data collected were analyzed using Structural Equation Model using LISREL version 8.70. This research used a survey to build an SEM model that tested the effect of organizational turbulence and industrial connections instruments on organizational climate directly, and tested mediation on organizational performance. All related indicators have outer loading more than 0.5 and T-value more than 1.96. Therefore, the conclusion is that all measurements are valid. Composite Reliability (CR) and VE for all indicators are >0.7 and >0.5 respectively. This research shows that industrial assosiation climate has a positive effect on business turbulence and industrial connections instruments. However, industrial connections instruments show a greater impact on the assosiation climate. This is because industrial connections instruments are the media used in the implementation of industrial connections in organizations. This research also confirms that industrial assosiation climate is positively related to organizational performance. The result of the indirect influence (IE) of 0.20 with t value is 8.47 means that the climate of Industrial connections is able to mediate the influence of Industrial connections Facilities on Organizational Performance.

Liberal Islam is a form of socio-religious deviation for its adherents. In the name of human rights in Islam excessively, the potential for liberal Islamic thinking is born. Meanwhile, human rights need to be upheld in order to create Islam that is open in thinking and solutions in solving problems for the sake of creating a harmonious life. This study aims to describe the results of research on the thoughts of the East Java Nahdlatul Ulama Figures on the dialectic of the emergence of liberal Islam in Indonesia based on the philosophical aspects and forms of thought in order to straighten the views of Indonesian Muslim figures who are considered liberal thinking based on their opinions of other religions. This research is based on a structural functional theoretical framework where each informant adjusts to his capacity in maintaining the balance of conflict. The approach in this study uses qualitative-analysis with a type of centralized interview research. The results show that the dialectic of liberal Islam is the power of human rights and ignores the creed oriented towards the advancement of legal products. While the liberal Islamic philosophy is a desire, differences in thinking methodology, excessive use of rationality.

Oxide semiconductors are conventionally being used as sensing materials in gas sensors, limiting the detection of gases at room temperature (RT). In this work, a hybrid of copper oxide (CuO) with functionalized graphene (rGO) is proposed to achieve gas sensing at RT. The combination of high surface area and presence of many functional groups in CuO/rGO hybrid material makes it highly sensitive for gas absorption and desorption. To prepare the hybrid material, a copper oxide suspension synthesized using copper acetate precursor is added to the graphene oxide solution during its reduction using ascorbic acid. Material properties of CuO/rGO hybrid and its drop-casted thin films are investigated using Raman, FTIR, SEM, TEM, and four-point probe measurement systems. We find that the hybrid material is enriched with oxygen functional groups (OFGs) and defective sites along with electrical conductivity (~1.5 kΩ/□). The fabricated QCM (quartz crystal microbalance) sensor with a thin layer of CuO/rGO hybrid, demonstrates a high sensing response which is twice the response of the rGO-based sensor for CO₂ gas at RT. We believe that the CuO/rGO hybrid can be highly suitable for existing and future gas sensors used for domestic and industrial safety.

In the past decade, considerable efforts have been devoted to the development of semitransparent organic solar cells. Numerous materials and architectures have been proposed for the future commercialization of these devices. Among these, the use of ternary active layers demonstrated a great promise for the development of efficient semi-transparent organic solar cells with the potential for future applications including self-powered greenhouses and powered windows. Researchers seek alternative solutions to the trade-off between device power conversion efficiency (PCE) and average visible transmittance (AVT), with photoactive materials being the key parameters that govern both (PCE) and (AVT) as well as device stability. Several new organic materials, including polymers and small molecules, were synthesized, and used in conjunction with a variety of techniques to achieve semitransparent conditions. In this review paper, we will look at the working principle and key parameters of semi-transparent organic solar cells, as well as the methods that have been used to improve the performance of ternary-based semi-transparent organic solar cells. The main approaches were concluded to be spectral enhancement and transparency increment of the active layer through bandgap tuning, utilizing novel organic semiconductors, and design architecture of the active layers.

Organic solar cells are contributing extensively to the production of future large area and cost-effective sources of renewable energy with a compact environmental impact. Moreover, due to tunable optical properties of the active medium, the semi-transparent organic solar cell can be fabricated and become a promising nominee for building Integrated Photovoltaics (BIPV), vehicles, and mobile electronic devices. Therefore, three newly synthesized polymers used as were host materials for the active medium and blended with beetroot dye. Hence, based on BHJ structure two ternary systems have been constructed and utilized to fabricate semitransparent solar cells and characterized. The results show that the natural dye has a crucial impact on solar cell characteristic parameters. Consequently, large value of V_OC close to 1V were obtained for ternary systems and acceptor material named PINDOLE exhibits potentials for electron transport layer (ETL) and shows an improvement in both fill factor and device efficiency.

Glycans are involved in various metabolic processes via the functions of glycosyltransferases and glycoside hydrolases. Analysing the evolution of these enzymes is essential for improving the understanding of glycan metabolism and function. Based on our previous study of glycosyltransferases, we performed a genome-wide analysis of whole human glycoside hydrolases using the UniProt, BRENDA, CAZy, and KEGG databases. Using cluster analysis, 319 human glycoside hydrolases were classified into four clusters based on their similarity to enzymes conserved in chordates or metazoans (Class 1), metazoans (Class 2), metazoans and plants (Class 3), and eukaryotes (Class 4). The eukaryote and metazoan clusters included N- and O-glycoside hydrolases, respectively. The significant abundance of disordered regions within the most conserved cluster indicated a role for disordered regions in the evolution of glycoside hydrolases. These results suggest that the biological diversity of multicellular organisms is related to the acquisition of N- and O-linked glycans.

Over the centuries, honey is known for its superior usage in culinary, and for its rich nutrition and therapeutic values which are scientifically proven in the medical field. The chemical composition of honey varies depending on its botanical sources and environment. Therefore, the nutrition content in honey is highly likely to be affected by contaminants, such as heavy metals and pesticides. To ensure the quality of honey, parameters such as the heavy metal content should be within the safe range of total standard mineral and trace elements as defined by the International Food Standard (Codex Alimentarius), and pesticides should not be present at all. The high concentration of heavy metal and pesticides not only deteriorates the quality and quantity of honey, but also causes harm to the bee colony itself. In the agriculture sector, the excessive usage of pesticides and fertilizer negatively impacts the overall honey production process. Bees, a pollinating agent, bring the polluted nectar back to their beehives, eventually contaminating the honey and depreciating its value. Hence, this article will comprehensively review the activities that contribute to heavy metal and pesticide contamination, the interactions of bees as a pollinating agent, the impact of the pollutant to the colonies, and subsequently to the honey production.

Rett syndrome (RTT), a neurodevelopmental disorder, is mainly caused by mutations in methyl CpG-binding protein 2 (MECP2), which alter the functions of domains to either bind to methylated DNA or interact with a transcriptional co-repressor complex. It has been established that alterations in cyclin-dependent kinase-like 5 (CDKL5) or forkhead box protein G1 (FOXG1) correspond to distinct neurodevelopmental disorders, given that a series of studies have indicated that RTT is also caused by alterations in either one of these genes. We tried to elucidate RTT through evolution and structure assessment of MeCP2, CDKL5, and FOXG1, by focusing on their binding partners and disordered structures. Here, we provide insight into the similarities of the FOXG1 and MECP2 binding partners evolution and function. On the other hand, we suggest that CDKL5 could be a potential candidate for a classical RTT treatment, particularly based on its disordered structure that spans after the catalytic domain to the C-terminus, which shows abundant linear motifs that can bind to molecules with divergent structures of similar affinity. Additionally, we provide insight into the relationship between disordered structure and disease.

Rett syndrome (RTT) is mainly caused by mutations in methyl CpG-binding protein 2, cyclin-dependent kinase-like 5, or forkhead box protein G1. These RTT-causing proteins harbor an intrinsically disordered region (IDR) whose conformation exhibits spatiotemporal heterogeneity, which not only confer versatility to the protein, but also implicates them in diseases. The IDR generally evolves more rapidly than an ordered structure. In this study, we examined the relationship between pathogenic RTT-associated point mutations in RTT-causing proteins and the evolutionary dynamics of sequence features including structural order–disorder, phosphorylation sites, and evolutionary rates. We also analyzed the molecular properties and evolution of proteins that interact with RTT-causing proteins in terms of phylogenetic profiles, tissue specificity, subcellular localization, expression level, and functions. The results indicate that constrained IDRs may function by forming contacts with other regions in the protein sequence causing pathogenic missense mutations likely to arise in the rapidly evolving IDR and affect molecular networks, leading to disease. The results also provide novel insights into the genetic basis for RTT and the evolution of the neocortex in higher vertebrates.

Background: The diversity of butterflies relies on the accessibility of food plants and the quality of their habitat. Methods: The purpose of this study was to evaluate the diversity butterfly based on latent GLM in 3 different Habitat. At the same time, we perform the step construction of Tweedie Distribution both in species levels and individual level. Results: Our finding can be shown by accuracy AIC, AICc, and BIC. Conclusions: In modelling with latent glm tweedie it can conclude that the our model is suitable for use at the species or individual level.

Decoctions, macerations and fumigations of the stem bark and wood of Terminalia brownii Fresen. are used in traditional medicine for fungal infections and as pesticides on field crops and in traditional granaries in Sudan. In addition, T. brownii is commonly used for protecting wooden houses and furniture. Therefore, using agar disc diffusion and macrodilution methods, eight extracts of various polarities from the stem wood and bark were screened for their growth inhibitory effects against filamentous fungi commonly causing fruit, vegetable and grain decay, as well as infections in the immunocompromised host. Ethyl acetate extracts of the stem wood and bark gave the best antifungal activities, with MIC values of 250 µg/ml against Nattrassia mangiferae and Fusarium verticillioides, and 500 µg/ml against Aspergillus niger and Aspergillus flavus. Aqueous extracts gave almost as potent effects as the ethyl acetate extracts against the Aspergillus and Fusarium strains, and were slightly more active than the ethyl acetate extracts against Nattrassia mangiferae. Thin layer chromatography, RP-HPLC-DAD and tandem mass spectrometry (LC-MS/MS), were employed to identify the chemical constituents in the ethyl acetate fractions of the stem bark and wood. The stem bark and wood were found to have a similar qualitative composition of polyphenols and triterpenoids, but differed quantitatively from each other. The stilbene derivatives, cis- (3) and trans- (4) resveratrol-3-O-β-galloylglucoside, were identified for the first time in T. brownii. Moreover, methyl-(S)-flavogallonate (5), quercetin-7-β-O-di-glucoside (8), quercetin-7-O-galloyl-glucoside (10), naringenin-4`-methoxy-7-pyranoside (7), 5,6-dihydroxy-3`,4`,7-tri-methoxy flavone (12), gallagic acid dilactone (terminalin) (6), a corilagin derivative (9) and two oleanane type triterpenoids (1) and (2) were characterized. Our results justify the traditional uses of macerations and decoctions of T. brownii stem wood and bark for crop and wood protection and demonstrate that standardized extracts could have uses for the eco-friendly control of plant pathogenic fungi in African agroforestry systems. Likewise, our results justify the traditional uses of these preparations for the treatment of skin infections caused by filamentous fungi.

In osteoarthritis (OA), oxidative stress plays a crucial role in maintaining and sustaining cartilage degradation. Current OA management requires a combination of pharmaceutical and non-pharmacological strategies, including intraarticular injections of hyaluronic acid (HA). However, several lines of evidence reported that HA oxidation by reactive oxygen species (ROS) is linked with HA cleavage and fragmentation, resulting in reduced HA viscosity. Resolvin D1 (RvD1) is a lipid mediator that is biosynthesized from omega-3 polyunsaturated fatty acids and is a good candidate with the potential to regulate of panoply of biological processes, including tissue repair, inflammation, oxidative stress, and cell death in OA. Herein, newly designed, and synthesized imidazolium RvD1 analogues were introduced to compare their potential antioxidant properties with commercially available RvD1. Their antioxidant capacities were investigated by several in vitro chemical assays including Oxygen Radical Absorbance Capacity, 2,2-Diphenyl-1-picrylhydrazyl Radical Scavenging, Ferric Ion Reducing Antioxidant Power, Hydroxyl Radical Scavenging, and HA Fragmentation Assay. All results proved that imidazolium RvD1 analogues showed excellent antioxidant performance compared to RvD1 due to their structural modifications. Interestingly, they scavenged the formed reactive oxygen species (ROS) and protected HA from degradation, as verified by agarose gel electrophoresis and gel permission chromatography. A computational study using Gaussian 09 with DFT calculations and B3LYP/6-31 G (d, p) basis set was also employed to study the relationship between the antioxidant properties and chemical structures as well as calculation of the molecular structures, frontier orbital energy, molecular electrostatic potential, and bond length. The results showed that the antioxidant activity of our analogues was higher than that of RvD1. In conclusion, the findings suggest that imidazolium RvD1 analogues can be good candidates as antioxidant molecules for the treatment of oxidative stress-related diseases like OA. Therefore, they can prolong the longevity of HA in the knee and thus may improve the mobility of the articulation.