Version 1
: Received: 8 September 2023 / Approved: 11 September 2023 / Online: 11 September 2023 (13:40:41 CEST)
How to cite:
Mutery, A.A.; Hussain, I.; Mumtaz, K. Advancements in Brain Diseases: Exploring the Complexities and Pursuing Therapeutic Breakthroughs. Preprints2023, 2023090701. https://doi.org/10.20944/preprints202309.0701.v1
Mutery, A.A.; Hussain, I.; Mumtaz, K. Advancements in Brain Diseases: Exploring the Complexities and Pursuing Therapeutic Breakthroughs. Preprints 2023, 2023090701. https://doi.org/10.20944/preprints202309.0701.v1
Mutery, A.A.; Hussain, I.; Mumtaz, K. Advancements in Brain Diseases: Exploring the Complexities and Pursuing Therapeutic Breakthroughs. Preprints2023, 2023090701. https://doi.org/10.20944/preprints202309.0701.v1
APA Style
Mutery, A.A., Hussain, I., & Mumtaz, K. (2023). Advancements in Brain Diseases: Exploring the Complexities and Pursuing Therapeutic Breakthroughs. Preprints. https://doi.org/10.20944/preprints202309.0701.v1
Chicago/Turabian Style
Mutery, A.A., Irfan Hussain and Kainaat Mumtaz. 2023 "Advancements in Brain Diseases: Exploring the Complexities and Pursuing Therapeutic Breakthroughs" Preprints. https://doi.org/10.20944/preprints202309.0701.v1
Abstract
Brain disorders pose a significant global healthcare challenge due to their complexity and profound impact on individuals and society. This review explores recent advancements in brain disease research, deepening our understanding and progress towards treatments. Technological innovations, like high-resolution imaging and optogenetics, play a pivotal role in illuminating cellular structures and dissecting neural circuits. Genetic analysis identifies dis-ease-associated genes and mutations, yet translating findings to clinical applications remains challenging. Epigenomics, transcriptomics, and proteomics provide molecular insights, un-covering disrupted pathways in conditions like Alzheimer's disease. Stem cell models elucidate developmental mechanisms, and immunotherapies, including CAR T cells, emerge as prom-ising strategies for brain cancers like glioblastoma. Genome editing tools, exemplified by CRISPR, enable precise modification of disease genes in models, deepening our understanding of pathogenesis. Multifaceted approaches integrating human studies, animal models, and bi-oinformatics propel the field forward. However, complexities persist, as disease specificity for cell types or brain regions remains an enigma, and genetic factors interact with environmental influences, highlighting disease intricacies. Ultimately, interdisciplinary efforts combining bi-ophysical and psychospiritual perspectives are essential to fully understand brain health and unlock transformative treatments for these debilitating disorders. A comprehensive under-standing of brain disorders is vital to improve the quality of life for millions and alleviate the global burden of neurological afflictions. Continued collaborative research will lead to an era of improved brain health worldwide.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
