Instant One-Pot Green Synthesis of Functional Ultra-Stable Gold Nanoparticles: Vaginal Candidiasis Point-of-Care Case Study

Mohamed Sallam; Kimberley Clack; Ema Romão; Cong Minh Nguyen; Amandeep Singh Pannu; Tanzena Tanny; Frank Sainsbury; Nam-Trung Nguyen; Pieter De Pauw; Nick Devoogdt; Nobuo Kimizuka; Serge Muyldermans

doi:10.20944/preprints202405.1467.v1

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preprints.org > chemistry and materials science > nanotechnology > doi: 10.20944/preprints202405.1467.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Instant One-Pot Green Synthesis of Functional Ultra-Stable Gold Nanoparticles: Vaginal Candidiasis Point-of-Care Case Study

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Version 1 : Received: 22 May 2024 / Approved: 22 May 2024 / Online: 23 May 2024 (10:04:24 CEST)
Version 2 : Received: 25 May 2024 / Approved: 27 May 2024 / Online: 27 May 2024 (09:52:00 CEST)

How to cite: Sallam, M.; Clack, K.; Romão, E.; Nguyen, C. M.; Pannu, A. S.; Tanny, T.; Sainsbury, F.; Nguyen, N.-T.; De Pauw, P.; Devoogdt, N.; Kimizuka, N.; Muyldermans, S. Instant One-Pot Green Synthesis of Functional Ultra-Stable Gold Nanoparticles: Vaginal Candidiasis Point-of-Care Case Study. Preprints 2024, 2024051467. https://doi.org/10.20944/preprints202405.1467.v1 Sallam, M.; Clack, K.; Romão, E.; Nguyen, C. M.; Pannu, A. S.; Tanny, T.; Sainsbury, F.; Nguyen, N.-T.; De Pauw, P.; Devoogdt, N.; Kimizuka, N.; Muyldermans, S. Instant One-Pot Green Synthesis of Functional Ultra-Stable Gold Nanoparticles: Vaginal Candidiasis Point-of-Care Case Study. Preprints 2024, 2024051467. https://doi.org/10.20944/preprints202405.1467.v1

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MDPI and ACS Style

Sallam, M.; Clack, K.; Romão, E.; Nguyen, C. M.; Pannu, A. S.; Tanny, T.; Sainsbury, F.; Nguyen, N.-T.; De Pauw, P.; Devoogdt, N.; Kimizuka, N.; Muyldermans, S. Instant One-Pot Green Synthesis of Functional Ultra-Stable Gold Nanoparticles: Vaginal Candidiasis Point-of-Care Case Study. Preprints 2024, 2024051467. https://doi.org/10.20944/preprints202405.1467.v1

APA Style

Sallam, M., Clack, K., Romão, E., Nguyen, C. M., Pannu, A. S., Tanny, T., Sainsbury, F., Nguyen, N. T., De Pauw, P., Devoogdt, N., Kimizuka, N., & Muyldermans, S. (2024). Instant One-Pot Green Synthesis of Functional Ultra-Stable Gold Nanoparticles: Vaginal Candidiasis Point-of-Care Case Study. Preprints. https://doi.org/10.20944/preprints202405.1467.v1

Chicago/Turabian Style

Sallam, M., Nobuo Kimizuka and Serge Muyldermans. 2024 "Instant One-Pot Green Synthesis of Functional Ultra-Stable Gold Nanoparticles: Vaginal Candidiasis Point-of-Care Case Study" Preprints. https://doi.org/10.20944/preprints202405.1467.v1

Abstract

The green synthesis of metallic nanoparticles is an emerging and promising field owing to its environmentally friendly nature and diverse applications. In this article, a new technology for the green synthesis of functional ultrastable biopolymer gold nanoparticles is introduced. This approach employs thiolated single-stranded DNA (ssDNA-SH) aptamers instead of conventional self-assembled monolayers, resulting in the production of highly stable aptamer-tagged gold-core-shell nanoparticles. A comprehensive discussion on the use of glucose as a simple reducing agent for the green synthesis of Au nanoparticles and the utilization of ssDNA-SH aptamers as smart and biologically functional capping agents is provided. The potential of this innovative approach for the green synthesis of nanoparticles is demonstrated through a case study involving the use of the naked eye for qualitative detection of human fungal infections caused by Candida albicans for women's health.

Keywords

Women’s health; Biosensing; Organometallic nanoparticles; Green-synthesis nanoparticles; Vaginal candidiasis; Candida albicans

Subject

Chemistry and Materials Science, Nanotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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