This paper proposes an integrated numerical–experimental methodology for the durability assessment and optimisation of a passenger-car rear axle. A dedicated rear-suspension durability test bench was designed to impose a controlled cyclic vertical excitation on a dependent axle, reproducing service-like translational and rotational amplitudes of the beam and stabilizer bar. A detailed flexible multibody model of the bench–axle system was developed in MSC ADAMS and used to tune the kinematic excitation and determine an equivalent design load at the wheel spindles, consistent with the stiffness of the suspension assembly. Experimental strain measurements at nine locations on the axle, acquired with strain-gauge instrumentation on the bench, were converted into stresses and used to validate an explicit dynamic finite element model in ANSYS. The FE predictions agree with the experiments within about 10% at the beam mid-span and correctly identify a critical region at the junction between the side plate and the arm, where peak von Mises stresses of about 104 MPa occur. The validated model then supports a response-surface-based optimisation of the safety-critical wheel spindle, yielding a geometry that lowers spindle-fillet stresses to around 180–185 MPa under the maximum admissible wheel load, with only a modest mass penalty.