Version 1
: Received: 20 November 2023 / Approved: 21 November 2023 / Online: 21 November 2023 (13:20:03 CET)
How to cite:
Rezig, I.; Yaduma, W.; McInerny, C. Processes Controlling the Actin-Myosin Contractile Ring During Cytokinesis in Fission Yeast. Preprints2023, 2023111334. https://doi.org/10.20944/preprints202311.1334.v1
Rezig, I.; Yaduma, W.; McInerny, C. Processes Controlling the Actin-Myosin Contractile Ring During Cytokinesis in Fission Yeast. Preprints 2023, 2023111334. https://doi.org/10.20944/preprints202311.1334.v1
Rezig, I.; Yaduma, W.; McInerny, C. Processes Controlling the Actin-Myosin Contractile Ring During Cytokinesis in Fission Yeast. Preprints2023, 2023111334. https://doi.org/10.20944/preprints202311.1334.v1
APA Style
Rezig, I., Yaduma, W., & McInerny, C. (2023). Processes Controlling the Actin-Myosin Contractile Ring During Cytokinesis in Fission Yeast. Preprints. https://doi.org/10.20944/preprints202311.1334.v1
Chicago/Turabian Style
Rezig, I., Wandiahyel Yaduma and Christopher McInerny. 2023 "Processes Controlling the Actin-Myosin Contractile Ring During Cytokinesis in Fission Yeast" Preprints. https://doi.org/10.20944/preprints202311.1334.v1
Abstract
Cytokinesis, as the last stage of the cell division cycle, is a tightly controlled process amongst all eukaryotes, and defective division can lead to severe cellular consequences, and is implicated in serious human diseases and conditions such as cancer. Both mammalian cells and the fission yeast Schizosaccharomyces pombe use binary fission to divide into two equal sized daughter cells. In S. pombe such cytokinetic division is driven by the assembly of an actin-myosin contractile ring (ACR) at the cell equator between the two cell tips. The ACR is composed of a complex network of membrane scaffold proteins, actin filaments, myosin motors, and other cytokinesis regulators. Contraction of the ACR leads to the formation of a cleavage furrow which is severed leading to the final cell separation during the last stage of cytokinesis, abscission. This review describes recent findings defining the three phases to establish cytokinesis in S. pombe: ACR assembly, ACR constriction, and its coordination with septation. Collectively, we provide an overview of current understanding of the mechanisms regulating the ACR-mediated cytokinesis in S. pombe.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.