Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Peptide-Based Biomaterials for Osteochondral Tissue Regeneration

Kausik Kapat
* ORCID logo ,
Sakshi Kumbhakarn
,
Rahul Sable
,
Prashil Gondane
,
Shruti Takle
,
Pritiprasanna Maity
Version 1 : Received: 28 December 2023 / Approved: 29 December 2023 / Online: 29 December 2023 (13:11:25 CET)

A peer-reviewed article of this Preprint also exists.

Kapat, K.; Kumbhakarn, S.; Sable, R.; Gondane, P.; Takle, S.; Maity, P. Peptide-Based Biomaterials for Bone and Cartilage Regeneration. Biomedicines 2024, 12, 313. Kapat, K.; Kumbhakarn, S.; Sable, R.; Gondane, P.; Takle, S.; Maity, P. Peptide-Based Biomaterials for Bone and Cartilage Regeneration. Biomedicines 2024, 12, 313.

Abstract

The healing of osteochondral defects (OCD) resulting from injury, osteochondritis, or osteoarthritis in middle- and old-age individuals, bearing lesions in the cartilage and bone, pain, and loss of joint function, presents challenges to the clinical practitioners because of non-regenerative cartilage and the limitations of current therapies. Bioactive peptide-based osteochondral (OC) tissue regeneration is becoming more popular because it does not have the immunogenicity, misfolding, or denaturation problems associated with original proteins. Periodically, reviews are published on the regeneration of bone and cartilage; however, none of them address the simultaneous healing of these tissues in the complicated heterogeneous environment of the OC interface. As regulators of cell adhesion, proliferation, differentiation, angiogenesis, immunomodulation, and antibacterial activity, potential therapeutic strategies for OC defects utilizing bone and cartilage-specific peptides should be examined and investigated. Therefore, the main goal of this review is to study how they contribute to the healing of OC defects, either alone or in conjunction with other peptides and biomaterials.

Keywords

Osteochondral; osteogenic; chondrogenic; cartilage; peptide-based; biomaterial

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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