This review examines how cultural orientations, as defined by Hofstede’s six dimensions, shape family structures, parenting practices, and child protection systems in Ghana and Latvia. Using a systematic review guided by the PRISMA framework, 441 records were screened, and twenty-five sources were synthesized to ensure methodological rigor and transparency. Findings reveal stark contrasts between Ghana’s collectivist kinship systems and Latvia’s individualist nuclear structures. In Ghana, extended family networks and hierarchical authority dominate, reinforcing Authoritarian parenting and widespread acceptance of physical discipline. Conversely, Latvia’s emphasis on autonomy and egalitarianism aligns with Authoritative parenting, prioritizing reasoning and emotional warmth, though high rates of single-parent households introduce economic and psychosocial vulnerabilities. These cultural orientations influence not only caregiving arrangements but also the resilience of child protection systems: collectivist contexts buffer children through shared responsibilities, while individualist settings heighten risks in cases of family dissolution. The review underscores the need for culturally responsive interventions by mobilizing kinship networks in Ghana and strengthening community supports for single-parent families in Latvia. Overall, this study contributes to global social work discourse by highlighting how macro-level cultural values translate into micro-level family practices and child welfare outcomes.