Many phenomena in resistance training are often attributed to intrinsic changes within the muscles targeted for hypertrophy. Examples include rapid “newbie gains” among novices, individual differences in training outcomes, and blunted anabolic responses to protein intake in experienced lifters. These are typically interpreted as reflecting diminishing responsiveness of muscles to repeated training stimuli. This article explores an alternative framework predicated on the fact that both performance and adaptation are seldom, if ever, limited only by the target muscle but also by supporting factors, including tendons, posture-specific musculature, neural coordination, skill, etc. Because these constraints often adapt at different rates than the target muscle, disparities in adaptation can create apparent stagnation even when muscle growth potential remains. This framework explains why alternating complementary exercises can sustain progress, why trainees respond differently to the same program, and why modality comparisons often yield null or mixed results. Practically, it underscores the importance of strategic variation, complementary exercise sequencing, individualized programming, and management of facilitating factors such as nutrition and recovery.