Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells

Talita Gabriela Luna Alves; Pedro Luiz Porfirio Xavier; Taismara Kustro Garnica; Arina Lázaro Rochetti; Thiago Henrique Annibale Vendramini; Felipe Haddad; Muhammad Munir; Márcio Antonio Brunetto; Heidge Fukumasu

doi:10.20944/preprints202401.0983.v1

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preprints.org > biology and life sciences > animal science, veterinary science and zoology > doi: 10.20944/preprints202401.0983.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells

Talita Gabriela Luna Alves

Pedro Luiz Porfirio Xavier

Taismara Kustro Garnica

Arina Lázaro Rochetti

Thiago Henrique Annibale Vendramini

Felipe Haddad

Muhammad Munir

Márcio Antonio Brunetto

Heidge Fukumasu

Version 1 : Received: 11 January 2024 / Approved: 12 January 2024 / Online: 12 January 2024 (07:03:45 CET)

How to cite: Alves, T.G.L.; Xavier, P.L.P.; Garnica, T.K.; Rochetti, A.L.; Vendramini, T.H.A.; Haddad, F.; Munir, M.; Brunetto, M.A.; Fukumasu, H. Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints 2024, 2024010983. https://doi.org/10.20944/preprints202401.0983.v1 Alves, T.G.L.; Xavier, P.L.P.; Garnica, T.K.; Rochetti, A.L.; Vendramini, T.H.A.; Haddad, F.; Munir, M.; Brunetto, M.A.; Fukumasu, H. Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints 2024, 2024010983. https://doi.org/10.20944/preprints202401.0983.v1

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MDPI and ACS Style

Alves, T.G.L.; Xavier, P.L.P.; Garnica, T.K.; Rochetti, A.L.; Vendramini, T.H.A.; Haddad, F.; Munir, M.; Brunetto, M.A.; Fukumasu, H. Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints 2024, 2024010983. https://doi.org/10.20944/preprints202401.0983.v1

APA Style

Alves, T.G.L., Xavier, P.L.P., Garnica, T.K., Rochetti, A.L., Vendramini, T.H.A., Haddad, F., Munir, M., Brunetto, M.A., & Fukumasu, H. (2024). Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells. Preprints. https://doi.org/10.20944/preprints202401.0983.v1

Chicago/Turabian Style

Alves, T.G.L., Márcio Antonio Brunetto and Heidge Fukumasu. 2024 "Investigation of the Oncolytic Properties of Newcastle Disease Virus on Feline Lymphoma Cells" Preprints. https://doi.org/10.20944/preprints202401.0983.v1

Abstract

Lymphoma is the most prevalent type of cancer in cats, and the search for alternative treatments is of utmost importance given the significant number of animals that exhibit tumor recurrence or are unresponsive to conventional chemotherapy treatment. Oncolytic viruses possess a unique ability to target and eliminate cancer cells while simultaneously stimulating an immune response against these malignant cells. The present study aimed to explore the oncolytic potential of Newcastle Disease Virus expressing green fluorescent protein (NDV-GFP) in a feline leukemia virus (FeLV)-positive lymphoma cell line. Our research suggests that NDV-GFP has a propensity to selectively target, infiltrate, and replicate with-in feline lymphoma cells, resulting in the induction of apoptosis in these cells, as opposed to non-tumor cells. Therefore, our research provides evidence supporting the development of novel oncolytic therapies based on NDV for the treatment of feline lymphomas.

Keywords

cat; virotherapy; oncolytic Newcastle Disease Virus; new therapies; cancer; lentogenic; in vitro; immunotherapy

Subject

Biology and Life Sciences, Animal Science, Veterinary Science and Zoology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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