In urban environments, the accuracy of traditional Global Navigation Satellite System (GNSS) could be compromised due to signal occlusion and multipath interference, particularly during critical operational phases such as drone take-off and landing. This study seeks to enhance drone positioning accuracy by integrating 4G and 5G communication antennas and applying multilateration (MLAT) techniques based on Time-Difference-of-Arrival (TDOA) and Angle of Arrival (AOA) measurements. The research focuses on a real-world case study in the metropolitan area of Valencia, Spain, where extensive mobile network data were analysed using the Cramér-Rao Lower Bound (CRLB) to identify zones with minimal positioning errors and, separately, optimal coverage for connectivity. The results suggest that integrating terrestrial antennas could enhance drone navigation; however, its current applicability remains limited to urban areas.