Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Autoimmune Haemolytic Anaemia and Anastomosing Haemangioma: “A Possible Relationship”

Version 1 : Received: 5 March 2024 / Approved: 6 March 2024 / Online: 6 March 2024 (04:33:45 CET)

How to cite: Losada, J.; Sarriugarte, A.; Soeda, I.; Maestro, B.; Irizar, E.; Losada, I. Autoimmune Haemolytic Anaemia and Anastomosing Haemangioma: “A Possible Relationship”. Preprints 2024, 2024030318. https://doi.org/10.20944/preprints202403.0318.v1 Losada, J.; Sarriugarte, A.; Soeda, I.; Maestro, B.; Irizar, E.; Losada, I. Autoimmune Haemolytic Anaemia and Anastomosing Haemangioma: “A Possible Relationship”. Preprints 2024, 2024030318. https://doi.org/10.20944/preprints202403.0318.v1

Abstract

The case of a patient with autoimmune haemolytic anaemia and an anastomosing haemangioma, is presented. The main dilemma was whether the haemangioma was the cause or the consequence of the autoimmune haemolytic anaemia and how both processes should be management. The diagnostic methods used are analytical and imaging techniques, which have not been conclusive in the diagnosis of anastomosing haemangiomas. Preoperative corticosteroid treatment does not prevent the recurrence of autoimmune haemolytic anaemia in the postoperative period. Surgical indication is established by the progression of proliferative activity, tumor enlargement and compression of the vena cava over time. Surgical resection of the tumor is the procedure used. The indication for surgical treatment of the anastomosing haemangioma and the decrease in alpha- fetoprotein after tumor resection are the most relevant results, although it increases again after a few weeks. The development of an anastomotic haemangioma may be secondary to autoimmune haemolytic anaemia. Angiogenesis resulting from the formation of erythroblastic islands at the periphery of the tumor and clonal expansions may be a mechanism to compensate for the haemolysis caused by autoimmune haemolytic anaemia

Keywords

anastomosing haemangioma; autoimmune haemolytic anaemia; Reprogramming Fibroblastic; Island erythroblastic; Clonal expansion

Subject

Medicine and Pharmacology, Surgery

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