Valladares, N.; Cabrero, M.A.; Jacobo-Jimenez, G.J.; Zavala-Cerna, M.G. Rapid Recovery after Reparation of Full-Thickness Chondral Defects of the Knee with the Use of Hyaluronan (HA)-Based 3-D Scaffold. J. Funct. Biomater.2023, 14, 491.
Valladares, N.; Cabrero, M.A.; Jacobo-Jimenez, G.J.; Zavala-Cerna, M.G. Rapid Recovery after Reparation of Full-Thickness Chondral Defects of the Knee with the Use of Hyaluronan (HA)-Based 3-D Scaffold. J. Funct. Biomater. 2023, 14, 491.
Valladares, N.; Cabrero, M.A.; Jacobo-Jimenez, G.J.; Zavala-Cerna, M.G. Rapid Recovery after Reparation of Full-Thickness Chondral Defects of the Knee with the Use of Hyaluronan (HA)-Based 3-D Scaffold. J. Funct. Biomater.2023, 14, 491.
Valladares, N.; Cabrero, M.A.; Jacobo-Jimenez, G.J.; Zavala-Cerna, M.G. Rapid Recovery after Reparation of Full-Thickness Chondral Defects of the Knee with the Use of Hyaluronan (HA)-Based 3-D Scaffold. J. Funct. Biomater. 2023, 14, 491.
Abstract
Articular cartilage injuries are found in up to 60 % of patients who undergo an arthroscopic knee procedure, those that totally affect articular cartilage (grade IV) have limited regenerative capac-ity and extended time for recovery, 3-D scaffolds represent a novel solution to address this type of injury. Our purpose was to analyze MRI findings and functional status of patients that underwent repair of chondral defects either by microfractures or Hyaluronan (HA) 3-D Scaffold. We con-ducted a retrospective study of patients with chondral defects. The outcomes analyzed in this study included anatomical changes envaulted by the Henderson score (based on MRI findings) at baseline, 6, and 12 months after surgery; and improvement in functionality, evaluated by the Modified Cincinnati Knee Rating System (MCKRS) at baseline and 6 months after surgery. Clini-cal and demographic characteristics were similar for both groups. There was a statistically sig-nificant improvement in Henderson score for the 3-D scaffolding treated group at 6 months, ver-sus the microfracture group (p < 0.0001). Improvement in functionality, measured by MCKRS was more frequently found in the 3-D scaffold treated group. In conclusion the use of HA 3-D scaf-folding was superior with faster recovery, evident after 6 months of the surgery, that progress to full recovery in all patients after a year of surgery. Future studies with a randomized design might help to sustain our findings. This study provides a level III of evidence.
Medicine and Pharmacology, Orthopedics and Sports Medicine
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