Version 1
: Received: 22 February 2024 / Approved: 22 February 2024 / Online: 22 February 2024 (15:56:38 CET)
How to cite:
Prerna, P.; Chadha, J.; Khullar, L.; Mudgil, U.; Harjai, K. A Comprehensive Review on the Pharmacological Prospects of Terpinen-4-Ol: From Nature to Medicine and Beyond. Preprints2024, 2024021323. https://doi.org/10.20944/preprints202402.1323.v1
Prerna, P.; Chadha, J.; Khullar, L.; Mudgil, U.; Harjai, K. A Comprehensive Review on the Pharmacological Prospects of Terpinen-4-Ol: From Nature to Medicine and Beyond. Preprints 2024, 2024021323. https://doi.org/10.20944/preprints202402.1323.v1
Prerna, P.; Chadha, J.; Khullar, L.; Mudgil, U.; Harjai, K. A Comprehensive Review on the Pharmacological Prospects of Terpinen-4-Ol: From Nature to Medicine and Beyond. Preprints2024, 2024021323. https://doi.org/10.20944/preprints202402.1323.v1
APA Style
Prerna, P., Chadha, J., Khullar, L., Mudgil, U., & Harjai, K. (2024). A Comprehensive Review on the Pharmacological Prospects of Terpinen-4-Ol: From Nature to Medicine and Beyond. Preprints. https://doi.org/10.20944/preprints202402.1323.v1
Chicago/Turabian Style
Prerna, P., Umang Mudgil and Kusum Harjai. 2024 "A Comprehensive Review on the Pharmacological Prospects of Terpinen-4-Ol: From Nature to Medicine and Beyond" Preprints. https://doi.org/10.20944/preprints202402.1323.v1
Abstract
Owing to their extensive biological potential, essential oils (EOs) and their bioactive phytochemicals have gained attention from the scientific community. Within this domain, Terpinen-4-ol (T-4-ol), a bioactive monoterpene alcohol and the major constituent of tea tree oil (TTO), has made its way into translational research. Recent literature on T-4-ol strongly indicates its diverse pharmacological properties, including but not limited to antimicrobial, antivirulent, antioxidant, anti-inflammatory, anti-hypertensive, and anti-cancer effects. Hence, this review provides a comprehensive overview of the multifaceted biological activities exhibited by T-4-ol, emphasizing its medicinal potential for widescale application. The antibacterial and antifungal effectiveness of T-4-ol has been discussed encompassing its role in combating a broad spectrum of bacterial and fungal pathogens, respectively. The review delves into the antivirulent prospects of T-4-ol, shedding light on its ability to attenuate virulence and mitigate bacterial pathogenesis. Scientific literature on the antioxidant and anti-inflammatory activity of T-4-ol highlighting its role in neutralizing reactive oxygen species and modulating inflammatory pathways has also been collated. Furthermore, the review elaborates on the cardioprotective and anti-hypertensive properties of T-4-ol and augments literature on its anti-cancer mechanism against various cancer cell lines. Overall, this review consolidates the existing knowledge on T-4-ol, providing a holistic understanding of its pharmacological abilities. The exploration of these diverse attributes positions T-4-ol as a promising candidate for further research and therapeutic repurposing in various biomedical applications.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
