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An integrative taxonomic analysis of Honduran Central America parasite isolated from non-ulcerated cutaneous leishmaniasis points to Leishmania (Leishmania) poncei n. sp. (Kinetoplastea: Trypanosomatidae)
Version 1
: Received: 22 August 2023 / Approved: 23 August 2023 / Online: 24 August 2023 (03:43:47 CEST)
How to cite:
Silveira, F. T.; Vasconcelos dos Santos, T.; Flores, G. V. A.; Pacheco, C. M. S.; Ochoa, W. H. S.; Sousa, E. C.; Valeriano, C. Z.; Da Matta, V. L. R.; Gomes, C. M. C.; Ramos, P. K.; Lima, L. V.; Campos, M. B.; Corbett, C. E. P.; Laurenti, M. D. An integrative taxonomic analysis of Honduran Central America parasite isolated from non-ulcerated cutaneous leishmaniasis points to Leishmania (Leishmania) poncei n. sp. (Kinetoplastea: Trypanosomatidae). Preprints2023, 2023081673. https://doi.org/10.20944/preprints202308.1673.v1
Silveira, F. T.; Vasconcelos dos Santos, T.; Flores, G. V. A.; Pacheco, C. M. S.; Ochoa, W. H. S.; Sousa, E. C.; Valeriano, C. Z.; Da Matta, V. L. R.; Gomes, C. M. C.; Ramos, P. K.; Lima, L. V.; Campos, M. B.; Corbett, C. E. P.; Laurenti, M. D. An integrative taxonomic analysis of Honduran Central America parasite isolated from non-ulcerated cutaneous leishmaniasis points to Leishmania (Leishmania) poncei n. sp. (Kinetoplastea: Trypanosomatidae). Preprints 2023, 2023081673. https://doi.org/10.20944/preprints202308.1673.v1
Silveira, F. T.; Vasconcelos dos Santos, T.; Flores, G. V. A.; Pacheco, C. M. S.; Ochoa, W. H. S.; Sousa, E. C.; Valeriano, C. Z.; Da Matta, V. L. R.; Gomes, C. M. C.; Ramos, P. K.; Lima, L. V.; Campos, M. B.; Corbett, C. E. P.; Laurenti, M. D. An integrative taxonomic analysis of Honduran Central America parasite isolated from non-ulcerated cutaneous leishmaniasis points to Leishmania (Leishmania) poncei n. sp. (Kinetoplastea: Trypanosomatidae). Preprints2023, 2023081673. https://doi.org/10.20944/preprints202308.1673.v1
APA Style
Silveira, F. T., Vasconcelos dos Santos, T., Flores, G. V. A., Pacheco, C. M. S., Ochoa, W. H. S., Sousa, E. C., Valeriano, C. Z., Da Matta, V. L. R., Gomes, C. M. C., Ramos, P. K., Lima, L. V., Campos, M. B., Corbett, C. E. P., & Laurenti, M. D. (2023). An integrative taxonomic analysis of Honduran Central America parasite isolated from non-ulcerated cutaneous leishmaniasis points to Leishmania (Leishmania) poncei n. sp. (Kinetoplastea: Trypanosomatidae). Preprints. https://doi.org/10.20944/preprints202308.1673.v1
Chicago/Turabian Style
Silveira, F. T., Carlos Eduardo P Corbett and Márcia Dalastra Laurenti. 2023 "An integrative taxonomic analysis of Honduran Central America parasite isolated from non-ulcerated cutaneous leishmaniasis points to Leishmania (Leishmania) poncei n. sp. (Kinetoplastea: Trypanosomatidae)" Preprints. https://doi.org/10.20944/preprints202308.1673.v1
Abstract
Non-ulcerated cutaneous leishmaniasis (NUCL) is an atypical and peculiar clinical form of the disease that was first described by Ponce et al. (1988) in Honduras (Central America), where iso-lated or disseminated popular and/or nodular skin lesions are commonly seen in adolescents and young adults. Leishmania (L.) chagasi was then incriminated as the causal agent of the disease, as well as of American visceral leishmaniasis (AVL), although NUCL has been shown to be more prevalent than AVL in the region. Considering, however, the dubious taxonomic character of the causal agent of NUCL, as there is no evidence of this form of disease associated with L. (L.) cha-gasi in South America, this study aimed to carry out a retrospective taxonomic analysis on a se-ries of studies on the diagnostic approach to the Honduran parasite in loco (El Tigre island, Amapala municipality, west coast of Honduras), where taxonomic characters of a biological (in vitro and in vivo), epidemiological (vector and canine reservoir), clinical-immunological (im-munopathological features of in situ skin lesion and systemic infection) and molecular (ge-nomic/phylogenetic analyses) nature were considered. The findings, particularly those of mo-lecular nature, such as: the Honduran parasite showed to be more ancestral (molecular clock analysis of the DNA polymerase alpha subunit gene) than all viscerotropic ones [L. (L.) chagasi, L. (L.) donovani and L. (L.) infantum], as well as presenting an absolutely unprecedented structural variation on chromosome 17 and the highest frequency of genomic SNPs (more than twice the number seen in the Brazilian parasite), in addition to representing a different phylogenetic lin-eage (mainly in the NJ - RNA Pol II tree) from those viscerotropic ones, have pointed to the characterization of a new leishmanine parasite, Leishmania (Leishmania) poncei n. sp. (Kinetoplas-tea: Trypanosomatidae), in honor of Professor Ponce, who was the first researcher to describe NUCL in Honduras.
Keywords
Non-ulcerated cutaneous leishmaniasis; visceral leishmaniasis; biological, epidemiological, clinical-immunological, and molecular taxonomic analysis; Leishmania (Leishmania) poncei; Honduras; Central America
Subject
Biology and Life Sciences, Parasitology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.