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Insight into the Critical Roles of Rab11 GTPase in Regulating Osteoclastogenesis through Modulating the Lysosome-Mediated Turnover of the Cell Surface Receptors
Version 1
: Received: 4 October 2023 / Approved: 9 October 2023 / Online: 10 October 2023 (06:09:04 CEST)
How to cite:
Tran, T.M. Insight into the Critical Roles of Rab11 GTPase in Regulating Osteoclastogenesis through Modulating the Lysosome-Mediated Turnover of the Cell Surface Receptors. Preprints2023, 2023100588. https://doi.org/10.20944/preprints202310.0588.v1
Tran, T.M. Insight into the Critical Roles of Rab11 GTPase in Regulating Osteoclastogenesis through Modulating the Lysosome-Mediated Turnover of the Cell Surface Receptors. Preprints 2023, 2023100588. https://doi.org/10.20944/preprints202310.0588.v1
Tran, T.M. Insight into the Critical Roles of Rab11 GTPase in Regulating Osteoclastogenesis through Modulating the Lysosome-Mediated Turnover of the Cell Surface Receptors. Preprints2023, 2023100588. https://doi.org/10.20944/preprints202310.0588.v1
APA Style
Tran, T.M. (2023). Insight into the Critical Roles of Rab11 GTPase in Regulating Osteoclastogenesis through Modulating the Lysosome-Mediated Turnover of the Cell Surface Receptors. Preprints. https://doi.org/10.20944/preprints202310.0588.v1
Chicago/Turabian Style
Tran, T.M. 2023 "Insight into the Critical Roles of Rab11 GTPase in Regulating Osteoclastogenesis through Modulating the Lysosome-Mediated Turnover of the Cell Surface Receptors" Preprints. https://doi.org/10.20944/preprints202310.0588.v1
Abstract
Osteoclasts (OCs) are the multinucleated, bone-resorbing giant cells originally differentiated from a monocyte/macrophage lineage. OC differentiation and maturation, also called osteoclastogenesis, are strictly regulated by a variety of signaling pathways primarily induced by the interactions of two prerequisite cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL) to their respective surface receptors, c-fms and RANK, in OC precursors (pre-OCs). Rab11 has emerged as the spatiotemporal regulators of intracellular vesicular transport in the endosomal recycling system; however, how it regulates osteoclastogenesis is incompletely understood. OC-triggered bone resorption is best characterized to be immensely dependent upon lysosomal function, the intracellular acidic organelles containing more than 50 acid hydrolases secreted into bone matrix microenvironment (BME). On the contrary, it is little known about the lysosomal function on modulating the turnover of c-fms and RANK surface receptors via Rab GTPase-mediated vesicular transport, thereby dictating osteoclastogenesis. In this review, I briefly describe the mechanism underlying lysosome-induced osteoclastogenesis via the Rab11-mediated modulation of the surface receptors in OCs.
Keywords
c-fms; RANK; Rab11; lysosomes and osteoclastogenesis
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
