Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

It’s written in the Clot: Rotational Thromboelastometry in Severe Burn Injury – A Holistic Coagulation Assessment

Eirini Nikolaidou
* ORCID logo ,
Andriana Lazaridou
,
Christina Iasonidou
,
Alexandra Tsaroucha
,
Sophia Papadopoulou
ORCID logo ,
Eleni Kaldoudi
,
Apostolos Sovatzidis
ORCID logo ,
Despoina Kakagia
Version 1 : Received: 24 July 2023 / Approved: 25 July 2023 / Online: 26 July 2023 (07:31:04 CEST)

How to cite: Nikolaidou, E.; Lazaridou, A.; Iasonidou, C.; Tsaroucha, A.; Papadopoulou, S.; Kaldoudi, E.; Sovatzidis, A.; Kakagia, D. It’s written in the Clot: Rotational Thromboelastometry in Severe Burn Injury – A Holistic Coagulation Assessment. Preprints 2023, 2023071771. https://doi.org/10.20944/preprints202307.1771.v1 Nikolaidou, E.; Lazaridou, A.; Iasonidou, C.; Tsaroucha, A.; Papadopoulou, S.; Kaldoudi, E.; Sovatzidis, A.; Kakagia, D. It’s written in the Clot: Rotational Thromboelastometry in Severe Burn Injury – A Holistic Coagulation Assessment. Preprints 2023, 2023071771. https://doi.org/10.20944/preprints202307.1771.v1

Abstract

The alterations of coagulation status in patients with Severe Burn Injury are associated with serious complications, increased morbidity and mortality. This study aims to compare Rotational Thromboelastometry(ROTEM)–a Viscoelastic Coagulation Assays(VCAs) with Conventional Coagulation Assays(CCAs) including Prothrombin time(PT), Activated Partial Thromboplastin time(aPTT), International normalized ratio(INR), Complete Blood Count(CBC) and Coagulation Factors during the early five post- burn days in Survivors and Non- Survivors with Severe Burn Injury in order to correlate these results with Burn Coagulopathy and Prognosis. Seventeen Sur-vivors and ten Non- Survivors, with a mean Total Burn Surface Area(TBSA) of 33,78% were in-cluded in our study. Even though CCAs measurements were abnormal, they were unable to detect overall burn patients’ coagulopathy. On the contrary, VCAs from day 2 to day 5 took pathological values, especially for Non- survivors. Those changes were underlined through pathological values of Coagulation Factors. As a result, CCAs were considered poor indicators of coagulation status in burn injury, whereas VCAs were more accurate in demonstrating coagulation alterations from the early post- burn period and detecting patients in greater risk of mortality. These advantages of VCAs could be used for timely intervention in high risk patients and for the guidance of blood product transfusions.

Keywords

Severe Burn Injury; coagulation; Rotational Thromboelastometry; Viscoelastic Coagulation Assays; Conventional Coagulation Assays; Coagulation Factors

Subject

Medicine and Pharmacology, Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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