Version 1
: Received: 19 October 2023 / Approved: 19 October 2023 / Online: 23 October 2023 (05:18:14 CEST)
Version 2
: Received: 31 October 2023 / Approved: 1 November 2023 / Online: 1 November 2023 (05:25:53 CET)
How to cite:
Vagin, K.; Gaynutdinov, T.; Rakhmatullina, G.; Nizamov, R.; Gallyamova, M. Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints2023, 2023101368. https://doi.org/10.20944/preprints202310.1368.v1
Vagin, K.; Gaynutdinov, T.; Rakhmatullina, G.; Nizamov, R.; Gallyamova, M. Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints 2023, 2023101368. https://doi.org/10.20944/preprints202310.1368.v1
Vagin, K.; Gaynutdinov, T.; Rakhmatullina, G.; Nizamov, R.; Gallyamova, M. Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints2023, 2023101368. https://doi.org/10.20944/preprints202310.1368.v1
APA Style
Vagin, K., Gaynutdinov, T., Rakhmatullina, G., Nizamov, R., & Gallyamova, M. (2023). Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature. Preprints. https://doi.org/10.20944/preprints202310.1368.v1
Chicago/Turabian Style
Vagin, K., Rustam Nizamov and Marina Gallyamova. 2023 "Activation of the Immune System against the Background of Its Imbalance Caused by Agents of Radiation Nature" Preprints. https://doi.org/10.20944/preprints202310.1368.v1
Abstract
By conjugating a radioantigen (o-quinone) with a protein - Esherichia coli endotoxin, a stable polyantigen complex-protein-quinoid radioantigen (BChA) - o-quinone imine (C6H10O-NH - protein) was obtained, including haptenic (o-quinone) and protein part of the antigenic complex (Esherichia coli endotoxin).
Using the above components (hyperimmune antiradiotoxic serum, ethanol extract of the Vita-Force apiphitopreparation, metabolic products of Bifidobacterium bifidum, Bacillus subtilis and a highly dispersed fraction of bentonite), a polyfunctional composition «Polyapisogen» was compiled, including polyglobulins (500 cm3 per 1 L),500 cm3 of 4% ethanol extract of the Vita-Force apiphitopreparation, in which a highly dispersed fraction of bentonite (20 g), metabolism products (2 g powder) and Bacillus subtilis metabolism products (4 g) are dissolved.
The polyfunctional preparation obtained by the above-described technology is used as an activator of the immune system against the background of its imbalance induced by agents of a radiogenic nature.
It was found that a single subcutaneous injection of the drug at a dose of 25 mg / kg of live weight (dry matter basis) had a radioprotective effect increasing the survival rate of affected animals upto 75%.
The studies carried out can serve as a basis for the creation of polyfunctional radioprotective, immunoprotective and bioprotective agents not only for isolated, but also for combined lesions of the body by agents of radiogenic and non-radiogenic nature using polyglobulins, convalescent serums, bee products, metabolic products of probiotic microorganisms and mineral sorbents.
Keywords
activator of the immune system; subpopulations of lymphocytes; polyglobulins; T-helpers (CD4); T-suppressors (CD8); radioprotector; hemoprotector; immunohemopoiesis
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.