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Version 1
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D-type Cyclins in Development and Disease
Version 1
: Received: 24 June 2023 / Approved: 25 June 2023 / Online: 25 June 2023 (03:20:27 CEST)
A peer-reviewed article of this Preprint also exists.
Saleban, M.; Harris, E.L.; Poulter, J.A. D-Type Cyclins in Development and Disease. Genes 2023, 14, 1445. Saleban, M.; Harris, E.L.; Poulter, J.A. D-Type Cyclins in Development and Disease. Genes 2023, 14, 1445.
Abstract
D-type cyclins encode G1/S cell cycle checkpoint proteins, that play a crucial role in defining cell cycle exit and progression. Precise control of cell cycle exit is vital during embryonic development, with defects in the pathways regulating intracellular D-type cyclins resulting in abnormal initiation of stem cell differentiation in a variety of different organ systems. Furthermore, stabilisation of D-type cyclins is observed in a wide range of disorders characterised by cellular over-proliferation, including cancers and overgrowth disorders. In this review, we will summarise and compare the roles played by each D-type cyclin during development and provide examples of how their intracellular dysregulation can be an underlying cause of disease.
Keywords
Cyclin D1; Cyclin D2; Cyclin D3; CDK4; cell cycle; proliferation; cancer; overgrowth
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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