Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Design of Cobalt Oxide Functionalized Carbon Paste Electrode for the Detection of Levofloxacin

Tijana Mutić
ORCID logo ,
Dalibor Stanković
* ORCID logo ,
Dragan Manojlović
ORCID logo ,
Djordje Petrić
,
Ferenc Pastor
,
Vyacheslav V. Avdin
,
Miloš Ognjanović
ORCID logo ,
Vesna Stanković
*
Version 1 : Received: 7 July 2023 / Approved: 10 July 2023 / Online: 11 July 2023 (10:22:36 CEST)

How to cite: Mutić, T.; Stanković, D.; Manojlović, D.; Petrić, D.; Pastor, F.; Avdin, V.V.; Ognjanović, M.; Stanković, V. Design of Cobalt Oxide Functionalized Carbon Paste Electrode for the Detection of Levofloxacin. Preprints 2023, 2023070682. https://doi.org/10.20944/preprints202307.0682.v1 Mutić, T.; Stanković, D.; Manojlović, D.; Petrić, D.; Pastor, F.; Avdin, V.V.; Ognjanović, M.; Stanković, V. Design of Cobalt Oxide Functionalized Carbon Paste Electrode for the Detection of Levofloxacin. Preprints 2023, 2023070682. https://doi.org/10.20944/preprints202307.0682.v1

Abstract

In this work we successfully prepared a modified cobalt oxide (Co3O4) carbon paste electrode to detect Levofloxacin (LEV). By synthesizing Co3O4 nanoparticles through the chemical coprecipitation method, the electrochemical properties of the electrode and LEV were thoroughly investigated using CV, SWV, EIS, while material properties were scrutinized using ICP-OES, TEM, SEM, and XRD. The results showed that the prepared electrode displayed a better electrocatalytic response than the bare carbon paste electrode. After optimizing SWV, the electrode exhibited a wide linear working range from 1 to 85 μM at pH 5 of BRBS as the supporting electrolyte. The selectivity of the proposed method was satisfactory, with good repeatability and reproducibility, strongly suggesting a potential application for determining LEV in real samples, particularly in pharmaceutical formulations. The practicality of the approach was demonstrated through good recoveries, and the morphology of the materials was found to be closely related to other parameters, indicating that the developed method can provide a cost-effective, rapid, selective, and sensitive means for LEV monitoring. Overall, this project has made significant progress towards developing a reliable method for detecting LEV and has opened up new opportunities for future research in this field.

Keywords

electrochemical sensor; carbon paste electrode; antibiotics

Subject

Chemistry and Materials Science, Analytical Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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