Version 1
: Received: 6 December 2023 / Approved: 6 December 2023 / Online: 6 December 2023 (10:58:58 CET)
How to cite:
Komolkriengkrai, M.; Matsathit, U.; Khimmaktong, W. Therapeutic Potential of Glabridin and Gymnemic Acid Alleviates Choroid Thickness and Neovascularization in Diabetic Rat. Preprints2023, 2023120398. https://doi.org/10.20944/preprints202312.0398.v1
Komolkriengkrai, M.; Matsathit, U.; Khimmaktong, W. Therapeutic Potential of Glabridin and Gymnemic Acid Alleviates Choroid Thickness and Neovascularization in Diabetic Rat. Preprints 2023, 2023120398. https://doi.org/10.20944/preprints202312.0398.v1
Komolkriengkrai, M.; Matsathit, U.; Khimmaktong, W. Therapeutic Potential of Glabridin and Gymnemic Acid Alleviates Choroid Thickness and Neovascularization in Diabetic Rat. Preprints2023, 2023120398. https://doi.org/10.20944/preprints202312.0398.v1
APA Style
Komolkriengkrai, M., Matsathit, U., & Khimmaktong, W. (2023). Therapeutic Potential of Glabridin and Gymnemic Acid Alleviates Choroid Thickness and Neovascularization in Diabetic Rat. Preprints. https://doi.org/10.20944/preprints202312.0398.v1
Chicago/Turabian Style
Komolkriengkrai, M., Udomlak Matsathit and Wipapan Khimmaktong. 2023 "Therapeutic Potential of Glabridin and Gymnemic Acid Alleviates Choroid Thickness and Neovascularization in Diabetic Rat" Preprints. https://doi.org/10.20944/preprints202312.0398.v1
Abstract
This study was to explore the effects of glabridin and gymnemic acid on the structural changes of the choroidal layer as well as the expression of VEGF and CD31 in diabetic rats. The animals were separated into five groups: the control group (C), the diabetic group (DM), the diabetic rats treated with glabridin 40 mg/kg body weight (DM+GB), the diabetic rats treated with gymnemic acid 400 mg/kg body weight (DM+GM), and the diabetic rats treated with glyburide 4 mg/kg body weight (DM+GR). There has been an increase in the thickness of both the choroid layer and the wall of the arteries in the diabetic group. A decrease in vascularity and choroidal neovascularization can be found in DM rats. After eight weeks of experimentation, the choroidal thickness and wall of choroid arteries, as well as the diameter of the lumen of choroid arteries in the DM+GB, DM+GM, and DM+GR groups, had improved. The expression of VEGF and CD31 was lower compared to the DM group. According to the findings of the current research, glabridin and gymnemic acid can improve and reduce the damage to the choroid, which is a factor that can sometimes result in vision loss.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
