PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
A Behavioral Test Score Could Be Linked to the Protein Expression Value of p62 and GLAST in the Brain of Mice with Neuropsychiatric Disorders-Related Behaviors
Version 1
: Received: 14 July 2023 / Approved: 17 July 2023 / Online: 17 July 2023 (11:00:23 CEST)
How to cite:
Ikeda, Y.; Yoshikawa, S.; Taniguchi, K.; Suga, N.; Matsuda, S. A Behavioral Test Score Could Be Linked to the Protein Expression Value of p62 and GLAST in the Brain of Mice with Neuropsychiatric Disorders-Related Behaviors. Preprints2023, 2023071075. https://doi.org/10.20944/preprints202307.1075.v1
Ikeda, Y.; Yoshikawa, S.; Taniguchi, K.; Suga, N.; Matsuda, S. A Behavioral Test Score Could Be Linked to the Protein Expression Value of p62 and GLAST in the Brain of Mice with Neuropsychiatric Disorders-Related Behaviors. Preprints 2023, 2023071075. https://doi.org/10.20944/preprints202307.1075.v1
Ikeda, Y.; Yoshikawa, S.; Taniguchi, K.; Suga, N.; Matsuda, S. A Behavioral Test Score Could Be Linked to the Protein Expression Value of p62 and GLAST in the Brain of Mice with Neuropsychiatric Disorders-Related Behaviors. Preprints2023, 2023071075. https://doi.org/10.20944/preprints202307.1075.v1
APA Style
Ikeda, Y., Yoshikawa, S., Taniguchi, K., Suga, N., & Matsuda, S. (2023). A Behavioral Test Score Could Be Linked to the Protein Expression Value of p62 and GLAST in the Brain of Mice with Neuropsychiatric Disorders-Related Behaviors. Preprints. https://doi.org/10.20944/preprints202307.1075.v1
Chicago/Turabian Style
Ikeda, Y., Naoko Suga and Satoru Matsuda. 2023 "A Behavioral Test Score Could Be Linked to the Protein Expression Value of p62 and GLAST in the Brain of Mice with Neuropsychiatric Disorders-Related Behaviors" Preprints. https://doi.org/10.20944/preprints202307.1075.v1
Abstract
Neuropsychiatric disorders are globally public-health concern, in which diagnosis might be based on symptoms that often vary across individuals. Schizophrenia is one of the major neuropsychiatric disorders, which may affect millions worldwide. Detection of predictive biomarkers is the most intensively developing approach for the disease. However, the biochemical alterations have not been comprehensively distinguished up to the present time. In addition, there is less confidence of finding a specific biomarker for neuropsychiatric disorders including schizophrenia, but rather a specific characteristic behavioral pattern. Maternal immune activation has been considered to be one of the important factors for the development of neuropsychiatric disorders. Here, the mouse model of neuropsychiatric disorders has been built, in which poly-I:C, sodium dextran sulfate (DSS) and κ-carrageenan (CGN) were used for the maternal immune activation during the pregnancy of individuals. Subsequently, we challenged to link some of biochemical changes of p62 and GLAST in the offspring mice brain to the alteration of several pathological behaviors. Consequently, it has been shown that autophagy might be involved in the development of neuropsychiatric disorders including schizophrenia. To our knowledge, this is the first report of the significant correlation between pathological behavior and the biochemical alterations in neuropsychiatric disorder model animals. The relative ease of conducting these evaluation-tasks would make them useful for testing novel therapeutics designed to ameliorate the symptoms of several psychiatric disorders.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
