Version 1
: Received: 14 September 2023 / Approved: 15 September 2023 / Online: 18 September 2023 (13:01:15 CEST)
Version 2
: Received: 23 March 2024 / Approved: 24 March 2024 / Online: 25 March 2024 (09:03:11 CET)
How to cite:
Kim, Y.Y.; Shin, H.S. Reduction of the Benzo[a]pyrene-Induced Hepatotoxicity by Neferine in Lotus and Daidzein, Genistein in Soybean. Preprints2023, 2023091105. https://doi.org/10.20944/preprints202309.1105.v1
Kim, Y.Y.; Shin, H.S. Reduction of the Benzo[a]pyrene-Induced Hepatotoxicity by Neferine in Lotus and Daidzein, Genistein in Soybean. Preprints 2023, 2023091105. https://doi.org/10.20944/preprints202309.1105.v1
Kim, Y.Y.; Shin, H.S. Reduction of the Benzo[a]pyrene-Induced Hepatotoxicity by Neferine in Lotus and Daidzein, Genistein in Soybean. Preprints2023, 2023091105. https://doi.org/10.20944/preprints202309.1105.v1
APA Style
Kim, Y.Y., & Shin, H.S. (2023). Reduction of the Benzo[<i>a</i>]pyrene-Induced Hepatotoxicity by Neferine in Lotus and Daidzein, Genistein in Soybean. Preprints. https://doi.org/10.20944/preprints202309.1105.v1
Chicago/Turabian Style
Kim, Y.Y. and Han Seung Shin. 2023 "Reduction of the Benzo[<i>a</i>]pyrene-Induced Hepatotoxicity by Neferine in Lotus and Daidzein, Genistein in Soybean" Preprints. https://doi.org/10.20944/preprints202309.1105.v1
Abstract
The objective of the this study was to reduce the benzo[a]pyrene-induced hepatotoxicity method in herbal medicine products and to give proof that neferine, daidzein, genistein possess antihepa-totoxic effects. B[a]P which classified as a group 1 carcinogen and metabolized to B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE) causes mutagenic DNA addition products. The reduc-tion of BPDE-DNA adduct formation by B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE) was derived by benzo[a]pyrene (B[a]P). In HepG2 cells, B[a]P exhibited toxicity and substance treatment of the cells with B[a]P with neferine in lotus and daidzein, genistein in soybean reduced the BPDE-DNA ad-ducts level. The level of B[a]P-metabolites in the substance treatment of the cells was presented that BPDE levels were reduced by neferine in lotus and daidzein, genisten in soybean. These results suggest that neferine in lotus and daidzein, genistein in soybean prevent B[a]P-induced hepato-toxicity for BPDE-DNA adduct formation.
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
