Version 1
: Received: 27 November 2023 / Approved: 27 November 2023 / Online: 28 November 2023 (06:56:44 CET)
How to cite:
Markelov, V.; Danilko, K.; Solntzev, V.; Piatnitskaia, S.; Shangina, O.; Bilyalov, A.; Chugunov, S.; Akhatov, I. Hydroxyapatite as a Material for Transplantology: Clinical Experience and Prospects of Application. Preprints2023, 2023111701. https://doi.org/10.20944/preprints202311.1701.v1
Markelov, V.; Danilko, K.; Solntzev, V.; Piatnitskaia, S.; Shangina, O.; Bilyalov, A.; Chugunov, S.; Akhatov, I. Hydroxyapatite as a Material for Transplantology: Clinical Experience and Prospects of Application. Preprints 2023, 2023111701. https://doi.org/10.20944/preprints202311.1701.v1
Markelov, V.; Danilko, K.; Solntzev, V.; Piatnitskaia, S.; Shangina, O.; Bilyalov, A.; Chugunov, S.; Akhatov, I. Hydroxyapatite as a Material for Transplantology: Clinical Experience and Prospects of Application. Preprints2023, 2023111701. https://doi.org/10.20944/preprints202311.1701.v1
APA Style
Markelov, V., Danilko, K., Solntzev, V., Piatnitskaia, S., Shangina, O., Bilyalov, A., Chugunov, S., & Akhatov, I. (2023). Hydroxyapatite as a Material for Transplantology: Clinical Experience and Prospects of Application. Preprints. https://doi.org/10.20944/preprints202311.1701.v1
Chicago/Turabian Style
Markelov, V., Svyatoslav Chugunov and Iskander Akhatov. 2023 "Hydroxyapatite as a Material for Transplantology: Clinical Experience and Prospects of Application" Preprints. https://doi.org/10.20944/preprints202311.1701.v1
Abstract
Abstract: The centrepiece of this analytical review is the metabolism of hydroxyapatite in its natural, bone, and synthetic forms, where the mitochondria-mediated mechanism may serve as the leading mechanism. The possibility that osteoblast mitochondria play an important role in the initial stages of bone mineralisation is discussed. Furthermore, the paper highlights the key role of mitochondria in the metabolism of synthetic hydroxyapatite.Differences between the results of in vivo and in vitro studies using synthetic hydroxyapatite of different morphologies are also detailed. It is noted that long-term infiltration with immune cells and in vivo studies are necessary to adequately evaluate hydroxyapatite as a bone-plastic material.Particular attention is given to the interaction of hydroxyapatite with immune cells and its ability to affect the ribosomes and mitochondria of cells. Due to its mechanical properties, scalability and potential use for the treatment of extensive bone defects of tumor origin, hydroxyapatite is a promising material.This study also highlights the importance of further development of in vitro research methods in the context of their biomimeticity. Overall, this work offers a theoretical direction for future studies of hydroxyapatite as a bone grafting material and emphasises the value of in vivo studies.
Keywords
hydroxyapatite; bone grafting; nanoparticles; immune response; mitochondria
Subject
Chemistry and Materials Science, Ceramics and Composites
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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