Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Magnetic Resonance Based Analytical Tools to Study Polyvinylpyrrolidone—Hydroxyapatite Composites

Alina Petrova
,
Georgy Mamin
,
Oleg I. Gnezdilov
ORCID logo ,
Inna V. Fadeeva
,
Olga S. Antonova
,
Anna A. Forysenkova
,
Iulian V Antoniac
* ORCID logo ,
Julietta V. Rau
ORCID logo ,
Marat Gafurov
*
Version 1 : Received: 6 October 2023 / Approved: 6 October 2023 / Online: 9 October 2023 (09:13:04 CEST)

A peer-reviewed article of this Preprint also exists.

Petrova, A.; Mamin, G.; Gnezdilov, O.; Fadeeva, I.; Antonova, O.; Forysenkova, A.; Antoniac, I.V.; Rau, J.V.; Gafurov, M. Magnetic Resonance-Based Analytical Tools to Study Polyvinylpyrrolidone–Hydroxyapatite Composites. Polymers 2023, 15, 4445. Petrova, A.; Mamin, G.; Gnezdilov, O.; Fadeeva, I.; Antonova, O.; Forysenkova, A.; Antoniac, I.V.; Rau, J.V.; Gafurov, M. Magnetic Resonance-Based Analytical Tools to Study Polyvinylpyrrolidone–Hydroxyapatite Composites. Polymers 2023, 15, 4445.

Abstract

Synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine and material science. Composite films of bioresorbable polymer of polyvinylpyrrolidone (PVP) and hydroxyapatite (HA) were obtained. HA was synthesized in situ in a solution of polymer mixture. We applied electron paramagnetic resonance (EPR) and nuclear magnetic resonance (NMR) approaches to study their properties. EPR in two frequency ranges allowed to derive spectroscopic parameters of the nitrogen-based light and radiation-induced paramagnetic centers in HA, PVP and PVP-HA with high accuracy. It was shown that PVP did not significantly affect the EPR spectral and relaxation parameters of the radiation-induced centers in HA. Magic angle spinning (MAS) 1H NMR shows the presence of two signals at 4.7 ppm and -2.15 ppm attributed to “free” water and hydroxyl groups, while the single line - to 31P. NMR relaxation measurements for 1H and 31P show that the relaxation decays are a multicomponent process that can be described by three components of the transverse relaxation times. The obtained results demonstrated that the applied magnetic resonance methods can be used for the control of quality of the synthesis of the PVP-HA composites and, potentially, for the development of analytical tools to follow the processes of the sample treatment, resorption, and degradation.

Keywords

polyvinylpyrrolidone; hydroxyapatite; composites; NMR; EPR.

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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