Version 1
: Received: 21 March 2024 / Approved: 24 March 2024 / Online: 25 March 2024 (06:21:26 CET)
How to cite:
Carreño-Flórez, G.P.; Boudreau, R.L.; Vicente-Manzanares, M.; Gallego-Gómez, J.C.; Cuartas-López, A.M. Role of c-Abl in DENV-2 Infection and Actin Remodeling in Vero Cells. Preprints2024, 2024031418. https://doi.org/10.20944/preprints202403.1418.v1
Carreño-Flórez, G.P.; Boudreau, R.L.; Vicente-Manzanares, M.; Gallego-Gómez, J.C.; Cuartas-López, A.M. Role of c-Abl in DENV-2 Infection and Actin Remodeling in Vero Cells. Preprints 2024, 2024031418. https://doi.org/10.20944/preprints202403.1418.v1
Carreño-Flórez, G.P.; Boudreau, R.L.; Vicente-Manzanares, M.; Gallego-Gómez, J.C.; Cuartas-López, A.M. Role of c-Abl in DENV-2 Infection and Actin Remodeling in Vero Cells. Preprints2024, 2024031418. https://doi.org/10.20944/preprints202403.1418.v1
APA Style
Carreño-Flórez, G.P., Boudreau, R.L., Vicente-Manzanares, M., Gallego-Gómez, J.C., & Cuartas-López, A.M. (2024). Role of c-Abl in DENV-2 Infection and Actin Remodeling in Vero Cells. Preprints. https://doi.org/10.20944/preprints202403.1418.v1
Chicago/Turabian Style
Carreño-Flórez, G.P., Juan Carlos Gallego-Gómez and Alexandra Milena Cuartas-López. 2024 "Role of c-Abl in DENV-2 Infection and Actin Remodeling in Vero Cells" Preprints. https://doi.org/10.20944/preprints202403.1418.v1
Abstract
Dengue is one the most significant mosquito-borne viral diseases globally, with its prevalence extending across tropical and subtropical regions, exerting a considerable financial strain on health systems. Despite decades of research leading to the development of a vaccine implemented in endemic countries, its usage remains restricted to a fraction of the population at risk of contracting dengue. Due to these limitations, there is a growing focus on research aimed at unraveling the cellular mechanisms crucial for Dengue virus (DENV) infection to pinpoint potential host targets. Multiple studies propose a pivotal role of cytoskeletal remodeling in DENV infection. Specifically, DENV alters the organization of actin to facilitate viral entry, replication, and release. In this study, we investigated the involvement of the protein c-Abl, a kinase crucial in actin dynamics, in the context of DENV infection. Our findings suggest that either silencing or pharmacological inhibition of the kinase c-Abl leads to accumulation of dengue ENV protein in vitro, associated with actin remodeling. These results illuminate cellular mechanisms that could serve as potential therapeutic alternatives for dengue management.
Keywords
DENV-2; c-Abl protein kinase; actin; Imatinib; artificial microRNA
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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