The Post-translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms

Irene Messana; Barbara Manconi; Tiziana Cabras; Mozhgan Boroumand; Maria Teresa Sanna; Federica Iavarone; Alessandra Olianas; Claudia Desiderio; Diana Valeria Rossetti; Federica Vincenzoni; Cristina Contini; Giulia Guadalupi; Antonella Fiorita; Gavino Faa; Massimo Castagnola

doi:10.20944/preprints202308.0600.v1

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preprints.org > biology and life sciences > biochemistry and molecular biology > doi: 10.20944/preprints202308.0600.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Post-translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms

^* ,

Diana Valeria Rossetti

Version 1 : Received: 5 August 2023 / Approved: 7 August 2023 / Online: 8 August 2023 (04:04:59 CEST)

A peer-reviewed article of this Preprint also exists.

Messana, I.; Manconi, B.; Cabras, T.; Boroumand, M.; Sanna, M.T.; Iavarone, F.; Olianas, A.; Desiderio, C.; Rossetti, D.V.; Vincenzoni, F.; Contini, C.; Guadalupi, G.; Fiorita, A.; Faa, G.; Castagnola, M. The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms. Int. J. Mol. Sci. 2023, 24, 12776. Messana, I.; Manconi, B.; Cabras, T.; Boroumand, M.; Sanna, M.T.; Iavarone, F.; Olianas, A.; Desiderio, C.; Rossetti, D.V.; Vincenzoni, F.; Contini, C.; Guadalupi, G.; Fiorita, A.; Faa, G.; Castagnola, M. The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms. Int. J. Mol. Sci. 2023, 24, 12776.

Abstract

In this review we extensively describe the main post-translational modifications that give rise to the multiple proteoforms characterized to date in the human salivary proteome and their potential role. Most of the data reported were obtained by our group in over twenty-five years of research carried out on human saliva mainly by applying a top-down strategy. At the beginning we describe the products generated by proteolytic cleavages, which can occur before and after secretion. In this section the most relevant families of salivary proteins are also described. Next, we report the current information concerning the human salivary phospho-proteome and the limited news available on sulfo-proteome. Three sections are dedicated to the description of the glycation and enzymatic glycosylation. Citrullination and N- and C- terminal PTMs and a miscellaneous of other modifications are described in the last two sections. Results highlighting the variation in the level of some proteoforms in local or systemic pathologies are also reviewed along the sections of manuscript to underline the impact and relevance of this information for the development of new diagnostic biomarkers useful in clinical practice.

Keywords

salivary proteins; top-down proteomics; post-translational modifications

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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