Version 1
: Received: 29 June 2023 / Approved: 29 June 2023 / Online: 29 June 2023 (11:50:24 CEST)
How to cite:
Saleh, Z.T.; Altarawneh, F.Z.; Elshatarat, R.A.; Alahmadi, H.A.; Al-Za’areer, M.S.; Yacoub, M.I.; Elneblawi, N.H.; Saifan, A.; Abdel-Aziz, H.R.; Saleh, A. Exploring the Neurobiology of Nicotine Dependence and Its Implications for Tobacco Use Treatment: A Literature Review Article. Preprints2023, 2023062137. https://doi.org/10.20944/preprints202306.2137.v1
Saleh, Z.T.; Altarawneh, F.Z.; Elshatarat, R.A.; Alahmadi, H.A.; Al-Za’areer, M.S.; Yacoub, M.I.; Elneblawi, N.H.; Saifan, A.; Abdel-Aziz, H.R.; Saleh, A. Exploring the Neurobiology of Nicotine Dependence and Its Implications for Tobacco Use Treatment: A Literature Review Article. Preprints 2023, 2023062137. https://doi.org/10.20944/preprints202306.2137.v1
Saleh, Z.T.; Altarawneh, F.Z.; Elshatarat, R.A.; Alahmadi, H.A.; Al-Za’areer, M.S.; Yacoub, M.I.; Elneblawi, N.H.; Saifan, A.; Abdel-Aziz, H.R.; Saleh, A. Exploring the Neurobiology of Nicotine Dependence and Its Implications for Tobacco Use Treatment: A Literature Review Article. Preprints2023, 2023062137. https://doi.org/10.20944/preprints202306.2137.v1
APA Style
Saleh, Z.T., Altarawneh, F.Z., Elshatarat, R.A., Alahmadi, H.A., Al-Za’areer, M.S., Yacoub, M.I., Elneblawi, N.H., Saifan, A., Abdel-Aziz, H.R., & Saleh, A. (2023). Exploring the Neurobiology of Nicotine Dependence and Its Implications for Tobacco Use Treatment: A Literature Review Article. Preprints. https://doi.org/10.20944/preprints202306.2137.v1
Chicago/Turabian Style
Saleh, Z.T., Hassanat R. Abdel-Aziz and Ahmad Saleh. 2023 "Exploring the Neurobiology of Nicotine Dependence and Its Implications for Tobacco Use Treatment: A Literature Review Article" Preprints. https://doi.org/10.20944/preprints202306.2137.v1
Abstract
The prolonged exposure to nicotine and the development of nicotine dependence have significant implications for cancer risk. Tobacco use, driven by nicotine addiction, is a major contributing factor to the development of various types of cancer. Smoking tobacco, in particular, has been strongly associated with an increased risk of lung cancer, as well as other malignancies. The harmful chemicals present in tobacco products, including carcinogens, can cause DNA damage and promote the initiation and progression of cancerous cells. This article presents a comprehensive literature review on the neurobiology of nicotine dependence and its implications for tobacco use treatment. Nicotine dependence is a complex phenomenon involving various neurobiological mechanisms. When nicotine enters the body, it binds to nicotinic acetylcholine receptors in the brain's reward circuitry, triggering the release of neurotransmitters like dopamine, serotonin, and norepinephrine. Over time, repeated nicotine exposure leads to neuroadaptive changes in the brain, resulting in increased motivation to seek and use the drug. Understanding the neurobiology of nicotine dependence is crucial for developing effective treatment strategies. Pharmacological interventions, such as nicotine replacement therapy and medications like bupropion and varenicline, can help individuals manage cravings and withdrawal symptoms. Additionally, behavioral therapies and counseling play a vital role in enhancing self-efficacy and providing support for smoking cessation efforts. By reviewing the existing literature, this article sheds light on the intricate neural pathways and processes involved in nicotine addiction. It emphasizes the importance of a multidimensional approach that combines pharmacological treatments and behavioral interventions to address the physiological and psychological aspects of nicotine dependence. This knowledge can inform the development of more targeted and personalized treatment approaches to help individuals overcome tobacco addiction and improve their chances of successful smoking cessation.
Keywords
Cancer; tobacco use; neurobiology of nicotine dependence; nicotine addiction; tobacco use treatment; smoking cessation; literature review article
Subject
Public Health and Healthcare, Nursing
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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